Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      I will believe it when I can hear it.

      Brainstorm is supposed to cure and reverse ALS. Now the articles are not as optimistic.
       
    2. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      The money that investors have put into Frequency Therapeutics goes into the company, not individuals' pockets. Unless they're paying themselves million dollar salaries, and I think the investors are sophisticated enough to be onto that. These guys reputations are too important to them. Karp and Langer spin out companies all the time. Any hint of dishonesty and no more investors. They might emphasise the potential of their products rather than the roadblocks along the way. That's to be expected. You're right to 'believe it when you see it' because until it's approved there are no guarantees, but I don't see any reason not to be cautiously optimistic.
       
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    3. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      I just have a good feeling about this company and what they are saying is true and this drug does actually work. We just don't know how much of an improvement to our hearing we will get using this drug. You're right if they mislead people they lose investors and their reputation is on the line no doubt.
       
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    4. Ken219
      Frustrated

      Ken219 Member

      Location:
      New York Area
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      Summer of 1990
      Cause of Tinnitus:
      Noise exposure?
      Spot on girl!
       
    5. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      I agree. Be optimistic, but also skeptical. It is big business, and they are in it to make money. They want to cure hearing loss, because they will make more money. But don't be surprised if in a few years they announce it is not working they way it needs to to be approved and put on the market. Happens all the time. But let's hope it does work and we can all get the little hairs to regrow and hear like a 20-year-old again.

      Cheers to that!
       
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    6. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
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      They never once stated that they have a "magical miracle cure" or anything like that. They have only stated that they saw an improvement in hearing in subjects in their last trial and this is in line with years of animal tests with this exact same type of drug. Why would you even say that?
       
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    7. Misticvega

      Misticvega Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Probably noise exposure?
      Fixed it for you, some of us are in our 20's ;)
       
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    8. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      I am skeptical, and I had not discovered and read your 50 page thread about your treatment.
       
    9. Street Novelist
      Depressed

      Street Novelist Member

      Location:
      Bay Area
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      February 2018
      Cause of Tinnitus:
      Listening to loud music through headphones
      I wish they would tell us when the next trial is going to be held.
       
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    10. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
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      May 1st 2018
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      Aspirin Toxicity/Possibly Noise
      My thread about my treatment has nothing to do with FX-322. Can I help you sir?
       
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    11. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      No I never knew that these types of treatments had come as far along as they have. To see your progress is a potential sign the FX-322 trials may be successful.

      I am new to all this tinnitus stuff. I have had some experience watching clinical trials.
       
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    12. punkaddict
      Cynical

      punkaddict Member

      Tinnitus Since:
      03/2019
      Cause of Tinnitus:
      Self-syringing (I think?)
      Anyone else had dreams of being injected with a drug to the ear and getting tinnitus cured?
      Had one a while ago, before even knowing about FX-322, Otonomy etc.

      Hopefully it's a sign :angelic:
       
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    13. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
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      Cause of Tinnitus:
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      Why isn't there anything going on to promote awareness of this in the tinnitus world?
       
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    14. spedgas
      Gloomy

      spedgas Member Benefactor

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      I guess because it’s still in an early trial phase. Perhaps it’s because we don’t know what effects it’s had on the few dozen people who have received it. It could be due to the fact that they don’t have any conclusions yet on dosages required. Or it could be that it’s a drug being designed to restore hearing and could potentially carry an off label use for tinnitus. It’s not being promoted because there are too many unknowns and it’s years away if it is ever marketed at all.
       
    15. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

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      Exactly, the answers to these questions could come much faster with the right kind of promotion and attention.

      You're basically saying that the reason that we shouldn't try to get more attention focused on this stuff to speed up the answering of these questions is because we don't know the answers to these questions.
       
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    16. spedgas
      Gloomy

      spedgas Member Benefactor

      Tinnitus Since:
      09/2018
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      Unknown
      You can focus all the attention you want on it. We all can. It won’t cause Frequency Therapeutics to rush the process just because they get more attention. If it proves to be effective they will know what they have and get it out there. They will get lots of attention then. Hopefully the competition they have gets them to speed up the process.

      What I’m saying is that right now they are just another drug research company working on a drug that may someday be helpful. They are no different than any other group out there developing drugs. There is nothing to promote or draw attention to.

      Drawing attention to them will not get them to divulge their information any faster.
       
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    17. Telis

      Telis Member Hall of Fame

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      11/2013
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      Drugs barotrauma
      I thought you found the cure to hearing loss in Korea and wanted promote awareness to that treatment?
       
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    18. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
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      Why can't I be all for all hearing regeneration technology? FX-322 may even be superior to bone marrow/PRP treatments, requiring far less procedures, and no bone marrow extractions.

      I've already stated my research implicates components of PRP act on LGR5+stem cells just like FX-322.

      They have to mix FX-322 with a gel to keep it in the middle ear. What if mixing FX-322 with PRP is even better because of PRP's healing effect on the eardrum?
       
      Last edited: Jun 19, 2019
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    19. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      A high dose FX-322 mixed with PRP. Who is not dreaming of it on this forum?

      Unfortunately we do not hear much about phase 2a.
       
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    20. Ken219
      Frustrated

      Ken219 Member

      Location:
      New York Area
      Tinnitus Since:
      Summer of 1990
      Cause of Tinnitus:
      Noise exposure?
      Those who control the money take the money.
       
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    21. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      There are some bright brains at Frequency Therapeutics. But O´boy do they like to go slow... :banghead:
       
    22. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

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      It's just the way it is. Otonomy is moving slow too.
      It's a combination of investors and the FDA.

      If I had millions of dollars I would take these drugs off the shelf that have been safety tested in mice and have humans injected and the results published in 3 months flat. I wouldn't worry about IP or a business model. Rich people spend ridiculous money on nonsense that does nothing all the time. I would be more than happy to blow a fortune on a cure for tinnitus and then make the product open source for any company to produce at the lowest possible price.
       
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    23. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
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      They likely will announce the details in September around the same time as their presentation of the phase 1 findings.
       
    24. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Summer vacation, they are on Cape Cod, or various beautiful places, eating farmers market foods, fresh fish and enjoying their well earned quality cars. Sorry man, they ain't gonna sacrifice their well earned lives for a bunch of cochlear zombies with blood dripping from their ears.
       
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    25. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

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      Too slow, they know now.

      Nice how business considerations take precedent over helping people that are suffering.
       
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    26. Street Novelist
      Depressed

      Street Novelist Member

      Location:
      Bay Area
      Tinnitus Since:
      February 2018
      Cause of Tinnitus:
      Listening to loud music through headphones
      Are they going to start the next trial this year? I don't care if they wait until September to announce the results of the last trial. We already know it was a success.
       
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    27. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      What controls the money though? I don't think the investors just hand over money without knowing in some detail how it's going to be spent. And if Frequency Therapeutics just siphon off money for themselves I think those investors can afford some very good lawyers.
       
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    28. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
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      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      I've read that's the plan.
       
    29. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      Yeah! The idea of fast tracking seems to differ among us. Nothing published of fast tracking status anyway. The end of phase 1/2 was published in April but the trial was finished months before. When details of phase 2a will be published in September, it might mean a start of the trial at the end of 2019. So a little less than a year. I do think that the FDA is the bottleneck. Really hope for a change in law. Or a scenario like: Mr. President re-elected, and then one morning getting sudden hearing loss + tinnitus...
       
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    30. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      Aren’t they in full Phase 2 right now? Is that supposed to end in September?

      With phase 1/2 completed earlier this year, around the time of the $40 million USD investment?
       
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