Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      Sure, but the generic company wouldn't go for it if it was that much more profitable to not accept the bribe as it would be here.

      Also, unlike the generic drug example the reputations of some big name researchers are at stake here.
       
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    2. Bndsmheowqhe

      Bndsmheowqhe Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Loud noise exposure
      The problem is that tinnitus isn't sexy enough. People are addicted to the chemical rush they experience when they get to pretend they're a good person by supporting a highly sympathetic figure such as an innocent child or a cute animal. The image of some cranky adults complaining about an 'imaginary' noise in their heads just doesn't get the juices flowing.
       
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    3. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      But the slogan "Support our troops" is well ingrained into the entire nation's heads after 17 years of the war on terror and tinnitus is the #1 service related disability. The image of a 22 year old that risked his life to fight for freedom getting disabled and tortured from this is something that needs to be promoted. Notice how you really NEVER see anything like what I just described.
       
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    4. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      It wouldn't be a good look, would it. Research gets done at one of the world's most prestigious universities using public and donated money with the aim of helping you and me. The result of that research gets spun off into a private company which then accepts a whole lot of money so that it is never used to help you and me. I think they could say goodbye to their professorships (is that a word?). FX-322 works or it doesn't. That's the only thing that's going to decide whether we get it.
       
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    5. Don Tinny

      Don Tinny Member

      Location:
      Argentina
      Tinnitus Since:
      2017 (worsening)
      Cause of Tinnitus:
      Loud concert with ear plugs
      Maybe the authorities don't want to create panic about this condition. Some sad spots could have negative psychological effects on those who already suffer from severe tinnitus.
       
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    6. Bndsmheowqhe

      Bndsmheowqhe Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Loud noise exposure
      “Government is the Entertainment division of the military-industrial complex.”

      ― Frank Zappa
       
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    7. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      “I dont know much about danc'in
      That's why I wrote this song
      One of my legs is shorter than the other
      And both of my feets too long.”


      ― Frank Zappa
       
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    8. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      They are claiming it did in this last round, and it certainly works in mice so I think it's safe to lean towards yes, right?

      Now, how well it works is the real question to me.

      It would be great if they could do the trials back to back and be more forthcoming with information.
       
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    9. Aleksa Uzunovic

      Aleksa Uzunovic Member

      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Noise induced hearing loss
      Uhhh, so when are these guys planning to get out of their holes and show us something? September? Dear God I hope that Audion makes it now, it's our biggest hope!
       
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    10. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      It seems like Audion and Frequency Therapeutics are both pretty close in the race.
       
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    11. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
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    12. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      Los Angeles, CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      They have had a lot of money coming in. That's why I was saying 3 years is plausible. They aren't playing any games.
       
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    13. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      I totally agree. Their presentation about the last trial is only about 2 months away. Very exciting.
       
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    14. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      Are the stocks available for purchase?
       
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    15. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Negatory.
       
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    16. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      Otonomy is the only publicly traded company working on hearing regeneration that I'm aware of.
       
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    17. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      Is it better for these companies to be public or private?
       
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    18. David Dorci

      David Dorci Member

      Tinnitus Since:
      02/09/19
      Cause of Tinnitus:
      Medication, Depression
      Dear David - thank you for your nice email and sorry to hear about your hearing loss.

      Frequency is working to develop a therapy to combat noise-induced hearing loss in this initial study. While we are still some time away from a commercially available treatment, we are working hard to move as quickly as possible to that outcome. The clinical trials will be conducted in 3 separate stages as explained by the National Institutes of Health, but the overall time frame will be dependent on the trial design. You may find further information on how trials are crafted and conducted here: https://clinicaltrials.gov/ct2/about-studies

      The cause of tinnitus is not clear in all cases, but this condition is almost always accompanied by hearing loss due to damaged cells within the inner ear. Because of this, regenerating hair cells may be helpful in patient suffering from tinnitus.

      Also, in the meantime you can learn about existing clinical studies being performed around the world at the FDA website - here is a link: https://www.clinicaltrials.gov/ct2/results?term=hearing+loss&Search=Search

      Please visit this link and enter your contact info to be part of Frequency’s outreach efforts and keep people informed of our progress: http://frequencytx.com/contact/index.php
      and any questions you have about Frequency’s study should be sent directly to clinicaltrials@frequencytx.com

      With warm regards,
      Jeff
      Jeff Karp B.Eng. PhD.
      Professor of Medicine
      Brigham and Women’s Hospital, Harvard
       
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    19. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      Private. IP owned by governments is prone to being subject to biased scrutiny upon a change of leadership, governments are poor at recycling lessons learned from failed research (whereas liquidators are often rather effective) and private funding avenues are more diverse in risk apatite levels (Companies can be seen to fail and spin it as learning [space x] governments can't, not in the short / med term anyway)

      In fact little innovation comes through governments for this reason; most 'government projects' are just government money pots that distribute risk among technical behemoths.

      IMHO anyway :)
       
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    20. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      Let’s hope Audion / Regain is different. They seem to be moving forward with a steady pace.
       
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    21. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      I'm pretty sure they are both using gamma secretase inhibitors.
       
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    22. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      In the US, a public company doesn't mean it is owned, operated, or has anything to do with the government. It just means its shares can be traded on a public market instead of being limited to private investors (who are called "sophisticated investors"). Examples of public companies: Amazon, Apple, Facebook, Google, Tesla, etc... Transitioning from private to public happens through an Initial Public Offering (IPO).
       
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    23. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      Aha, of course! Thank you :)
       
    24. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      The problem with going public is many times the company's founders find themselves spending all their time satisfying the shareholders, instead of doing what they did before going public.
       
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    25. Gorbeh3

      Gorbeh3 Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Hearing Loss
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    26. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Shouldn't people seeking cochlear implants be made aware of the potential of this drug and be advised to hold off on a decision until more data is released???

      Imagine getting a cochlear implant and then finding out later you could have just gotten an injection of FX-322. I'd personally be pissed.
       
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    27. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
      No, they are offered privately to hedge funds and fund managers with specific "treats" that you would never get from an IPO or public traded stock many of which involve enormous yield potential, they mix and match prospective biotech as part of their risk management/prospecting, lots of money has been invested in CAR T therapy for instance, every broker dreams of the next big thing.
       
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    28. AUTHOR
      AUTHOR
      RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      I'm in that boat right now. I'm holding off to see what happens, but I'm not so sure that is the best decision. Once you are a CI candidate you just get by in life. Words are difficult to understand. I can't talk on the phone anymore so I just use text. The longer I wait, the longer I forget what words sound like and the more training it's going to take to learn how to hear again. Plus we still aren't sure if people that are CI level will benefit from this drug. But... I'm holding out... Even if this works it's years away before we can go see a doctor and get an injection of FX-322.
       
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    29. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      It would be nice if people in your position could get early access through an open trial within the next year or so.
       
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    30. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      71 days till we hopefully have some news. This is right before my cake day, so it's gotta be good, right?!

      I'd be happy with 5+ dB gain from multiple test subjects with significant NIHL... But hope for more! Who knows what multiple exposure might achieve even if we see a 1-3 dB gain?

      I'd be interested to know what others on here would consider to be a good result at this point?

      Otherwise I am glad at this to have some undisclosed measure of pre-confirmed success, but worry it will slip in the next phase...
       

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