Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. zhiyuan
      Depressed

      zhiyuan Member

      Location:
      China
      Tinnitus Since:
      03/2019
      Cause of Tinnitus:
      sudden hearing loss
      Where did they say this?
       
    2. Contrast

      Contrast Member Benefactor Hall of Fame

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      injury from noxious noise
      He requested you to source the information of your statement.
       
    3. Contrast

      Contrast Member Benefactor Hall of Fame

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      I believe @Aaron123 posted the source along time ago about "moderate hearing loss being the therapeutic limit". It is somewhere in this thread multiple times.

      I'll look for it.
       
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    4. Contrast

      Contrast Member Benefactor Hall of Fame

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      Yes, synapses and nerves are more fragile then hair cells. That's the controversy. Hair cell regeneration might not help everyone because synapto-neuropathy plays a larger role in SHNL then scientist previously thought. Facts don't care about feelings, if nerve damage outweighs hair cell death the treatment will be ineffective. Someone correct me if I am wrong.

      upload_2019-8-3_2-32-7.png
       
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    5. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
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      U.S. Army/Field Artillery Veteran / loud computer
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    6. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      I don't think Frequency Therapeutics have put a definite limit on whom FX-322 may or may not be able to help. Stay optimistic.
       
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    7. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      Pretty sure they only tested it in those people because they were already receiving a cochlear implant so their ears were effectively already fucked and there was no real risk of causing further loss.
       
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    8. spedgas
      Gloomy

      spedgas Member Benefactor

      Tinnitus Since:
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      This is what I saw too. I believe the people in the trial were already scheduled for cochlear implants.
       
    9. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran / loud computer
      Of course that too, but the cochlear implant candidate appears to be their target consumer.

      Check out this website:

      https://www.frequencytx.com/our-approach/hearing-and-beyond.php

      They appear to be setting themselves up to disrupt the cochlear implant market specifically. They keep targeting "chronic" and "disabling" hearing loss, and even direcelty compare their procedure to cochlear implantation.
       
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    10. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      Pretty sure you're right.

      On the subject of what level of hearing loss FX-322 might help, there was a thread on Reddit where Will McLean's (it was supposed to be Will McLean anyway, according to people on this group) opinion was that people with profound hearing loss may not have the supporting cells to benefit from FX-322. He was talking about people with pretty much no hearing at all, and it was not stated as an absolute fact. People seem to think that the scientists have all the answers and the trials are to rubber-stamp what they already know. I really doubt that.
       
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    11. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      They're talking themselves up to investors, comparing themselves in the best light against the 'competition'. Of course they'll sell to sell to that market, assuming it works for people with that degree of hearing loss. It doesn't make it their target market. It's probably not big enough to justify the billions they seem to be expecting to make, and many people in that group probably will have more going on than just sudden sensorineural hearing loss. Last but not least, none of participants in the San Antonio trial were cochlear candidates as far as I know. So no, not their target market.
       
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    12. Misticvega

      Misticvega Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Probably noise exposure?
      Well, this is disconcerting.

      I'm trying to better understand the relationship between hyperacusis, tinnitus and just plain hearing loss.

      Do people with hearing loss only, no tinnitus, suffer from hyperacusis?
       
    13. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
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      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      Have you ever thought hyperacusis defined as "Pain from sound is not the same thing as "noises sounding abnormally loud?

      These problems are not well understood and many times go unreported.
       
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    14. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

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      That's a pretty big "if". Some hypothetical treatment which would restore 30% of your lost hearing could be life-changing for someone with 50 dB loss thresholds, but more or less meaningless to someone with tinnitus despite ~10 dB loss thresholds.
       
    15. Misticvega

      Misticvega Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Probably noise exposure?
      I'm grateful for the existence of Frequency Therapeutics and all others out there researching into hearing loss, tinnitus, and hyperacusis. It is a shame, however, these conditions appear to be so far behind in research. Perhaps I'm naive though. I myself am going in circles with all of this. One minute it is a hair cell problem, next the nerves. One minute it's because of stress, the next because of noise. Maybe one day we'll have definitive answers.

      Gonna take a break from the forums and do the best I can. Hopefully Frequency Therapeutics will offer more insight early next year.

      P.S. Apologies for the self-pity and mopey attitude, just really down with my tinnitus and hyperacusis lately.
       
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    16. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Why aren't heroes of basic logic like you involved in tinnitus research? Instead we have fashionistas like Derek Hoare stealing tax dollars to play games.
       
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    17. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
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      4-15-2017
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      @Contrast, @Rb86,

      There is no mention of tinnitus on the Frequency Therapeutics page. Where are you getting the idea that Frequency's main focus is to get rid of tinnitus?? There is no need to spread disinformation.
       
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    18. Peter61

      Peter61 Member

      Location:
      The Netherlands
      Tinnitus Since:
      08/2012
      @Flamingo1
      Frequency's main focus is to cure hearing loss and to restore hearing. That also automatically means curing tinnitus and hyperacusis, because they are the direct result of hearing loss, isn't it ? If your hearing is being restored, and the hair cells in the inner ear are being regenerated, tinnitus and hyperacusis automatically disappear. That's what I've understood. I don't know, we'll see. Fact is that Frequency has made a substantial partnership with Astellas, a Japanese pharma giant. They have paid Frequency 80 million dollars upfront for selling FX-322 outside of the US, and they will pay more than half a billion dollars to Frequency later in milestones. They do that for a reason. I assume it means that FX-322 could possibly be what will finally give us, tinnitus sufferers, back the heavenly silence we crave so much.
       
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    19. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      My mistake, as I already corrected. "Hearing loss". Being that it's a widely accepted theory that NIHL-based tinnitus is the brain making up for lack of sensory input from the nerves/hairs etc, it is very reasonable to speculate that curing or majorly improving hearing loss will then give new sensory input to the brain, allowing it to stop the tinnitus.

      That's my logic anyway. The funny thing about all of this, AGAIN, it's all speculative. There's no misinformation spreading because there are no facts. There is no concrete knowledge of tinnitus. I don't think this therapy would be too much of interest on a tinnitus forum if the end goal here wasn't tinnitus reduction or removal.
       
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    20. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

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      I hope that is the case but there are definitely changes to the underlying nerves involved in tinnitus. Whether or not these changes are a result of hearing loss and will be corrected by restoring hearing or not is something that I want the answers to.
       
      Last edited: Aug 4, 2019
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    21. Chriscom

      Chriscom Member Benefactor

      Location:
      Northern Virginia USA
      Tinnitus Since:
      May 2019
      Cause of Tinnitus:
      Likely infection/ear stress after walking pneumonia
      Frequency's main focus is to cure hearing loss and to restore hearing. That also automatically means curing tinnitus and hyperacusis, because they are the direct result of hearing loss, isn't it? If your hearing is being restored, and the hair cells in the inner ear are being regenerated, tinnitus and hyperacusis automatically disappear. That's what I've understood.

      Just to be clear, there are people--including on this forum--who have tinnitus without hearing loss.

      Tinnitus can disappear with the return of hearing, but not always. A friend had a rare condition whose name escapes me, but there were perforations on some inner bone structure, which when repaired restored his hearing. He still has tinnitus.

      Similarly, lots of people who finally start using hearing aids after hearing loss report lower tinnitus. That includes me, who started using a hearing aid a couple days ago after two months of hearing loss. My tinnitus isn't gone but it's lower on average.

      It stands to reason that restoring the original, natural structure of the hair cells could eliminate tinnitus but I doubt any specialist in the field guarantees that.
       
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    22. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
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      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Perforations on an inner ear bone structure?
      First off, the specialists in the tinnitus field are people like Pawel Jastreboff, so who cares what they think in the first place?
       
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    23. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      Was it semicircular canal dehiscence?
       
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    24. neo-t
      Angelic

      neo-t Member

      Location:
      West Virginia, United States
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Unknown
      Sorry to randomly come into this thread, but what’s the current state of FX-322 currently? Is it starting a next phase? Is it still in its second phase? I’ve been trying to read places but it’s been a bit confusing for me haha.
       
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    25. lewis.D

      lewis.D Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      Unknown
      I believe currently Frequency are at the end of a phase 1/2 in which there was positive results.

      They are going to be reporting on September 18th or 19th on their findings and I'm assuming they'll enter phase 2a which will most likely be a few more months. This involves more participants in trials to do a wider test range.

      If the FDA fast tracks FX-322 then they'll be in stage 3 by the middle - end of 2020.

      By 2020-2021 (sometime) we should know if this is going to work or not.

      If the FDA doesn't fast track, then most likely stage 3 will start in 2021 if not later.

      I believe that we'll know if there's a cure for deafness within the next 1-5 years, which would help with a large majority of tinnitus (but perhaps not all tinnitus).
       
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    26. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
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      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran / loud computer
      It will likely begin phase 2 very soon, probably within the next few months before the end of the year. They have just gotten a bunch of investors, mainly one really big pharmaceutical company, to pour in money and help them conduct trials worldwide along with a deal to sell the treatment once it is commercialized.
       
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    27. neo-t
      Angelic

      neo-t Member

      Location:
      West Virginia, United States
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Unknown
      @lewis.D @ChrisBoyMonkey

      Ahh. Alright. Reading all these articles was a bit confusing, so I needed some kind of explanation haha.

      Thank you!
       
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    28. Chriscom

      Chriscom Member Benefactor

      Location:
      Northern Virginia USA
      Tinnitus Since:
      May 2019
      Cause of Tinnitus:
      Likely infection/ear stress after walking pneumonia
      I don't think so. I'm pretty sure now his condition was otosclerosis.

      The Web MD description of the disorder you mention sounds like what I recall him describing to me:
      The canal that sits highest in your ear, the superior semicircular canal, is covered by bone. When you have SSCD, this bone has a hole or very thin place in it.

      The key word being "hole." But I don't recall him saying anything about motion and other issues, and when I asked him via text what the name of his affliction was, he said otosclerosis. He's a busy guy so that'll be it for awhile. Other online sources say otosclerosis is the abnormal growth of bone of the middle ear. This bone prevents structures within the ear from working properly and causes hearing loss.

      According to online resources, the treatment for semicircular canal dehiscense is to patch the hole. The treatment for otosclerosis is a staepdectomy, which builds another structure that replaces the function of the damaged stapes, which no longer moves, due either to a congenital issue or abnormal mineralization.

      And here is where either he or I stumbled over language; Wikipedia says with otosclerosis, it is possible to improve hearing by removing the stapes bone and replacing it with a micro prosthesis - a stapedectomy, or creating a small hole in the fixed stapes footplate and inserting a tiny, piston-like prothesis. He talked about the surgery rebuilding stuff in there, so I think that's it.
       
    29. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      Doctors who preform CI surgeries have first hand knowledge of the ear. So I wouldn't immediately discount their information, especially if it relates to the structure of inner ear.
       
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    30. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      OK thanks. I know a thing or two about otosclerosis since I have it myself and gone through the surgery.
       
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