Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Daniel Lion
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      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

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      Cool, thanks.
      I just wanted to know where to look. I shall have a look at there website again, right now.
      This has never been done before in the history of human kind, I suppose having the goal posts shift is to be expected. Perhaps their knowledge will grow exponentially over the coming years....I sure hope so. If it does turn out to be high frequencies, a lot of people here would be happy as where that’s where they having hearing loss...
      Wait and see , fingers crossed.
      Take care..
       
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    2. Daniel Lion
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      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

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      Hi guy,

      I just had a poke around the website, again, I couldn’t find the quote you referenced. They did say they would do a standard audiogram and a high frequency one, as well as word recognition tests, and tinnitus. Was that what you were referring to? I also couldn’t find, I am sorry, where they said it would have a hard time treating less than 3500 Hz.

      Can you cut and paste a quote please, I just can’t find it... argghhhhh.

      When you mentioned coping mechanism to ChrisBoyMonkey, I got the feeling of what you were saying, but it eluded me a little bit. Could you elaborate on what you are saying... were you saying we are clinging to FX-322 to give us hope from our affliction even though it’s an illusion and not viable?
       
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    3. hopeful4future

      hopeful4future Member

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      I also looked through the site again and couldn’t find that.
       
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    4. Daniel Lion
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      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

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      Quotes are really different than paraphrasing, you know.

      Hopefully jJurger will set the record straight. It’s important to me, as a forum member's interpretation and synthesis is obviously different than the company's speak.

      So @Jurger, help us out here.

      I am still hopeful and yes, it's probably not healthy... shit!
       
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    5. Matty1996

      Matty1996 Member

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      Hair cell regeneration in general is something we should be hopeful for and be optimistic about, any advance in the field at all is great thing.

      If some people use it to help them cope with their daily struggles, let them- there really is no point other than fruitless negativity to try and spoil that for some people.
       
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    6. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      C'mon guys. Get those research skills up.
      :bookworm:
      Secondary Outcome Measures :
      1. Extended High Frequency Pure Tone Audiometry [ Time Frame: Screening to Day 210 ]
        Pure tone audiometry will be measured to determine a subject's threshold for hearing at extended high range frequencies (Hz)
      2. Tinnitus Assessment [ Time Frame: Screening to Day 210 ]
        Measured by the Tinnitus Functional Index (TFI), with a scale ranging from 0 to 100 that defines severity categories based on 25 self-reported answers.

      Source:

      https://clinicaltrials.gov/ct2/show/NCT04120116
       
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    7. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      They are increasing the dose in this trial and that could very well get more into the lower frequencies. Stop making up stuff please.
       
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    8. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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    9. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      Don't let @Jurger destroy your optimism with his made up quotes and know it all assumptions about the future.

      This drug is dose dependent and with increased dosage it very well could reach much more of the cochlea in significant quantities. We just won't know until this trial concludes so it is irresponsible to say it will or won't for a fact.
       
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    10. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      Give us a quote and a link to it that states that.
       
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    11. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

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      Don't assume I'm hanging on to this for hope. My point is exactly that you talk in general. You don't know what will happen here.
       
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    12. PeteJ
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      PeteJ Member

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      I am not gloating. Why would you even interpret that way? What evidence? The other negative is if there is something good coming, it's a long time from now. It will be an unknown too of the extent of how much it will really help. I am sure everyone is keen on learning about your "evidence.' Is it applicable to loud severe tinnitus? As for researchers who are working on hearing loss, are they getting anywhere? I was told they were at least 10 years away, whatever that means.
       
    13. F-u-T

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      I see no reason to be down about this drug at this point. It looks like it will be most effective for high frequencies due to restriction of delivery methods. If the drug works all they have to due is find a more effective delivery method to treat the lower frequencies. If it is effective for hearing restoration even initially at only higher frequencies I think a lot of people will be jumping for joy.
       
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    14. Jurger

      Jurger Member

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      https://investors.frequencytx.com/static-files/6d161090-16f5-49f4-9606-8caceb5a88a1 Page 22-23

      https://edge.media-server.com/mmc/p/nfxzf922 From about 14:30
       
    15. Jurger

      Jurger Member

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      Not saying it’s not viable. I’m saying we have very little data to be super enthusiastic about. This drug did two things: 1. It increased 10 dB in 4 patients out of 15 that got it at 8000 Hz. 2. It roughly doubled the word scores of those patients. That’s it. This has been discussed at length here. Not trying to be an asshole, but this is turning more into a thread where data is misinterpreted or exaggerated for therapeutic effect instead of discussing the research somewhat dispassionately and keeping us updated on the development of this drug.
       
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    16. Joker

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    17. HootOwl

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      I think it’s important to remember that drug delivery methods are evolving along side hair cell regeneration. Hough is working on nanoparticle delivery. Pipeline already claims complete penetration of the cochlea in animal models. And Otonomy has figured out a way to get their compound for Meniere’s deep into the apex in human trials (although from what I understand their methods are patented, which kind of sucks).

      Even if Frequency Therapeutics isn’t able to get sub 3500 Hz in the beginning that doesn’t mean they never will. And in the meantime you have other biotech companies doing just that. I personally think the overlap is heartening, and that there will be something for all of us in due time.
       
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    18. Mathieulh
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      It's half the equation, once you have a drug that you know works, you can focus on looking for a better delivery system as you will finally have something to deliver, at this moment we have neither.

      I shall also add that plenty of people suffer from damages in the high frequencies region of the cochlea and would benefit from the drug (assuming it does work) and the current delivery mechanism as it is.

      Finally delivery mechanisms are regarded as medical devices, making the regulatory process much faster than that of actual drugs.
       
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    19. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

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      Why does everyone always want to fight on Thanksgiving?
       
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    20. Daniel Lion
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      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

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      10 decibels for 4 patients at 8000 Hz is huge, to me and obviously to all the investors who poured in money. I forgot how many were in the first trial, maybe 34? How many received the single shot vs. placebo? Pretty impressive from my perspective. ( post edit, jurger said 15 patients and 4 showed 10 dB changes)

      The page you referenced said the drug concentrated in the higher frequencies. Perhaps as other forum members have speculated, that with improved delivery, the drug can make it further down the spiral and work its magic on lower frequencies.

      I appreciate your call for being dispassionate and you countering the over the top optimism... it’s healthy to have a middle ground in this discussion that’s grounded in reality, even if it’s not what we really want.

      Now we can only wait and see, and hopefully REGAIN will have good news, despite one of the founders sobering words, in line with your assertions, about our expectations.
       
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    21. HootOwl

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      Dude are you serious? This entire part of the forums is dedicated to researchers “getting somewhere”. Have you seen the new Pipeline Therapeutics thread? This is a biotech firm with Heller as a lead advisory member that came out of fucking nowhere, with pretty promising data using a biologic that is quite potent for treating synaptopathy. This means there are potential dark horses we haven’t even heard of us that could pop up within the next 1-3 years, and add even more options to the mix.

      I understand you're suffering and lashing out (I’ve done that myself irl, ngl) but remember that some of us - myself included - have significant other hearing issues like music/hearing distortion that we would kill to have fixed and we’re hoping they can help us get back to our normal lives.
       
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    22. Jurger

      Jurger Member

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      This is the research part of the forum, not the parade part. To say that giving an honest appraisal of the research done by medical companies amounts to “fruitless negativity” is frankly absurd and a sure way of creating an echo chamber in here.
       
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    23. Matty1996

      Matty1996 Member

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      Lol okay drama queen.

      I simply stated any advance in the field is a good thing, no matter how small. Your honest appraisal reeks of doomsaying and oestrogen imo.
       
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    24. thinlay
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      thinlay Member

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      I smell it too ahahah.

      We must remain positive and hopeful, otherwise we have nothing left.
      Especially in the history of science, any advancement or innovation, makes people react in fear and distrust. Until this science becomes an element of everyday life.

      Twenty years ago if you would have said we would move with a phone as powerful as a computer or that we will know your geographical position all the time, people would have reacted in the same way.
       
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    25. jeff W

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    26. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      Your "honest appraisal" includes invented quotations. I already pointed that out and you never made a retraction.
       
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    27. john paul
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      john paul Member

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      [QUOTE="Jurger, post: 484892, member: 38521"This drug did two things: 1. It increased 10 dB in 4 patients out of 15 that got it at 8000 Hz. 2. It roughly doubled the word scores of those patients. That’s it. [/QUOTE]
      That's it?
      Are you kidding?
      This is an insane breakthrough for all of humankind. Pretty much on par with bringing back the dead IMO.
       
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    28. Rb86

      Rb86 Member

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      What does it mean to say it increased 10 dB who got it at 8000 Hz. Got what?
       
    29. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      An injection of FX-322.
       
    30. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      It is becoming apparent that some people are seeking to destroy our rationally based optimism about this drug and hearing loss technology in general. Well, most of us are smart enough to think for ourselves and we aren't even being irrationally over-optimistic about this either, so these people can cry all they want.
       
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