Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. HootOwl

      HootOwl Member Benefactor

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      I believe someone on here’s mentioned Otomagnetics as being the lead innovator for nanoparticle delivery?

      That got me interested so I did some superficial digging and found out that their CEO is pursuing orphan drug status for their delivery method, meaning by the time Frequency Therapeutics hits the general market we might actually have a better delivery method hit at around the same time, possibly even before.

      I’m emailing them for some clarification regarding a few other issues (namely delivery to the apex) but this is I think excellent news. I firmly believe the dominoes continue to stack in our favor.

      —————

      “As the next step, Batra plans to pursue Orphan Drug status, a move that is possible because the childhood cancer population they are addressing numbers less than 200,000 patients. This status will make it possible for the technology to move from Phase 1 Clinical Trials directly to Phase 3. As a result, Batra is aiming to have their platform on the market and improving patients lives by late 2021 at the latest.”
       
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    2. john paul
      English

      john paul Member

      Tinnitus Since:
      11/11/17
      Cause of Tinnitus:
      acoustic trauma
      Those who received FX-322 drug, gained 10 dB of hearing at 8000 Hz. Probably more above that but we're still stuck in the dark ages when it comes to hearing tests.
       
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    3. mrbrightside614

      mrbrightside614 Member

      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      unknown; acoustic trauma/hyperacusis/sshl
      Am I inventing the idea that we were going to get one of these guys on the Tinnitus Talk Podcast, or just one from Hough Ear Institute and Prof. Thanos Tzounopoulos? Either way, should be big time podcasts and I can barely wait for them.
       
    4. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Just Hough Ear Institute and Dr. Thanos.

      No word from Frequency Therapeutics. I've heard @Markku and @Hazel have tried to contact them but they do not seem to want to get back to them.
       
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    5. RingingBrother

      RingingBrother Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise induced hearing loss
      Its possible some of the negative posters are working for and/or invest in the hearing aid industry and want this to fail.
       
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    6. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      My theory is that the very real idea of a cure, more specifically, the patient community's awareness of it, make these CBT shrinks mad because they don't even think we should even be made aware of such a thing because the best thing they can "offer" is habituation, and thinking about a cure delays the habituation process.
       
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    7. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      They will bring this about how? The success or otherwise of FX-322 is in no way affected by any views expressed in this forum.
       
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    8. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      That's a bit of a stretch. We can all want and wish our hearts out. The science will answer one way or another.
       
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    9. Mathieulh
      No Mood

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      Indeed, investing in CBT when it should be done on research and telling people "not to think" about their affliction is akin to claiming that bloodletting will heal tinnitus.

      Unfortunately most tinnitus "experts" in the medical field are but crooks who make money off of our suffering.

      If they have nothing to offer, they should just say so, instead of charging for visits and offering "relief" in the form of so called (palliative) "therapies". If you get stabbed, nobody sane will tell you to "just ignore the pain" and "learn to live with it", this is utterly ridiculous and the fact that we get advised this "course of treatment" and that this is "standard of care" in the 21st century is appalling at best.
       
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    10. mrbrightside614

      mrbrightside614 Member

      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      unknown; acoustic trauma/hyperacusis/sshl
      I have to say that decreasing 10dB at 8000Hz, and likely more at uncharted frequencies, is actually fucking huge. I’m one of the fortunate people with a low frequency tone with which I can compare my high frequency electric hiss. I can tell you that if this drug only targeted the higher frequencies, I would shell out thousands upon thousands for relief from the high frequency. Much harder to mask, physiologically more anxiety inducing.
       
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    11. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      If restoring HF hearing loss treats HF tinnitus, then this very well may be more of a practical treatment for HF tinnitus over hearing loss, right?
       
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    12. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      Is there a thread or sticky with all the important dates, quarters in 2020 when we can expect trial results? Audion, Frequency Therapeutics, Dr. Shore, Otonomy, etc...
       
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    13. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      Audion should have results by end of April 2020.
      Frequency Therapeutics end of September 2020.
       
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    14. mrbrightside614

      mrbrightside614 Member

      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      unknown; acoustic trauma/hyperacusis/sshl
      God I hope they pivot to list tinnitus as a primary application.
       
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    15. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      This doesn't have a timeline, but I uploaded and attached a table I found with most of the currently known players. Inception is now Pipeline btw. Otologic Pharmaceutics I believe is the biotech partnering with Hough.
       

      Attached Files:

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    16. Mathieulh
      No Mood

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      It's actually pretty impressive given the very low dose administered during the trial.
       
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    17. patorjk

      patorjk Member

      Tinnitus Since:
      2005
      Cause of Tinnitus:
      Several reasons
      Earlier in this thread someone said one of the founders of Audion had expressed caution when it came to both Regain and FX-322, however, I can't find that now (I can find the post if I search for "regain sobering" but I can't find what the founder supposedly said). What was the story behind this? Did they want to keep people from getting too excited?
       
    18. mrbrightside614

      mrbrightside614 Member

      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      unknown; acoustic trauma/hyperacusis/sshl
      I was just thinking about something that may have been covered, but I can’t commit myself to 194 pages of back-checking.

      What happens to the dead hair cells? Are they not subject to macrophages or other cellular waste removal systems? Would this be an important pre-treatment therapy, as to erase the brains familiarity with its old pathways?
       
    19. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      Audion/Regain is the same company.
       
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    20. patorjk

      patorjk Member

      Tinnitus Since:
      2005
      Cause of Tinnitus:
      Several reasons
      I was using Regain to refer to the drug they were putting forth, I thought it was being called "Regain" but I guess that's the project name and the drug is still untitled.
       
    21. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Drug is called LY3056480.
       
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    22. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      http://www.audiontherapeutics.com/

      The drug they are using is LY3056480. Phase 2 results will be out end of April 2020 and hopefully they are good so they can move on to Phase 3 and release the drug.

      Here is more information about the clinical trials:

      http://www.isrctn.com/ISRCTN59733689
       
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    23. john paul
      English

      john paul Member

      Tinnitus Since:
      11/11/17
      Cause of Tinnitus:
      acoustic trauma
      Just from guessing I'd say most of the high frequencies are the first to go as well as the easiest to lose. The fact that tinnitus is usually a high pitched tone is suggestive of this also. Brain is lacking input from these frequencies and making it up. People with multi tonal tinnitus suggests damage on a larger range of frequencies both low and high. The fact that it's permanent non-stop also suggests brain senses input at all times even though we don't realise it. So as much as 12 kHz+ is pretty much irrelevant for hearing.

      Telling someone who goes for a standard hearing test that their hearing is perfect is laughable at best. It's literally half a frigging test.
       
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    24. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      It makes great sense because HF waves carry the most energy at the same amplitudes as other waves and the HF part of the cochlea is the nearest to the oval window where the stirrup bone that transfers the sound from the anvil and hammer connects.
       
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    25. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      Sounds like something I posted. The guy didn't mention any company by name. He was sounding a general note of caution I guess. Wait for the science to be proven before you get people's hopes up is what he was saying.
       
    26. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Wasn't he asked about Regain when he answered that though?
       
    27. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I think the pessimistic tone of that comment was derived from this not being a 100% cure for hearing loss. Tinnitus patients are going to be like puppies getting scraps off the table, which is fine with me.
       
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    28. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      He was talking about Regain but I think the line about not getting people's hope up was meant as a good guideline for scientists to follow. My memory's not clear on this. No idea how to find the article.
       
    29. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      Another day, another signalling pathway. This may be worth a topic on its own. I wish someone with knowledge could compare and contrast with Frequency Therapeutics. Chen and the Frequency Therapeutics honchos all work for the same institutions. Different labs, same university affiliations. Chen seems to be claiming that his study is the first to achieve hair cell regeneration. Really? Anyway, for what it's worth...

      https://www.news-medical.net/news/2...er-to-developing-hearing-loss-treatments.aspx
       
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    30. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      My guess is "reprogram using transcription factors" is different enough to the progenitor cell activation that Frequency Therapeutics does to claim to be the first.
       
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