Frequency Therapeutics — Hearing Loss Regeneration

Just Hough Ear Institute and Dr. Thanos.

No word from Frequency Therapeutics. I've heard @Markku and @Hazel have tried to contact them but they do not seem to want to get back to them.

 

Its possible some of the negative posters are working for and/or invest in the hearing aid industry and want this to fail.

 

My theory is that the very real idea of a cure, more specifically, the patient community's awareness of it, make these CBT shrinks mad because they don't even think we should even be made aware of such a thing because the best thing they can "offer" is habituation, and thinking about a cure delays the habituation process.

 

They will bring this about how? The success or otherwise of FX-322 is in no way affected by any views expressed in this forum.

 

That's a bit of a stretch. We can all want and wish our hearts out. The science will answer one way or another.

 

Indeed, investing in CBT when it should be done on research and telling people "not to think" about their affliction is akin to claiming that bloodletting will heal tinnitus.

Unfortunately most tinnitus "experts" in the medical field are but crooks who make money off of our suffering.

If they have nothing to offer, they should just say so, instead of charging for visits and offering "relief" in the form of so called (palliative) "therapies". If you get stabbed, nobody sane will tell you to "just ignore the pain" and "learn to live with it", this is utterly ridiculous and the fact that we get advised this "course of treatment" and that this is "standard of care" in the 21st century is appalling at best.

 

I have to say that decreasing 10dB at 8000Hz, and likely more at uncharted frequencies, is actually fucking huge. I’m one of the fortunate people with a low frequency tone with which I can compare my high frequency electric hiss. I can tell you that if this drug only targeted the higher frequencies, I would shell out thousands upon thousands for relief from the high frequency. Much harder to mask, physiologically more anxiety inducing.

 

If restoring HF hearing loss treats HF tinnitus, then this very well may be more of a practical treatment for HF tinnitus over hearing loss, right?

 

Is there a thread or sticky with all the important dates, quarters in 2020 when we can expect trial results? Audion, Frequency Therapeutics, Dr. Shore, Otonomy, etc...

 

Audion should have results by end of April 2020.
Frequency Therapeutics end of September 2020.

 

God I hope they pivot to list tinnitus as a primary application.

 

This doesn't have a timeline, but I uploaded and attached a table I found with most of the currently known players. Inception is now Pipeline btw. Otologic Pharmaceutics I believe is the biotech partnering with Hough.

 

It's actually pretty impressive given the very low dose administered during the trial.

 

Earlier in this thread someone said one of the founders of Audion had expressed caution when it came to both Regain and FX-322, however, I can't find that now (I can find the post if I search for "regain sobering" but I can't find what the founder supposedly said). What was the story behind this? Did they want to keep people from getting too excited?

 

I was just thinking about something that may have been covered, but I can’t commit myself to 194 pages of back-checking.

What happens to the dead hair cells? Are they not subject to macrophages or other cellular waste removal systems? Would this be an important pre-treatment therapy, as to erase the brains familiarity with its old pathways?

 

Audion/Regain is the same company.

 

I was using Regain to refer to the drug they were putting forth, I thought it was being called "Regain" but I guess that's the project name and the drug is still untitled.

 

Drug is called LY3056480.

 

http://www.audiontherapeutics.com/

The drug they are using is LY3056480. Phase 2 results will be out end of April 2020 and hopefully they are good so they can move on to Phase 3 and release the drug.

Here is more information about the clinical trials:

http://www.isrctn.com/ISRCTN59733689

 

Just from guessing I'd say most of the high frequencies are the first to go as well as the easiest to lose. The fact that tinnitus is usually a high pitched tone is suggestive of this also. Brain is lacking input from these frequencies and making it up. People with multi tonal tinnitus suggests damage on a larger range of frequencies both low and high. The fact that it's permanent non-stop also suggests brain senses input at all times even though we don't realise it. So as much as 12 kHz+ is pretty much irrelevant for hearing.

Telling someone who goes for a standard hearing test that their hearing is perfect is laughable at best. It's literally half a frigging test.

 

It makes great sense because HF waves carry the most energy at the same amplitudes as other waves and the HF part of the cochlea is the nearest to the oval window where the stirrup bone that transfers the sound from the anvil and hammer connects.

 

Sounds like something I posted. The guy didn't mention any company by name. He was sounding a general note of caution I guess. Wait for the science to be proven before you get people's hopes up is what he was saying.

 

Wasn't he asked about Regain when he answered that though?

 

I think the pessimistic tone of that comment was derived from this not being a 100% cure for hearing loss. Tinnitus patients are going to be like puppies getting scraps off the table, which is fine with me.

 

He was talking about Regain but I think the line about not getting people's hope up was meant as a good guideline for scientists to follow. My memory's not clear on this. No idea how to find the article.

 

Another day, another signalling pathway. This may be worth a topic on its own. I wish someone with knowledge could compare and contrast with Frequency Therapeutics. Chen and the Frequency Therapeutics honchos all work for the same institutions. Different labs, same university affiliations. Chen seems to be claiming that his study is the first to achieve hair cell regeneration. Really? Anyway, for what it's worth...

https://www.news-medical.net/news/2...er-to-developing-hearing-loss-treatments.aspx

 

My guess is "reprogram using transcription factors" is different enough to the progenitor cell activation that Frequency Therapeutics does to claim to be the first.

 

Wth they don't even tell you what the title of the paper is.

Renewed proliferation in adult mouse cochlea and regeneration of hair cells

 

This paper is actually pretty amazing. It seems like this "one two punch" method could regenerate OHCs and IHCs and even some if the supporting structures. I will try to write Dr. Chen this week and ask him more...

 

Another interesting aspect of this paper is he seems to be using a new model where they grow cochlear cells in a "bony incasing" to mimic in vivo testing. Seems like this could accelerate pre-clinical studies if widely used.