Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Mathieulh
      No Mood

      Mathieulh Member Benefactor

      Location:
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      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      Actually, I do know, I recognize a professional actor when I see one, too many choreographed moves, no hesitation in the talking pattern, over exaggerated, unnatural emotions...

      This is 100% an actor and 100% scripted, and likely 100% not genuine.
       
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    2. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
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      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      Just look at the 5 year price history of the Auris Medical stock, EARS, and it will be clear that they have not succeeded yet!

      https://finance.yahoo.com/quote/ears
       
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    3. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      I can see her read, and I can see how she emphasizes what she's saying emotionally, but that doesn't mean an actor. They could've taken someone who wanted to share their story and worked with them to do that. That could've been take 25.

      You don't know unless you have proof. Just like we don't know if the drug truly works until evidence from real trials comes out.
       
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    4. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      So? Nobody has succeeded yet. Don't read a fickle marketplace as evidence for this stuff. It's all on a hunch. Same goes for frequency. People think if the stock skyrockets or goes up that there's inside information out there that someone got a hold of and they know it works. Which is a falsehood.

      As I keep saying over and over, we all don't know SHIT until the scientific evidence is published. And even then, until the drug is on the market and really being used.
       
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    5. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      Did I mention biotech stocks are dangerous!? EARS
       
    6. PeteJ
      Depressed

      PeteJ Member

      Tinnitus Since:
      02/2019
      Cause of Tinnitus:
      acoustic trauma?
      Neuromod and this is shit. No one hears anything about this fucking shit.

      People have screaming tinnitus. My tinnitus is something like 70 FUCKING DECIBELS and I would do anything to go back and live life again to see if I could avoid this, to preserve my hearing.

      I don't see anyone getting help here or just a small minority. No one with severe tinnitus anyway. It's fucking useless.
       
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    7. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      This hasn't been released yet. How do you know how many people it will help? They are still conducting trials.
       
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    8. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
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      04/2019
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      U.S. Army/Field Artillery Veteran
      He's just a severe and extremely negative sufferer. He's done this before.
       
    9. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I get it. I also feel like my hearing stuff is so unique, what helps others won't help me.

      I feel for you, @PeteJ but i think some brilliant minds are working towards helping us. Hang in there.
       
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    10. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
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      04/2019
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      U.S. Army/Field Artillery Veteran
      I hope this stuff will work for you too. If you still can hear, then it might have a chance.

      Even if not these signals specifically, the same concept might be able to be used to develop a treatment for you eventually..
       
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    11. dustyoffski

      dustyoffski Member

      Tinnitus Since:
      2014
      Cause of Tinnitus:
      hearing loss
      Hi,

      I don't think Fast Track status indicates anything about the drug's likelihood to succeed, only the seriousness of the condition. It's definitely good news that it got fast track status, because it means we can figure out if this is finally the jackpot or not. But the fact is still that most drugs don't make it through phase 3, and this one has yet to make it through phase 2, which means the statistic odds are against it actually succeeding.
       
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    12. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
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      04/2019
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      Except they already saw early positive results from merely the safety study. Not exactly a variable past failures had.
       
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    13. patorjk

      patorjk Member

      Tinnitus Since:
      2005
      Cause of Tinnitus:
      Several reasons
      Are they upping the dose for the Phase II trials? I know there's a potential for 4 doses, but I haven't seen anywhere where they say if the individual dosages will be larger. Normally in Phase I studies they test a really high dosage to ensure there are no negative effects, but I didn't get that vibe from what I read on this drug.
       
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    14. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      That usually goes for every drug that hits the Phase 2 mark. If a drug doesn’t show early positive results, it wouldn’t be at Phase 2. We’ve seen plenty of examples of drugs not being successful in later Phases. Hell, scroll back in this thread. This time last year everybody was over the moon about this drug being the drug for hearing loss. The holy grail. Now we already have to concede it will probably only work well for high frequency hearing loss >3500 Hz. Even Frequency is basically admitting that with that “designed for high frequencies” nonsense.
       
    15. Mathieulh
      No Mood

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      That's not so much the drug's fault and more the lack of a proper delivery method to reach the Apex though.
       
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    16. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

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      CA
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      Since when? All they needed is to show some promise from from preclinical testing then safety from phase 1.
       
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    17. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      They also got funding from Astellas as well so I would think this drug will be successful.
       
    18. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      A lot of drugs go through a Phase 1/2 first where efficacy is also tested.
       
    19. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      Not denying that. In fact, that’s why the “designed for high frequency loss” is nonsense to me; it’s an excuse for not getting the drug in the entire cochlea. But regardless, the fact remains this drug will barely treat <3500 Hz as is. And that wasn’t the vibe on this thread a year ago. It’s just to show expectations can shift pretty rapidly regardless of previous positive results.
       
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    20. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Hi Jurger,

      I seemed to have missed that statement by Frequency Therapeutics... my bad.

      When and where did they say that “designed for high frequencies”?

      Thanks in advance.
       
    21. hopeful4future

      hopeful4future Member

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Gun Shot
      You would think that Frequency Therapeutics would have excluded patients with hearing loss below 3500 Hz in the phase 2 trial if they didn’t think it would work in the lower frequencies. If they would have excluded it wouldn’t you think they would have had better results and a better chance at moving on to phase 3?
       
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    22. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
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      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      And all those other hearing loss restoration drugs also had early positive results from the phase 1/2?
       
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    23. PeteJ
      Depressed

      PeteJ Member

      Tinnitus Since:
      02/2019
      Cause of Tinnitus:
      acoustic trauma?
      I think it's bullshit. If it was such revolutionary progress, something would come out about it.

      Plus, everyone is so different and the variables are all over the place.

      But, there is nothing that indicates that anything out there will help.
       
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    24. PeteJ
      Depressed

      PeteJ Member

      Tinnitus Since:
      02/2019
      Cause of Tinnitus:
      acoustic trauma?
      Done what? Told the truth?
       
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    25. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
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      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Only if you believe the truth is that nothing will ever work when in fact that is not the truth. We already have evidence of it. If you want to keep gloating, keep it to yourself. Dragging others down with false negativity is not the way.
       
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    26. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Settle down children. We're all stuck in fuckville together. But I have faith that genuine progress is being made. I really do.

      Regardless of anybody's thoughts, what gives me hope is that there's several players in this tinnitus game who have strikingly similar methods of attack. The science is really honing in. It's just slow as hell.

      In the meantime, I watch nature to give me a little peace.
       
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    27. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      What do you mean by "something would come out about it"?
       
    28. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      I’m talking about drugs in general. There’ve been plenty of drugs that showed some efficacy at first only to fail in later phases. Come on man, leave your feelings outside for a second, assuming this drug will pass Phase 2a, 2b and 3 based on what we have now is a coping mechanism, and you know it.
       
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    29. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      In their corporate presentation on their website.
       
    30. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      Dude, they themselves are saying this about their drug, not me. As for excluding patients, why would they do that at this early stage? Maybe phase 2 paints a different picture, but right not they’re saying the drug will have a hard time treating loss <3500 Hz. It’s on their website.
       
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