Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

  1. Watch Hazel share good news about tinnitus
    1. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      Word recognition improvement = actual hearing improvement.
       
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    2. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

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      Prison
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      Thought so. I did look at the presentation slides and with the severe hearing loss trial the information was the same as the last presentation slides for it.

      Only thing that I thought might be new is mentioning that they will finish dosing participants for the Phase 2b trial in Q3/2022 and release results in Q4/2022 or Q1/2023 and if the phase is successful they will move on to the pivotal phase.
       
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    3. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Ah, keep telling yourself that. I have 45-50 WRS and I can’t hear shit out of my left ear.
       
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    4. NYCGuy
      Wishful

      NYCGuy Member Benefactor

      Location:
      NY
      Tinnitus Since:
      10/2021
      Cause of Tinnitus:
      Neck, Jaw or Stress, who knows.
      Seems not great news from Frequency Therapeutics. If they are not able to recover that much of the hearing, there is no hope for us with tinnitus, right?

      Maybe this may help people with very mild hearing loss.
       
    5. ThomasF
      Confused

      ThomasF Member

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown
      There's this Audiologist on YouTube that has spoken of Frequency Therapeutics in the recent past as well as how their medication is supposed to aid hearing as a whole. Something regarding inner cochlear hair cells being responsible for different things than outer hair cells. The medication is able to aid in the regeneration of at least one of those types of cells or, more accurately, it activates the progenitor cells inside the ear to replace the damaged hair cells. Supposedly the medication itself has been shown to work but there was something problematic about the delivery method. For people with hearing loss induced tinnitus, replacing the hair cells is a likely candidate for a cure.

      Side-note: It feels like an evolutionary mess up that birds can replace their gosh darn hair cells and we (most if not all mammals) cannot. Boy I really hope someone got fired for that blunder.
       
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    6. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

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      Depends if your hearing loss is at the higher frequencies. From the previous trials it seems that the drug can travel down to 8 kHz due to the audiogram improvements at 8 kHz. Unfortunately they did not do an audiogram test higher than 8 kHz in the previous trial.

      So basically in its current formula it can travel down to 8 kHz so that's like 50% it can restore. With FX-345 the theory is that it can get down to 4 kHz so that is 80% restoration.
       
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    7. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      We don't hear in linear Hertz, though. We hear logarithmically. Improving everything above 8 kHz is essentially improving your highest pitch octave (out of roughly 9 of them). So more like 10% coverage, not 50%.
       
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    8. DimLeb

      DimLeb Member

      Tinnitus Since:
      14/03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy Or Maybe Loud Music
      Lol. It got messed up big time, when somewhere in evolution some mammals could still survive even with all these hearing disorders and broken ears...
       
    9. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      Then it sounds like you can hear shit out of your left ear. You can hear 45 - 50 words.
       
    10. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      I thought it was telling one of the questions was why they don’t focus on FX-345...
       
    11. Keith Handy
      Ape-like

      Keith Handy Member

      Location:
      Rochester, NY, USA
      Tinnitus Since:
      11/2020
      Cause of Tinnitus:
      Stress + sleep deprivation + noise
      To be fair, though, they might have had to crank the volume for him on the tests. I wasn't aware for some time that they actually don't have a "set volume" for word tests and will adjust it to what you can hear.
       
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    12. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      Absolutely. 7-10MM population can benefit from FX-322, why abandon it if they can get it through pivotal and start generating revenue?
       
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    13. Chad Lawton

      Chad Lawton Member

      Tinnitus Since:
      2/19/18
      Cause of Tinnitus:
      Possible Ototoxicity + Noise Exposure
      Why is it telling? The smartest thing for them to do is get FX-322 to market as quickly as possible to unlock a revenue stream, otherwise they are on track to run out of cash by end of 2023. They've already spent enough money on it it that it doesn't cost that much more to take it to pivotal rather than abandon it. Otherwise if they shelf FX-322 it will add an extra 2 years to the timeline of bringing something to market. We are probably 3 to 4 years from seeing something on market, FX-345 will be 5 to 6.
       
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    14. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      I can if I go in for an audiogram and it’s inserted directly into my ear. I can’t hear anything in noisy backgrounds. And if I take my hearing aid out, it’s all muffled.
       
    15. Koz
      Dreaming

      Koz Member

      Location:
      North East England
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Unilateral sensorineural hearing loss
      Careful, the shills on copium don't like audiograms here.
       
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    16. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

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      I think with the severe hearing loss trial there were word improvements in noise.
       
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    17. Chad Lawton

      Chad Lawton Member

      Tinnitus Since:
      2/19/18
      Cause of Tinnitus:
      Possible Ototoxicity + Noise Exposure
      I suppose us shills are just trying to balance out the Audiogram Eeyores :ROFL:
       
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    18. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      I think you're winning.
       
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    19. Survivor234
      Hurting

      Survivor234 Member

      Tinnitus Since:
      2021
      Cause of Tinnitus:
      Noise-induced/Headphones
      To be honest, based on what I understand, it won't even help people with tinnitus. If your tinnitus is caused by overexcited neurons and damaged hair cells, regrowing new ones won't fix those issues. Tinnitus is likely going to require multiple treatments which undoubtedly would make it a very lucrative and costly symptom to remove. And if your tinnitus is caused by TMJ, anxiety, or sinus infections then it's likely that it won't be dealt with at all by these treatments.
       
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    20. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      If it does get approved, no one is going to use it if all it does is increase your word scores by 10%.
       
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    21. Survivor234
      Hurting

      Survivor234 Member

      Tinnitus Since:
      2021
      Cause of Tinnitus:
      Noise-induced/Headphones
      That's just a problem with measurement rather than what it actually does. Word-in-noise scores was the metric the FDA wanted them to use for approval so they're using it. There is no reason to believe that it doesn't do exactly what it sets out to do which is activate progenitor hair cells in the inner ear.

      Furthermore, the audiograms they were testing for Phase 1B trial was up to 8 kHz which FX-322 doesn't even fully reach to (FX-345, on the other hand, does). Phase 2B is testing up to 16 kHz so we should see more patients with improvements.

      The only reason why it wouldn't work or fix tinnitus is if either A. your tinnitus is not noise or hearing loss induced or B. your tinnitus is caused by damaged hair cells. Other than that, it should, at the very least, help.
       
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    22. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
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      20+ Years of Live Music, Motorcycles, and Power Tools
      Consider the number of treatments for hearing loss that people willfully try that have no measurable benefit over placebo or are not FDA approved, IE: steroids, HBOT, Sulodexide, etc. None of these have a target patient group, yet people spend thousands of dollars gambling on hope. Add to that, the likelihood of health insurance coverage in the US is nil. This happens every day.

      Then, consider that same population that has the option to try a drug that is FDA approved and shows a significant improvement for certain hearing loss conditions. And, their doctor can reliably prescribe and administer it. Also, by the sound of the recent Q&A, it might be covered under their health insurance.

      Which one do you think patients will choose? Which one would a doctor recommend?
       
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    23. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      No, it was the only signal they were able to achieve so they discussed with the FDA a way for them to achieve clinical significance and pass trials.
       
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    24. Survivor234
      Hurting

      Survivor234 Member

      Tinnitus Since:
      2021
      Cause of Tinnitus:
      Noise-induced/Headphones
      Do you have any evidence of that?
       
    25. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Yes, they said it in there presentations.
       
    26. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      People don’t even get hearing aids to help with their hearing. Why are they going to get a shot in their ear for a drug that doesn’t do anything?
       
    27. Survivor234
      Hurting

      Survivor234 Member

      Tinnitus Since:
      2021
      Cause of Tinnitus:
      Noise-induced/Headphones
      Where?
       
    28. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      I don’t remember which specific presentation but I’ve been following them very closely. Do you own research.
       
    29. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      “...all it does is increase your word scores by 10%.” - Gb3, Tinnitus Talk, 15 January, 2022.

      That's why.
       
    30. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
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