Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. RingingBrother

      RingingBrother Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise induced hearing loss
      Looks like maybe a minor correction where the hearing level stabilizes. It seems to hold steady a year later except for subject 5. Who knows if they went to a ton of concerts in between the exams.
       
    2. Chad Lawton

      Chad Lawton Member

      Tinnitus Since:
      2/19/18
      Cause of Tinnitus:
      Possible Ototoxicity + Noise Exposure
      It appears that some of the hearing benefits gained from FX-322 fade over time but subjects don't lose all of the benefit. This is consistent from both their Phase 1/2 trial as well as their FX-322-111 study where a number of subjects lost statistical significance but still retained clinical significance.

      I speculate this waning benefit has to do with the anatomy of the cochlea and the amount of space the new hair cells have to fit into. If you look at the image I have attached which is from the Lgr5 study published in 2017, look at the images in Row E at the bottom left. The mouse cochlea had 6 rows of outer hair cells after FX-322 after treatment when they normally only have 3 rows before treatment much like humans. This is most likely caused by every single outer hair cell going through mitosis due to FX-322. The ear naturally functions with 3 rows of outer hair cells so I would hypothesize that when you increase it to 6 rows of outer hair cells, not all the new hair cells survive and some either die off or are cleared by the body in the years following FX-322 treatment. Or maybe the inner ear struggles to provide enough blood/nutrients to that many hair cells which causes some to die off? That's my hypothesis anyways.

      lgr5 study.PNG
       
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    3. Geatly

      Geatly Member

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      Noise induced, by jackhammering into concrete on constructio
      That's actually amazing if it produces more rows, of course if it works properly.
       
    4. Chad Lawton

      Chad Lawton Member

      Tinnitus Since:
      2/19/18
      Cause of Tinnitus:
      Possible Ototoxicity + Noise Exposure
      Based on all the preclinical and clinical data we've seen so far, I believe it works properly. The 33% average response rate we have been seeing makes sense when you consider how little cochlear penetration FX-322 has and the heterogeneity of hearing loss. I'm hopeful that FX-345 will at least double the response rate to over 66% and that we will see minor/modest audiogram improvements in the 6 kHz to 8 kHz range at a minimum.
       
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    5. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      Sure, damage can be immediate, but are people with already damaged hearing, presumably cautious about their ears, let's say, rushing out to the gun-range right after taking FX-322?
       
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    6. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      I was just referring to NIHL in general. They are definitely not running to the gun range afterwards, but I think the theory Chad presented is plausible.
       
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    7. Eliot Martin

      Eliot Martin Member

      Tinnitus Since:
      10/2021
      Cause of Tinnitus:
      Medications
      Does FX-322 restore hair cells only? I read somewhere it's not only for hair cells but cochlear synapses as well.
       
    8. Chad Lawton

      Chad Lawton Member

      Tinnitus Since:
      2/19/18
      Cause of Tinnitus:
      Possible Ototoxicity + Noise Exposure
      It only restores hair cells. The hair cells that it restores have fresh cochlear synapses but it doesn't re-connect old synapses to old hair cells. At least they haven't provided any evidence of this in their preclinical research.
       
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    9. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      Does that mean the old synapses lost cause tinnitus? Do we know if growing new ones can help revert the issue?
       
    10. Chad Lawton

      Chad Lawton Member

      Tinnitus Since:
      2/19/18
      Cause of Tinnitus:
      Possible Ototoxicity + Noise Exposure
      They could. We don't know. That's where OTO-413 may help.
       
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    11. ThomasF
      Creative

      ThomasF Member

      Location:
      Florida
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Probably loud music
      I wonder if a series of treatments will help keep more of the gains as the daughter cells develop more to the needs of the cochlea. After all the relationship between the progenitor cells and the inhibition factor isn't fully known and could be hampering the full development of the cells into proper hair cell replacement.
       
    12. star-affinity
      Wishful

      star-affinity Member Podcast Patron Benefactor

      Tinnitus Since:
      1993, increase in 2020, then new in 2021
      Cause of Tinnitus:
      Unsure about the first. Too many beers? Music during sleep.
      If one could understand how it works in birds when they damage their hearing I guess we would have the answer?

      Or is there more to the difference between birds and humans than that our progenitor cells are ”turned off” while the ones in birds are not?
       
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    13. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      The difference is that bird/reptilian/amphibian progenitors can still be signaled by the body to "turn on" and complete mitosis. Mammals lack the ability to signal the progenitor cells in the cochlea when needed, but the functionality is still there. This is what FX-322 is trying to do. Note that mammals can can still do it in places like the small intestine and brain.
       
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    14. ThomasF
      Creative

      ThomasF Member

      Location:
      Florida
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Probably loud music
      In humans there is a chemical that blocks the cell division for our progenitor cells. As I understand it both FX formulae are meant to obscure or prevent this chemical from being received by the progenitor cells.
       
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    15. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Hall of Fame Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      12/2013
      I experience some residual inhibition by introducing 7000 Hz noise, but hearing aids have never helped me.
       
    16. RingingBrother

      RingingBrother Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise induced hearing loss
      Anyone know if there is a chance that the FDA might announce a surprise approval out of nowhere if there continues to be no adverse reactions? Since Frequency Therapeutics have Fast Track status, maybe they won't have to go through the full process.
       
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    17. justguts
      Tired

      justguts Member

      Tinnitus Since:
      05/2021
      Cause of Tinnitus:
      Unknown
      I wish.
       
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    18. Chad Lawton

      Chad Lawton Member

      Tinnitus Since:
      2/19/18
      Cause of Tinnitus:
      Possible Ototoxicity + Noise Exposure
      Fast Track does not mean they can skip trials, it means they can have more interactions with the FDA and the final application review process is shaved down from 1 year to 6 months.
       
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    19. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Well don’t you want studies that shows it works first?
       
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    20. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      And as we've learned from Lenire, even that is dubious.
       
    21. UHPTS
      Wishful

      UHPTS Member

      Tinnitus Since:
      October 2019
      Cause of Tinnitus:
      Ear infection
      FREQ stock now available at the Dollar Store.
       
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    22. Eliot Martin

      Eliot Martin Member

      Tinnitus Since:
      10/2021
      Cause of Tinnitus:
      Medications
      Imagine FX-322 or FX-345 actually restores hearing but since the benefits are not long lasting, you suddenly lose your hearing on an important day such as work. LOL. That would be funny.
       
    23. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      Time to accumulate and cross our fingers. I've got 20,000.00 shares. Let's go FREQ.
       
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    24. just1morething
      Benevolent

      just1morething Member Benefactor Hall of Fame

      Location:
      U.S.
      Tinnitus Since:
      ?
      Cause of Tinnitus:
      ?
      Yeah you need to buy stock in FREQ If you haven’t already... It’s a bargain.
       
    25. RingingBrother

      RingingBrother Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise induced hearing loss
      Will they allow expanded access/compassionate use if it makes it to Phase 3 and is still safe?
       
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    26. Nick47

      Nick47 Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      I would wait for the Phase 2 results first. Are they due in August 2022? Or am I confused with OTO-313? I I imagine many seasoned people on here have seen multiple trials fail at Phase 2.
       
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    27. Chad Lawton

      Chad Lawton Member

      Tinnitus Since:
      2/19/18
      Cause of Tinnitus:
      Possible Ototoxicity + Noise Exposure
      FX-322 data is expected Q4 of this year or Q1 of 2023. If you wait to buy until after Phase 2 data, your potential gains will be cut down drastically if you are purchasing it after positive Phase 2 data as the price should see some recovery then. It's higher risk/higher reward if you buy now.
       
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    28. Geatly

      Geatly Member

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      Noise induced, by jackhammering into concrete on constructio
      I would love to buy their shares, but unfortunately I can't find a seller, web page or anything where it is sold here in Slovakia. If anyone knows of any seller that sells Frequency Therapeutics stock in Slovakia, let me know.
       
    29. Nick47

      Nick47 Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      How do you actually buy stock? It's something I have never done.
       
    30. Chad Lawton

      Chad Lawton Member

      Tinnitus Since:
      2/19/18
      Cause of Tinnitus:
      Possible Ototoxicity + Noise Exposure
      You open up a brokerage account. It's like opening up a checking account with a bank but instead of writing checks to buy whatever you want with your bank account, you use the money in your brokerage account to buy stocks. TD Ameritrade, Fidelity, Robinhood are just a few examples of brokerages you can use.
       
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