Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. scotty03874

      scotty03874 Member Podcast Patron Benefactor

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues after ear surgery
      Hey Chad, if this trial is successful, what number do you think the stock could jump up to again? Is it possible to get back up to $50's per share like back in February 2021? Fingers crossed for both hearing improvement and financial gains. But hearing improvements are FAR more important to me for my quality of life!

      I currently have 21,000 shares. My cost/average is just under $2.00. What are your thoughts on the stock forecast if we get positive results and get to Phase 3 (Fast Track), then hopefully get through FDA approval? What's your opinion?
       
      • Like Like x 2
      • Agree Agree x 1
      • Good Question Good Question x 1
    2. just1morething
      Benevolent

      just1morething Member Podcast Patron Benefactor Hall of Fame

      Location:
      U.S.
      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Airplane barotrauma to left ear, noise exposure.
      I see FREQ shares are at about $5/share so you would have a nice profit so far if your average is about $2/share. I hope their intratympanic formula is a success long term, whenever that may be. I haven’t been following them lately since their last year’s trial failure. After their stock dropped to about $1/share, I wasn’t much of a believer in any success.
       
    3. SmallRonnie
      Ape-like

      SmallRonnie Member Podcast Patron Benefactor

      Location:
      Ireland
      Tinnitus Since:
      H since 2018. T since 2021
      Cause of Tinnitus:
      Loud noise
      This was partly fueled by the bubble in all stocks around the same time so highly unlikely it will bounce right back, if ever. Stock prices after the dotcom bubble took 15 years to get back to ATH with some never recovering.
       
      • Like Like x 1
      • Agree Agree x 1
    4. Chad Lawton

      Chad Lawton Member

      Tinnitus Since:
      2/19/18
      Cause of Tinnitus:
      Possible Ototoxicity + Noise Exposure
      Really depends what share price we end up at right before data drop. I think it's reasonable that we could double up overnight to anywhere from $10 to $20 on good data. If FX-322 proves efficacy, it revalidates their entire platform and it's game on from there. If FX-345 also comes back with positive data 6 months later, then we may start seeing that $40-$50+ range. Or I could be completely wrong and Phase 2b data comes back negative and we fall back down below $1.
      The share price has no effect on the outcome of their trials and has been pretty disconnected from the underlying fundamentals of the company. It only affects their ability to raise capital in the future to keep the company funded. At $1, the company was being valued at 1/3 of their cash pile which was near bankruptcy levels yet the company had and still has enough funding to see 3 more trial results before they run out of cash.
       
      • Informative Informative x 4
      • Like Like x 2
      • Winner Winner x 1
    5. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
      If there was good data and FDA allowed them to market their drug, I guess shares would increase significantly, because it would be the first drug for inner ear applications on the planet.

      It would be a proof of concept for their platform.

      But I have no clue what price it would reach.

      If it was a widely applicable drug, I would see a bright future for Frequency Therapeutics. But as we learned, there is also a big chance that the drug might fail.
       
    6. in_LA

      in_LA Member

      Location:
      Los Angeles
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Loud music
      I'm hoping this is the case. If this drug fails, it might be a while before other companies try to treat hearing loss. There's a chance if this doesn't work, other companies might try to bypass the ear altogether before we get actual hearing regeneration.

      But who knows for sure.
       
    7. Nick1996

      Nick1996 Member

      Tinnitus Since:
      03/2010
      Cause of Tinnitus:
      Possibly stress
      I have heard from an audiologist that he expects FX-322 to go to Phase 3. What's the consensus here? I dread the day the report comes out and mentions failure.
       
      • Optimistic Optimistic x 3
      • Like Like x 1
      • Informative Informative x 1
    8. CRGC
      No Mood

      CRGC Member

      Location:
      Montreal
      Tinnitus Since:
      06/2022
      Cause of Tinnitus:
      SNRI/Noise
      I hope the audiologist is right! But there's really no way for anyone to know at this point. I totally agree about the feeling of dread... I still remember how my heart sank the day the OTO-313 results came out.
       
      • Agree Agree x 4
    9. NYCGuy
      Depressed

      NYCGuy Member Benefactor

      Location:
      NY
      Tinnitus Since:
      10/2021
      Cause of Tinnitus:
      Neck, Jaw or Stress, who knows.
      I saw an ENT who told me OTO-313 was a success. He even saw it fixing people's tinnitus but then it was a total failure. Just be extra careful hoping for too much with FX-322.
       
      • Agree Agree x 1
      • Informative Informative x 1
    10. patorjk
      No Mood

      patorjk Member Benefactor

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Several reasons
      I think the odds are 50/50 - a coin flip basically. On one hand Phase 2a failed, along with several of their other Phase 1b trials. Insanity is doing the same thing over and over again and hoping for different results.

      On the other hand, they are targeting groups they think the drug helped. If it legit works, this narrowing of focus should help them push through the barrier of statistical significance. It won't be the holy grail of curing hearing loss that people thought it might be before Phase 2a, but proof it works will bode well for their platform and for FX-345.
       
      • Agree Agree x 5
    11. Jupiterman

      Jupiterman Member

      Tinnitus Since:
      04/2022
      Cause of Tinnitus:
      Sudden loud noise
      If any of FX-322/FX-345 work and get to market, I believe they will only work to a limited extent. It could be something like a 60% chance of reducing your tinnitus by 40%.

      It may work better on some people than it does for others. It may end up being viewed as simply a 'Prednisone type' treatment that can be effective outwith the acute phase.
       
      • Agree Agree x 4
    12. RingingBrother

      RingingBrother Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise induced hearing loss
      I think they avoid the word cure because it's only a small hearing improvement and won't go back to 100%.
       
      • Agree Agree x 2
    13. in_LA

      in_LA Member

      Location:
      Los Angeles
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Loud music
      That's where FX-345 could improve on, but yeah, those with severe hearing loss will be left in a lurch for a while. But I'm hoping it can restore 40 percent of their hearing back.
       
    14. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      No, there are cochlear implants.
       
      • Like Like x 1
    15. patorjk
      No Mood

      patorjk Member Benefactor

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Several reasons
      From the data we've seen in the previous studies, for those with moderately-severe hearing loss, FX-322 won't restore 40% of their hearing. At best it will help them with word clarity - giving those people 10-20% better clarity in word recognition (with a few people being super responders and having bigger improvements). It has not been shown to help with improving audiogram scores. It's been theorized that this may be because FX-322 is regenerating inner hair cells (IHCs), which deal with word clarity. Outer hair cells (OHCs) deal with amplifying sound.

      As an aside, I recently saw a CBS report where they talked about a participant in the Phase 2a study who got "84%" of his hearing back. This came out on December 22, and since then Frequency Therapeutics' stock has surged 160%. I wonder if that report is giving people unrealistic expectations. It seems unintuitive that the drug would cause his hearing to come back all of a sudden and that no one else would have this kind of benefit. I worry that people are entering these trials who have problems unrelated to damaged hair cells (ie, nerve issue, mental issue, etc) and that that could wildly throw off the results. Imagine if someone like this were in the placebo group.
       
      • Agree Agree x 3
      • Like Like x 1
    16. Jonno02
      Wishful

      Jonno02 Member Benefactor

      Tinnitus Since:
      2022
      Cause of Tinnitus:
      Loud music / ETD
      To me anyway, the pharmaceutical route is a while off a total solution. Just now I'm pinning my hope on a 'treatment' rather than a cure, i.e. Dr. Susan Shore's device.

      In my experience, what will probably happen is FREQ will show promising data and/or an effective foundation to build a really successful treatment off. If this does happen, a multi-national major pharmaceutical company will most likely buy them and provide the necessary funding to really get a proper treatment developed. I don't think, right now anyway, this will be the cure we hope for, but I think it will be the proof of principal to perk up the ears of those with the required capital to inject into the development of cellular regeneration.

      This is a relatively juvenile area of study right now. If FREQ show that they can actually regrow cells thought to be lost forever and show that it really is possible (regardless of whether it's a 5% improvement only at this stage) they'll really garner the interest of companies like Roche, Pfizer, J&J etc.
       
      • Like Like x 3
      • Agree Agree x 1
      • Optimistic Optimistic x 1
    17. ColinUK

      ColinUK Member

      Tinnitus Since:
      2013 initial, worsened 2020
      Cause of Tinnitus:
      Initial Music Gig, Worsened Cinema or possible covid
      If FX-322 works to any extent, they have done something that has never been done in our history before. This would be a breakthrough. It would show that it is possible regenerate hearing. It could be a Pandora's box accelerating development in this field. This is what I really truly hope for; I am not expecting it to be the cure-all but if it works, it's the start of a new medical treatment in an area where currently none exist.

      I really hope FX-322 gets through the clinical trial successfully. I don't care if it's not a cure, just that it works at all.
       
      • Agree Agree x 7
      • Like Like x 3
      • Winner Winner x 2
      • Helpful Helpful x 1
    18. scotty03874

      scotty03874 Member Podcast Patron Benefactor

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues after ear surgery
      I can't agree more.
       
      • Like Like x 1
      • Agree Agree x 1
    19. Jonno02
      Wishful

      Jonno02 Member Benefactor

      Tinnitus Since:
      2022
      Cause of Tinnitus:
      Loud music / ETD
      Absolutely! The most difficult thing is showing it’s possible and achievable! If they manage to regenerate working hair cells, it could quite possibly be one of the biggest scientific discoveries of our lifetime. I have everything crossed for this study going well!
       
      • Like Like x 1
      • Agree Agree x 1
      • Helpful Helpful x 1
      • Hug Hug x 1
    20. xerpes

      xerpes Member

      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Acoustic trauma
      I'll be happy about anything that doesn't end my hope for a treatment.
       
      • Optimistic Optimistic x 2
      • Agree Agree x 1
      • Winner Winner x 1
    21. NoahCanada

      NoahCanada Member

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      acoustic trauma
      Frequency Therapeutics posted this video today:

       
      • Like Like x 15
      • Winner Winner x 3
      • Informative Informative x 2
      • Agree Agree x 1
    22. CarlosEstan
      Inspired

      CarlosEstan Member Benefactor

      Tinnitus Since:
      12/2022
      Cause of Tinnitus:
      Noise Induced
      The economy was roaring I will give you that, but FREQ was an over priced play that fell when investors found out this wasn't a get rich quick scheme. Hypothetically, the share will rise to that of its actual value, which with an effective drug should be somewhere around $20-$100 a share. I mean the way they are setting themselves up, they will have the only effective drug on the market resulting in having complete control of the market.

      They will more than likely make it to $50 a share again assuming everything works out; but I would pull my money out if it reached that price. The competition is taking notes after all.
       
      • Like Like x 1
    23. Jonno02
      Wishful

      Jonno02 Member Benefactor

      Tinnitus Since:
      2022
      Cause of Tinnitus:
      Loud music / ETD
      Wow, that’s promising!
       
      • Like Like x 3
    24. lello

      lello Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      unknown
      Could someone post a summary? I can't get subtitles in my language :(

      Thank you.
       
      • Agree Agree x 1
    25. SmallRonnie
      Ape-like

      SmallRonnie Member Podcast Patron Benefactor

      Location:
      Ireland
      Tinnitus Since:
      H since 2018. T since 2021
      Cause of Tinnitus:
      Loud noise
      There's nothing new in it.
       
      • Agree Agree x 4
      • Funny Funny x 1
    26. xerpes

      xerpes Member

      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Acoustic trauma
      I think there are some apps out there that can translate the subtitles. Do a Google search or check your app store.
       
    27. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      Yep. It's mostly an attempt to put a positive spin on results that are, at best, mild.
       
      • Agree Agree x 3
      • Like Like x 1
      • Optimistic Optimistic x 1
    28. RingingBrother

      RingingBrother Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise induced hearing loss
      How do you feel about FX-345?
       
      • Good Question Good Question x 1
    29. Jonno02
      Wishful

      Jonno02 Member Benefactor

      Tinnitus Since:
      2022
      Cause of Tinnitus:
      Loud music / ETD
      Any early treatment will be mild.

      If they can prove that hair cells can be restored, that could be a game changer?
       
      • Winner Winner x 1
    30. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
      If there is proof of regeneration, that would be fantastic and the first time in a human cochlea.

      I really pray for some positive results from where they might optimize the drug for all kinds of inner ear hearing loss.
       
      • Like Like x 3
      • Agree Agree x 1
Loading...

Share This Page