Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. AUTHOR
      AUTHOR
      all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
      -
      Cause of Tinnitus:
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      Yeah, you may have a 600 mg bottle, but 300mg/kg would mean 24,000mg for an 80 kg man (176 lbs). You'd soon be getting through that bottle... not that it would matter:)
       
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    2. AUTHOR
      AUTHOR
      all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
      -
      Cause of Tinnitus:
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      As far as I can remember the non-NAC ingredient is only sold to pharma companies and is VERY expensive.

      Please someone tell me if I have my facts on that right as I don't want to be giving false information.
       
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    3. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Mostly right. It's sold to research facilities (e.g. at universities) as well which was an "in" members were trying to use to get it.
       
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    4. ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      It's only $1070 for 200 mg.

      https://www.selleckchem.com/products/NXY-059.html
       
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    5. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      Quick question from a lay person - isn’t the amount of NAC needed for a dose enough to induce liver failure (300mg / kg)? I’m probably an idiot but what am I missing?
       
    6. sssing

      sssing Member Benefactor

      Tinnitus Since:
      2019
      Cause of Tinnitus:
      cold
      That’s a lot of NAC to take! I’m not sure about liver failure since NAC is used to prevent liver failure with aspirin overdose.
       
    7. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      Yes, there is a case report in the NAC thread where a young girl died from NAC overdose. But I am not sure if 24 g in one shot is already in the toxic range.
       
    8. paul mclean

      paul mclean Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      falling asleep with headphones in on loud
      Interesting part of the patent.

      "Our results show HPN-7/NAC can restore hearing dysfunction caused by noise, and ABR wave amplitudes can be used to monitor synapse loss and treatment effects with medicine.

      In summary, our results shows that HPN-07 represents a safe pharmacological means to regenerate lost ribbon synapses in the inner ear, providing a promising non-invasive alternative for treating cochlear synaptopathy and its associated prevalent clinical manifestations, such as difficulty understanding speech in noisy environments, presbycusis, hyperacusis and tinnitus."
       
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    9. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      I mean a normal daily dose is like 1200 mg.
      Let’s storm the factory so we can go on with our lives.
       
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    10. paul mclean

      paul mclean Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      falling asleep with headphones in on loud
      @GBB, that's 2 patents I've read on cochlear synaptopathy that have said it is the cause of tinnitus and repairing synapses heals tinnitus.

      I contacted a biotech company about the price of NXY-059 and it is quite expensive. 500 grams is $22,000 USD.

      You can get NAC really cheap from wholesalers online. Wonder what the lowest dose is where there is therapeutic benefit?

      "To promote or enhance synaptogenesis and neuritogenesis, 2,4-DSPBN can be administered at a dose of, for example, between about 1 mg/kg to about 500 mg/kg body weight, or between about 5 mg/kg to about 400 mg/kg body weight, or between about 10 mg/kg to about 300 mg/kg body weight, or at about 10 mg/kg body weight, or at about 20 mg/kg body weight, or at about 50 mg/kg body weight, or at about 100 mg/kg body weight, or at about 150 mg/kg body weight, or at about 200 mg/kg body weight, or at about 250 mg/kg body weight, or at about 300 mg/kg body weight."
       
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    11. MRItechssuck
      Disappointed

      MRItechssuck Member

      Location:
      USA
      Tinnitus Since:
      Mild 2000-2018 sev 10/17/2019
      Cause of Tinnitus:
      Loud noise, MRI
      I have been taking NAC at 1800mg for almost a year... no changes. YMMV.
       
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    12. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      Does anyone know what the PoC study consists of?
       
    13. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      It would be interesting to super dose NAC under the supervision of a doctor, if they would agree to help. Can anyone with a medical background on this forum comment on what the upper range intake *might* be?
       
    14. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Toxicology studies should be available online... if there are any. I couldn't find any. In fact, this reference says there is no data available except for the LD50 for mice and rats (lethal dose for 50% of sample sizes -- 4400mg/kg for mice and 5050mg/kg for rats):

      https://www.caymanchem.com/msdss/20261m.pdf
       
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    15. paul mclean

      paul mclean Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      falling asleep with headphones in on loud
      @MRItechssuck

      Nothing will happen with just NAC. Adding NAC to NPH-07 (2,4-DSPBN) has high synergy together but you need (2,4-DSPBN) most importantly.
       
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    16. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Maybe NAC isn't effective enough solo.
       
    17. MRItechssuck
      Disappointed

      MRItechssuck Member

      Location:
      USA
      Tinnitus Since:
      Mild 2000-2018 sev 10/17/2019
      Cause of Tinnitus:
      Loud noise, MRI
      With the 1800 mg of NAC, I have also been taking between 1000-3000mg of Turmeric (no difference), 300 mg of TRU Niagen a day (only the last 6 months), B complex vitamin, Astaxanthin (a saint on here took it) but I had to stop that because it seemed to worsen things a bit.

      Was the FDA going to reclassify NAC as a controlled medicine? I thought I read that.

      I’m not familiar with NPH-07 (2,4-DSPBN)...

      Maybe there will be a miracle pill in the future, but there have been too many disappointments.
       
    18. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I reckon right now there is no real reason to be taking NAC solo or other medication for that matter either. There's something telling me that these medicines firstly don't work solo and secondly there is probably something done with the way Hough Ear Institute has made up their mix which supposedly makes it work.
       
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    19. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      I can't speak for Oblato, but I can share with you what they have shared with us. They intended on starting phase 2 trials this year. They would still like to. However, there is a global pandemic that is effecting ALL research right now at the clinical trial level. We are still doing our part at the pre-clinical level to help usher in the treatment.

      Yes, once approved you can take it for anything a doctor is willing to prescribe it for. The question then comes to whether or not insurance will cover it. That is why having it approved for the indication of tinnitus is so important - to make it more affordable to more people.

      This is why NGOs are on the frontier of innovation in drug development. Generally speaking, their treatments are less expensive when they get to the market.
       
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    20. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      PoC studies are not done on humans. The hope is to get it into a phase 2 clinical trial.
       
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    21. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      We have developed a novel way to objectively measure the presence of tinnitus. :)

      The phase II study with our pill, it is hoped, will be for the primary indication of tinnitus.
       
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    22. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      I don't think we have ever said 2024. If so, that would have been an error. We have consistently said mid-2020's. However some people thought that meant mid-2020, not 2020s - as in the decade. So we started messaging that it is hoped to be in the market 2025/26.

      With the global pandemic and its effects on clinical trials for everything - I feel it best to say 2026/27 because of the delays related to the pandemic.

      We don't run the trials, the biotech company does.
       
    23. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      We didn't choose cochlear implant trauma. Which indication they (the biotech firm) choose is still in the air right now.

      The delays in clinical research has to do with the pandemic, and less with what indication is chosen.
       
    24. ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      Presence of tinnitus?

      As in binary 1 and 0?

      Are you able to objectively rate the loudness of tinnitus?

      And why do you keep this info hidden?

      Many other companies and researchers would benefit from being able to have access to objective measurement of tinnitus.

      Share the knowledge. If you are the good not-for-profit guys you claim to be...
       
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    25. paul mclean

      paul mclean Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      falling asleep with headphones in on loud
      Justin,

      Any chance of your drug being fast tracked like FX-322 was? And how long does fast tracking take off time to hit shelves?

      Funny, I was just watching a video with you in it explaining the FDA approval process.
       
    26. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Is this a novel way that is applicable to just rodents (i.e. tells you whether they do or don't have tinnitus) or is it applicable to humans too?

      And is it more descriptive than a binary yes or no? I.e. does it measure severity?
      Understood, but Frequency Therapeutics has said the reason COVID-19 only delayed their trial slightly (a few months) was because they are able to carry their studies in outpatient ENT clinics which remain open and at capacity so, in that sense, indication seems to be a factor because they probably couldn't have done that if their study population was undergoing surgery.
       
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    27. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      There are three questions I have which relate to your comment about the phase 2 study.

      1. Out of interest, is Hough Ear Institute the party hoping tinnitus will be the primary indication for the phase 2 clinical trial of the pill?

      2. What do you mean when you use the term primary indication and what does this mean in the context of clinical trials?

      3. If tinnitus is the primary indication for the clinical trial, what effect does this have on the other potential indications (like ototoxicity) which the pill could be put through clinical trials for too?
      This makes much more sense now regarding the timeline. The mid 2020/mid 2020s issue I was aware of and I knew it was the latter.

      I absolutely understand why we would possibly have setbacks and also delays with what is going on currently.
       
    28. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      This is interesting. So this Hough Ear Institute pill is just a super high dose of NAC mixed with Disufenton Sodium? That doesn’t sound that hard to mix together to be honest, just grind up the necessary dose of NAC and Disufenton Sodium and drink it.

      Is it as simple as it sounds?
       
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    29. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Totally doable if you have many thousands of dollars to spare.
       
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    30. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      Do we know yet if this is a pill you have to take regularly? Or would one dose be sufficient?
       
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