Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. AUTHOR
      AUTHOR
      all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
      -
      Cause of Tinnitus:
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      Yeah, when I made the thread I had no idea about the drug really, just that it wasn't getting much attention. I presume the mods could change the name if they wanted.
       
    2. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      It is incredibly obvious that they are trying the panhandle route. There's also something that they are not letting up about this either.
       
    3. weab00
      Alone

      weab00 Member Benefactor

      Location:
      depression-ville
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      noise, whiplash; 08/20 H
      Yeah like why does Justin De Moss selectively answer questions when he pops in the thread once every few months?

      He clearly scrolls by 10 people all asking how do you measure tinnitus objectively, why are you crowdsourcing donations, etc. but instead ignores them which arises suspicions.
       
    4. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Not to mention the fact that there still isn’t a clear answer as to why they need to take this through the tinnitus indication first and not through the other indications like ototoxic medication impact even though this data is available now.

      If this medicine is the only option and also it does prove itself to work then great. However at this time I am actually wondering whether we will see something else surpass it like PIPE-505 that seemingly also might do some similar stuff? This lack of transparency is interesting and also probably the reason some people do not have much faith in it.
       
    5. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      So it seems that based off of the latest Hough Ear Institute post that their medicine most likely is a synapse drug doing the same things that OTO-413 and PIPE-505 are purportedly doing.

      I definitely do think that the only things which seem different about their methodology is to try to test specifically for tinnitus.
       
      • Agree Agree x 1
    6. weab00
      Alone

      weab00 Member Benefactor

      Location:
      depression-ville
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      noise, whiplash; 08/20 H
      What will the advantage of Hough Ear Institute's Pill be if OTO-413 comes out several years before they even hit the market? Pricing?
       
    7. Lucifer

      Lucifer Member Podcast Patron Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      Another difference is that Hough Ear Institute's synapse drug is a tablet whereas PIPE-505 is an injection. I wonder what the side effects of these synapse drugs will have between a pill and an injection.
       
      • Good Question Good Question x 1
    8. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I'd assume a successful PIPE-505 or OTO-413 would be able to possibly charge a higher price if they had less treatments to compete against and therefore they would benefit from being the first available.

      I can't see that there would be any benefit for Hough Ear Institute if they released their treatment after Pipeline or Otonomy on account of the fact that they are really just another option to treat synapse regrowth. Right now it seems that their treatment is no different to the others and also at this stage there tends to be no indication that they will do anything more for tinnitus either. The only benefit might be that this treatment from Hough Ear Institute can be used to treat tinnitus through insurance, as apparently this is a possible benefit from their Proof of Concept trial. Though this benefit might be totally negated if it is correct that tinnitus is caused by stuffed synapses since it might be possible to get one of the other treatments through insurance under the guise of stuffed synapses to truly treat tinnitus.
      I don't know if there are any side effects or noticeable differences between the treatment types aside from the risks associated with the injection like a burst ear drum. However I think that the thing which doesn't matter as much when it comes to synapse medicine is the fact that there are no issues with extra growth like with a hair cell medicine. Therefore this tends to be why you are allowed to take this in a tablet form unlike a hair cell medicine like FX-322 where it leads to uncontrolled growth.

      I have got a feeling that one of the best outcomes we could potentially see from a synapse drug injected such as OTO-413, is that it will actually also demonstrate the effectiveness of Otonomy's theory that the treatment can correctly treat you throughout the ear due to their delivery process. Essentially this also will provide good indications that OTO-6XX may work within the entire hearing range if it is effective because it will demonstrate that their delivery technique can really go deep.

      I definitely think that the treatment result from OTO-413 will help hugely with Otonomy's progression for OTO-6XX too.
       
      • Agree Agree x 1
    9. wwtsai

      wwtsai Member Podcast Patron Benefactor

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      SNHL
      I received an update as a donor earlier today:

      "I wanted to give you this special update on our research since you have been so gracious to support this work.

      Our hair cell regeneration technology continues to demonstrate its effectiveness in significantly restoring hearing function in our preclinical studies. Now, we are looking ahead at the specific considerations that we will need to accommodate for testing this technology in a clinical setting.

      With this focus in mind, HEI researchers will be performing several quick and strategic studies. These will help us to better predict how our technology will respond in human subjects in order to better anticipate the optimal therapeutic effects and potential side effects.

      We will also be testing whether strategic modifications to both the drug structure and the carrier which encapsulates it has any effect on the efficacy, stability, ease of delivery, and operational precision in the inner ear. The results from these studies will allow us to refine our formulations and clinical approach to create the safest, most effective, drug product that we can."​

      I can't really make heads or tails of the update other than that it's progressing? Regardless, I wanted to post it here.
       
      • Like Like x 2
      • Informative Informative x 1
    10. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Hough Ear Institute seems to be moving much more quickly than they tended to previously. I wonder whether this has anything to do with the fact that there is so much going on this area.
       
    11. weab00
      Alone

      weab00 Member Benefactor

      Location:
      depression-ville
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      noise, whiplash; 08/20 H
      We want answers Justin.

      Ddmt7ga.jpg
       
      • Winner Winner x 2
    12. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I don’t think that there will be much out of them till the study is complete.

      It will be interesting to see whether Pipeline Therapeutics or Otonomy can attain an improvement in tinnitus from their comparable treatments.

      Especially since Hough Ear Institute has not stated the reasons why their treatment treats tinnitus.
       
    13. weab00
      Alone

      weab00 Member Benefactor

      Location:
      depression-ville
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      noise, whiplash; 08/20 H
      Why are Hough Ear Institute keeping a way to measure the true loudness of tinnitus hidden away in a lab? Are they lying? This is knowledge that could be used to advance research for thousands of researchers.
       
    14. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      Money talks, altruism walks.
       
      • Winner Winner x 1
    15. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      It is I think one of two things:

      - Hough Ear Institute is staying silent because their treatment will help tinnitus but it is a synapse treatment that is the same as PIPE-505 and actually doesn’t have any different benefits to the other treatments. For example their pill doesn’t specifically treat tinnitus any differently to the others.

      - Hough Ear Institute has got a really good thing going on and as a result it is incredibly likely that they are keeping quiet on it until they have sufficiently validated results.

      Either way I think that the reality is that Hough Ear Institute might not be coming out and saying anything directly about it because they have a history of not being direct about these things.
       
      • Agree Agree x 1
    16. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      I'll bet 100 bucks with someone they haven't found a real way to do this that doesn't have some messy assumptions/critical flaw/massively limiting factor. Basically there is an Achilles heel here or it's just flat out wrong. If you discovered this you could get a Nobel prize honestly - no reason to just mention it in passing and do nothing...
       
      • Agree Agree x 1
    17. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I must say it does seem very interesting that they haven’t commented on this. It could be they are avoiding answering and telling porkies on by bending the truth like they did with the trial process and also again with the financing for this study.
       
    18. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      What I'm wondering is if there was a way to measure tinnitus, wouldn't that open up the ability to rightfully sue doctors and pharmaceutical companies whose "treatments" either caused or worsened people's conditions.
       
    19. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      Probably not if it’s listed as a side effect.
       
      • Agree Agree x 1
    20. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      Agreed but if doctors don't inform you or give you the information to find that out as was part of my case with microsuction and Ciprofloxacin and Nabumetone, then the liability falls with them.
       

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