Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. AUTHOR
      AUTHOR
      all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
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      Yeah, when I made the thread I had no idea about the drug really, just that it wasn't getting much attention. I presume the mods could change the name if they wanted.
       
    2. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      It is incredibly obvious that they are trying the panhandle route. There's also something that they are not letting up about this either.
       
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    3. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      Yeah like why does Justin De Moss selectively answer questions when he pops in the thread once every few months?

      He clearly scrolls by 10 people all asking how do you measure tinnitus objectively, why are you crowdsourcing donations, etc. but instead ignores them which arises suspicions.
       
    4. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Not to mention the fact that there still isn’t a clear answer as to why they need to take this through the tinnitus indication first and not through the other indications like ototoxic medication impact even though this data is available now.

      If this medicine is the only option and also it does prove itself to work then great. However at this time I am actually wondering whether we will see something else surpass it like PIPE-505 that seemingly also might do some similar stuff? This lack of transparency is interesting and also probably the reason some people do not have much faith in it.
       
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    5. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      So it seems that based off of the latest Hough Ear Institute post that their medicine most likely is a synapse drug doing the same things that OTO-413 and PIPE-505 are purportedly doing.

      I definitely do think that the only things which seem different about their methodology is to try to test specifically for tinnitus.
       
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    6. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      What will the advantage of Hough Ear Institute's Pill be if OTO-413 comes out several years before they even hit the market? Pricing?
       
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    7. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

      Location:
      Hell
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      Another difference is that Hough Ear Institute's synapse drug is a tablet whereas PIPE-505 is an injection. I wonder what the side effects of these synapse drugs will have between a pill and an injection.
       
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    8. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I'd assume a successful PIPE-505 or OTO-413 would be able to possibly charge a higher price if they had less treatments to compete against and therefore they would benefit from being the first available.

      I can't see that there would be any benefit for Hough Ear Institute if they released their treatment after Pipeline or Otonomy on account of the fact that they are really just another option to treat synapse regrowth. Right now it seems that their treatment is no different to the others and also at this stage there tends to be no indication that they will do anything more for tinnitus either. The only benefit might be that this treatment from Hough Ear Institute can be used to treat tinnitus through insurance, as apparently this is a possible benefit from their Proof of Concept trial. Though this benefit might be totally negated if it is correct that tinnitus is caused by stuffed synapses since it might be possible to get one of the other treatments through insurance under the guise of stuffed synapses to truly treat tinnitus.
      I don't know if there are any side effects or noticeable differences between the treatment types aside from the risks associated with the injection like a burst ear drum. However I think that the thing which doesn't matter as much when it comes to synapse medicine is the fact that there are no issues with extra growth like with a hair cell medicine. Therefore this tends to be why you are allowed to take this in a tablet form unlike a hair cell medicine like FX-322 where it leads to uncontrolled growth.

      I have got a feeling that one of the best outcomes we could potentially see from a synapse drug injected such as OTO-413, is that it will actually also demonstrate the effectiveness of Otonomy's theory that the treatment can correctly treat you throughout the ear due to their delivery process. Essentially this also will provide good indications that OTO-6XX may work within the entire hearing range if it is effective because it will demonstrate that their delivery technique can really go deep.

      I definitely think that the treatment result from OTO-413 will help hugely with Otonomy's progression for OTO-6XX too.
       
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    9. wwtsai
      Assassinator

      wwtsai Member Podcast Patron Benefactor

      Location:
      San Francisco
      Tinnitus Since:
      Mild (2016) Bothersome (8/20)
      Cause of Tinnitus:
      SNHL
      I received an update as a donor earlier today:

      "I wanted to give you this special update on our research since you have been so gracious to support this work.

      Our hair cell regeneration technology continues to demonstrate its effectiveness in significantly restoring hearing function in our preclinical studies. Now, we are looking ahead at the specific considerations that we will need to accommodate for testing this technology in a clinical setting.

      With this focus in mind, HEI researchers will be performing several quick and strategic studies. These will help us to better predict how our technology will respond in human subjects in order to better anticipate the optimal therapeutic effects and potential side effects.

      We will also be testing whether strategic modifications to both the drug structure and the carrier which encapsulates it has any effect on the efficacy, stability, ease of delivery, and operational precision in the inner ear. The results from these studies will allow us to refine our formulations and clinical approach to create the safest, most effective, drug product that we can."​

      I can't really make heads or tails of the update other than that it's progressing? Regardless, I wanted to post it here.
       
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    10. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Hough Ear Institute seems to be moving much more quickly than they tended to previously. I wonder whether this has anything to do with the fact that there is so much going on this area.
       
    11. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      We want answers Justin.

      Ddmt7ga.jpg
       
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    12. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I don’t think that there will be much out of them till the study is complete.

      It will be interesting to see whether Pipeline Therapeutics or Otonomy can attain an improvement in tinnitus from their comparable treatments.

      Especially since Hough Ear Institute has not stated the reasons why their treatment treats tinnitus.
       
    13. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      Why are Hough Ear Institute keeping a way to measure the true loudness of tinnitus hidden away in a lab? Are they lying? This is knowledge that could be used to advance research for thousands of researchers.
       
    14. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      Money talks, altruism walks.
       
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    15. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      It is I think one of two things:

      - Hough Ear Institute is staying silent because their treatment will help tinnitus but it is a synapse treatment that is the same as PIPE-505 and actually doesn’t have any different benefits to the other treatments. For example their pill doesn’t specifically treat tinnitus any differently to the others.

      - Hough Ear Institute has got a really good thing going on and as a result it is incredibly likely that they are keeping quiet on it until they have sufficiently validated results.

      Either way I think that the reality is that Hough Ear Institute might not be coming out and saying anything directly about it because they have a history of not being direct about these things.
       
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    16. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      I'll bet 100 bucks with someone they haven't found a real way to do this that doesn't have some messy assumptions/critical flaw/massively limiting factor. Basically there is an Achilles heel here or it's just flat out wrong. If you discovered this you could get a Nobel prize honestly - no reason to just mention it in passing and do nothing...
       
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    17. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I must say it does seem very interesting that they haven’t commented on this. It could be they are avoiding answering and telling porkies on by bending the truth like they did with the trial process and also again with the financing for this study.
       
    18. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      What I'm wondering is if there was a way to measure tinnitus, wouldn't that open up the ability to rightfully sue doctors and pharmaceutical companies whose "treatments" either caused or worsened people's conditions.
       
    19. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      Probably not if it’s listed as a side effect.
       
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    20. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      Agreed but if doctors don't inform you or give you the information to find that out as was part of my case with microsuction and Ciprofloxacin and Nabumetone, then the liability falls with them.
       
    21. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      I’ve attempted to reach Oblato Inc several times to inquire about future trials. The internet states they have 1 employee, $28,000 annual budget, and the CEO is Won Suk Yang.

      What’s going on here, is the size of this company normal in this field?

      Do they have a team to make something happen? Maybe they need to be questioned where they’re at on their end?
       
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    22. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
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      Cause of Tinnitus:
      Explanation in About You
      Which site are you using? A lot of these “data” sites are extremely inaccurate and use awful algorithm crawlers that pull data from subpar sources. The company I work for has shown up as having 13 employees one and 50 on another (both are grossly wrong). And the annual revenue and budgets the site reported were so far off you would think the business would have already gone bankrupt.

      Despite the severe lack of transparency Hough Ear Institute has displayed, I would say with confidence that there is no way that Oblato is a one-man operation. If they truly are an established biotech firm.
       
    23. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Oblato is interestingly enough also developing a brain tumour medicine and this has also been acquired from another Oklahoma based firm as well.

      What I think you need to consider is two things about Oblato and their operations:

      1. Oblato is actually a subsidiary of GTreeBNT and as a result although it is strange to see Oblato only having one employee, it is not surprising or even necessarily abnormal. At this time it appears Oblato is set up probably to run GTreeBNT operations in the US, however it wouldn't be surprising to not see Oblato expand until the time comes to actually commence the clinical trials. It is also possible that Oblato may actually use GTreeBNT's resources to assist with completing the clinical trials such as staff. Hence this could be why Oblato hasn't appointed any of their own staff for this and is actually just using Oblato as their legitimate front for the US operations.

      2. Hough Ear Institute is also controlling a lot more of the trials than we are actually led to believe. I wouldn't be surprised by this since Hough Ear Institute have seemingly been the ones dictating stuff like that the tinnitus proof of concept study needing to be done prior to the commencement of the clinical trials. Thus I wouldn't be surprised if Oblato was taking a back seat with this stuff at present.

      Having said that, I think Hough Ear Institute is at the moment making quite quick progress suddenly with their pill. This is evident by the fact that the proof of concept study could now be finished in 6 to 12 months and also that seemingly there could be a quicker progression to clinical trials too. Hough Ear Institute has indicated that the trials will commence post the proof of concept study. However the question still remains whether it was Hough Ear Institute, Oblato or both organisations that decided to proceed with required operations much more quickly than previously anticipated.

      Anyway I can consequently see something happen with the pill pretty quickly. I strongly believe that Hough Ear Institute and/or Oblato will move quickly with this treatment if it is successful like they claim because they face potential challenges from competitors otherwise, especially for the synapse component of the medicine.
       
    24. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      Might as well be $2,800 and Sun Wu Kong.
       
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    25. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Hough Ear Institute interestingly is indicating on their Facebook page they want donations again for the pill.

      This is getting quite interesting now that they still apparently need funding, yet have started the proof of concept study for tinnitus that they said wouldn't get funded until they got the required amount donated and have also said that the study timeframe will now be 6 to 12 months.

      My view is that this is just getting really interesting, yet ridiculous at the same time too. I think Hough Ear Institute has the funding lined up for this, otherwise they wouldn't have been able to start the study.

      Something tells me that this tends to be an attempt at just getting more money out of people now to mitigate their costs.
       
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    26. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      Well that's shady af. Why put our faith in a company that resorts to these kinds of tactics.
       
    27. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I don't blame them for wanting to gain funds to fund the proof of concept study as a not for profit entity. What I do dislike though is the consistently changing positions from Hough Ear Institute. It is essentially seeming more and more like a case of them being disingenuous about what is really going on. I believe them that they have started the study. Still what I don't know is what will happen if they do not obtain the required donations by the time that the trial ends. Essentially they can try to collect more donations for all I care, just as long as the study gets done and isn't protracted because of the lack of funding.
       
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    28. twa
      Irritated

      twa Member Benefactor

      Location:
      US
      Tinnitus Since:
      2017- mild /Sept. 2020-moderate
      Cause of Tinnitus:
      meds/acoustic trauma
      If all goes well, would Hough Ear Institute's pill be able to help current tinnitus patients who have had acoustic trauma?
       
    29. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I think that they are attempting to treat noise-induced tinnitus.

      Though the question remains whether the additional component in the medicine is what will treat tinnitus or whether it is just going to be the regrowth of the synapses. Seems that this won’t get answered until the pill gets tested.

      Also we will very likely have a better understanding of the effects of synapses on tinnitus when we find out about the benefit that other synapse only treatments provide to tinnitus like PIPE-505 or OTO-413 because if these mitigate tinnitus then it tends to tell us that the synapses alone actually are what has a large effect on tinnitus.
       
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    30. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      Hi. I am new to the forum. I emailed Justin from Hough Ear Institute to ask about this. Here is the email response he gave me a couple weeks ago:

      Hi Mica,

      Yes, we believe we have found a way to objectively measure the presence of tinnitus. That method however is not something I can share or expand on.

      I can tell you that one of the prevailing theories for tinnitus is the lost of meaningful nerve connection between the cochlea and the auditory nerve. Our pill restores those meaningful connections.

      At your service,
      JUSTIN DE MOSS, M.A., CFRE
      Chief Philanthropy Officer
       
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