Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. OptimusPrimed
      Spaced

      OptimusPrimed Member Benefactor

      Tinnitus Since:
      10/2007
      Cause of Tinnitus:
      Acoustic trauma - Repeated gun blasts
      And then be disappointed with them instead lol. There is nothing but disappointments and suffering in this field unfortunately.
       
    2. ThomasF
      Creative

      ThomasF Member

      Location:
      Florida
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Probably loud music
      Please don't give up hope my friend. Medical science is making strides every day in understanding the mind. A real solution will manifest in the efforts of numerous groups from across the world.
       
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    3. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      You can apply for compassionate use, see attached email:

      Hey Scott!

      The short answer is yes, our hearing loss pill, NHPN-1010, is available through the FDA’s expanded access program and anyone in the US can apply to receive it. You can find information about how to apply here.

      Unfortunately, HEI has nothing to do with the application process so I don’t know anything about it. I do know you’ll need to apply through your physician since it’s not a fully approved therapeutic. I also know, you’ll need to contact Oblato, Inc. to get samples of NHPN-1010 since they are our licensing partners for this therapeutic and the actual manufacturers.

      Best of luck to you! If you would like to know more about our other research endeavors, sign up to receive our newsletter.

      ASHLEY EVERETT
      Philanthropy Coordinator
       
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    4. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor Hall of Fame

      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Nonnatural energy source
      Wow!!! OK, who is going to be the brave soul to give this a go?
       
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    5. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      Dude, nice! I’ve been trying to figure this out for months! Good find. So Ashley is from where though?
       
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    6. DocTors_94
      In pain

      DocTors_94 Member Benefactor

      Location:
      Spain
      Tinnitus Since:
      11/2021
      Cause of Tinnitus:
      Loud noise/ Covid? / Benzos / Ototoxicity
      I would take it for sure. Any way I could get it living in Spain? You just can't imagine how desperate I am...
       
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    7. Bambam0
      Cool

      Bambam0 Member Podcast Patron Benefactor

      Tinnitus Since:
      2/2018
      Cause of Tinnitus:
      Drums
      I think Ashley is the new @Justin De Moss - aka Philanthropy Director for Hough Ear Institute. Are we all applying for this or what? Or is this only for acute NIHL?
       
    8. ThomasC
      Lonely

      ThomasC Member Benefactor

      Location:
      France
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      hearing loss
      It seems she is a member of Hough Ear Institute's staff. I've just checked on Google.
       
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    9. IntotheBlue03

      IntotheBlue03 Member

      Location:
      Philadelphia PA
      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      Cervical/TBD
      Any takers on this? I haven’t followed this but assuming it’s for exclusively noise induced/hearing loss tinnitus?
       
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    10. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      I spoke with Justin from Hough Ear Institute on the phone a year ago. Their drug candidate was actually indicated for something else, which I forget, maybe seizures? And they had a number of people report in the trial that their hearing and tinnitus had improved, not something anyone was looking for...

      So it would seem the drug is safe for humans.
       
      • Informative Informative x 4
    11. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      Keep in mind that this pill is not the OPI-001 (chronic hearing damage/tinnitus), but for acute trauma.

      There is absolutely 0 evidence as of yet that this works for tinnitus. It is not even trialed for tinnitus patients! Only a Phase 1 for safety purposes on healthy patients!
       
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    12. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      I think as many people should apply for it as possible yes. My next doctor’s visit I will. I mean why not. If people here have ear problems bad enough, definitely apply for it. We got nothing to lose. It should help either way.

      I think it’s most interesting for somebody who has hyperacusis, noxacusis, distortions, 6 tinnitus sounds like myself to see what improves.
       
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    13. Gee82

      Gee82 Member

      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Noise
      I can’t help but wonder why Justin de Moss never mentioned compassionate use here before. Anyway, any idea if Europeans can access it too?
       
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    14. chinup

      chinup Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Loud music
      Well which is it?
       
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    15. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC

      Phase 1 study was only for healthy individuals. Neither the primary nor secondary outcome was measuring anything related to hearing or tinnitus. Purely safety.

      Any improvement were merely anecdotal, not a single piece of research paper anywhere. We know how subjective tinnitus is, placebo effect etc. There were only studies done on lab rats.

      Don't get me wrong, very curious to the outcomes of individuals that manage to get their hold on this, but there is more evidence that Magnesium pills have positive impact on tinnitus than this pill...!
       
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    16. JPGL
      Frustrated

      JPGL Member Benefactor

      Location:
      Spain
      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      Hearing loss? Noise? Stress? Unknown
      Does anyone know if I can apply for compassionate use? I live in Spain.
       
      • Good Question Good Question x 1
    17. DimLeb

      DimLeb Member

      Tinnitus Since:
      03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy or Maybe Loud Music
      I believe that since it passed the safety trial, one has nothing to lose by trying the pill out.

      Unfortunately for us here in Europe, I don't see how we could apply for it.
       
    18. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
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    19. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      So was that article true? And Justin had no idea what he was talking about.
       
    20. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      From Hough Ear Institute.
       
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    21. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      Only the USA right now for compassionate use.
       
      • Helpful Helpful x 1
    22. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      Yes, her signature line said Philanthropy Director.
       
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    23. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      I will 100% if I get approved...
       
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    24. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Justin was talking about how and why Hough Ear Institute acquired this drug candidate. I'd say a guy who was an employee of Hough Ear Institute knows a little more than you. But please do prove him wrong.
       
    25. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      He told us it wasn’t available for compassionate use. It looks like it is according to the above post?
       
      • Good Question Good Question x 1
    26. IntotheBlue03

      IntotheBlue03 Member

      Location:
      Philadelphia PA
      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      Cervical/TBD
      Not sure if I’m going to go through with it but I’m going to ask my PCP about applying for this. He prescribed me Topamax which I refused to take right off the bat so what’s the harm in an off label investigatory anti-seizure med?
       
    27. Gee82

      Gee82 Member

      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Noise
      To all my European fellows: I wrote an email to the FDA enquiring if non-US residents would be eligible to the expanded access. Here’s their reply:

      “Typically, if a patient is not an United States citizen, then approval would be needed from the regulatory agency governing their own respective country. In addition, the treating physician would also need to obtain agreement from the drug company who would be providing the drug for the patient’s use.”​

      It sounds to me that we can still apply, but we probably have to check in with EMA first. I will try to contact them to see if they can help.
       
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    28. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      I will be going to doctors to find one who will write a good summary of my case. I will keep everybody updated. Definitely need something to reconnect my nerves.
       
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    29. Franci003

      Franci003 Member

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      Unknown
      I was emailing with a lady from Hough Ear Institute who got back to me and said it will be aimed at basically all types of tinnitus, regardless of the cause, with or without hearing loss.
       
      • Informative Informative x 3
    30. Joeseph Stope
      Innocent

      Joeseph Stope Member

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      noise? infection? negative stress? other?
      Not one to pee on your parade or on your placebo-effect (which can have significant influence on outcome) but don't set your heart and soul on it.

      But prove me wrong. I'll be very happy.
       
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