Hough Ear Institute's Hair Cell Regeneration Project

Which article are you referring to which talks about the patient having tinnitus and hyperacusis while receiving this treatment? Does it mention their hyperacusis and tinnitus going away after they had the treatment?

 

Yeah it’s the same.

https://www.sigmaaldrich.com/US/en/product/sigma/sml2163

 

Just don't get what's happened here? Hough Ear Institute took donations of people to develop hearing loss treatments, now that's shelved and it's a cancer drug?? Or are they still developing it as a hearing loss / tinnitus treatment?

 

I feel bad for everyone who donated to them. To be honest they were never clear in their messaging. This is looking more and more as a scam.

@Hazel and @Markku, how do you feel about Hough Ear Institute still being listed as a worthy cause to donate to?

 

Hough Ear Institute are bullshitting us.

 

I'm one of the people who donate to Hough Ear Institute, I had hope but it seems my money is gone for nothing.

 

FDA OKs expanded access program for HLB Therapeutics' tinnitus treatment candidate

 

I think one of the guys (Justin De Moss) who used to work for Hough Ear Institute and post here in this thread said that the article is not true.

 

Hough Ear Institute did say there would be a two year study until 2022. If nothing starts by then or 2023, they are definitely bullshitting.

 

It was already scammy enough that they were gathering donations for a non-existent reason, and now it looks like they gave the drug away. That's really bad. I want my 50 euros back lol.

 

Nope. Justin said he didn’t know.

 

The amount of involvement the US Government has with this drug makes it being a scam a bad idea. Especially with Hough Ear Institute receiving money from both the DoD and the State Government of Oklahoma. There is the potential that the drug might not help those with long-term tinnitus. There is evidence with animal testing that implies the drug can aid with long-term tinnitus. Keep in mind that what works for animals like rodents may not work for humans. Though it is a much smaller leap than quail to humans like studies from the 80s observed.

Right now it is too soon to tell that this drug will be the cure nerve damage tinnitus sufferers have been waiting for. There is a lot of research out there and keeping a hopeful outlook has more fruitful potential than blanket skepticism.

 

I'd argue the opposite, actually. Putting your hope in something which has a high chance of failure puts you up for disappointment. Keep that hope for Otonomy or Susan Shore's device.

 

I like to see many possibilities coming from multiple attempts.

 

And then be disappointed with them instead lol. There is nothing but disappointments and suffering in this field unfortunately.

 

Please don't give up hope my friend. Medical science is making strides every day in understanding the mind. A real solution will manifest in the efforts of numerous groups from across the world.

 

You can apply for compassionate use, see attached email:

Hey Scott!

The short answer is yes, our hearing loss pill, NHPN-1010, is available through the FDA’s expanded access program and anyone in the US can apply to receive it. You can find information about how to apply here.

Unfortunately, HEI has nothing to do with the application process so I don’t know anything about it. I do know you’ll need to apply through your physician since it’s not a fully approved therapeutic. I also know, you’ll need to contact Oblato, Inc. to get samples of NHPN-1010 since they are our licensing partners for this therapeutic and the actual manufacturers.

Best of luck to you! If you would like to know more about our other research endeavors, sign up to receive our newsletter.

ASHLEY EVERETT
Philanthropy Coordinator

 

Wow!!! OK, who is going to be the brave soul to give this a go?

 

Dude, nice! I’ve been trying to figure this out for months! Good find. So Ashley is from where though?

 

I would take it for sure. Any way I could get it living in Spain? You just can't imagine how desperate I am...

 

I think Ashley is the new @Justin De Moss - aka Philanthropy Director for Hough Ear Institute. Are we all applying for this or what? Or is this only for acute NIHL?

 

It seems she is a member of Hough Ear Institute's staff. I've just checked on Google.

 

Any takers on this? I haven’t followed this but assuming it’s for exclusively noise induced/hearing loss tinnitus?

 

I spoke with Justin from Hough Ear Institute on the phone a year ago. Their drug candidate was actually indicated for something else, which I forget, maybe seizures? And they had a number of people report in the trial that their hearing and tinnitus had improved, not something anyone was looking for...

So it would seem the drug is safe for humans.

 

Keep in mind that this pill is not the OPI-001 (chronic hearing damage/tinnitus), but for acute trauma.

There is absolutely 0 evidence as of yet that this works for tinnitus. It is not even trialed for tinnitus patients! Only a Phase 1 for safety purposes on healthy patients!

 

I think as many people should apply for it as possible yes. My next doctor’s visit I will. I mean why not. If people here have ear problems bad enough, definitely apply for it. We got nothing to lose. It should help either way.

I think it’s most interesting for somebody who has hyperacusis, noxacusis, distortions, 6 tinnitus sounds like myself to see what improves.

 

I can’t help but wonder why Justin de Moss never mentioned compassionate use here before. Anyway, any idea if Europeans can access it too?

 

Well which is it?

 

Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC

Phase 1 study was only for healthy individuals. Neither the primary nor secondary outcome was measuring anything related to hearing or tinnitus. Purely safety.

Any improvement were merely anecdotal, not a single piece of research paper anywhere. We know how subjective tinnitus is, placebo effect etc. There were only studies done on lab rats.

Don't get me wrong, very curious to the outcomes of individuals that manage to get their hold on this, but there is more evidence that Magnesium pills have positive impact on tinnitus than this pill...!

 

Does anyone know if I can apply for compassionate use? I live in Spain.