Human Hearing Loss Could Be Reversible

Discussion in 'Research News' started by Nick Pyzik, Jul 19, 2016.

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    1. Nick Pyzik
      Depressed

      Nick Pyzik Member

      Tinnitus Since:
      6/23/15
      Cause of Tinnitus:
      Listening to in-ear headphones & playing in a band
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    2. Tim Hogan
      Suicidal

      Tim Hogan Member

      Location:
      UK, England
      Tinnitus Since:
      June 2016
      Cause of Tinnitus:
      Cold/Flu (Minor) >>> Botched Acoustic Reflex Test (Severe)
      I sure wish Science would hurry up sometimes...
       
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    3. Foncky
      Doubtful

      Foncky Member Benefactor

      Location:
      Europe
      Tinnitus Since:
      03/2004
      Cause of Tinnitus:
      An explosion, music, and fate.
      It's always great to read all that.

      You'll learn more about the Notch approach here :
      Hearing Restoration Summit: Andy Groves, Ph.D....


      In this 2012 video, Andy Groves explains that blocking the Notch signal allows the supporting cells to transform into hair cells. But this is only possible in very young mice (equivalent to a 5-6 months human foetus), so in 2012 they were trying to understand how to make that possible in older animals.

      I'm sure certain companies are working hard on the subject but can't tell about it yet. However, it's fuc**** complicated so let's not get our hopes too high. But let's have hope.
       
    4. Codaz

      Codaz Member

      If anyone needs anything Dutch translated (since Audion Therapeutics is a Dutch company) hook me up.

      What I found about them:

      Audion Therapeutics is building on research from the Edge laboratory of the Massachusetts Eye and Ear Infirmary (MEEI). Audion’s lead program focuses on small-molecule drugs that trigger the regeneration of hair cells in the inner ear. Audion has exclusive rights to MEEI-developed technology and the IP portfolio comprises molecules and drug-discovery tools for hearing and hearing-loss research.

      It is a very small company though. And 8,3 mln euro's of funding might not be enough to succesfully develop such a major discovery.

      If you look here it's part of the Horizon2020 programme which funds these types of researches.

      The due date for the project is november 2018.

      http://www.narcis.nl/research/RecordID/OND1358497/Language/nl
       
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    5. newarrior

      newarrior Member

      Tinnitus Since:
      12/1996
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    6. The Red Viper
      Angry

      The Red Viper Member Team Research

      Location:
      US
      Tinnitus Since:
      March 15, 2016
      Cause of Tinnitus:
      Current Theory: Leftover infection ETD + neck muscle injury
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    7. Vinnitus
      Bookworm

      Vinnitus Member Benefactor

      Location:
      Amsterdam
      Tinnitus Since:
      28/04/2016
      Cause of Tinnitus:
      Acoustic Trauma
      So currently there are these organizations:
      • Decibel Therapeutics
      • SciFluor (SF0034)
      • Frequency Therapeutics
      • Audion Therapeutics
      • Novartis/GenVec (CGF166)
      • Auris Medical (AM-101, AM-102, AM-111)
      • Otonomy (OTO-311)
      • Autifony (if they are still doing something?)
      • UCSF (Steven Cheung and deep brain stimulation)
      All working on solving Tinnitus and/or reversing hearing loss. You would say something useful would come out of it in the near future.
       
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    8. Codaz

      Codaz Member

      As long as there is action-reaction what is the effect of taking drugs on the long term? If taking a drug might cure my T, but loses my hearing over a period of 10 years why should I take it? Also with this research. If a drug restores you hearing but gives you T over a period of 10 years why should you take it. People can (partially) live with diminished hearing (through a hearing aid). Second, if you take those drugs what are the long term effects of it. Most medical research shows short term benefits.
      There is so much that we don't know. I'm very glad with the activity, better than none but I'm afraid of multiplying problems in stead of curing them.
       
    9. Mario martz
      Creative

      Mario martz Member

      Tinnitus Since:
      02/2016
      Also the University of Kyoto and Boehringer Ingelheim
      http://asia.nikkei.com/Tech-Science...-drugmaker-to-research-hearing-loss-treatment
      They are working in a drug to treat hearing loss.
      and we need to remember that this guys in the university of kyoto were the one who....
      New Stem Cell Transplantation Method Restores Damaged Auditory Pathways
      http://ata.org/news/news/new-stem-cell-transplantation-method-restores-damaged-auditory-pathways

      i have high hopes in this one.
      Look how many scientist are working on it, and still there are people claming that nobody is doing anything, or that maybe in 100 years lol

      There is Hope!
       
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    10. Ears Hurt

      Ears Hurt Member

      Location:
      USA
      Tinnitus Since:
      10/2012
      Cause of Tinnitus:
      Whiplash or Buzzer (abuse from ex)
      • Like Like x 3
    11. Mario martz
      Creative

      Mario martz Member

      Tinnitus Since:
      02/2016
      To be honest this is what i pray for everyday :)
      a soon relief for all of us, and to be honest there a reasons to be excited and have hope.
      there are people in here that has had T/Hyperacusis for more than 20 years.
      and back in the day there was no forum, no studies, no trials no nothing.

      we are some how "lucky" and with more chances for a potencial treatment in the short term.
      lets keep praying and pushing.
       
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    12. Ears Hurt

      Ears Hurt Member

      Location:
      USA
      Tinnitus Since:
      10/2012
      Cause of Tinnitus:
      Whiplash or Buzzer (abuse from ex)
      @Mario martz
      Yes, me too. Lets hope our prayers are answered for all.
      I couldn't imagine how terrible it would have been to go to the doctor 20 years ago with T or H.
      It's bad enough today; I couldn't imagine what was said in the past.

      It's a blessing we can talk to each other; it is nice to be linked with people that understand.
      So, thank you to each and everyone of you that lifted my hope and helped me along the way! I feel like my T has become worse over time, but I have in a way become numb to it to function. I still find myself crying frequently and missing my old self.
      And a big thank you to whomever in the future finds a cure/treatment to help all of us.
       
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    13. Mario martz
      Creative

      Mario martz Member

      Tinnitus Since:
      02/2016
      Lets hope for better days to come :)
       
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    14. Vinnitus
      Bookworm

      Vinnitus Member Benefactor

      Location:
      Amsterdam
      Tinnitus Since:
      28/04/2016
      Cause of Tinnitus:
      Acoustic Trauma
      This is most certainly true. I remember I was searching the internet during the first few weeks of my first bout of Tinnitus in 2010, because I was in great distress. Let me tell you; it was quite a wasteland. There was no Otonomy, Decibel, Auris Medical or whatever. I was blessed it went away on its own back then. Also, there were no scientifically supported treatments to try (for some types of tinnitus) like ACRN or notched noise therapy. 2010 is just a few years ago. Today, the research companies regarding the development of inner-ear treatments are popping up like mushrooms all over the world. It is booming.

      I guess we have good reason to be optimistic.
       
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    15. lapidus

      lapidus Member

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      Tinnitus Research: 1970-2013
      Total number of tinnitus research articles published in peer-reviewed medical journals during each 5-year period.

      2013winterdmc_graphnoheader-jpg.596.jpg
       
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    16. bill 112
      Studious

      bill 112 Member

      Location:
      Republic Of Ireland
      Tinnitus Since:
      02/2012
      Cause of Tinnitus:
      Noise exposure
      I remember when I got T there was little to no help just anecdotal stories on Google and that was it,I had to find people with T and ask them for advice in my locality which all later turned out to be shitty advice that worked for them but not for me.

      Either way right now is an amazing opportunity for everyone here,if we were to go back to 1980 there was literally zero help or hope but fast forward to 2016 and there's people being relieved of MS thanks to Stemcells,something unthinkable only a few years ago.Keep hope alive!
       
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    17. Stefan K

      Stefan K Member

      Tinnitus Since:
      May 2016
      Cause of Tinnitus:
      Possibly Music/Power Tools
      May I ask why you never followed through with your stemcell treatment bill? How's your T these days?
       
    18. GregCA
      Crappy

      GregCA Member

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      It's a good progression, but it's still very low compared to other conditions.

      If you go to pubmed, you'll find the following number of publications for the following keywords:
      tinnitus -> 10642
      alopecia -> 18415
      multiple sclerosis -> 66168
      alzheimer -> 86827
      cancer -> 3329722

      Yes, figuring out a way to get rid of our bald spots gets about twice as much attention as tinnitus. I want to go see a bald guy and tell him "wanna trade?".

      The American Tinnitus Association has funded research to the tune of $6M, over the course of the past 35 years. That's $170k/year. How much do you think that covers? It covers about one guy full time in a lab. That's it. Not two. One.

      One telling fact on the British Tinnitus Association website is that when they show videos about research, it's always the same researcher (Dr Roland Schaette) featured. One guy. He's the man! I'm sure he's making progress, but he's only one! In one of his videos he even mentions that he wants to move forward, but he is unsure about the future as he needs funding.

      This research needs to scale up. We need awareness and funds. Funds will come with awareness.
       
      • Like Like x 1
    19. vegasjon

      vegasjon Member

      Tinnitus Since:
      2012
      Ding ding ding!!!
       
    20. bill 112
      Studious

      bill 112 Member

      Location:
      Republic Of Ireland
      Tinnitus Since:
      02/2012
      Cause of Tinnitus:
      Noise exposure
      My T and H are still unbearable Stefan if I'm honest.

      As for the Stemcell treatment I'm struggling to find a reputable clinic offering somewhat of a genuine treatment.I constantly find clinics and of course me being the sceptic that I am do backround checks only to be not impressed with what I find.
      Also none and I mean none of these clinics are offering a targeted treatment but more so are attempting to shotgun the problem which isn't something I agree with,I can't see how pumping cells into my body may regenerate spiral ganglion cells near the brain,I can't see how that would work.It is possible to regenerate these cells as proven in I believe a University in Tokyo but that was targeted specifically and not pumped into the body and just hoping for the best.
      Basically I'm not convinced nor impressed by what's currently being offered,it's all a cash grab on a new science by uneducated money hoares from what I can see so far.

      I haven't given up on it yet but more so waiting on the right legit clinic or service to be available that ticks all the boxes,this shit ain't cheap unfortunately.
       
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