Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. Manny
      Dead

      Manny Member Benefactor Hall of Fame

      Location:
      United States
      Tinnitus Since:
      1/2018
      Cause of Tinnitus:
      central gain << NIHL
      What makes you think that it would restore any other part of the auditory system besides hair cells?
      Edit: just saw Phendran's comment, but still not sure about anything "behind" the cochlea, which FX's gel presumably wouldn't reach (i.e. it would only reach the cochlea, not anything more internal e.g. auditory nerve fibers leading to the brain).
       
    2. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      maybe we need to
      okay, sorry. I was referring to people that have noise induced hearing loss and T. my apologies. I realize that there are many other types of inner ear, vascular, nervous system, and brain conditions that could affect hearing. that was an ignorant statement for me to make.
       
      Last edited by a moderator: Dec 3, 2018
    3. Manny
      Dead

      Manny Member Benefactor Hall of Fame

      Location:
      United States
      Tinnitus Since:
      1/2018
      Cause of Tinnitus:
      central gain << NIHL
      Actually I too was speaking of NIHL (my HL, T and H are noise-induced). But even within NIHL, apparently there can be synaptic and auditory nerve fiber damage.
       
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    4. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      Tinnitus can be induced by silent chamber/ear plugs and go away once removed
      http://www.tinnitus.org/HB_Nov00.pdf
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366980/
      upload_2018-8-2_18-49-54.png


      Tinnitus from stadectomies (middle ear damage) usually can go away when the original problem is correctly

      upload_2018-8-2_18-31-22.png
      http://www.tinnitusjournal.com/arti...on-tinnitus-in-patients-with-otosclerosis.pdf



      Tinnitus from sensori-neural hearing loss (inner ear damage) can usually be reduced or go away via cochlear implants.


      upload_2018-8-2_18-33-50.png
      http://www.tinnitusjournal.com/articles/can-cochlear-implants-decrease-tinnitus.pdf

      Can researchers please address curing hearing loss as the most convincing way of treating tinnitus?
      or prove these studies wrong
       

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    5. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
      Some work on SGN's, glad to see it.
       
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    6. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
      Here guys have a look at this, this injury (now called uvl)
      Acute Unilateral Vestibulopathy (Formerly...




      which is roughly the equivalent of sudden sensorineural hearing loss, there is much debate (some of it more like fighting) over what exactly causes this injury, one theory set out here is that the different vascular layouts vary slightly in their pathways and this may be the reason for the disorder and also the reason for "rare" spontaneous recovery, as it is considered an irreversible deficit, what I found worrying was the described difference in skill/talent of preparing donated temporal bones for inspection, this means that the knowledge at the bench (if not correctly recorded for future generations) could be lost. The amount of information that goes through nerve viii is quite incredible,

      Sensorion : Pourquoi vous sentez-vous...


      Do have a peep, its an unusual paper.
       
      • Informative Informative x 1
    7. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
      • Good Question Good Question x 4
    8. bell

      bell Member Benefactor

      Tinnitus Since:
      2004
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    9. dmorg

      dmorg Member Benefactor

      Location:
      Philadelphia, United States
      Tinnitus Since:
      2011
      Cause of Tinnitus:
      don't know, hearing loss related?
      I haven’t heard of Akous but I have heard of Spark Therapeutics as they are near Philadelphia. They did treat a boy with a gene therapy for his eyes that has been effective. I believe they charged a mere $425,000 per eye.
       
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    10. lymebite
      Vegged out

      lymebite Member Podcast Patron Benefactor

      Location:
      United States
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Unknown
      A new blog post today by Gulf Coast Stem Cell in Mississippi, USA:

      "Could Stem Cells Prove to Be Music to the Ears of Tinnitus Sufferers?"

      http://www.gulfcoaststemcell.com/stem-cells-music-to-the-ears-of-tinnitus-sufferers/

      It seems a bit unclear from the blog post whether or not they are suggesting their currently available stromal vascular fraction (SVF) stem cell therapy could be effective for tinnitus, or if they are just referring to the possibility in the future when places like Frequency Tx, Decibel Tx, and others make available targeted therapies developed specifically for hearing disorders.

      GCSC-August2018-CouldStemCellsProveToBeMusicToTheEarsOfTinnitusSufferers-300x158.png
       
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    11. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      upload_2018-8-9_14-15-4.png
       
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    12. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
    13. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      outer hair cell
       
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    14. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Over Head Camshaft.
       
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    15. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      upload_2018-8-12_17-49-5.png
      We can make this a reality in 5 years or so
       
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    16. Manny
      Dead

      Manny Member Benefactor Hall of Fame

      Location:
      United States
      Tinnitus Since:
      1/2018
      Cause of Tinnitus:
      central gain << NIHL
      "treatments include cochlear hair cell regeneration" I know it's just Google's thing probably made by a bot...but still nice to see, obviously it's on the radar.
      EDIT: Scammed by Contrast ;) ;/
       

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    17. Manny
      Dead

      Manny Member Benefactor Hall of Fame

      Location:
      United States
      Tinnitus Since:
      1/2018
      Cause of Tinnitus:
      central gain << NIHL
      "OHCs die at a rate of .5% per year." I find that very interesting because that actually means the rate of decay slows as one ages.
      Where's that a quote from?
       
    18. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      no read the post, it's an edit I made to show what the future could be if we are diligence.
       
      Last edited by a moderator: Dec 3, 2018
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    19. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      • Like Like x 5
    20. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      That's just like your nephrons in your kidneys.
       
      Last edited by a moderator: Dec 3, 2018
    21. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      Most people here throw around the word "cure" when the word they intended to use was treatment. Everyone here would be ecstatic for regenerative treatment which improves hearing and reduces tinnitus. This is much more likely in the near term then a cure. That said what would people consider a "cure". I would maybe say a 40 dB improvement in hearing at your worst freq over the 16KHz span and hearing silence with 30dB earplugs in. The earplug test is a good one and you can try them to see how loud your tinnitus is;)
       
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    22. Iliasp

      Iliasp Member

      Tinnitus Since:
      03/2017
      Cause of Tinnitus:
      Acoustic trauma, Hearing loss
      Cure is defined by success of the treatment
      Relief from symptoms to an adequate degree or full recovery is what everyone seeks and that would be cure “more or less”
       
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    23. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      Why cochlear hair cell regeneration and or ribbon synapse repair (curing sensori-neural hearing loss) should help reduce tinnitus based on evidence in current hearing loss treatments

      Treatments for sensori-neural hearing loss induced tinnitus
      http://www.tinnitusjournal.com/articles/can-cochlear-implants-decrease-tinnitus.pdf
      https://blog.medel.com/cochlear-implants-tinnitus-cure/
      Cochlear implants reduce tinnitus

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315113/
      electro stimulation of the audiotory nerve reduces tinnitus

      Treatments for conductive hearing loss induced tinnitus

      https://www.ncbi.nlm.nih.gov/pubmed/15379354
      middle ear surgery reduces tinnitus

      Treatments and experiments if blockage or ear wax was the cause of tinnitus
      https://www.tinnitus.org.uk/ear-wax
      ear wax removal

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366980/
      Roland Schaette's ear plug experiments.

      https://tinyurl.com/yd6jepka
      1953 similar study to Roland's study.

      @85dB T
      @Autumnly
       
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    24. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
      Yes! It's the information where the hi-tech is!
      Direct perception - Gibson's bottom up...
       
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    25. RingerBell

      RingerBell Member Benefactor

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
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    26. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
      Everything would have been before.

      Now Frequency might well have already completed clinical trials, or even enter the market.

      It's all about George W. Bush, Jr., who severely banned any research and use of stem cells, as president of the United States.

      It was stagnation, lasting as long as 8 years.

      And it was not until 2009 that Barack Obama came and lifted the ban on research and use of stem cells.

      He said people are waiting now, not tomorrow!
      I really respect Obama for that.
       
      • Agree Agree x 6
    27. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      They aren't using embryonic stem cells, they are using progenitor cells, silly. But yeah I agree to lift the ban on embronic stem cells.
       
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    28. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
      Bushes ban on es cell line use was the greatest thing that ever happened to the field, it shone a light on the area and provided media attention and funding opportunities they could have only dreamed of. It backfired badly.
       
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    29. Ozwel
      Disappointed

      Ozwel Member

      Location:
      Paris, FR
      Tinnitus Since:
      2005
      Cause of Tinnitus:
      Auditive trauma
      It is VERY interesting to see HSV (virus) studies related to ear damage.

      It is not the first time I see this virus linked to meniere and tinnitus studies.

      It would be very interesting to see who here has already tried to check if he has HSV (1 and 2) in his blood. I guess we'd be surprised to see the results... But it is also known as "mouth and genital herpes" so my other guess is that most of us wouldn't tell if we have it (even though we are all pretty much anonymous). For info 60% of infected people have this virus without herpes showing up on skin/mouth/genitals.

      Now those whose tinnitus is due to HSV infection, the question is: it is impossible to cure that virus (very common one) so if we use an antiviral treatment (which exists) to make the virus sleep, will the tinnitus go away?
       
    30. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
      Could be, or it could be an overblown response to the pathogen because of genetic contributions from the host. Another one is how does it get to into the ear? Gacek reckons the route it enters the ear could indicate the pathology. One of the reasons this is relevant to this thread is that we need to know if the damage caused by viruses like hsv is similar to toxic medications or old age or even ischemic damage, so we can find out of the inury sites respond to cell therapies. This chap has some mesmerizing IHMC talks, in fact he was brought back to do more due to the popularity of his interview, a leader in the field.


      HerpesVirus Transport - Greg Smith - Stem Cell...
       

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