Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Not might... will make this happen.
       
      • Agree Agree x 2
      • Optimistic Optimistic x 1
    2. bell

      bell Member Benefactor

      Tinnitus Since:
      2004
      In 2005 they said “in 10 years” too...
       
    3. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      I appreciate you are a pessimist due to your experiences. This is very valid position to take. But what has really struck me is that most of the studies relevant to this stuff that I am referencing in the last two pages have been produced within the last decade. Identifying the cell types, finding them in human ears, identifying how to make them replicate... I would imagine, due to this, that our understanding has increased a fair bit - we are way in front of our 2005 selves. :)
       
      • Optimistic Optimistic x 2
    4. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      acustic trauma, neuro-lyme/rx co-op toxins
      Just check your hair cells by doing OAE test.

      One specific brain region where all cranial nerves are rooted. Spinal cord and other nerves provide most of information by it. Brainstem contain 3/4 of all neurons in brain and is very susceptible to all kind of toxins. In damaged or brang in hiperactivity mode (f.ex by wrong input from hair cells) brainstem can occur wrong couplings and connections between nucleuses causing tinnitus, visual snow, vestibular problems, hearing loss etc. For me, very probable.

      img?img_id=ag5zfmltYWdlbGVhcm5lcnIQCxIHUXVpenplcxj_19FGDA.png


      tmp15F73.jpg
       
      • Informative Informative x 5
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    5. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      For those of us with this type of damage, what do you suppose our best hope is? Also, can any spontaneous healing occur in this area?
       
      • Good Question Good Question x 2
    6. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Glad to see you're still around good friend.
       
      • Like Like x 2
    7. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      acustic trauma, neuro-lyme/rx co-op toxins
      I think spontaneus regeneration is possible but it is a long process in case of central hearing loss. Maybe something natural but i did not find any crucial herbs yet.
      Maybe stem cells will help in the future.

      Stimulation of synapse formation between stem cell-derived neurons and native brainstem auditory neurons.
      "This study developed novel methods to co-culture neural stem cell-derived spiral ganglion-like neurons (ScNs) and mouse auditory cochlear nucleus (CN) neurons to understand whether ScNs of the peripheral nervous system (PNS) synapse with CN neurons of the central nervous system (CNS) (...)
      These results reveal that stem cell-derived PNS neurons are able to form functional connections with native CNS neurons, which is critical for stem cell-based neural pathway regeneration."

      https://www.nature.com/articles/s41598-017-13764-8

      Maybe strong psychodelics like LSD or DMT would help but who knows. You are abnormal MAO so it can be not the smartest idea.

      Psychedelics Promote Structural and Functional Neural Plasticity
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082376/

      Psychedelic Drugs May Change the Structure of Brain Cells

      https://www.livescience.com/62802-psychedelic-drugs-change-nerve-cells.html

      We Have The Best Evidence Yet That Psychedelic Drugs Can Repair Broken Neural Networks
      https://www.sciencealert.com/psychedelic-drugs-mdma-lsd-repair-broken-neural-networks-in-brain


      In the case of tinnitus my theory is that we need something that would reset the mode of work of brainstem or help to ignore false inputs.

      Hi, friend!
       
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    8. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      acustic trauma, neuro-lyme/rx co-op toxins
      I think long term use of big doses of CBD can be very useful. It protects and regenerates the brain's neurons and increases BDNF factor.
       
      • Like Like x 1
    9. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Anyone know if regenerated neurons can regenerate new synaptic potassium ion channels or if they reuse the same ones?
       
      • Good Question Good Question x 2
    10. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      acustic trauma, neuro-lyme/rx co-op toxins
      What's the difference?
       
      • Good Question Good Question x 2
    11. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      For me, at least, there is a huge difference. My neurons are otherwise normal in my brain stem but certain ototoxins can bind to and then deform the potassium ion channels (in my case kv3.1). New neurons using the same deformed channels would do zero to help my hearing unless there were new channels formed, too.
       
      • Good Question Good Question x 2
    12. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      acustic trauma, neuro-lyme/rx co-op toxins
      New neurons using deformed channels of old neurons? Is this even possible?

      Cartoon-of-a-multipolar-neuron-and-the-molecular-composition-of-the-AIS-A-Neurons-are.png

      41583_2006_Article_BFnrn1938_Fig1_HTML.jpg
       
      • Like Like x 2
    13. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      If they are new doesn't that mean they are new?
       
      • Agree Agree x 2
    14. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Have you found anything else new? I'm taking 7,8 DHF and curcumin.
      I'm thinking I have disregulated TRKB receptors.
       
      • Like Like x 1
    15. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      acustic trauma, neuro-lyme/rx co-op toxins
      The problem is in the potassium channels of the synapses that are between any given neuron chain and the rest of the nervous system. We should ask some specialist about that who knows how the process of the neuro and synaptogenesis and synaptoplasticity according to KV channels appears and what is going to happen with old, damaged neurons and synapses during this process.

      KV channels play a crucial role in synapse regeneration process.
       
      • Agree Agree x 2
    16. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      acustic trauma, neuro-lyme/rx co-op toxins
      Why do you think that?
       
    17. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Because I was on blood thinners the night this started. That can thin out the blood and I read that anoxia can cause a disruption of TRKB signaling also curcumin can influence TRKB signaling and when I take a lot of curcumin it silences my tinnitus.
       
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    18. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      acustic trauma, neuro-lyme/rx co-op toxins
      Didn't you have acoustic trauma?
       
    19. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Yes. And too much aspirin, and about 6 hours of sex. All in the night before this started.
       
      • Funny Funny x 1
    20. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      acustic trauma, neuro-lyme/rx co-op toxins
      And you cured your tinnitus with curcumin?
       
      • Good Question Good Question x 1
      • Funny Funny x 1
    21. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      acustic trauma, neuro-lyme/rx co-op toxins
      @tarmaced it is not so funny if I tell you that I had pneumatic drills in my ears when I was on doxycycline for treating Lyme's disease. I had eaten 5-10g curcumin daily month by month and the tinnitus kept fluctuating, but overall it was fading. I remember that it was very quiet and I heard it only in silent places when I started to eat big doses of CBD. Second day I took a big dose under tongue and after 10 mins I drank i water. Next day I had complete silence. I used to eat all this stuff to this day and continue to do this because my ears still have some strange behaviours but I have more or less normality and I come back to this forum only because maybe I would help someone.

      Herbs like curcumin and CBD strongly affect the brain's neural regeneration by affecting NGF, IGF1 and BDNF. Moreover they are strongly anti-cancer. Just killing cancer cells.

      If you are interested in this topic I can provide research sources and more information.
       
      • Agree Agree x 1
    22. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I am not cured. I think you and I could collaborate on more research though.
       
    23. PolishSoldier87
      Moonlighting

      PolishSoldier87 Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      acustic trauma, neuro-lyme/rx co-op toxins
      Say at least that it's better than year ago...
       
      • Like Like x 1
    24. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I'm worried this means it's hopeless for me :(.
       
      • Hug Hug x 2
    25. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      Not that kind of funny. I have kept tabs on these discussions and take 3g a day.

      No benefit for me yet, alas, but given the topic of this thread... The hope that a herb will do the trick for us tickles my blacker sense of humor.

      No offense meant :)

      Especially to someone here to help!
       
    26. TomBradyGOAT

      TomBradyGOAT Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Who knows
      6 hours!!!!! Wow. I am really out of shape. I am not by fast to the draw but definitely couldn't last that long. I would need oxygen and an ER visit if I tried to last that long. Props to you. :rockingbanana:
       
      • Agree Agree x 1
    27. Juan

      Juan Member

      Tinnitus Since:
      08/2014
      Cause of Tinnitus:
      Several causes
      How can you get that sort of diagnosis?
       
    28. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Yeah but I also went to that Minbo Shim doctor and got an assload of bone marrow and PRP injected into my ears and I'm not 100% sure if that did or didn't do anything.
       
      • Like Like x 2
    29. Bndsmheowqhe

      Bndsmheowqhe Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Loud noise exposure
      I thought it was working.
       
      • Friendly Friendly x 1
    30. Jazzer

      Jazzer Member Benefactor Hall of Fame

      Location:
      UK
      Tinnitus Since:
      1/1995
      Cause of Tinnitus:
      Noise
      Wow - John.

      I believe the last time I asked you what your assessment of the tinnitus noise reduction was, you estimated about 90% - please correct me if I’ve got that wrong bud.

      Your current view is surely a let down.
      If so I’m so sorry my friend.
       

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