Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. Jan64

      Jan64 Member Benefactor

      Location:
      Utrecht, the Netherlands
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      noise
      It is important to take the prednison in the morning... Otherwise you encounter sleeping problems...
       
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    2. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      And anxiety attacks... heartpounding... and...
       
    3. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      Action on Hearing Loss sponsored research where a large-scale screening of already FDA-approved drugs and bioactive molecules is performed in zebrafish to find new drugs that restore hearing. This research will conclude next month. The study is performed by Dr Lavinia Sheets at the University of Washington in St Louis. I find the part where they are screening drugs the FDA already approved for other pathologies particularly interesting.

      Anyone know more about this?
       
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    4. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
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    5. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      Well, if they find a FDA-approved drug you could in theory ask your doctor/ENT to prescribe it...
       
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    6. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
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    7. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      One of the largest Dutch newspapers today published a letter from neurologists, geriatrics etc. calling on the minister of Health to invest more in dementia prevention. Their message basically is that since dementia costs Dutch a society a lot of money and decades long research haven’t resulted in a cure, we should focus more on prevention. One of the first factors they list, after exercise and normal blood pressure, is improved hearing. Wondering how we might use this to our advantage.
       
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    8. Duderonomy

      Duderonomy Member

      Tinnitus Since:
      18/10/2019
      Cause of Tinnitus:
      long headphone exposure
      Would this help noise induced tinnitus?
       
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    9. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
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    10. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      2 1/2 years old now.
       
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    11. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      Ha! You’re right. Guess June 2019 was when it was published in the AMS.
       
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    12. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      What’s going on with the Stanford Initiative to Cure Hearing Loss? They haven’t updated their Twitter and website for a while. Some of the involved labs are still recruiting though. They also changed finding a cure “within a decade” to within the “foreseeable future”... How about trying to get dr. Heller or dr. Jackler on the podcast?
       
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    13. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      https://medicalxpress.com/news/2018-08-imaging-ear-gold-standard.amp

       
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    14. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      From the article:

      The level of radiation needed for her CLS study is far too high to use in living humans "but our goal is always ultimately to help people, and we are highly optimistic about the future potential of this work."
       
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    15. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Pretty sure some dudes from Stanford are behind Frequency Therapeutics.
       
    16. JohnK
      Busy

      JohnK Member

      Location:
      SF Bay Area
      Tinnitus Since:
      10/26/2015 (habituated) 5/13/2019
      Cause of Tinnitus:
      Doxycycline (2015) Otimize ear drops [neomycin] (2019)
      Is that a generic "pretty sure" or a classic JohnAdams "pretty sure, wink wink"
       
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    17. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Will McLean was in Hellar Lab I believe. No wink wink like I know that BDNF and NT3 injections are safe wink wink.
       
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    18. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      He was in Langer lab, or at least worked with him (according to his Linkedin). I do think work from the Initiative (indirectly) contributed to the drugs that are in clinical trials right now. For example, Heller published with Albert Edge, who is involved with REGAIN and also worked with McLean.
       
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    19. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Edge was more than "involved" with REGAIN, he was one of the principal founders and scientists according to what I read about the project. Regardless, I sure hope I, we, can get a shot at their treatments... and perhaps the delivery will be improved soonish as well.
       
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    20. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      Albert Edge seems to have collaborated with almost everybody. I'd love to get his perspective on the state of the art. I don't think he's directly involved with Regain now. Could be wrong.
       
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    21. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      Yeah, it’s a small world. Everyone probably knows each other to some degree.
       
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    22. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
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    23. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      I wonder why they didn't note Hough Ear institute.

      I hope for the Meniere's sufferers, Otonomy actually offers some genuine relief, because they took a liquid steroid which is already injected (and doesn't cure it) and turned it into a gel. Whoopdy do.
       
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    24. Mr.Drop
      Stressed

      Mr.Drop Member

      Tinnitus Since:
      07/2007
      Cause of Tinnitus:
      Ear trauma, ototoxicity
    25. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      They didn't mention Frequency Therapeutics either and seem to have gotten Autifony's AUT00063 mechanism of action wrong, too.
       
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    26. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      https://www.news-medical.net/news/2...ls-damaged-by-noise-prevent-hearing-loss.aspx

      “Audiologist and molecular biologist O'neil Guthrie, an associate professor in NAU's Department of Communication Sciences and Disorders, is collaborating with New Jersey-based Optigenex on a three-year contract totaling $551,000.

      Guthrie will conduct a pre-clinical investigation of a novel therapy using the company's patented ac-11 technology based on carboxy alkyl esters, which help the body's natural ability to repair DNA.

      Guthrie believes this therapy, which will be administered as a single oral formulation, has the potential to repair cells damaged by noise and prevent hearing loss. As an added benefit, the technology can also target ROS and inflammation to prevent cell death in the cochlea.

      By developing a single drug given orally as a vitamin or gummy that addresses all three problems, Guthrie hopes to make the drug as safe and effective as possible, avoiding unknown or poorly understood interactions between multiple drugs and their side effects.”

      “"The possibility of finally developing a treatment for hearing loss is particularly exciting," Guthrie said. "This is because, in addition to being a research scientist, I am also a licensed clinical audiologist with more than 17 years' experience, so I am familiar with the day-to-day struggles of individuals who suffer with hearing loss.”

      Another thing that looks promising in the inner ear field.
       
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    27. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      I hadn't heard that noise produces a chain reaction which results in DNA mutation. Has this been confirmed elsewhere.
      How does this exactly work? Has this been proven and to what degree? Can someone elaborate??
       
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    28. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      https://www.researchgate.net/public...rineural_functions_following_noise_injury/amp

      This is work from the guy involved in this. I’m not a scientist so I can’t answer this. As a layman all I can say that the fact that there have never been this many drugs in the (pre-)clinical phase for hearing loss is a very good sign. The way I observe it multiple flavors of drugs are steadily reaching patients, probably starting with preventative drugs and then onto restoration drugs, again in multiple flavors (small molecules, gene therapy, stem cells). There also seems to be a category that overlaps those goals, Hough’s pill being an example of that.
       
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    29. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
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    30. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I'm starting to think that the blood-labyrinth barrier (BLB) is our unfortunate enemy in this as it may be the thing preventing healing growth factors from entering the cochlea. Our intestinal stem cells are basically the same thing and they regenerate just fine, they also are not blocked from the systemic blood flow by the BLB.
      Blood-supply-and-blood-labyrinth-barrier-a-Blood-vessels-in-a-cat-cochlea-highlighted.jpg
       
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