Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      Don't dead cells get flushed out by the body anyway, like just deteriorate to nothingness?

      I can't imagine that being a useful reason to dry fast.


      Also some cases of hearing loss has a lot more to do with nerves (just nerves) then it does hair cells dying.
       
      • Like Like x 1
      • Agree Agree x 1
    2. Telis

      Telis Member Hall of Fame

      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Drugs barotrauma
      I’ve done both dry and water fasts, it helped the first time I had tinnitus, I’ve since had a worsening (noise trauma) and have only been able to go for a couple of days here and there due to the extreme stress of the new tinnitus.

      Fasting induces healing, reduces inflammation, aids with autophagy, increases the body’s stem cell production. It’s safe unless you’re unhealthy, or don’t break the fast properly. How many days are you going? My longest was 8 days only water, it’s a great feeling, you’ll get increased energy, better mental clarity, hunger goes after the first day or so, you’ll shed a couple of pounds, and hopefully get some benefits in regards to your tinnitus. I’m not sure one fast will do a lot unless you are planing on going like a month or so. You might have to start practicing it often to get all the benefits, it takes time.

      This is the wrong thread though. There are actually fasting threads, or maybe start another.
       
      • Like Like x 2
      • Informative Informative x 1
    3. Ninix

      Ninix Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      Sound
      Sorry for my poor skill in this domain but I would like to know after a sound traumatic if we recover ear hair cell automatically the level of tinnitus is decreased
       
    4. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      that's the idea.
       
      • Agree Agree x 2
    5. Ninix

      Ninix Member

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      Sound
      Do you know is there are study to prove this idea?
       
    6. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      Los Angeles, CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      It hasn't actually been done yet but the general consensus of the science community is that it will probably be of help.

      Studies such as REGAIN have mentioned that they will be monitoring this, even if it's not the primary outcome they will be measuring.
       
      • Like Like x 1
    7. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      What about the nerves that are connected to that hair cell and then ports the cell info to the auditory nerve?
      I saw a graphic here somewhere that showed the hair cell getting damaged and the nerves connected to the cell disconnected and then atrophied and non existent. How do they get reconnected or regenerated?
       
      • Good Question Good Question x 1
    8. Daniel Lion
      Ape-like

      Daniel Lion Member Benefactor

      Location:
      se asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Hey man. What do you want? New nerves? New hair cells? Or a steak and cheese?

      Earing, sorry... bad joke...
      Apologies.
       
    9. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      I don´t know how, but they have found that new synapses connect to regenerated HC. They described it as a miracle.
       
      • Informative Informative x 2
      • Agree Agree x 1
    10. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      The initial work to discover this was done in the Heller Lab at Stanford University. One of the people over this lab is Robert Jackler. In a presentation he stated that once the hair cell is regenerated that the nerve regrows and reconnects. He called it a "god darned miracle".

      start at around 28:00
      Stanford's Initiative to Cure Hearing Loss
       
      • Like Like x 4
      • Informative Informative x 1
    11. RODRIGO

      RODRIGO Member

      Location:
      Valencia (Spain)
      Tinnitus Since:
      05/2013
      Using hearing aids usually decreases or eliminates tinnitus while being used.
       
      • Informative Informative x 2
    12. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      Something I have been wondering about... My "speech in noise" problems aren't horrendous but music is unlistenable. Many people with mostly "hidden hearing loss" seem to enjoy music just fine.

      Is it possible macrolide ototoxicity affected the auditory center in my brain stem as well? How would anyone know if they have brainstem involvement with their hearing loss and tinnitus? I'm really hoping this is is not the case for me because that means no treatment on the horizon would help me :(.
       
      • Good Question Good Question x 1
    13. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      Quite the contrary. Bimodal stimulation, for instance, is built to work on our overactive part of the brainstem called Dorsal Cochlear Nucleus (DCN).
       
      • Informative Informative x 1
    14. Candy

      Candy Member Benefactor Advocate

      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Unidentified
      You mean what if hidden hearing loss is not a problem but the auditory cortex alone is?

      All of us with no obvious hearing loss have lots of questions... I mean I got retested and have normal thresholds but yet my tinnitus is very bothersome at the moment. Same with others.

      And what if some of those with some hearing loss didn’t even get the tinnitus from hearing deficiencies, it could be a coincidence.

      Is there a piece of the puzzle missing? So far that piece has been “hidden hearing loss” but is there more to it as that is only one theory? That’s why I’m more interested in neurons being turned down...
       
      • Like Like x 1
    15. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      If something affected your auditory regions in your brain then I'd expect it to have affected other parts too. If hearing is your main problem my guess is that your issue is in the inner ear.
       
      • Agree Agree x 3
    16. Mathieulh
      Busy

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      What causes noise induced tinnitus, as I have previously mentioned, is cochlear peripheral neuropathy, which directly affects the auditory cortex as it no longer receives proper input from the nerves endings attached to/located in the cochlear. If these nerve endings (which, by the way, don't regenerate once dead) get fixed, so will your noise induced tinnitus, as your auditory cortex will once again receive the proper inputs it expects.

      This also means fixing the stereocilia alone will NOT fix your tinnitus (it may likely improve your hearing however if you have perceivable hearing loss)
       
    17. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      It sounds weird to say on a tinnitus forum but I'm less concerned with the tinnitus (it sucks don't get me wrong...) than the utter and complete loss of ability to hear undisorted music.

      I do have pronounced hearing loss from 11.4 khz and up on pure tone so I know the cochlea is affected, but from what I understand macrolide ototoxicity results in a channelopathy that can simultaneously affect the cochlea *and* the dorsal cochlear nucleus.

      I know I have something more than very high frequency hearing loss because I hear distortions in frequencies I can easily hear the pure tones of.

      Are there any supplements/regimines or research on the horizon for channelopathies that also affect the potassium ion channels in the brainstem? Anyone know if brainstem toxicity can still heal/improve after 6 months? I'm just hoping it still can.
       
      • Like Like x 1
      • Informative Informative x 1
    18. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      I think it just affects a particular subtype of potassium ion channel (suited for processing very dynamic sound) that occurs in both the cochlea and the brainstem. Macrolide ototoxicity is unique among the ototoxicities. It's also usually reversuble but my Dr put me on an irresponsible and prolonged dose.
       
      • Hug Hug x 2
    19. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      Of what?
       
    20. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      Azithromycin, a Macrolide antibiotic.
       
    21. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Fasting can put your body into a sort of repair mode.
       
    22. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      I believe there is a test audiologists use called an Auditory Brainstem Response, which can test retro-cochlear and brainstem involvement in hearing loss. It's common and often used to test hearing loss in infants, who are not able to respond to tone audiometry testing.
       
      • Like Like x 1
    23. zhiyuan

      zhiyuan Member

      Location:
      China
      Tinnitus Since:
      03/2019
      Cause of Tinnitus:
      sudden hearing loss
      So drugs like REGAIN, FX-322 and CGF166 for hair cell regeneration will work on both hair cells and nerves?
       
    24. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      I don't have trouble with pure tone just complex sound. There is certain kind of KV 3 potassium ion channel involved in sound layering, esp dynamic sound. I was told ABR testing would look normal in my case regardless.
       
    25. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      We don't know. We can only speculate. But I believe I've read somewhere that someone from Frequency Therapeutics said that they had indications that this is the case. That nerves do grow out and attach to the new hair cells.
       
      • Agree Agree x 1
    26. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      I'm not going to lie, if my doctor prescribed me a medication that gave me tinnitus, I would go to him and punch him in the face a few times.

      "Judge, he ruined my life"
      The question here is why does the nerve reconnect?
       
    27. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      What if you have damaged your ears though? If using earbuds and headphones can cause further damage then how is that different from hearing aids?
       
      • Good Question Good Question x 1
    28. Mathieulh
      Busy

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      Wouldn't hearing aids only work for people with perceivable hearing loss in the 200Hz-8kHz range?
       
      Last edited: Jul 8, 2019
      • Agree Agree x 5
    29. RODRIGO

      RODRIGO Member

      Location:
      Valencia (Spain)
      Tinnitus Since:
      05/2013
      The headphones only complete your lack of hearing, in the frequencies and intensity that is needed. It's like an equalizer with power that makes your ear listen to the same frequencies and with the same sensitivity as a healthy ear. Fills your hearing loss. They also have an exit limit, no more power than the limit of healthy ear can come out.
       
    30. RODRIGO

      RODRIGO Member

      Location:
      Valencia (Spain)
      Tinnitus Since:
      05/2013
      Hearing loss usually manifests towards 3000 - 4000 Hz and intensifies with increasing frequency. Losing hearing at 15,000 Hz is normal, no adult has that frequency at 50 years old. And it does not cause tinnitus, as far as I know. The brain does not miss these frequencies, they are not audible in nature and society. In my case I have a slight acoustic trauma, from -30 dB to 4000 Hz in the left ear, and when I use earphones for TRT, the tinnitus decreases a lot. For me it is a sign that proper hearing will help many people reduce or eliminate their tinnitus.
       

Share This Page

Loading...