Neuroinflammation Mediates Noise-Induced Synaptic Imbalance and Tinnitus in Rodent Models

Yes I take a lot of that lol but the researchers are working on something specifically for blocking that with the aim of keeping it out of the auditory cortex.

 

@Telis Please PM me - over time, I've read your posts and noticed we had a lot of similarities (I also have the sound reactivity when someone uses the letter "s"). I'm hoping maybe we can help each other. Take care.

 

https://en.wikipedia.org/wiki/Spirulina_(dietary_supplement)

 

Ahhhhhhhhh very interesting indeed.

Curcumin is a TNF blocker.


https://www.ncbi.nlm.nih.gov/pubmed/23425071

 

Anyone tried this stuff yet?

 

I ordered spirulina like two days ago. Do you think I can take some at the same time as the curcumin?

 

That is EXACTLY what I was thinking. I'm getting some of that today and taking it with curcumin tonight. I haven't taken any curcumin in like 2 weeks either so this will be an interesting experiment.

 

Keep us informed of the results! I try as soon as I receive my order, within 2/3 days!

I think we're about to find a cure.

 

Well, just look at this:

https://www.ncbi.nlm.nih.gov/pubmed/20713883

"NSAID-mediated increases in TNF are reversed by either the addition of exogenous PGE(2) or by a PGE(2) EP2 receptor agonist, revealing that PGE(2) signaling via its EP2 receptor provides a valuable mechanism for controlling excess TNF production."

NSAIDS (aspirin) can cause tinnitus and they also increase TNF, and this study says that elevated TNF can cause tinnitus.

 

Is there an easy way to know our amount of TNF in the blood or in the brain?

It would be interesting to compare our levels with “regular” people.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150313/

 

You better be right, or else.

 

https://www.ncbi.nlm.nih.gov/pubmed/29895492

https://www.amazon.com/Tebonin-Egb-...iloba+extract&qid=1565648897&s=gateway&sr=8-3

 

John,
Why did you discontinue Curcumin?
Thanks

 

Blood thinner = thinning hair.

 

Well it smells like dead fish and tastes the same.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713369/

 

Everything I read online says Turmeric/Curcumin prevents hair loss.

 

well then........ crap....

 

NSAIDs probably cause thinning to a much larger degree.

An example of this is people over on r/nootropics on Reddit also like to talk about how Curcumin is an MAOI, but it's only an MAOI in a 'very mild capacity'. Nothing that would be large enough to interact with medications like antidepressants anyway.

 

Did you feel any improvement in your tinnitus with spirulina and curcumin?

 

I've been taking 2 grams of curcumin for 5 months and I have now upped the intake to 4 grams a day. I can't say it has done anything for my T, but.. I also suffer from gout and was having attacks every 2 to 3 months. I haven't had one sense. I refused to take allpurinol because it can cause tinnitus, so if anyone suffering from gout doesn't wanna risk over the counter meds because of Tinnitus, I would highly recommend curcumin. Here is the brand I take which was recommended from another thread on here and it seems to be the best I can find.
https://www.amazon.com/gp/product/B00BCN1CF6/ref=ppx_yo_dt_b_asin_title_o00_s00?ie=UTF8&psc=1
I take that with other supplements daily.
4 to 10 grams of taurine, 1200mg NAC, 30mg zinc, 800mg magnesium, 2000ui Vit D, 500mg Vit C, 200mcg B12 and 250mg of Vit B1. All of that split in a morning dose and an evening dose.

Probably taking too much stuff but you get desperate. My problem is I don't know which ones are actually helping now outside of 2 supplements. I must admit the taurine and curcumin have made a noticeable difference. The taurine took the "dentist drill" flucuating tone completely away after 2 weeks by only taking 3 grams a day spread out 1 gram per 6 hours. I found further relief by upping the dose to 6 grams a day 2 grams every 6 hours. Now I take 4 grams a day split into 2 grams morning and evening. If I have a catastroiphic/severe spike I will take 10 grams (taurine) in one swallow which calms me down. Then at night I take 4 grams of REM fresh melatonin and try and crash.
I am not a doctor nor have a played one on TV. Check with your health care provider before making and changes in your medications or supplementation. This is just my experiences so far.

 

I also found that taking creatine powder, a weight training supplement that binds water in your muscles, helped relieve the neck muscle tension. It's so soothing I might continue taking it even without training.

 

razo,
Do you happen to take Whey protein powder as well for more protein to build muscle? Are you a pretty serious weight lifter or trainer?

 

No, I do it just for wellbeing. I use some protein powder, but the effect of creatine is separate from this.

 

Quite a few normal old H1 antihistamines will drop TNF alpha production in half (at least) I did have a good response to cetirizine the other night.. but after I got on this site everyone was saying everything is toxic.. so I didn't take it again
https://www.medscape.com/viewarticle/503104_3

 

In relation to that, this article is interesting, sobering, and informative on the inferiority of using mice models.

 

Regarding TNF alpha... I think this is the way to go because damm sure my brain feels fizzy and inflamed like there's a immune system reaction going on there. Have any of you guys tried "Fisetin" it's a supplement that block TNF and seems to protect you from metabolic syndrome while on keto. It's also in Persimmons and I told my wife just the other day... there's something in Persimmons that helps Tinnitus for sure!. I never knew what Fisetin was when I said that. http://www.pkdiet.com/diet_persimmon.php . I've also been wondering why no one seems to have success against Tinnitus with a hardcore keto diet.. yet some people have success on a carnivore diet. This didn't make much sense to me other than the Carnivore diet barely has you in Ketosis and sometimes not at all. Anyway.. You can see here that the Keto diet increases TNF alpha.. . https://pubs.rsc.org/en/content/articlelanding/2019/fo/c8fo01615a#!divAbstract

Being someone that's been on keto for the most part for several years I kinda feel a bit sick that it probably helped induce my tinnitus.. It works very well with general inflammation and I have an immune system disease that I try to limit with diet.. Lets say "another" immune system disease since it seems Tinnitus is this same kind of thing. Anyway who's up for some diet experiments. Oh yeah.. I had a full day free of Tinnitus after I had a B12 shot this other week so I think Nitric Oxide plays a part in this Taurine inhibits both NO and TNF alpha AND help GABA receptors.

PS creatine seems to help a little, no clue why and Taurine definitely works. Ok maybe this explains Creatine too https://www.ncbi.nlm.nih.gov/pubmed/29698843

 

@foam what is your immune disease? I have one too, but I don't think it could be related. Anyway if you could tell me that would be interesting.

 

I'll send you a message about it