Neuroinflammation Mediates Noise-Induced Synaptic Imbalance and Tinnitus in Rodent Models

Discussion in 'Research News' started by Krolo, Jun 18, 2019.

    1. Bndsmheowqhe

      Bndsmheowqhe Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Loud noise exposure
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753829/
       
      • Informative Informative x 1
    2. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran / loud computer
    3. Cal18
      Nerdy

      Cal18 Member Benefactor Advocate

      Location:
      San Diego
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      2010 / 2016 Both SSRI Withdrawal and Mild Hearing Loss
      @Telis Please PM me - over time, I've read your posts and noticed we had a lot of similarities (I also have the sound reactivity when someone uses the letter "s"). I'm hoping maybe we can help each other. Take care.
       
    4. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      • Informative Informative x 1
    5. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      • Informative Informative x 1
    6. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Anyone tried this stuff yet?
       
    7. Simon Czt

      Simon Czt Member

      Location:
      France
      Tinnitus Since:
      06/2018
      Cause of Tinnitus:
      Acoustic trauma
      I ordered spirulina like two days ago. Do you think I can take some at the same time as the curcumin?
       
      • Agree Agree x 1
    8. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      That is EXACTLY what I was thinking. I'm getting some of that today and taking it with curcumin tonight. I haven't taken any curcumin in like 2 weeks either so this will be an interesting experiment.
       
      • Agree Agree x 1
      • Optimistic Optimistic x 1
    9. Simon Czt

      Simon Czt Member

      Location:
      France
      Tinnitus Since:
      06/2018
      Cause of Tinnitus:
      Acoustic trauma
      Keep us informed of the results! I try as soon as I receive my order, within 2/3 days!

      I think we're about to find a cure.
       
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      • Hug Hug x 1
    10. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Well, just look at this:

      https://www.ncbi.nlm.nih.gov/pubmed/20713883

      "NSAID-mediated increases in TNF are reversed by either the addition of exogenous PGE(2) or by a PGE(2) EP2 receptor agonist, revealing that PGE(2) signaling via its EP2 receptor provides a valuable mechanism for controlling excess TNF production."

      NSAIDS (aspirin) can cause tinnitus and they also increase TNF, and this study says that elevated TNF can cause tinnitus.
       
      • Informative Informative x 1
    11. Ozwel
      Disappointed

      Ozwel Member

      Location:
      Paris, FR
      Tinnitus Since:
      2005
      Cause of Tinnitus:
      Auditive trauma
      Is there an easy way to know our amount of TNF in the blood or in the brain?

      It would be interesting to compare our levels with “regular” people.
       
      • Good Question Good Question x 1
    12. Bndsmheowqhe

      Bndsmheowqhe Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Loud noise exposure
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150313/
       
    13. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      You better be right, or else.
       
      • Friendly Friendly x 1
    14. Bndsmheowqhe

      Bndsmheowqhe Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Loud noise exposure
      • Informative Informative x 2
    15. John Mahan

      John Mahan Member

      Location:
      US
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      unknown
      John,
      Why did you discontinue Curcumin?
      Thanks
       
      • Like Like x 1
    16. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Blood thinner = thinning hair.
       
    17. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Well it smells like dead fish and tastes the same.
       
      • Funny Funny x 1
    18. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
    19. Heinrich_S7
      Relaxed

      Heinrich_S7 Member

      Tinnitus Since:
      Uncertain
      Cause of Tinnitus:
      noise exposure
      Everything I read online says Turmeric/Curcumin prevents hair loss.
       
      • Informative Informative x 2
    20. JohnAdams
      Murderous

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      well then........ crap....
       
    21. Heinrich_S7
      Relaxed

      Heinrich_S7 Member

      Tinnitus Since:
      Uncertain
      Cause of Tinnitus:
      noise exposure
      NSAIDs probably cause thinning to a much larger degree.

      An example of this is people over on r/nootropics on Reddit also like to talk about how Curcumin is an MAOI, but it's only an MAOI in a 'very mild capacity'. Nothing that would be large enough to interact with medications like antidepressants anyway.
       
      • Informative Informative x 1
    22. Simon Czt

      Simon Czt Member

      Location:
      France
      Tinnitus Since:
      06/2018
      Cause of Tinnitus:
      Acoustic trauma
      Did you feel any improvement in your tinnitus with spirulina and curcumin?
       
    23. Johnny Karate
      Lurking

      Johnny Karate Member

      Location:
      USA
      Tinnitus Since:
      12/02/18
      Cause of Tinnitus:
      Viagra, naproxen, jamming out in bands loud music for years
      I've been taking 2 grams of curcumin for 5 months and I have now upped the intake to 4 grams a day. I can't say it has done anything for my T, but.. I also suffer from gout and was having attacks every 2 to 3 months. I haven't had one sense. I refused to take allpurinol because it can cause tinnitus, so if anyone suffering from gout doesn't wanna risk over the counter meds because of Tinnitus, I would highly recommend curcumin. Here is the brand I take which was recommended from another thread on here and it seems to be the best I can find.
      https://www.amazon.com/gp/product/B00BCN1CF6/ref=ppx_yo_dt_b_asin_title_o00_s00?ie=UTF8&psc=1
      I take that with other supplements daily.
      4 to 10 grams of taurine, 1200mg NAC, 30mg zinc, 800mg magnesium, 2000ui Vit D, 500mg Vit C, 200mcg B12 and 250mg of Vit B1. All of that split in a morning dose and an evening dose.

      Probably taking too much stuff but you get desperate. My problem is I don't know which ones are actually helping now outside of 2 supplements. I must admit the taurine and curcumin have made a noticeable difference. The taurine took the "dentist drill" flucuating tone completely away after 2 weeks by only taking 3 grams a day spread out 1 gram per 6 hours. I found further relief by upping the dose to 6 grams a day 2 grams every 6 hours. Now I take 4 grams a day split into 2 grams morning and evening. If I have a catastroiphic/severe spike I will take 10 grams (taurine) in one swallow which calms me down. Then at night I take 4 grams of REM fresh melatonin and try and crash.
      I am not a doctor nor have a played one on TV. Check with your health care provider before making and changes in your medications or supplementation. This is just my experiences so far.
       
      Last edited: Aug 14, 2019
      • Informative Informative x 2
    24. razo

      razo Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Audio exposure
      I also found that taking creatine powder, a weight training supplement that binds water in your muscles, helped relieve the neck muscle tension. It's so soothing I might continue taking it even without training.
       
      • Like Like x 1
    25. John Mahan

      John Mahan Member

      Location:
      US
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      unknown
      razo,
      Do you happen to take Whey protein powder as well for more protein to build muscle? Are you a pretty serious weight lifter or trainer?
       
    26. razo

      razo Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Audio exposure
      No, I do it just for wellbeing. I use some protein powder, but the effect of creatine is separate from this.
       
      • Like Like x 1
    27. foam

      foam Member

      Tinnitus Since:
      7/2019
      Cause of Tinnitus:
      Unknown
      Quite a few normal old H1 antihistamines will drop TNF alpha production in half (at least) I did have a good response to cetirizine the other night.. but after I got on this site everyone was saying everything is toxic.. so I didn't take it again
      https://www.medscape.com/viewarticle/503104_3
       
    28. derpytia
      Pooptoast

      derpytia Member Benefactor

      Location:
      Rescue, California
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Hearing loss / ETD
      In relation to that, this article is interesting, sobering, and informative on the inferiority of using mice models.
       
    29. foam

      foam Member

      Tinnitus Since:
      7/2019
      Cause of Tinnitus:
      Unknown
      Regarding TNF alpha... I think this is the way to go because damm sure my brain feels fizzy and inflamed like there's a immune system reaction going on there. Have any of you guys tried "Fisetin" it's a supplement that block TNF and seems to protect you from metabolic syndrome while on keto. It's also in Persimmons and I told my wife just the other day... there's something in Persimmons that helps Tinnitus for sure!. I never knew what Fisetin was when I said that. http://www.pkdiet.com/diet_persimmon.php . I've also been wondering why no one seems to have success against Tinnitus with a hardcore keto diet.. yet some people have success on a carnivore diet. This didn't make much sense to me other than the Carnivore diet barely has you in Ketosis and sometimes not at all. Anyway.. You can see here that the Keto diet increases TNF alpha.. . https://pubs.rsc.org/en/content/articlelanding/2019/fo/c8fo01615a#!divAbstract

      Being someone that's been on keto for the most part for several years I kinda feel a bit sick that it probably helped induce my tinnitus.. It works very well with general inflammation and I have an immune system disease that I try to limit with diet.. Lets say "another" immune system disease since it seems Tinnitus is this same kind of thing. Anyway who's up for some diet experiments. Oh yeah.. I had a full day free of Tinnitus after I had a B12 shot this other week so I think Nitric Oxide plays a part in this Taurine inhibits both NO and TNF alpha AND help GABA receptors.

      PS creatine seems to help a little, no clue why and Taurine definitely works. Ok maybe this explains Creatine too https://www.ncbi.nlm.nih.gov/pubmed/29698843
       
      • Like Like x 1
    30. Gabriel
      Balanced

      Gabriel Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      I focused on verifying if I had tinnitus
      @foam what is your immune disease? I have one too, but I don't think it could be related. Anyway if you could tell me that would be interesting.
       

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