Neuroinflammation Mediates Noise-Induced Synaptic Imbalance and Tinnitus in Rodent Models

Discussion in 'Research News' started by Krolo, Jun 18, 2019.

    1. foam

      foam Member

      Tinnitus Since:
      7/2019
      Cause of Tinnitus:
      Unknown
      I'll send you a message about it
       
    2. Bill Bauer
      No Mood

      Bill Bauer Member Hall of Fame

      Tinnitus Since:
      February, 2017
      Cause of Tinnitus:
      Acoustic Trauma
      Take Proscar - problem solved.
       
      • Like Like x 1
    3. Mal58

      Mal58 Member

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Loud noise? Headphones?
      How do they know the mice have tinnitus?
       
      • Good Question Good Question x 1
    4. Notch

      Notch Member

      Tinnitus Since:
      25/3/2019
      Cause of Tinnitus:
      Dentist clean
      Silent gap test.
       
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    5. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Well it stopped thinning but I'm cautiously keeping an eye on it.
       
    6. Mal58

      Mal58 Member

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Loud noise? Headphones?
      OK, I googled it:

      "testing if the mice can detect a short gap in a constant, low-level background noise that happens just before a loud noise. If the mouse can hear it, then over time, it learns that the gap means there’s about to be a loud noise, so they don’t jump as much when it happens. But if the mouse has tinnitus, that is, if it’s constantly hearing a ringing in its ears, then it won’t hear the gap warning it about the noise, so they jump just as much the tenth time it happens as they did the first time. "
       
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    7. dayma
      Frustrated

      dayma Member Benefactor

      Tinnitus Since:
      1/6/2018
      Cause of Tinnitus:
      UNKNOWN
      I am a lifter and use both. Never really helped with inflammation. I do massages and kryo for that.
       
    8. Bill Bauer
      No Mood

      Bill Bauer Member Hall of Fame

      Tinnitus Since:
      February, 2017
      Cause of Tinnitus:
      Acoustic Trauma
      I don't believe that the thinning can just stop by itself. The thinning process can be very slow, but keep in mind that Proscar doesn't really cause one to regain the lost hair. Proscar allows you to slow down the thinning. Ideally, for about 10 years or so, you will get to mostly keep the amount of hair you have had when you began taking Proscar. So if this is important to you, and you are ok with the possible side effects of Proscar, it is better to begin taking it as soon as possible.
       
    9. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Yeah, I know, my ol' pal has been on it since he was 20. I don't think my hair thinning was natural. I think it was from eating like 12 curcumin capsules every day.
       
      • Like Like x 1
    10. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Here's a link from a local radio station where it seems they got an interview with the University of Arizona's lead researcher on the tinnitus neuroinflammation research Dr. Shaowen Bao. They added a few seconds of it on the link.

      https://kjzz.org/content/1132831/ua-rodent-study-identifies-possible-tinnitus-treatment-target

      The station said that Dr. Bao cautioned it is new research, and if human trials will happen, it would be "years in the future".

      Let's hope by years they mean only like 2.
       
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    11. just1morething
      Benevolent

      just1morething Member Benefactor

      Location:
      U.S.
      Tinnitus Since:
      2008
      Cause of Tinnitus:
      barotrauma, noise exposure, TMJ, neck?
      Becoming a "chrome dome" has to be better than having noise in your nut.
       
      • Agree Agree x 2
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    12. Erik11

      Erik11 Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      noice
      Where the hell do I get this pill? What kind of ethics do these companies have, here we suffer in pains and have to W.A.I.T
       
      • Agree Agree x 1
    13. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      Are you guys just joking about Proscar, or what?

      That's a drug that's pretty well known to cause tinnitus in some subset of the population. I will gladly lose my beautiful mane before I risk my ears more.
       
    14. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      It's not a company it's the University of Arizona. Dr. Shaowen Bao is the lead researcher and unfortunately he doesn't seem to be in a hurry to speed up his work, but I agree he really should be all over this if he has found the actual cure. It would be moronic to find the cure to something then not do anything with it.
       
    15. MisticRayn

      MisticRayn Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Meloxicam possibly
      I’m new to this forum. Would this work for drug induced tinnitus? I’m a bit leery of drugs at this point.

      Also, how do they know when mice have and don’t have tinnitus? They can’t ask them. Serious question. Is there a method?
       
    16. Bill Bauer
      No Mood

      Bill Bauer Member Hall of Fame

      Tinnitus Since:
      February, 2017
      Cause of Tinnitus:
      Acoustic Trauma
    17. MisticRayn

      MisticRayn Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Meloxicam possibly
      • Friendly Friendly x 1
    18. GlennS

      GlennS Member Podcast Patron

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      I had to google what proscar is. Propecia, aka finasteride.

      I used to take it through the gray market because I was too embarrassed to try to get a prescription. It probably helped slow my hair loss. I stopped taking it once I found out about the potential sexual side-effects. I've been off it long enough and lost enough hair since then that I'd have to get back on it ASAP if it were to have any benefit. You have to understand that people pushing 50 like me tend to develop ED problems all on their own so it's something I'm concerned about.
       
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    19. Erik11

      Erik11 Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      noice
    20. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      • Agree Agree x 1
    21. MattS
      Relaxed

      MattS Member

      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Power Tools
      In my opinion, the limbic system theory does not hold up when you really dig into it. It *may* play a role in the annoyance to the sounds, but the chances that it serves as a route cause seems unlikely.

      This would likely be a different theory. However, one could tie the two together if they were really motivated to. For instance, it could be the inflammatory process that gets the limbic system all hot/bothered. But again, this seems unlikely to me.
       
    22. MattS
      Relaxed

      MattS Member

      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Power Tools
      Exactly Chris. As a neuroscientist who studies the limbic system, this is my feeling exactly.
       
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    23. MattS
      Relaxed

      MattS Member

      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Power Tools
      I think the thought is that the limbic response may contribute to the chronic nature of tinnitus, rather than its onset. And so it could technically come after tinnitus onset and still be a "cause" of long-term, chronic tinnitus. In other words, if it wasn't for the limbic response, the tinnitus percept would disappear before it became chronic.

      That said, I still don't buy it. The limbic response seems far more likely to me to be reactionary, rather than causal. In fact, that goes for most of the brain responses that researchers are finding. The big thing these days is to say that so many parts of the brain are involved, and that tinnitus is thus far more complicated than ever imagined. But this seems a bit straw-man to me. Far more likely, there's a root cause somewhere that hasn't yet been identified, and all these other brain regions - emotion regions and attention regions and memory regions - are all trying to deal with the fact that there's this annoying sound present.
       
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    24. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      That's exactly how I feel too. It makes much more sense, and also falls more with the TNF-alpha inflammation in the auditory center and hyperactive fusiform cells in the dorsal cochlear nucleus theories.
       
    25. Heinrich_S7
      Psychedelic

      Heinrich_S7 Member

      Tinnitus Since:
      Uncertain
      Cause of Tinnitus:
      noise exposure
      If this ever does become "The Cure" then I hope we only have to take it for a short duration.

      It's also made me ponder what would happen if you stayed on curcumin for years, if that would heal the tinnitus away.
       
    26. MattS
      Relaxed

      MattS Member

      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Power Tools
      Ask @JohnAdams - he gave it his best shot.
       
    27. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      • Informative Informative x 3
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    28. LostOutWest
      Conehead

      LostOutWest Member Benefactor

      Tinnitus Since:
      09/2019
      Cause of Tinnitus:
      Unknown
      Hi all -

      In case you all didn't see, that the VA is starting a clinical trial with Enbrel (a TNF inhibitor for arthritis, inflammation-related diseases) as a means of tinnitus suppression.

      https://www.clinicaltrials.gov/ct2/show/NCT04066348

      Would be great to hear from any forum members that may have taken Enbrel, Humira, Remicade, or any other TNF-inhibitors as to whether it had any impact on their tinnitus.
       
      • Informative Informative x 5
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    29. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      As far as I can tell turmeric/curcumin only offer a temporary suppression.
       
    30. LostOutWest
      Conehead

      LostOutWest Member Benefactor

      Tinnitus Since:
      09/2019
      Cause of Tinnitus:
      Unknown
      Bears mentioning that Shaowen Bao (The U of Arizona Professor who is deep into TNF's link to Tinnitus) is one of the Principal investigators on the upcoming VA trial of Enbrel for Tinnitus.
       
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