Neuroinflammation Mediates Noise-Induced Synaptic Imbalance and Tinnitus in Rodent Models

Hello,

An interesting link :
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606192/

Abstract
Effects of C-phycocyanin (C-PC), the active component of Spirulina platensis water extract on the expressions of N-methyl D-aspartate receptor subunit 2B (NR2B), tumor necrosis factor–α (TNF-α), interleukin-1β (IL-1β), and cyclooxygenase type 2 (COX-2) genes in the cochlea and inferior colliculus (IC) of mice were evaluated after tinnitus was induced by intraperitoneal injection of salicylate. The results showed that 4-day salicylate treatment (unlike 4-day saline treatment) caused a significant increase in NR2B, TNF-α, and IL-1β mRNAs expression in the cochlea and IC. On the other hand, dietary supplementation with C-PC or Spirulina platensis water extract significantly reduced the salicylate-induced tinnitus and down-regulated the mRNAs expression of NR2B, TNF-α, IL-1β mRNAs, and COX-2 genes in the cochlea and IC of mice. The changes of protein expression levels were generally correlated with those of mRNAs expression levels in the IC for above genes.

Spirulina platensis could be an already on the market, and safer alternative to anti TNF-a médicine.

 

Has anyone heard that tinnitus is caused by brain inflammation? And there might be a cure? I have seen something on my Facebook timeline but I don't know how to post it in here.

 

Yes, and personally I'm excited about it. I hope the research translates to humans and that a treatment gets out to us ASAP. But until then, we're looking forward to bimodal neuromodulation. We have been discussing the brain inflammation on this thread:
https://www.tinnitustalk.com/thread...mbalance-and-tinnitus-in-rodent-models.35353/

 

Hello, so you take 6 capsules per day.
Did you have beneficial effects?
Other question: are there important side effects?

 

@jeannie
Yes it’s promising indeed! I take curcumin and without a doubt, it helps my tinnitus.
I suspect neuro inflammation is a large contributor to my tinnitus.

 

Brain inflammation might make sense for me alongside the hearing loss because ever since getting hearing loss/ tinnitus, inflammation symptoms in other areas of my body started and have gradually gotten worse (though I'm not sure the worsening is correlated with my subsequent incidents of more hearing loss. I haven't even thought of inflammation being the problem or I would have at least tried to pay attention to it).

It's always been mainly in my eustachian tubes but now my skin has patches of psoriasis and I'm feeling like my joints are slightly achy at times. I can cut down on some of the inflammation with small short term doses of steroids or antihistamines but it doesn't really take it all away. Inflammation has been a huge health concern for me in the past year alongside my tinnitus and depression.

 

How about reducing inflammation through fasting? From what I understand about fasting the brain goes through a heal and rebuild process. One of the many benefits of fasting is reduced inflammation in the body and in the brain.

 

Hey Telis, when you fasted, were the effects long term? Or did your tinnitus come back when you stopped fasting?

 

Yes, absolutely. I'm dong some research into this and plan to start very soon. I respond to prednisolone and curcumin so I definitely think it's something for me to try.

 

Maybe exercise can help too. I am not very sporty but even walking or riding my bike feels good afterwards, and one is in better mood too!

 

They were long term, I was doing a lot better until I stepped into a 120 dB MRI machine with crap ear protection, now I’m half deaf and haven’t been able to will myself to fast, I’m not in the state of mind. I’ve got serious PTSD from this incident, my tinnitus is so bad after the MRI I can’t sleep for more than 10 min at a time and am on a lot of drugs and alcohol just to get through the day. I need to be somewhat relaxed when I fast, not white knuckle my way through it, I’m not able to at this point.

I’m not sure why more people aren’t interested in this, fasting is one of the best ways to heal the brain and the body, reduces inflammation better than any drug. I guess it’s easier to wait for the next pill or whatever.

 

Hi Telis, I also did the MRI mistake. I was in a very good situation with my loud tinnitus but had to do MRI 4 weeks ago and that changed the game now. And now I am again here at Tinnitus Talk and looking for hope. The last time when I was going through a hard time was when the Autifony drug was in a clinical trial but it failed. Now again I have a hard time and I can see everyone is excited about this Lenire device which I am not optimistic about.

 

@Telis when you were fasting how did you approach it? water/intermittent/dry/days at a time?

 

So sorry for your challenges, that's so rough. This line of thought is very interesting; in addition to hearing loss and tinnitus, I recently developed an inexplicable inflammation inside my mouth, which responded to Prednisone though it's not completely gone yet. No specific sores, just a generalized sensitivity on and under my tongue, and especially inside my lips (a little on the exposed, external parts of the lips too). My physician has no explanation for it and said if it doesn't completely calm down, or if it comes back in force, she'd send me to a rheumatologist. Meanwhile my ENT isn't super sure about the reason for my hearing loss--the top candidate is ear infection after pneumonia--and, since I have other nasal issues (not major, just chronically annoying) and we're looking for more hearing loss clues, I'm having an MRI in early August. (I'm mindful of the importance there of hearing protection).

(I had an ECoG test recently that showed fluid imbalance in my bad ear. In that test they put an electrode on your forehead and earphone attachments and pulse you (no pain) for 30-40 minutes.)

 

Fasting reduces TNF inflammation? Does nothing for my tinnitus. Why?

 

It is true TNF alpha maybe br necessary, but it is safe to presume the researchers working on the treatment are aware of that and testing for adverse effects such as those, and may even redesign a treatment if necessary.

 

@JohnAdams

Have I been doing it wrong? I've been taking one 250mg capsule occasionally of curcumin but noticed no effect.

Should I really up the dose?

 

I did read in another thread he was taking 8 grams a day. So you are not even getting close with 250mg.

I also started with Curcumin last week, upped the dose today (6 pills of 900mg). Let's see if I notice any difference.

 

I take 3 grams at dinner.

 

Please tell us how it's going. Any difference?

 

This may be an asinine question but does Curcumin need to be built up in your system like a vitamin or supplement? I don't expect to pop a Curcumin pill and be healed or have an effect immediately. I am assuming this takes time?

Captain Jack

 

Keep me in the loop bro.

 

Let me know how it turns out. I have the results of my brief stint with turmeric and I'm gearing up to give it another go (I am poor and ran out of money to buy more).

 

Captain, I noticed a next day effect. I've been on and off experimenting with this for about a year and I have found, for me, that the best time to take it is at dinner and it usually is working by the next morning. I take ~3,000 mg.

 

Sure will! So far so good. I've lost about 3kgs in 2 weeks and my head is feeling a lot clearer. Tinnitus is low, but that's normal until the time of my period. So I'll see if I get any difference then.

 

Not really. I had 1 really, really good day. With tinnitus at 3-4/10 instead of the 6-7/10. A level I for sure can get used to. Didn't experience that in a long time. Unfortunately the day after it was back at 6/10 and today back at 6-7/10. This number is my awareness/loudness combination number. Totally not scientific, just how I experience it.

Also that good day happened to be after the day I started with a low carb diet as well and in the night before I had a great night of sleep.

So it can be the regular tinnitus randomness I experienced. I'm trying to go for 3 pills during dinner as JohnAdams does. I'm taking "Turmeric Curcumin 1000mg" and that contains 900mg Curcuma, 100mg Curcuma extract and 5mg Black Pepper extract. I think JohnAdams was taking something different.

Something else, not related: I experience that a sleep can reset my tinnitus. From good to bad or vice versa. Maybe it's the mood I wake up with... or maybe it's the position I have been sleeping in... no clue.

Anyway, will keep you guys posted about my progress.

 

The BTA has a pretty sobering article on their website about this research.

 

Here's the link if anyone is interested. It's interesting research, but this is why justsayinmice exists.

 

I'm literally to read this, but I need to ask if hearing loss can cause brain inflammation and what is a laymenized explanation of how it happens?

 

Yes, the research found brain inflammation is the tinnitus sufferers' response to hearing loss. The inflammation is caused by excess TNF-alpha proteins in the auditory cortex, causing abnormal neuronal transmissions.

They made a dug that cured noise induced tinnitus in mice by blocking this protein, backwards tested the TNF-alpha protein by causing tinnitus in non-noise induced mice by introducing the protein in the auditory cortex.

So they figured out that this protein is what is causing tinnitus and it is curable.

It's still new research but it's a sign that we might have a full on cure if their research is right and the drug proves safe and effective for human use. They haven't started human trials yet, they are currently testing the drug itself for human safety.