Neuroinflammation Mediates Noise-Induced Synaptic Imbalance and Tinnitus in Rodent Models

Hello,

An interesting link :
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606192/

Abstract
Effects of C-phycocyanin (C-PC), the active component of Spirulina platensis water extract on the expressions of N-methyl D-aspartate receptor subunit 2B (NR2B), tumor necrosis factor–α (TNF-α), interleukin-1β (IL-1β), and cyclooxygenase type 2 (COX-2) genes in the cochlea and inferior colliculus (IC) of mice were evaluated after tinnitus was induced by intraperitoneal injection of salicylate. The results showed that 4-day salicylate treatment (unlike 4-day saline treatment) caused a significant increase in NR2B, TNF-α, and IL-1β mRNAs expression in the cochlea and IC. On the other hand, dietary supplementation with C-PC or Spirulina platensis water extract significantly reduced the salicylate-induced tinnitus and down-regulated the mRNAs expression of NR2B, TNF-α, IL-1β mRNAs, and COX-2 genes in the cochlea and IC of mice. The changes of protein expression levels were generally correlated with those of mRNAs expression levels in the IC for above genes.

Spirulina platensis could be an already on the market, and safer alternative to anti TNF-a médicine.

 

Has anyone heard that tinnitus is caused by brain inflammation? And there might be a cure? I have seen something on my Facebook timeline but I don't know how to post it in here.

 

Yes, and personally I'm excited about it. I hope the research translates to humans and that a treatment gets out to us ASAP. But until then, we're looking forward to bimodal neuromodulation. We have been discussing the brain inflammation on this thread:
https://www.tinnitustalk.com/thread...mbalance-and-tinnitus-in-rodent-models.35353/

 

Hello, so you take 6 capsules per day.
Did you have beneficial effects?
Other question: are there important side effects?

 

@jeannie
Yes it’s promising indeed! I take curcumin and without a doubt, it helps my tinnitus.
I suspect neuro inflammation is a large contributor to my tinnitus.

 

Brain inflammation might make sense for me alongside the hearing loss because ever since getting hearing loss/ tinnitus, inflammation symptoms in other areas of my body started and have gradually gotten worse (though I'm not sure the worsening is correlated with my subsequent incidents of more hearing loss. I haven't even thought of inflammation being the problem or I would have at least tried to pay attention to it).

It's always been mainly in my eustachian tubes but now my skin has patches of psoriasis and I'm feeling like my joints are slightly achy at times. I can cut down on some of the inflammation with small short term doses of steroids or antihistamines but it doesn't really take it all away. Inflammation has been a huge health concern for me in the past year alongside my tinnitus and depression.

 

How about reducing inflammation through fasting? From what I understand about fasting the brain goes through a heal and rebuild process. One of the many benefits of fasting is reduced inflammation in the body and in the brain.

 

Hey Telis, when you fasted, were the effects long term? Or did your tinnitus come back when you stopped fasting?

 

Yes, absolutely. I'm dong some research into this and plan to start very soon. I respond to prednisolone and curcumin so I definitely think it's something for me to try.

 

Maybe exercise can help too. I am not very sporty but even walking or riding my bike feels good afterwards, and one is in better mood too!

 

They were long term, I was doing a lot better until I stepped into a 120 dB MRI machine with crap ear protection, now I’m half deaf and haven’t been able to will myself to fast, I’m not in the state of mind. I’ve got serious PTSD from this incident, my tinnitus is so bad after the MRI I can’t sleep for more than 10 min at a time and am on a lot of drugs and alcohol just to get through the day. I need to be somewhat relaxed when I fast, not white knuckle my way through it, I’m not able to at this point.

I’m not sure why more people aren’t interested in this, fasting is one of the best ways to heal the brain and the body, reduces inflammation better than any drug. I guess it’s easier to wait for the next pill or whatever.

 

Hi Telis, I also did the MRI mistake. I was in a very good situation with my loud tinnitus but had to do MRI 4 weeks ago and that changed the game now. And now I am again here at Tinnitus Talk and looking for hope. The last time when I was going through a hard time was when the Autifony drug was in a clinical trial but it failed. Now again I have a hard time and I can see everyone is excited about this Lenire device which I am not optimistic about.

 

@Telis when you were fasting how did you approach it? water/intermittent/dry/days at a time?

 

So sorry for your challenges, that's so rough. This line of thought is very interesting; in addition to hearing loss and tinnitus, I recently developed an inexplicable inflammation inside my mouth, which responded to Prednisone though it's not completely gone yet. No specific sores, just a generalized sensitivity on and under my tongue, and especially inside my lips (a little on the exposed, external parts of the lips too). My physician has no explanation for it and said if it doesn't completely calm down, or if it comes back in force, she'd send me to a rheumatologist. Meanwhile my ENT isn't super sure about the reason for my hearing loss--the top candidate is ear infection after pneumonia--and, since I have other nasal issues (not major, just chronically annoying) and we're looking for more hearing loss clues, I'm having an MRI in early August. (I'm mindful of the importance there of hearing protection).

(I had an ECoG test recently that showed fluid imbalance in my bad ear. In that test they put an electrode on your forehead and earphone attachments and pulse you (no pain) for 30-40 minutes.)

 

Fasting reduces TNF inflammation? Does nothing for my tinnitus. Why?