Neurotrophin 3 Regenerates Cochlear Synapses

You must all be doctors or children of doctors, I don't understand how you get all kinds of medicines to try

 

Nothing to both. Tried Noopept, too, but it had no effect (or maybe I developed visual snow on it, unsure, because it only appears at night, but it's very strong then. This coincided with my second trauma (MRI), so it could just be that).

 

Wife is a doctor, mum is a doctor, brother's wife is a doctor

 

You should be cured by now there's no excuse.

 

None of them stopped me from having the MRI... Lol. Before that I had the 'only in a quiet room' tinnitus and some distortions. Sometimes the high frequency one would be audible over noise, but it was rare. Now it rages over everything and the distortions come from most sounds.

 

They didn't stop it because they prefer you to be alive with a louder tinnitus, than not having the exam and have something seriously wrong in your brain.

I have to do an MRI.

Did you wear double hearing protection and was it a 1.5 Tesla or 3 Tesla MRI?

 

3 T with foam earplugs and foam pads on the ears. Earmuffs did not fit into the head enclosure, that was weird. I also had trouble putting the foam earplugs in (narrow ear canals).

 

And yet you decided to continue, it looks like you were exposed to 115 dB without hearing protection for 30 minutes.

 

It was insufficient protection, the plugs were in, but I can never insert them fully, they always stick out. The pads had some attenuation, too. It did not seem too loud when I was in there.

 

it looks like tinnitus can never be cured.

 

Not really.

Seems like certain solutions for regenerating hair cells/cochlea repair are inevitable at this point, so that's more of a when and not an if. But realistically, it could be decades away...

Whether it has an effect on tinnitus or not, we don't know yet.

 

The article also talks about destroyed synapses. You need to connect the hair cell to the nerve. This requires new synapses.

 

Yes, this is a part of cochlea repair. There are several companies trying to get drugs to market for this particular issue. There are also many scientists around the world researching the ear to get a better understanding of these things.

But to be honest, we don't know if this will solve tinnitus at all. Seems like there is very little push to solve the tinnitus issue in itself, but a lot to help hearing loss at least.

 

What is special today? 5-10 years ago there was also research and development. Why aren't today's events fraudulent?

 

Rhodiola Rosea Salidroside is the type that boosts BDNF, there are two other types also.

 

Anyone ever try Forskolin for this?

Histamine-neurotrophin-3 interactions in cultured rat astrocytes

"Different activators of basic intracellular histamine receptor second messenger systems (forskolin, dibutyryl cAMP, dBcAMP; as well as calcimycin, i.e. Ca2+ ionophore A23187) and phorbol 12-myristate 13-acetate, TPA) markedly increase the cellular level of NT-3 protein."