Otonomy OTO-313 — Treatment of Tinnitus

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Otonomy to present at the ARO with regards to OTO-313.

      "In particular, we are pleased to present information on our clinical program for OTO-313, including the Phase 1/2 clinical trial in tinnitus patients to be initiated next quarter, and preclinical data related to our OTO-510 program for otoprot.....”

      http://investors.otonomy.com/news-r...s-multiple-presentations-association-research

      I guess the million dollar question is whether OTO-313 is for acute or for chronic tinnitus as previously talked about, it’s based on a similar MOA to AM-101 that failed. AM-101 was for chronic tinnitus.

      Anyway, I will try and get in touch with Otonomy and see if I can obtain any information after they’ve presented that may shed some light on this.
       
    2. papu
      Chatty

      papu Member Benefactor

      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Acoustic Trauma
      AM 101 was intended for the acute phase of tinnitus (first 3 months), later they extended the trial for up to a year and both fail to give any positive result.

      Similar way of acting in the same receptor (NMDA) but with a stronger (more affinity or more potent) product than AM 101 as i understand

      AM 101 did not do anything for the single acoustic trauma that cause my tinnitus started the trial at the 3 month mark (placebo vs AM 101 dont know) and did a second round with AM 101 at the 6 month mark
       
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    3. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Found this before:

      http://mundotinnitus.com/en/nst-001-tinnitus-cure/

      Allegedly, this drug NST-001 had passed 2 clinical trials and the company disappeared.

      Here it is claimed this drug NST-001 is OTO-311 and now OTO-313.

      Otonomy has allegedly bought this off this company called NeuroSystec.
       
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    4. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
    5. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Otonomy did a presentation at ARO 2019 and one the leading presentations was that of OTO-313.

      @David have you got any news what they presented at Baltimore?
       
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    6. Striveon

      Striveon Member

      Tinnitus Since:
      08/2018
      Cause of Tinnitus:
      Unknown
      Are you serious :( ? Are you sure it's for acute...? I also had the same impression :(
       
    7. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      No I am not sure it’s for acute. In fact a conversation I had with @attheedgeofscience who has a financial background, a recent slide seemed to indicate they could be targeting acute and chronic.

      Of course though, this is speculation.

      I think he suggested it may have something to do with the target population.

      We’ll just have to wait and see.

      My hope is in Neuromod and bimodal neuromodulation at this point rather than an NMDA receptor antagonist.

      Otonomy seem to think there is still hope in this MoA.
       
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    8. Deamon22

      Deamon22 Member Benefactor Ambassador

      Tinnitus Since:
      06/2018
      Cause of Tinnitus:
      Head Trauma/Cold?
      https://www.globenewswire.com/news-...-2-Clinical-Trial-of-OTO-313-in-Tinnitus.html

      "We are excited to advance the clinical development of OTO-313 by initiating this trial, which will evaluate the therapeutic potential of OTO-313 in patients with tinnitus,” said David A. Weber, Ph.D., president and CEO of Otonomy. “We expect results from this study in the first half of 2020 and will use the information to inform the design and plan for further clinical development.”
       
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    9. GSC
      Volatile

      GSC Member

      Tinnitus Since:
      02/2019
      Cause of Tinnitus:
      Acoustic trauma.
      YAY.
       
    10. Lane

      Lane Member

      Tinnitus Since:
      February, 2018
      Cause of Tinnitus:
      Ototoxic Drug
      Last edited: Apr 11, 2019
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    11. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      What a week.
       
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    12. TibuJenkins

      TibuJenkins Member

      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Ear wax removal with suction by ENT
      I'm planning on contacting the ENT quoted in the article Dr Susan King. I live in Houston so it wouldn't be that hard to drive to San Antonio.

      "Tinnitus is a common problem affecting millions of people,” said Susan Marenda King, M.D., Neurotologist and Otologist at the Ear Medical Group in San Antonio, and Clinical Professor at the University of Texas Health Science Center. “The constant annoyance of tinnitus can negatively impact a patient's quality of life by disrupting their ability to concentrate, enjoy leisure activities and obtain restful sleep. Unfortunately, we currently have no drug therapy to offer these patients. I am excited about the potential of OTO-313 and pleased to be part of the Phase 1/2 clinical trial.”
       
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    13. GSC
      Volatile

      GSC Member

      Tinnitus Since:
      02/2019
      Cause of Tinnitus:
      Acoustic trauma.
      Are they recruiting? Did you check on clinicaltrials?
       
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    14. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Even if this drug is successful, which seems to work on the same theory of MoA as Auris Medical's AM-101 - which failed. We still have no idea if it will only be for acute tinnitus. Going by the science of it, for those of us have long term, established tinnitus, it ends up in the brain and starts in the ear. So treating the ear early on may work, but I have no idea what the science behind it would be if it was to be aimed at chronic tinnitus.

      I tried to contact them to see if they’ll answer some questions but the 2 email addresses didn’t seem to be active.
       
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    15. Clint Azzopardi
      Woot

      Clint Azzopardi Member

      Tinnitus Since:
      October 2018
      Cause of Tinnitus:
      Not sure, Gentamicin or allaergy or both !
      Sorry if this might be a silly question but what is the difference between chronic and acute tinnitus?
       
    16. SergioN

      SergioN Member

      Tinnitus Since:
      25/07/2005
      Cause of Tinnitus:
      Acoustic trauma + ototoxicity
      Chronic tinnitus = suffering it for more than 6-9-12 months...it depends on which literature you choose.
      Acute = less than that.
       
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    17. GSC
      Volatile

      GSC Member

      Tinnitus Since:
      02/2019
      Cause of Tinnitus:
      Acoustic trauma.
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    18. Ray552

      Ray552 Member

      Tinnitus Since:
      12/18
      Cause of Tinnitus:
      Noise trauma
    19. lymebite
      Vegged out

      lymebite Member Benefactor

      Location:
      United States
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Unknown
      Email Andrea Velasquez at:

      andrea.velasquez@worldwide.com
       
    20. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      There are alot of people from different companies working on this and I know for a fact healing is possible. This should give us hope.
       
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    21. Daniel Lion
      Ape-like

      Daniel Lion Member Benefactor

      Location:
      se asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      By "fact" are you referring to Korea specifically or to scientific breakthroughs generally? Or are you referring to all of the above. Is that an OK question to ask?
       
    22. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      My own experience.
       
    23. Daniel Lion
      Ape-like

      Daniel Lion Member Benefactor

      Location:
      se asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Sweet... thanks for your reply.
       
    24. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      The trial has been posted, just thought I'd let everyone know!
       
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    25. Ray552

      Ray552 Member

      Tinnitus Since:
      12/18
      Cause of Tinnitus:
      Noise trauma
      How do you sign up though ?
       
    26. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      My thoughts...

      Just checked the recruitment on ClinicalTrials.gov...

      There is no timeframe to how long you must have had tinnitus, whether it be over 3
      months or 20 years....

      This could mean that they have an idea that it may be helpful for both acute and chronic tinnitus. A conversation I had with @attheedgeofscience and a presentation he saw, given the figures they were talking about, it would suggest they are targeting both chronic and acute tinnitus.

      OR

      It doesn’t matter as the primary outcome by the looks of it and small sample size that they are just testing the safety of this drug.

      Otonomy are difficult to get hold of, it would be great if Tinnitus Talk could have a Q&A with them. @Markku, @Hazel - I tried to contact them via the emails on their website and the email address appears invalid...
       
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    27. Sevv

      Sevv Member

      Tinnitus Since:
      14.04.2019
      Cause of Tinnitus:
      Loud concert
      I guess there's nothing about Europe, eh?
       
    28. Markku
      Inspired

      Markku Founder Staff Benefactor Hall of Fame Advocate

      Tinnitus Since:
      04/2010
      Cause of Tinnitus:
      Syringing
      We had a conference call with three key people from Otonomy (Chief Scientific Officer, VP of Patient Access and Quality, Senior Director of Clinical Sciences) back in 2017. They were keen to hear about the patient perspective and they were open to a Q&A, however if my memory serves right, they felt at the time that their clinical programs were in a place where a Q&A wasn't suitable.

      I can definitely try catching up again.
       
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    29. Finlandzeeeee

      Finlandzeeeee Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Unknown, acoustic trauma
      Does anyone know if you need to be US citizen to sign up for this trial?
       
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    30. Redknight

      Redknight Member

      Location:
      Lisburn, N.Ireland
      Tinnitus Since:
      03/2019
      Cause of Tinnitus:
      Unknown
      "Initial trauma to the inner ear has been shown to trigger excess production of glutamate, which leads to the hyperactivation of NMDA receptors and, in turn, cell death. Blocking the NMDA receptor could therefore have a protective effect – but it is unclear how this mechanism would work once the damage to hair cells had been done." - sounds like this is for acute T only, but they want to test that assumption
       
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