Otonomy OTO-313 — Treatment of Tinnitus

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Hearing aids don't cover frequencies above 10000 Hz (most are lower than that as well) and this is where a lot of hearing loss occurs.
       
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    2. Chriscom

      Chriscom Member Podcast Patron Benefactor

      Location:
      Northern Virginia USA
      Tinnitus Since:
      May 2019
      Cause of Tinnitus:
      Likely infection/ear stress after walking pneumonia
      Yes.

      There are a variety of efforts under way, I'd say a few in fairly advanced stages. Spend some time in the threads, including Lenire in the Treatments section--it's a new device being rolled out in Dublin with plans to expand in Europe and later the U.S. There's a user-experience thread and a general comment threat about it--some improvement reported but I'd say the jury is still out there. I won't try to summarize it all because I'll get it wrong, but work I'm keeping an eye on includes a similar approach by Dr Susan Shore; a hearing-regeneration effort by Frequency Therapeutics using a drug called FX-322 starting Phase 2 trials now (hearing restoration is thought to have a good shot at reducing or eliminating tinnitus); the OTO efforts; and an Ototech/Otolith device designed for motion sickness that reported tinnitus elimination or sharp reduction--more trials to start soon.

      Some of these avenues may produce "only" reductions to levels that most folks could live with and others may have a better shot at complete elimination. But yes, there are non-crazy people who think a cure is possible and are working on it.
       
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    3. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      You asked this on another thread. Yes of course we do. Otherwise there wouldn't be research being done at the cost of millions upon millions of dollars. This entire thing is a matter of time. And good research.
       
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    4. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      This drug is stupid. It has to be continuously delivered.
      "After constant perfusion of gacyclidine for 40-63 h, four out of six patients experienced a temporary relief from their tinnitus. No serious side effects were recorded in any of the cases. Gacyclidine might present a potent drug for the suppression of sensorineural tinnitus in humans and therefore should be considered for future double-blinded, placebo-controlled clinical trials. For lasting effective treatment, controlled intracochlear and long-term delivery of the drug seems to be necessary."
      https://www.researchgate.net/public...perfusion_on_tinnitus_in_humans_A_case_series

      However, it is interesting that local cochlear delivery of this drug suppresses tinnitus.

      Whoops there goes muh tinnitus is in muh brain theory.
       
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    5. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Like I've told you before, they made a formulation that makes it an extended slow release.

      Yes, there goes your tinnitus in the brain theory. If you look further, you would know that gacyclidine acts on NMDA, a receptor for glutamate which is a neurotransmitter, which you guessed it, is from the brain.
      https://www.ncbi.nlm.nih.gov/m/pubmed/11474423/
       
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    6. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      You really think something injected into the middle ear reaches the brain?
      FYI NMDA receptors are on all nerves, not just on brain neurons.
      Shao_khan_laugh.gif
       
    7. F-u-T

      F-u-T Member

      Location:
      AZ USA
      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Acoustic Trama
      F24C7CB6-32FA-48B9-88A6-F2F891A05C76.gif
       
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    8. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I have probably had more injections of shit into my middle ear than anyone else in North America. I understand the dynamics of this very well.

      I am the Chief Science Officer of MPP for a reason.
       
    9. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      You're the Chief Science Officer of My Poopoo Palace?
       
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    10. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Yep
       
    11. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Looks like you'll need injections of it every few days, it does not repair the damage.
       
    12. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Better than ringing.
       
    13. Pawel1
      Wishful

      Pawel1 Member

      Tinnitus Since:
      January 2016
      Cause of Tinnitus:
      Loud Music
      There was a paramedic guy on this forum, which has done Lidocaine ear injections to himself, many times. I assume that injections are only related with mild discomfort. I would love to travel a few hours every day, just to have these injections done. Being Tinnitus-free, would allow me to work more and save enough money to buy a nice self-driving car, anyway.

      But, these injections will probably be similar type of thing like diabetic injections.. There will be so much awareness about this stuff, that your family or friends could do the injections to you at home.
       
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    14. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Now that I have had so many IT injections, I think that having a weekly injection of this would be better than having tinnitus. I still think this is a dumbass approach to this disease but whatever.
       
    15. Mathieulh
      No Mood

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      Rather than weekly injections, a constant delivery system, surgically installed that would slowly diffuse the drug into the cochlear might be prefered.
       
    16. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      this is something we need to try and avoid.
       
    17. Mathieulh
      No Mood

      Mathieulh Member Benefactor

      Location:
      Paris, France
      Tinnitus Since:
      05/24/2019
      Cause of Tinnitus:
      Chronic headphones use and acute noise induced trauma.
      I am not saying it is ideal, I am saying that between this and absolutely nothing, I'd choose this.

      Sure, if you give me a choice between this and FX-322, I'd likely pick the later.
       
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    18. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Luckily for me my situation is entirely manageable without having a medicine pump injection. I guess my comment was a little selfish as many people would require such a system to survive.
       
    19. Pawel1
      Wishful

      Pawel1 Member

      Tinnitus Since:
      January 2016
      Cause of Tinnitus:
      Loud Music
      If they could create a constant delivery system, surgically installed that would slowly diffuse the drug into the cochlear system, then this would bring everything to a whole new level. The researchers could try injecting so many things into the ear, for example anesthetics like Lidocaine or Ropivacaine, but they would use less toxic drugs that work for Tinnitus temporarily. This stuff could definitely work for Hyperacusis, as well.
       
    20. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      John... that is such a nice to thing to say... you touched my heart man. You have no idea what that statement means to me and so many others. Bless your heart... thank you for not forgetting us.
       
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    21. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      It's not a permanent solution.
       
    22. acute
      Depressed

      acute Member

      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Loud music. Stress, meds, Invisalign ?
      The more I read the more seems like all future "promising treatments" in the pipeline are going to be failures and useless to treat tinnitus...

      Sad.
       
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    23. Chriscom

      Chriscom Member Podcast Patron Benefactor

      Location:
      Northern Virginia USA
      Tinnitus Since:
      May 2019
      Cause of Tinnitus:
      Likely infection/ear stress after walking pneumonia
      There are no guarantees but there are substantial reasons, given the various research tracks, to be cautiously optimistic about what's going to become available over the next 3-5 years I'd say, no doubt with further improvements after then.

      I sure as heck would rather have developed this in 2019 than any previous decade in human history.
       
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    24. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Daily reminder that there are several medicines out there right now that have been shown to be safe and show promise at treating tinnitus but this beast of a system is not going to let us have access to them for years.
       
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    25. Auron
      Dead

      Auron Member

      Location:
      Planet Earth
      Tinnitus Since:
      Spring
      Cause of Tinnitus:
      Acoustic Shock
      Audion ,FX-322, oto-413 and Susan Shore's device are the 4 most promising for T/Hearing loss relief in my opinion .Hang in there.We might be out of this mess soon™ ...
       
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    26. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Wrong.
       
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    27. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      For whatever it's worth, I was just denied OTO-313 phase 2 involvement because I have tinnitus in both bars. Apparently you can only have it in one to be a part of the study. That's directly from the center holding the study near me.
       
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    28. acute
      Depressed

      acute Member

      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Loud music. Stress, meds, Invisalign ?
      Being denied for having tinnitus in both ears makes zero sense.

      What kind of drug are they trying to develop?

      Tinnitus is a matter of the brain and inner ear. Almost all tinnitus patients have it in both ears and in the head. What a shitty drug.
       
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    29. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Yeah it makes no sense to me. I emailed them last night basically saying the medical community doesn't even know enough about tinnitus to qualify somebody based on bilateral or unilateral conditions. Asked them why. Doubt I get a response
       
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    30. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I'm telling you guys this drug is stupid anyway. It has to be administered over and over again.
       

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