Otonomy OTO-313 — Treatment of Tinnitus

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. star-affinity
      Gloomy

      star-affinity Member Benefactor

      Tinnitus Since:
      1993, increase in 2020, then new in 2021
      Cause of Tinnitus:
      Maybe during a soundcheck – sudden sound from speaker
      I had to quote you on this since the research covered in this video seem to show quite the opposite when it comes to loss of auditory nerve fibers – flowchart at 35:39.

      Hidden Hearing Loss: The Effects of Synaptopathy


      Noise exposure -> Loss of auditory nerve fibers -> Increase in central gain -> Tinnitus/Hyperacusis

      So, while the loss of nerve connections might mean less nerve activity, it leads to "central gain" which I guess means the brain is "doing things" with this loss of input from the nerves that used to be there. I sure hope fixing those nerves will also mean the tinnitus stops. Hope this can be confirmed in research at some stage.
       
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    2. PortugalTheMan
      Surfing

      PortugalTheMan Member

      Location:
      Portugal
      Tinnitus Since:
      01/2021
      Cause of Tinnitus:
      Anxiety / Maybe years listening to music on headphones
      Any news about the results of this drug? :)
       
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    3. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      Read the last 2-3 pages and you'll find everything you want to know. In short, the Phase 2 trial is currently running.
       
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    4. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Autoimmune hyperacusis from Sjogren's Syndrome
      What in the world are you talking about? I know @Contrast doesn't frequent here much, but here is the full post that he made. His entire post is about an increase in central gain. In fact, the whole point of his post was that he was skeptical of peripheral tinnitus as opposed to only central gain.
       
    5. star-affinity
      Gloomy

      star-affinity Member Benefactor

      Tinnitus Since:
      1993, increase in 2020, then new in 2021
      Cause of Tinnitus:
      Maybe during a soundcheck – sudden sound from speaker
      I don’t know what I’m talking about. :D
      I’m trying to figure stuff out. And you’re right – @Contrast didn’t say anything that contradicted what’s said in that Stanford talk. I don’t know how I was thinking. Maybe I still have trouble seeing the difference between peripheral and central tinnitus. But I think I get it now. Tinnitus being “central” means tinnitus is not really ever generated in the ear, since a loss of synapses means less nerve signals to the brain, which if anything should mean “quietness,” not more sound in the form of tinnitus.

      Sorry for my confusion. As long as we can fix the type of tinnitus that comes with a hearing loss by fixing the synapses I’d be happy, which seem to be something @Contrast also thinks OTO-413 can do.

      I think my concern also was that I read about those situations where even cutting the auditory nerve didn’t get rid of the person’s tinnitus, but I take it that could be because the nerve signal from a working inner ear is still missing and the brain just keeps doing what it did when it was connected to the cochlea – fixing those broken/disconnected nerve fibers would be the only solution to stop the tinnitus. I guess/hope…

      Edit:
      Could it also be that damaged synapses/nerve fibers that gets disconnected from the hair cell start to “misfire” i.e. sending signals to the brain that corresponds to the frequencies to which those synapses used to get info from when connected to their hair cell? This would mean the tinnitus is peripheral, right?

      I was just thinking about my latest high frequency tinnitus which I thinking corresponds to the frequencies where I also have hearing loss. Haven’t confirmed that yet, though.
       
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    6. Cernuto
      Spaced

      Cernuto Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Noise Induced
      When you unplug a guitar cable from a guitar with the amplifier turned up, you'll hear a buzz. The end of the guitar cable is picking up noise. It acts as an antenna and the amplifier amplifies the noise picked up. I wonder if this is an analogy for tinnitus? I may be completely wrong.
       
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    7. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      You may be completely right.
       
    8. PortugalTheMan
      Surfing

      PortugalTheMan Member

      Location:
      Portugal
      Tinnitus Since:
      01/2021
      Cause of Tinnitus:
      Anxiety / Maybe years listening to music on headphones
      I was talking about the people who are taking part in the trial. I wanted to know if anyone had more news about if they are improving or not.
       
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    9. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      Give it a week’s patience :)
       
    10. TrevorSanders

      TrevorSanders Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      Noise Exposure/Ototoxic Medication
      I'm still debating if I should get the injection or not. I really can't risk my tinnitus worsening. What are your guys' opinions?
       
    11. canteven

      canteven Member

      Tinnitus Since:
      03/01/2021
      Cause of Tinnitus:
      Noise
      Excitedly waiting for results too!
       
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    12. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      For you, the window of opportunity is here now since this probably won’t help for long timers. I understand the fear and anxiety but in retrospect, in my case, I would do it.

      If you’re improving already, then maybe not...
       
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    13. rei

      rei Member Benefactor

      Tinnitus Since:
      2006 but not a problem till 10/19
      Cause of Tinnitus:
      loud music spiked with lyme disease
      I've had this same thought, that's why the whole idea of tinnitus being stuck in the brain doesn't seem right to me.
       
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    14. patorjk

      patorjk Member Benefactor

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Several reasons
      Go for it. If your tinnitus is less than 6 months old, it has a good chance of working. If it's older than a year I wouldn't bother (plus it could harm the study if people with tinnitus older than a year try to enter it).

      Take a look at their latest presentation:

      https://investors.otonomy.com/static-files/742c1d13-d0a2-4615-815a-9571ab41277c (slides 6-13)

      The initial Phase 1 study showed a signal. The drug is gacyclidine + Otonomy's slow release gel. Gacyclidine was previously shown to have an effect in the paper titled "Effects of extracochlear gacyclidine perfusion on tinnitus in humans: a case series". If you checkout that paper you'll see charts on a hand full of case studies that were done.
       
    15. Gee82

      Gee82 Member

      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Noise
      Tinnitus is likely to get worse over time anyway; if I had a chance for a treatment now I would jump on it.
       
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    16. aorelia

      aorelia Member

      Tinnitus Since:
      2021
      Cause of Tinnitus:
      Headphones
      Anyone in the trial with bilateral tinnitus and not just unilateral? I mentioned this to the clinic and they said there is still an opportunity for me to get in the trial.
       
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    17. TrevorSanders

      TrevorSanders Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      Noise Exposure/Ototoxic Medication
      I've had my tinnitus for around 10 months and I've noticed that worsening trend already. I'm pretty positive I'm going to go through with it. I'll let y'all know how it goes when I get the injection on Thursday and the following weeks after.
       
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    18. TrevorSanders

      TrevorSanders Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      Noise Exposure/Ototoxic Medication
      That’s interesting. They were pretty adamant about me making sure I only had ringing in one ear.
       
    19. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      Ah oops, your post seemed to talk about the trial in general.

      But I wouldn't put too much trust in these anecdotal posts. Let's hope the full results are good.
       
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    20. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      I know it's only being tested for acute (<1 year) tinnitus, but do they have any clue as to whether it might be good for chronic cases? If not, it won't be much good for any of us on here if it eventually hits the market (although I know I'd be happy to give it a try regardless).
       
    21. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      That will be something that might get examined and evaluated potentially after this trial.

      There tends to be every chance that if the treatment becomes beneficial for the acute cases and successfully completes trials, that it can then be tried on long term cases to see the benefit on them.
       
    22. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      4/7/19
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      7-22 is the big day that's exciting. Please keep us all posted...
       
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    23. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      4/7/19
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      100% go for it. It's not going to make you worse!
       
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    24. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      If it’s a success, they’ll have lots of resources and optimism about accelerating their research into their other drugs.

      It will speed them up with 5 years on OTO-6XX and such!
       
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    25. hopes

      hopes Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Unknown
      OTO-313 won't be a cure for sure. But if it can help some people reducing their tinnitus level, I'll try it.
       
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    26. Bobb77
      Cynical

      Bobb77 Member Benefactor

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Noise drama and stress
      Hello Sentinel,

      Any update from you, how are you doing?
       
    27. Sentinel
      No Mood

      Sentinel Member

      Tinnitus Since:
      Late November/Early December 2020
      Cause of Tinnitus:
      Really epic hobbies
      Tinnitus is fluctuating wildly. I'm horribly sick with what I suspect is COVID-19. Vomiting, joint pain, nightmares, pins and needles all over my skin, bad headaches.

      Hopefully getting tested today. Tinnitus was so bad the other night it cut straight through my masking. On top of that I'm pretty depressed right now. Haven't eaten in two days since keeping food down is difficult.

      I'm sorry to be so disappointing, my life is a mess right now but I'll keep you guys informed of any changes.

      Thanks for reaching out.
       
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    28. Lukee

      Lukee Member Podcast Patron Benefactor Ambassador

      Location:
      Toronto, Canada
      Tinnitus Since:
      01/2021
      Cause of Tinnitus:
      Wim Hof Breathing Exercises
      Sorry to hear about this... get tested ASAP.

      Are you vaxxed?
       
    29. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      OTO-313 gives you COVID-19, confirmed!

      Seriously, that's tough luck =( I wish you a speedy recovery.
       
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    30. TrevorSanders

      TrevorSanders Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      Noise Exposure/Ototoxic Medication
      Jesus. This does not make me want to get the injection tomorrow.
       
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