Otonomy OTO-313 — Treatment of Tinnitus

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      I hope it turns out to be food poisoning and that you get better tomorrow!

      Hugs.
       
      • Hug Hug x 1
    2. star-affinity
      Gloomy

      star-affinity Member Benefactor

      Tinnitus Since:
      1993, increase in 2020, then new in 2021
      Cause of Tinnitus:
      Maybe during a soundcheck – sudden sound from speaker
      You're up for the OTO-313 injection tomorrow?

      I wish you best of luck! I hope/think the trouble @Sentinel has (hope you get better soon) isn't related to the OTO-313 injection. Maybe it was the placebo that was given – we don't know yet, right?
       
      • Agree Agree x 3
    3. TrevorSanders

      TrevorSanders Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      Noise Exposure/Ototoxic Medication
      I’m leaning towards bailing out of the trial. I really can’t risk my tinnitus getting worse. @Sentinel’s post kinda scared me as well. I am sorry everyone, I hope my reasoning sits well with all of you.
       
      • Hug Hug x 1
    4. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Autoimmune hyperacusis from Sjogren's Syndrome
      Sorry to hear, @Sentinel. Get well soon.
       
      • Hug Hug x 1
    5. Sentinel
      No Mood

      Sentinel Member

      Tinnitus Since:
      Late November/Early December 2020
      Cause of Tinnitus:
      Really epic hobbies
      You're good buddy, the injection didn't do this to me. Go ahead and go for it by all means.

      I'm starting to feel a little better.
      Not vaxxed. Hopefully able to get tested tomorrow.
       
      • Like Like x 3
    6. Sentinel
      No Mood

      Sentinel Member

      Tinnitus Since:
      Late November/Early December 2020
      Cause of Tinnitus:
      Really epic hobbies
      Yeah it's got nothing to do with the injection.
       
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    7. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      if you’re not sure, then perhaps you could postpone it to next week..?
       
    8. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      If you puked like a dog, most likely it was something you ate...?

      Tinnitus is awful when you’re sick...

      Hope you’re recovering :)
       
      • Hug Hug x 1
    9. Joeseph Stope
      Innocent

      Joeseph Stope Member

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      noise? infection? negative stress? other?
      My sympathies Sentinel.

      Did you test for COVID-19 anti-bodies? Did you test for food-poisoning? Something else?
       
    10. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Then why did you post it?
       
    11. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      Because people were asking how he's doing.
       
      • Agree Agree x 1
    12. Wrfortiscue
      Provocative

      Wrfortiscue Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Trauma
      Also helps to cope lol, at least for me.
       
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    13. Sentinel
      No Mood

      Sentinel Member

      Tinnitus Since:
      Late November/Early December 2020
      Cause of Tinnitus:
      Really epic hobbies
      Jeez dude.

      Someone asked how I was doing. I didn't realize I was gonna have my face ripped off for simply saying what was going on. I'll keep it strictly to injection-related shit from now on.
       
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    14. SD7
      Angry

      SD7 Member

      Tinnitus Since:
      Left mid May, Right mid June 2021
      Cause of Tinnitus:
      Unsure of left, acoustic right
      In contrast to FX-322, do we know how far the solution goes into the cochlea?
       
    15. Massi91

      Massi91 Member

      Location:
      Hannover, Germany
      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Perforated eardrum and prob. Noise Trauma
      I think it´s the same principle, Frequency Therapeutics and Otonomy both use the Gel injection system.

      Just different molecules I think.
       
      • Agree Agree x 1
    16. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      Hey man, we’re curious what you decided :) ?
       
    17. patorjk

      patorjk Member Benefactor

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Several reasons
      Otonomy claims its gel can deliver drugs throughout the cochlea. It's also a slow release gel. They believe it to be a competitive advantage.

      Screen Shot 2021-07-23 at 3.59.03 PM.png
       
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    18. SD7
      Angry

      SD7 Member

      Tinnitus Since:
      Left mid May, Right mid June 2021
      Cause of Tinnitus:
      Unsure of left, acoustic right
      Very impressive. If this is the case, then at least in principle the delivery hump is resolved.

      I know OTO-313 is primarily for acute cases but gives lots of hope to OTO-413 if successful.

      I’m optimistic.

      If we could just get verification one day that regenerating the synapses and/or hair cells solves both hearing loss and the accompanying tinnitus, that'd be great.
       
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    19. Bobb77
      Cynical

      Bobb77 Member Benefactor

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Noise drama and stress
      What have you decided?
       
    20. SD7
      Angry

      SD7 Member

      Tinnitus Since:
      Left mid May, Right mid June 2021
      Cause of Tinnitus:
      Unsure of left, acoustic right
      I don’t live near any of these areas. They only have one place for California! And I’m not even two months in or I’d be down.
       
    21. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      So... @Sentinel choked in his own vomit. @TrevorSanders chickened out... Great progress everyone!

      We have our hearing back in no time :D
       
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    22. TrevorSanders

      TrevorSanders Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      Noise Exposure/Ototoxic Medication
      I decided not to do it after reading about the adverse effects. It would be around a 30% chance of my tinnitus worsening. I just couldn't take that risk.
       
      • Like Like x 1
    23. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Thanks for the update.
       
    24. Joeseph Stope
      Innocent

      Joeseph Stope Member

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      noise? infection? negative stress? other?
      Emm... what is your source for this? Just curious.

      Mind you, if the chances of tinnitus worsening are that high, then you made the right decision.
       
    25. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      Well thanks for the info. Ear stuff is Russian roulette no matter what you do or not do, so we understand <3
       
      • Agree Agree x 4
    26. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      @TrevorSanders, did you know about this 30% before you applied to the trial or did they tell you?

      You sure it has nothing to do with @Sentinel's comments?
       
    27. TrevorSanders

      TrevorSanders Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      Noise Exposure/Ototoxic Medication
      Thank you for understanding.
       
    28. TrevorSanders

      TrevorSanders Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      Noise Exposure/Ototoxic Medication
      I can't find it at the moment, but it was a slide on one of their presentations.
       
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    29. Fields
      Busy

      Fields Member

      Location:
      Netherlands
      Tinnitus Since:
      04/2020
      Cause of Tinnitus:
      Noise trauma
      Thanks for keeping us in the loop. You have to do what's best for you, so you made the right choice.

      A 30% chance of adverse results with no guarantee of actual improvement doesn't sound like a risk I'd want to take either.
       
    30. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      You realize that an adverse event can be a headache or temporary fullness of ear which I believe I read on the same slide.
       
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