Prof. Tzounopoulos (University of Pittsburgh)

Discussion in 'Research News' started by attheedgeofscience, Feb 18, 2015.

    1. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      I personally donated to "tinnitus research". I hope that is the correct one for Dr. Tzounopoulos? Because I did not see any specific one naming him.
       
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    2. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      @IvanRus, did you ever find out how to donate to the professor himself?
       
    3. valeri

      valeri Member Benefactor Hall of Fame

      Location:
      Australia
      Tinnitus Since:
      09/2011
      I thought he was getting funded by US Defense?!
      Regardless I would love to see some joined effort of tinnitus community to support his research!
       
      • Agree Agree x 2
    4. Deamon22

      Deamon22 Member Podcast Patron Benefactor Ambassador

      Tinnitus Since:
      06/2018
      Cause of Tinnitus:
      Head Trauma/Cold?
      @DebInAustralia Hey Deb, i‘ve seen that you have connections to the professor, could you maybe ask him where we have to donate to, so that the money also ends up with him?:)
       
      • Agree Agree x 2
    5. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
      No, I did not address the professor with this question.

      But I will do it if someone doesn't do it first.

      Monetary resources can significantly accelerate research progress.
       
    6. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      Great, thank you @IvanRus. I really want to make sure my donations go directly and only to his research.
       
    7. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma, benzo/mirtazapine withdrawal, or combo!
      This is the guy who added a Fluoride atom to the Retigabine molecule, right?

      So, the compound is there? Let's test it, then!
      Is funding the only thing that's needed?
       
    8. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      As far as i can tell, yes!
       
    9. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
      Stop. In the latest video, which is dated in 2014 (!!!) Professor Tzounopoulos says that in a year or two they hope to start clinical trials of the drug KV7.

      Karl, now 2018 is coming to an end, and, judging by his answer in the letter @DebInAustralia, they are now at the "early preclinical stages of the study." Something obviously went wrong according to plan, unfortunately for us.

      What could be the problem? This is very sad, we could already be close to entering the market of this drug.

      Probably he does not have enough funding. It seems that we should announce a new fundraising around the world in order to transfer this money specifically to Tzounopoulos.

      This drug could facilitate our existence for these 10-15 years, until we learn how to regenerate the hair cells.
       
      • Agree Agree x 1
    10. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
      To be honest, today I see Doctor Tzounopoulos research as the most rational and the most promising.

      He really can create a pill that will muffle Tinnitus. We can live peacefully and whole, even often taking these medications. As epileptics, which happily live for decades, taking anticonvulsants daily.

      If I were a millionaire, I would not hesitate to donate a large sum to Dr. Tzounopoulos for research on tinnitus.
       
      • Agree Agree x 5
    11. Soren

      Soren Member Benefactor

      Location:
      Denmark
      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      Loud sound
      What about getting Thanos Tzounopoulos and his research trending on Twitter. A full blown Twitter storm. All we need is a lot of people and 1 hashtag. If we all use the same hashtag at the same time and only the one hashtag we can make it trend.

      But if so what should the tag be? #TzounopoulosTinnitus #TzounopoulosFunding
       
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    12. 1000

      1000 Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Trauma
      Great idea. Promote it. Start it out and get everyone who has posted in this thread to do the same.

      Posting it everywhere on Twitter.
       
      • Like Like x 2
    13. Soren

      Soren Member Benefactor

      Location:
      Denmark
      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      Loud sound
      For it to work the tweets should be directed at someone like the ATA or Tinnitus Research Initiative or both.

      Who have the means to support the research of Dr. Thanos?

      While still just tweeting away with hashtag.

      Anybody in here up for that? We would still need a hashtag.
       
      • Like Like x 3
    14. 1000

      1000 Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Trauma
      I like your idea, but who else is down for this?...
       
    15. Soren

      Soren Member Benefactor

      Location:
      Denmark
      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      Loud sound
      At the moment I am trying to get other communities on Twitter to help, but nothing so far.
       
      • Like Like x 1
    16. PDodge
      Cowboy

      PDodge Member Benefactor

      Location:
      Woods of Alberta
      Tinnitus Since:
      01/2017
      Cause of Tinnitus:
      Bear ate my Cochlea
      I'm in, how can i help?
       
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    17. Soren

      Soren Member Benefactor

      Location:
      Denmark
      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      Loud sound
      It is at a very early stage right now. As I said earlier I am trying to get some communities to help through Twitter. We`re in the recruitment phase right now. So we need to convince people to join in. Be that on here, Twitter, Facebook or other places.
       
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    18. Greg Sacramento

      Greg Sacramento Member Benefactor Hall of Fame

      Tinnitus Since:
      April 2011
      Cause of Tinnitus:
      syringing and now somatic T dental work
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    19. Soren

      Soren Member Benefactor

      Location:
      Denmark
      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      Loud sound
      After seeing this video and learning that the goal was to start trials after about 2 years of the video. It makes be really sad. Knowing that we had a small chance to know if this would have worked in humans by now.

      Researching a Viable Treatment for Tinnitus
       
      • Agree Agree x 3
    20. 1000

      1000 Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Trauma
      I got someone to email Prof. Tzounopoulos to send him a donation.

      He replied with a: I will pass it on...
       
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      • Informative Informative x 1
    21. reggie green
      Balanced

      reggie green Member

      Tinnitus Since:
      03/08/2001
      I have talked to him on the phone. Calling him is better than email I think. More personal.
       
      • Informative Informative x 1
    22. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      Why not ask him what the current state of his research is? If it is that promising, I would think he should be able to get funding through the big pharma companies.
       
      • Agree Agree x 1
      • Good Question Good Question x 1
    23. 1000

      1000 Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Trauma
      Go ask him if you can.
       
    24. 1000

      1000 Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Trauma
      • Informative Informative x 1
    25. TuxedoCat
      No Mood

      TuxedoCat Member Benefactor Ambassador Advocate

      Location:
      US
      Tinnitus Since:
      April 2017
      Cause of Tinnitus:
      high frequency hearing loss
      Guys, It looks like the Professor has research grants through February 2022. I know very little about the Professors research, but believe he may have produced 2 molecules for further development in conjunction with the first grant from the US Army listed below. One molecule was an analog of trobalt which was purchased by SciFluor who then modified it further by including fluorine to make it more receptor specific and therefore more potent with fewer side effects. However, this molecule may have failed in preclinical animal studies. There was also another molecule which may have been more extensively modified, but I know nothing about it, who owns it or if its ever been tested in laboratory or animal studies. Attheedgeofscience may know more about it as he was part of a Tinnitus Talk team that explored this science including trobalt and KVreceptors. -TC

      http://www.otolaryngology.pitt.edu/people/thanos-tzounopoulos-phd

      Research Grants
      U.S. Army-DOD, Tzounopoulos, Development of Therapeutic Drugs that Prevent the Triggering of Tinnitus, W81XWH-14-1-0117, July 2014 - July 2017
      NIH, Tzounopoulos, Cell-Specific Synaptic Plasticity in the Auditory Brainstem, 5R01 DC007905, March 20076 - February 2022
      Allergan, Tzounopoulos, Cortical Mechanisms Underlying Tinnitus, 5910001-20012000358, August 2016 - August 2019
      NSF, Tzounopoulos, NSF-IOS-BSF: Influence of neuronal zinc homeostasis on cortical responses to sound, IOS-1655480, September 2017- July 2021
       
      • Informative Informative x 7
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    26. TuxedoCat
      No Mood

      TuxedoCat Member Benefactor Ambassador Advocate

      Location:
      US
      Tinnitus Since:
      April 2017
      Cause of Tinnitus:
      high frequency hearing loss
      Guys, so the second drug that the Professor and others at Pittsburgh developed is called RL-81. I have run across any further information about this compound.
      https://www.upmc.com/media/news/pitt-team-redesigns-epilepsy-drug

      If you are thinking of donating to tinnitus research at University of Pittsburgh, you may wish to do some due diligence first. Some questions to ask would be: Is tinnitus being actively researched right now? If yes, by whom? What is the project and how much money is already available to that person for the tinnitus research project? Personally, I would not donate unless the researcher already has a fairly sizable amount of money or is actively campaigning to raise money for a specific tinnitus research project. If the Professor already has a grant, will my money be added to it? If there is no active tinnitus research at U P, then the money I send may sit there unused for eons until enough accumulates to fund a tinnitus project. Also, I would want to know how much of the money I send will go directly to the research and how much will go to overhead. University of Pittsburgh has a fairly sizable endowment. -TC
       
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    27. Jack Straw
      Balanced

      Jack Straw Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Location:
      US
      Tinnitus Since:
      1990s
      Cause of Tinnitus:
      Infection, Acoustic Trauma
      From what I saw in the video it seems like these drugs are preventative for tinnitus....

      Am I missing something?
       
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    28. Allan1967

      Allan1967 Member Benefactor Hall of Fame

      Tinnitus Since:
      1997
      Cause of Tinnitus:
      Ear infection
      Excellent - give a little and often.

      I am giving to the University of Pittsburgh.

      Do I know if it will work?

      No.

      But I have to try right?
       
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      • Agree Agree x 3
    29. EDDTEKK

      EDDTEKK Member

      Location:
      Belgium
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Infection
      Is there any news on this drug? Why it takes so long?
       
      • Good Question Good Question x 3
    30. IAmCalifornia
      Wishful

      IAmCalifornia Member Benefactor

      Location:
      Pennsylvania
      Tinnitus Since:
      this year
      Cause of Tinnitus:
      i wish i knew
      I was wondering for a while who I should donate regularly to. I will donate to him.
       

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