Resaphene Suisse AG: Breakthrough in Tinnitus — Tinniwell

Discussion in 'Research News' started by Jack Rubinacci, Aug 14, 2018.

    1. Jack Rubinacci

      Jack Rubinacci Member

      Tinnitus Since:
      2003
      Cause of Tinnitus:
      Recording
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    2. Autumnly
      Wishful

      Autumnly Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Noise-induced
      • "Tinniwell is essentially an MP3 player but one which is equipped with special functions. Using headphones with active noise cancellation, the tinnitus sufferer can configure the device to their ear noise very precisely with respect to character (tone or sound), frequency (pitch) and volume." source
      • "Since subjective tinnitus is caused by hyperactivity of the nerve cells, tinnitus therapy with tinniwell makes use of one of the most remarkable capabilities of the human brain: the so-called neuroplasticity. This stimulates surrounding, healthy brain areas and thus uses the effect of lateral inhibition: the targeted activation of adjacent nerve cells, which include the perception spectrum outside of tinnitus, inhibits the activity of the cells responsible for the tinnitus tone." source
      The idea of neurofeedback and "tailor-made notched music" method is not new. They call everything regarding tinnitus treatments a breakthrough.
      • "The treatment takes place through special therapeutic headphones with built-in, individually adjustable heating. The light warming helps to stimulate the vagus nerve, producing a pleasant relaxing effect." source
      I'm wary of tinnitus treatments like this one. Tinnitracks, Tinnitus Pro, Tinniwell... We also don't know if it's safe for every tinnitus patient to wear in-ear earbuds or headphones.
       
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    3. Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      What do you think of Susan Shore's device?
       
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    4. TheDanishGirl
      Sad

      TheDanishGirl Member Benefactor Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      05/2017 (H since 06/2017)
      Cause of Tinnitus:
      long term noise exposure (headphones), maybe some stress.
      *Sigh*..........just *Sigh*

      That's all I have to say about that!
       
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    5. Stakovic

      Stakovic Member

      Tinnitus Since:
      1998
      Cause of Tinnitus:
      Unknown
      I want to sell my MP3 too.
      Who wants it? This thread is reserved only for MP3 market.
       
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    6. Nonomat
      Wishful

      Nonomat Member Benefactor

      Location:
      France
      Tinnitus Since:
      06/2019 (mild) - 11/2019 (intrusive)
      Cause of Tinnitus:
      Noise induced
      Resaphene Suisse AG: Charité Ethics Committee in Berlin Approves Study on Tinniwell Tinnitus Therapy

      The Charité's ethics committee has approved the double-blind study on the tinnitus therapy device tinniwell with Resaphene Suisse AG, ISIN CH0367465439, WKN A2JG91. A total of 60 people took part in the study and the head is Prof. Dr. med. Birgit Mazurek commissioned. The results are expected for Q4 / 2020 or Q1 / 2021.

      The double-blind study has the same design as a first clinical user observation by Dr. med. Johannes Ebbers. This documented an average relief of 54% within 4 weeks; in one patient the tinnitus was even 100% healed in time. Based on the above facts, Resaphene assumes similar results in the double-blind study. If this is achieved, the tinniwell can become the new global standard in tinnitus therapy. There is currently no known competitor who can deliver comparable therapy results. It is estimated that over 100 million patients are affected in the target markets of Europe and the US.

      If the study is successfully completed, the management of Resaphene assumes the participation of further institutional investors or the sale of intellectual property to a hearing aid manufacturer as part of an exit strategy of the previous shareholders. No binding contracts have yet been concluded for this.​

      This is the website of the company:

      https://resaphene.ch/en/

      Maybe German people can know more about this. Like @Autumnly states above this just seems to be a neurofeedback device. "There is currently no known competitor who can deliver comparable therapy results" Hmmm I mean Neuromod kinda does... Don't quite know what to make of this. Still unlike some more questionable trials about tinnitus, this one is double-blind. So I guess that's something :dunno:
       
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    7. BBakkers
      Not amused

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
      @Nonomat

      This solution comes a bit out of the blue. Don't know what to think of it as well. Perhaps anyone else know more about Tinniwell?
       
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    8. Nonomat
      Wishful

      Nonomat Member Benefactor

      Location:
      France
      Tinnitus Since:
      06/2019 (mild) - 11/2019 (intrusive)
      Cause of Tinnitus:
      Noise induced
      "Resaphene Suisse AG, based in Roggwil, Switzerland, is a medical technology company that was founded in 2015 and has been selling a tinnitus therapy device under the name tinniwell since 2016."

      Yeah well I think that's all I need to know....
       
    9. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      It looks to me more like Notch Therapy:
      Clinical studies at the University of Münster confirm the effectiveness of frequency-filtered music in tinnitus therapy.

      Then they talk about lateral inhibition, which is a key mechanism in notch therapy.
       
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    10. ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      Hasn't this been proven mostly ineffective by now?
       
    11. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      Not really. There is some modest success. See https://www.ncbi.nlm.nih.gov/pubmed/25951605

      There are more studies on notched therapy that you can peruse on pubmed.

      It's not a silver bullet, but it does appear to help a fraction of sufferers.
       
    12. Autumnly
      Wishful

      Autumnly Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Noise-induced
      I'm tired of German sources completely ignoring any other research that's currently going on, keeping the reader as uninformed as possible while only promoting German producers of at best moderately effective treatment approaches.

      Relief for chronic tinnitus – without pharmaceuticals (tinnitwell study)
      Results of a clinical observation study with the “tailor-made notched music” method

      • the first study was only based on 29 patients
      • they measured tinnitus severity using Göbel and Hiller’s Tinnitus Mini Questionnaire (for whatever reason they didn't use THI or TFI), 0 points = no distress, 24 points = maximum distressed
      • they don't mention for how long the patients had had tinnitus only that they had "decompensated tinnitus"
      • "significant improvements in the amount of tinnitus perceived (measured using the questionnaire score) were observed for all patients"
      • "After a four-week Tinniwell treatment, the stress index had decreased by an average of 45.6%. The energy reserve had increased by an average of 15.5%, the psycho-emotional state had improved by 22.5%, and the biological age had decreased by 6.3 years (13.1%)." [psycho-emotional state??? energy reserve???]
      • "The average tinnitus score (highest possible score: 24 points) dropped from an initial 15.5 points to 7.3 points. This corresponds to a reduction in tinnitus from average moderately severe tinnitus to mild tinnitus. Expressed in percentages, on average the tinnitus decreased by 54.1% [They mean tinnitus distress, right? They don't mention tinnitus loudness/volume]
       
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    13. Nonomat
      Wishful

      Nonomat Member Benefactor

      Location:
      France
      Tinnitus Since:
      06/2019 (mild) - 11/2019 (intrusive)
      Cause of Tinnitus:
      Noise induced
      Yeah, I guess I have to start to differentiate. Tinnitus trials =/= Good news.
       
    14. Momme

      Momme Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Loud noise?
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    15. Mentos

      Mentos Member Benefactor

      Location:
      Cracow, Poland
      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Noise induced, loud rock concert
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    16. UKBloke

      UKBloke Member Podcast Patron Benefactor

      Tinnitus Since:
      1991
      Cause of Tinnitus:
      Loud Music / family history
      It's a similar scenario with the Aurex 3 device. Back in the news lately accompanied by statements about how the offering "will" control/treat tinnitus. One checks the website, reads the fancy paper promising an FDA cleared "consumer variant available in 2019", and then of course nothing - notwithstanding the fact that 2019 was last year.
       
    17. Momme

      Momme Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Loud noise?
      I just got a reply from them. I asked them if anyone got worse in the study, they replied no. And it's already in the market for 2479 euro.
       
    18. UKBloke

      UKBloke Member Podcast Patron Benefactor

      Tinnitus Since:
      1991
      Cause of Tinnitus:
      Loud Music / family history
      They have a medical device currently in double-blind study with results due Q4 / 2020 or Q1 / 2021, yet right now they'll sell us same medical device for nearly 2.5K euro?

      Can someone please explain to me what the heck is going on.
       
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    19. PhoenixAcademy

      PhoenixAcademy Member

      Tinnitus Since:
      1995
      Cause of Tinnitus:
      Noise?
    20. UKBloke

      UKBloke Member Podcast Patron Benefactor

      Tinnitus Since:
      1991
      Cause of Tinnitus:
      Loud Music / family history
      A curiously worded press release, using quite emphatic language:

      [my emphasis]

      "By monitoring Resaphene in 250 patients from January 2019 - February 2020, 4 phases of therapy have now been identified. In phase 1, tinnitus becomes louder during or immediately after treatment. This can only occur after 2 days or 5 weeks. This is the indication that the therapy is working on the patient. In phase 2, the tinnitus tone drops and becomes quieter. Phase 3 is a big surprise for the patients because the tinnitus now partially disappears during the day. In the final phase 4, it also disappears at night. It is then recommended to continue the therapy for a further 3 weeks at the last known frequency, since the tinnitus will then permanently disappear. A premature termination leads to the tinnitus being present in its old appearance again within a week. Overall, phase 4 was observed after 3-4 months with a daily therapy duration of two hours.

      In the past, two studies were carried out at the University of Münster on the topic of Tailor-Made Notched Music Training. In the second study, the subjects were advised to stop the therapy if the tinnitus worsened. According to our knowledge, this was the reason for the poor results from this study. An improvement in the patient's tinnitus is always preceded by a worsening."
       
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    21. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      This sounds like Lenire.
       
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    22. UKBloke

      UKBloke Member Podcast Patron Benefactor

      Tinnitus Since:
      1991
      Cause of Tinnitus:
      Loud Music / family history
      That's exactly what I was thinking.
       
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    23. Turgy

      Turgy Member

      Location:
      Germany
      Tinnitus Since:
      2008
      Cause of Tinnitus:
      acoustic trauma
      There is a study showing that the average relief of 54% is demonstrated after 4 weeks. In addition, we were named test winner in the field of tinnitus therapies by the specialist magazine Webgesundheit.

      The price for the rent of 6 weeks is 379 euros (financing from 6.57 euros per month possible).

      they made the offer to me.
      upload_2020-5-23_17-48-54.png
       
    24. Mentos

      Mentos Member Benefactor

      Location:
      Cracow, Poland
      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Noise induced, loud rock concert
      Is it for tonal tinnitus only? I read it is based on matching tinnitus frequency.
       
    25. Turgy

      Turgy Member

      Location:
      Germany
      Tinnitus Since:
      2008
      Cause of Tinnitus:
      acoustic trauma
      tinniwell can determine the personal tinnitus frequency and suppress it with counter-sound.
      that's what it says in the flyer.
       
    26. Amv

      Amv Member

      Tinnitus Since:
      16/7/2017
      Cause of Tinnitus:
      -
      Hi, anyone has more news about Tinniwell? It is German technology so that makes it more attractive and reliable. Anyone who has tried it or know someone who has? Best regards!
       
    27. Mentos

      Mentos Member Benefactor

      Location:
      Cracow, Poland
      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Noise induced, loud rock concert
      They sell the device for 2479 euros, rental only available for Austria, Germany and Swiss citizens for around 600 euros for 4 weeks.
       

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