Sound Pharmaceuticals (SPI-5557 & SPI-1005)

Discussion in 'Research News' started by joe, Jan 26, 2012.

  1. Watch Hazel share good news about tinnitus
    1. DimLeb

      DimLeb Member

      Tinnitus Since:
      14/03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy Or Maybe Loud Music
      Do we know anything more about this? It sure is one of the most promising drugs for a lot of conditions here, even more so than Frequency Therapeutics and Otonomy. I don't know why it's not as much discussed about.
       
      • Good Question Good Question x 3
    2. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      I have no idea, and I was going through the beginning of this thread.

      They passed the Phase 2 for ear problems in 2013.

      What happened? I don’t know too much about this drug or company. I’m guessing the Phase 3 failed? And the drug is being used for COVID-19 and other diseases. Then if it comes out we can try it. Just like the Hough Ear Institute pill, which is now called OKN-007.
       
      • Informative Informative x 2
    3. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      No, they presented the results from the SPI-1005 Phase 2 in June 2019 (the trial lasted between September 2017 - March 2019):

      Sound Pharmaceuticals announces positive topline results from the SPI-1005 Phase 2b Meniere’s Disease clinical trial

      According to their pipeline they are either still preparing for Phase 3 or are in it now, hard to tell from the graphic on their website. The last news they gave us about it was in June 2020:

      Sound Pharmaceuticals advances pivotal Phase 3 clinical trials in Meniere’s Disease

      But yeah, I'd also like some more updates from this company.
       
      • Informative Informative x 2
      • Like Like x 1
    4. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      SEATTLE, Nov. 5, 2013 /PRNewswire/ -- “Sound Pharmaceuticals (SPI) has successfully completed enrollment of its Phase 2 clinical trial with SPI-1005 at the University of Florida. This study enrolled 80 healthy subjects with normal or slight hearing loss and exposed the volunteer to calibrated music using an iPod®and insert earphones.“

      Go look on page one of this thread. Instead of Meniere's it was for hearing loss. They did a Phase 2 in 2013. It was Nick's post. But yeah this company is pretty confusing.
       
      • Informative Informative x 1
    5. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      You're right, my bad. I completely missed that they were doing SPI-1005 for acute, mild to moderate NIHL too. I thought it was only for Meniere's (and now COVID-19). It's still listed on their pipeline chart and stuck between Phase 2 and 3. It's really strange it hasn't moved forward if Phase 2 was successful so long ago.
       
      • Agree Agree x 1
    6. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      Yeah so strange. This drug is good to fall back on. Definitely better than nothing. I'm not gonna put all hopes on it.
       
      • Like Like x 2
    7. OptimusPrimed
      Spaced

      OptimusPrimed Member Benefactor

      Tinnitus Since:
      10/2007
      Cause of Tinnitus:
      Acoustic trauma - Repeated gun blasts
      I too won't put a ton of hopes on this one.

      I'm most hopeful about Susan Shore's device to be honest. But that is not a guarantee, and I cannot wait for these things for the rest of my life.

      For now I will focus on self-improvement and controlling what I can control. I'm putting my effort into meditation, occasional fasting, daily cold-showers, grounding, avoiding processed foods and salicylate high foods, consuming fermented foods and raw meat, getting lots of sunlight, exercising, preventing further damage, and just living life as best as I can.
       
      • Like Like x 2
      • Agree Agree x 1
    8. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      Yea, well said. I’m lucky because my tinnitus is not horrible. I can live with it. My distortions that beep can be horrible but it’s not always bad. The hyperacusis is killin me. Severe pain hyperacusis is not fun at all. Makes me wanna die. I hope it improves with time.
       
      • Hug Hug x 4
      • Agree Agree x 1
      • Optimistic Optimistic x 1
Loading...

Share This Page