Theory: Could This Help With Hidden Hearing Loss and Tinnitus?

Discussion in 'Alternative Treatments and Research' started by Nick McConnell, Apr 14, 2016.

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    1. Nick McConnell
      Frantic

      Nick McConnell Member

      Tinnitus Since:
      02/2016
      Cause of Tinnitus:
      Not Quite Sure


      Does this mean that some hidden hearing loss might be reversed on its own over time and that we might help the body restore even more?
       
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    2. Bobby B
      Fine

      Bobby B Member Benefactor

      Tinnitus Since:
      11/2015
      Cause of Tinnitus:
      long term NIHL and recent acoustic trauma
      Good find !
      LLLT is listed as one of the ways to increase the BDNF amongst a lot of others
       
    3. Nick McConnell
      Frantic

      Nick McConnell Member

      Tinnitus Since:
      02/2016
      Cause of Tinnitus:
      Not Quite Sure
      If you look at the third link, it says at one point that BDNF is necessary to maintain the synapses in the ear but that it doesn't seem to take a partin regenerating them. I seem to have missed that before I posted the last link.
       
    4. Mario martz
      Creative

      Mario martz Member

      Tinnitus Since:
      02/2016
      Fuck yeah! this sound awesome
       
    5. Nick McConnell
      Frantic

      Nick McConnell Member

      Tinnitus Since:
      02/2016
      Cause of Tinnitus:
      Not Quite Sure
      • Agree Agree x 1
    6. Nick McConnell
      Frantic

      Nick McConnell Member

      Tinnitus Since:
      02/2016
      Cause of Tinnitus:
      Not Quite Sure
      I wonder if there is another way to increase nt3 production.
       
    7. Path Maker

      Path Maker Member Benefactor

      Tinnitus Since:
      12/2015
      Cause of Tinnitus:
      acoustic
      @Nick McConnell
      So from what you just said, would that make all the great tips in the last link kind of null and void? What are your thoughts?

      And thanks - you put together a good series of links!
       
    8. Nick McConnell
      Frantic

      Nick McConnell Member

      Tinnitus Since:
      02/2016
      Cause of Tinnitus:
      Not Quite Sure
      Perhaps not. Nt3 can still cause regeneration and exercise can apparently increase nt3 in the spine:

      https://www.ibp.ucla.edu/research/GomezPinilla/publications/Exc93.pdf
      http://www.ncbi.nlm.nih.gov/pubmed/11285004

      I don't know if it increases it in the brain as well.

      And people with depression apparently have more nt3 as well though I can't really say that this would lead to healthier ears:

      http://www.ncbi.nlm.nih.gov/pubmed/11032384
      http://www.nature.com/mp/journal/v5/n5/full/4000743a.html
       
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    9. Path Maker

      Path Maker Member Benefactor

      Tinnitus Since:
      12/2015
      Cause of Tinnitus:
      acoustic
      Thanks! In any case, because of you I discovered the website of the "self-hacker" guy - it's interesting, to say the least!
       
    10. Nick McConnell
      Frantic

      Nick McConnell Member

      Tinnitus Since:
      02/2016
      Cause of Tinnitus:
      Not Quite Sure
      Found another article that might be useful:

      http://www.buffalo.edu/news/releases/1998/02/3026.html

      " They also found that the damaged nerve endings that transmit impulses from hair cells to the brain can recover from injury, but at a significantly slower rate than the brain. "

      It might be outdated. Does anyone have an opinion on this or know of some more updated info on this?
       
    11. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      There is no guarantee that nt3 will stop t because i dont think it can reverse the plastic changes that have occurred centrally
       
    12. Bobby B
      Fine

      Bobby B Member Benefactor

      Tinnitus Since:
      11/2015
      Cause of Tinnitus:
      long term NIHL and recent acoustic trauma
    13. Nick Pyzik
      Depressed

      Nick Pyzik Member

      Tinnitus Since:
      6/23/15
      Cause of Tinnitus:
      Listening to in-ear headphones & playing in a band
      The brain can regenerate nerve fibers, it's just that they aren't in-going nerve fibers that allow the subjects brain to clearly and emotionally process sound.

      http://www.hopkinsmedicine.org/news...y_new_contributor_to_age_related_hearing_loss
       
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    14. Nick McConnell
      Frantic

      Nick McConnell Member

      Tinnitus Since:
      02/2016
      Cause of Tinnitus:
      Not Quite Sure
      Interesting. Should this be a concern with the study that says they restored hearing using Nt3? Is it possible that the reconnected synapses in the study were not meaningful in terms of hearing restoration? Or am I confused about something?
       
    15. Mario martz
      Creative

      Mario martz Member

      Tinnitus Since:
      02/2016
      This is interesting BUMP!
       
    16. Mario martz
      Creative

      Mario martz Member

      Tinnitus Since:
      02/2016
      I didnt understood nick,
      so basically the dead nerve fibers can regenerate but they wont help?
      ...
      but if deaf mice, did recover their hearing, this means their hearing might not be... that good?
       
      • Creative Creative x 1
    17. Ludwig
      Aggressive

      Ludwig Member

      Tinnitus Since:
      17 february 2016
      Cause of Tinnitus:
      Acoustic trauma
      Some days ago Charles Liberman (a great researcher in hearing & Tinnitus problem) answer me that:

      Hello Alessandro,

      I am sorry to hear of your troubling condition. You must understand that I am a basic researcher, not a clinical doctor. I don’t see patients, I work on animal models and try to understand the basic biology of the inner ear and how it is damaged by noise and other insults. Yes, we have some new ideas about the possible role of synaptic damage to the cochlear nerve in the generation of tinnitus, and we are working on neurotrophin-based treatments to repair the synaptic damage. The results are encouraging, but we are still some years away from clinical trials.

      I wish you the best of luck in dealing with this debilitating problem.

      M. Charles Liberman, Ph.D.

      Director, Eaton-Peabody Laboratories
      Massachusetts Eye and Ear Infirmary
      243 Charles Street
      Boston, MA 02114

      Tel: 617-573-4233
       
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    18. Cityjohn
      Studious

      Cityjohn Member Team Research

      Location:
      Amsterdam
      Tinnitus Since:
      5:10 PM 03/02/2016
      Cause of Tinnitus:
      Food poisoning.
      There is a slight caveat here, most studies ever done with mice are not replicable in humans, and Fluoxetine is a drug with quite the street price because it is comparable to taking speed and mushrooms.

      Now the ketogenic diet I've tried, I used to powerlift at the college gym and went into ketosis to go for a dry look... boy let me tell you, I did not have an easy time focusing in class.
      As far as I know ketosis is a last resort your brain has to switch to burning fat in the event there is no glucose to be converted from the diet. I don't doubt for a minute that the brain badly needs glucose to function properly and that ketose is not a substitute, never mind something that lessened my brain fog.
       
    19. Alue

      Alue Member

      Tinnitus Since:
      01/2016
      Cause of Tinnitus:
      Acoustic Trauma
      You got Charles Liberman to respond to your e-mails? I'd love to pick his brain about a few things. His work is what we base a lot of 'hidden hearing loss' and cochlear-nerve degeneration theories on.

      I'm glad they are working on treatments, it just sucks how long it will be before any sort of treatment would become available even if it is a breakthrough. Years away for clinical trials and at lest a decade away from available treatment.
       
      • Agree Agree x 1
    20. Mentos

      Mentos Member Benefactor

      Tinnitus Since:
      03/2015
      I also recieved 2 replies from Charles Liberman when I asked him about hidden hearing loss, cochlear synaptopathy an diagnostics of this condition:

      "I'm sorry to hear about your noise damage, but yes I agree that you likely have what we call cochlear synaptopathy. We are still quite a way from clinical trials. You can stay abreast of developments by following Decibel Therapeutics online"

      and

      "We are working on a diagnostic battery. The idea that tinnitus might be suppressed is only a hypothesis at present. We will be working on the question in animal models"

      I saw Decibel Therapeutics is a project with investigates more into it, their plan is to start clinical trials within 3 years counted from October 2015 when the preoject was kicked - off. Let's hope their hipothesis turns out to be
      true for those of us who have normal audiogram and no hair cel loss but only synaptic damage.
       
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    21. Beste
      Disappointed

      Beste Member

      Tinnitus Since:
      02/16/2016
      Cause of Tinnitus:
      Benzo/Clonazepam, Stress
      Finally a study for us who have no detected hearing loss. Man, I feel so hopeless.
       
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    22. lymebite
      Breezy

      lymebite Member Benefactor Team Research

      Location:
      United States
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Unknown
    23. VRZ78

      VRZ78 Member

      Tinnitus Since:
      08/2016
      Cause of Tinnitus:
      infection
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