TU Delft & Prof. Dirk De Ridder — Bimodal Stimulation Device for Treating Tinnitus

Discussion in 'Research News' started by Christiaan, Mar 18, 2022.

    1. Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      I've just discovered that Dr. De Ridder has collaborated with Delft University of Technology on developing a bi-modal stimulation device that is quite similar to Shore's Auricle.

      There are plans to start clinical trials with this device, but so far I can't find any information about when it might take place.

      Here's a summary of the research paper:

      Abstract

      Approximately 15-20% of the world population is affected by tinnitus, a hearing condition associated with phantom sound perception. A large number of sufferers experience a severe level of tinnitus and they are not able to conduct a normal life because they develop insomnia, depression, and distress.

      However, currently there are no treatments that have demonstrated to be effective in modulating tinnitus or suppressing its related annoyance from a long-term perspective. What is known is that the patients exhibit abnormal electrical activity in multiple areas of the auditory and the central nervous systems. This is the reason why the focus of the scientists has shifted to multi-modal stimulation: multiple stimulations of equal or different nature (e.g. double electrical stimulation or acoustic-electrical stimulation) are applied at the same time in the attempt to induce neuroplasticity and restore the normal electrical activity in the targeted areas. Multi-modal stimulation has brought significant improvements both in terms of tinnitus intensity and distress, but the studies conducted are too little to derive conclusions.

      The challenge of this work is to design a portable multi-modal stimulator that is able to provide bilateral acoustic and electrical stimulation simultaneously. The device works at the same time as an audio player and a transcutaneous electrical nerve stimulator, with the purpose of contemporaneously stimulating the auditory cortex and the autonomic nervous system or the dorsal cochlear nucleus through the vagal nerve or the C2 nerve, respectively. Bi-modal stimulation is based on the random presentation of pure tones matched to the tinnitus frequency pitch combined with two possible electrical stimulation wave forms: a novel one characterized by the superposition of a low-frequency noise on a DC component ("noise + DC" stimulation) and the second one is burst stimulation. Both the electrical stimulations are current-driven and largely customizable due to the wide programmability of the stimulation parameters. The analog design is realized in such a way that two identical output currents are delivered to the tissue, allowing for bilateral stimulation. The low power consumption and the small dimensions and weight of the device will permit the tinnitus patient to use it for several hours per day while performing his daily life without impairments.

      Capture d’écran 2022-03-18 à 15.26.09.png
       

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    2. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
      Good find @Christiaan! Can't you just ask him about it? Sign me up!
       
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    3. AUTHOR
      AUTHOR
      Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      Yep, I'm planning to ask him about it. Next appointment on 11th of April.
       
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    4. EDDTEKK

      EDDTEKK Member

      Location:
      Germany
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Acoustic Trauma
      I and a friend of mine attended years ago a study which also stimulated the vagus nerve through the ear. The device was called NEMOS by Cerbomed and the study was done at the Regensburg clinic.

      The company actually stopped selling it. There was no effect on tinnitus.

      Now it looks like they just add sound(s) to this? I doubt this will be effective honestly.
       
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    5. AUTHOR
      AUTHOR
      Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      Based on preclinical animal models, there is reason to belief that pairing sound with electrical stimulation induce greater effect on tinnitus percept and promotes neuroplasticity than using electrical intervention alone. See: Engineer, N. D. et al. Reversing pathological neural activity using targeted plasticity Nature 470, 101–4 (2011).

      It's also the question of finding the optimal stimulation parameters. For example, recent animal research demonstrated that moderate intensity of VNS (0.4 and 0.8 mA) drive greater plasticity compared to VNS at higher intensities (1.2 and 1.6 mA). More info: Borland, M. et al. Cortical map plasticity as a function of vagus nerve stimulation intensity. Brain Stimul. 9, 117–23 (2016).

      There's also TT'er @Archer in the MicroTransponder thread, who reported that VNS + sound intervention helped diminish his tinnitus: https://www.tinnitustalk.com/posts/545124/
       
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    6. Pharz

      Pharz Member Benefactor

      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Exposure to loud noise
      @Christiaan, do you know if they will conduct trials here in the Netherlands?
       
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    7. AUTHOR
      AUTHOR
      Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      I've asked a foundation (Stichting Brain Innovations) via e-mail a few days ago about this matter. They've responded that they'll get back to me as soon as possible. The foundation is closely connected to the Delft University of Technology research.
       
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    8. Pharz

      Pharz Member Benefactor

      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Exposure to loud noise
      Thanks for your response. I’d be happy to know if there is a trial or compassionate use of this soon. Could you please let us know when you know more.

      Thanks :)
       
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    9. AUTHOR
      AUTHOR
      Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      Sure thing, @Pharz.

      Have you also checked the NeuroVR thread? You can sign up to their newsletter for future trials in the Netherlands.
       
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    10. AUTHOR
      AUTHOR
      Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      Ok, so there's good news for people in Europe. I've just received an email from a Professor who is connected to the TU Delft study. Professor Serdijn mentions in this email that Brai3n clinic will start a trial with the bimodal device for tinnitus. He adds that there's no clear planning when this study will start, but it's best advised to contact Dr. De Ridder about this particular matter.
      --------------------------------------------------------------------
      Beste heer Van Romondt, beste Christiaan,

      Het antwoord hierop is een volmondig ‘ja’. Het proefonderzoek zal plaatsvinden in de BRAI3N-kliniek van Prof.Dr. Dirk de Ridder. Zijn email-adres staat in het Cc-veld van deze email. Hij kan u het beste informeren over wanneer de eerste onderzoeken kunnen plaatsvinden.

      Met vriendelijke groet,
      Wouter Serdijn
       
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    11. EDDTEKK

      EDDTEKK Member

      Location:
      Germany
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Acoustic Trauma
      Anybody knows when the clinical trial will start and how to take part in it?
       
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    12. AUTHOR
      AUTHOR
      Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      Dr. De Ridder has told me that he's currently working on a redesign of the TU Delft device and that he hopes that the device is ready sometime in May for a future trial. I guess we just have to contact him around that time to know more when the trial will take place. At least one thing we know for sure is that the trial will take place at the Brai3n clinic.
       
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    13. EDDTEKK

      EDDTEKK Member

      Location:
      Germany
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Acoustic Trauma
      Any news? Do you guys really think this can work?
       
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    14. Mentos

      Mentos Member Benefactor

      Location:
      Cracow, Poland
      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Noise induced, loud rock concert
      I was trying to set up an online appointment with Dirk de Ridder and ask about it but he is only available for that in September. It seems a black box for the moment.
       
    15. blamingeverything

      blamingeverything Member Benefactor

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      high frequency hearing loss
      September isn't so far away. Did you book it?
       
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    16. AUTHOR
      AUTHOR
      Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      I emailed Dr. De Ridder a few days ago. I'm still waiting for an answer.
       
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    17. Mentos

      Mentos Member Benefactor

      Location:
      Cracow, Poland
      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Noise induced, loud rock concert
      I’m trying to arrange a 1-1 meeting with him in August since I will be in the Netherlands for 2 weeks that time.
       
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