USC Stem Cell Lab Finds Clues on How Key Gene Enables Hearing (ATOH1)

Discussion in 'Research News' started by Yahzib Rafiq, Jul 14, 2016.

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    1. Yahzib Rafiq

      Yahzib Rafiq Member

      Location:
      England, UK
      Tinnitus Since:
      01/1995
      Cause of Tinnitus:
      Sensorineural hearing loss due to premature birth
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    2. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      This is good news that they found two more genes that interact with ATOH1. I wonder how many more there are though. If its hundreds or thousands we are in a for the long haul.
       
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    3. Yahzib Rafiq

      Yahzib Rafiq Member

      Location:
      England, UK
      Tinnitus Since:
      01/1995
      Cause of Tinnitus:
      Sensorineural hearing loss due to premature birth
      That is what Stefen Heller told me when I contacted him a few months ago. The current ATOH1 trial is only an teaser...they will intend to improve on the formula and hopefully release it as an "cocktail" of genes
       
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    4. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      I remember reading a while back that Genvec had a new formula that they came out with. It was posted on one of the other threads. I wonder if they had this info at the time. Maybe we are closer than we think?
       
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    5. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      That would not surprise me. In one year much more is known about mechanisms in the inner ear. You would expect that also is the case for this clinical trial.
      On the other hand, how much can they change in an ongoing clinical trial?. I remember this was discussed in another thread. Some "tweaking" is possible.
      I still think that the scientists at GenVec must be pretty clever and will take notice of scepticism from some other scientists.
       
    6. Ian Mac

      Ian Mac Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Vestibular Nueritis, loud music (dubstep)
      I'm as skeptical as my tinnitus is constant.
       
    7. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      Is your tinnitus constant? (-;
      Perhaps it is too optimistic, but that there is a lot more insight than, lets say, 5 years ago I think is realistic.
      If this insight is useful for practical applications is what we al would like to know.
       
    8. Foncky
      Doubtful

      Foncky Member Benefactor

      Location:
      Europe
      Tinnitus Since:
      03/2004
      Cause of Tinnitus:
      An explosion, music, and fate.
      About one hundred genes are involved in our ears.
       
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    9. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      So how many do we actually know about then?
       
    10. Foncky
      Doubtful

      Foncky Member Benefactor

      Location:
      Europe
      Tinnitus Since:
      03/2004
      Cause of Tinnitus:
      An explosion, music, and fate.
      From what I've read, a few.

      That does not mean we have to understand everything to start finding "cures" for certain types of deafness.
       
    11. Ian Mac

      Ian Mac Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Vestibular Nueritis, loud music (dubstep)

      It's constantly fluctuating really fast, like meeer weeee pssssst werrr meeee weee all those sounds going so fast sometimes all of them just in one second
       
    12. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      In sync. with your heartbeat?
       
    13. Ian Mac

      Ian Mac Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Vestibular Nueritis, loud music (dubstep)
      Way way faster than my heartbeat. It will fluctuate 5-10 times per heartbeat so 5 to 10 times faster than my heartbeat. It's the same 3 sounds in my right ear but they manifest new each time there isn't any pattern just really fast and the same 3 sounds new every nanosecond.
       
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