Xenon Pharmaceutical's XEN1101 — Kv7 Potassium Channel Modulator

Discussion in 'Research News' started by jer, Mar 3, 2018.

  1. Watch Hazel share good news about tinnitus
    1. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      Very true, the hype is a bit overblown imo. However, someone in the company said they are looking at tinnitus too:

      Xenon Pharmaceuticals Inc (XENE) Q2 2020 Earnings Call Transcript | The Motley Fool
       
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    2. DimLeb

      DimLeb Member

      Tinnitus Since:
      14/03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy Or Maybe Loud Music
      @Nobody19, one may wonder then, why didn't they test the drug on tinnitus, which is a far more common condition around the world? Epilepsy is like 1.2% of the total population or even less lol.
       
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    3. Mentos

      Mentos Member Benefactor

      Location:
      Cracow, Poland
      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Noise induced, loud rock concert
      • Good Question Good Question x 1
    4. 2noist

      2noist Member

      Tinnitus Since:
      04/02/2015
      Search for tinnitus in the transcript. Below is the only part that mentions tinnitus.

      Simon Pimstone -- Chief Executive Officer

      Sure. I'll take a stab at this, and Ian, please comment. It's Simon. Yes, I think in terms of the first question, no, we've been communicating for some time now. We're exploring indications outside of the focal epilepsy indication, which remains our primary indication for this drug, but there's a tremendous amount of literature that's building in the role of the KB72 and/or 3 channel in neuronal hyperexcitability that underlies a number of interesting neurological disorders where hyperexcitability appears to perhaps drive, for example, apoptosis in motor neuron disease in hyperexcitability through this channel, mediating Pain signaling. Hyperexcitability through this channel thought to have potentially a role in anhedonia and major depressive disorder. And we know these channels are also expressed in the ear and the hair cells, in particular, and the potential for treatment using a Kv7.2 modulator for tinnitus is also of interest.

      So we're looking at a number of these types of disorders.​
       
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    5. Mentos

      Mentos Member Benefactor

      Location:
      Cracow, Poland
      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Noise induced, loud rock concert
      Maybe because it’s easier to measure the improvement by counting number of seizures in a month. Current tinnitus indicators are vague, same for depression.
       
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    6. JPGL
      Frustrated

      JPGL Member

      Location:
      Spain
      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      Hearing loss? Noise? Stress? Unknown
      What is the timeline for this drug or the XEN-496?
       
    7. DocTors_94

      DocTors_94 Member

      Tinnitus Since:
      2021
      Cause of Tinnitus:
      Unknown
      Anyone knows how contact Xenon Pharmaceuticals? I tried to email to the address they have on their webpage and it says it is invalid. Thank you.
       
    8. DocTors_94

      DocTors_94 Member

      Tinnitus Since:
      2021
      Cause of Tinnitus:
      Unknown
      Official Title: A Phase 3 Study of Adjunctive XEN496 in Pediatric Subjects With KCNQ2 Developmental and Epileptic Encephalopathy

      Actual Study Start Date: March 29, 2021

      Estimated Primary Completion Date: November 2022

      Estimated Study Completion Date: December 2022
       
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