Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

Discussion in 'Research News' started by attheedgeofscience, Sep 19, 2014.

    1. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      I think we will be able to get it 0ff- label, if not there's always Spain. Gotta love Spain. Spanish eyes? More like Spanish drugs.
       
    2. dan
      Chatty

      dan Member Hall of Fame

      Location:
      Toronto, Canada
      Tinnitus Since:
      06/2011
      Cause of Tinnitus:
      Loud noise
      I still have hope for QUIET-2.
       
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    3. Blackbird26

      Blackbird26 Member

      Don't you mean Spanish fly? ;)
       
      • Funny Funny x 1
    4. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Well, we can hope they can make some changes... Heck, make a KV7 modulator.
       
    5. RaZaH
      Cheeky

      RaZaH Member Benefactor Hall of Fame

      Location:
      Reykjavík, Iceland
      Tinnitus Since:
      2012/04
      Cause of Tinnitus:
      Benzo + loud noise
      @Mikey Cliff
      Dont know how to break this to you but you were not alone fighting the world war.
      But yeah ...of course you are "the leaders of the free world" freedohm and all that crap. USA USA !
      :p
       
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    6. Dubbyaman
      Angry

      Dubbyaman Member Advocate

      Location:
      Northern Indiana
      Tinnitus Since:
      10/2014
      Cause of Tinnitus:
      Excessive loud noise
      Lets all jump back in time and FU##ING GOOGLE TINNITUS!!!!!!!!
       
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    7. OnceUponaTime
      Busy

      OnceUponaTime Member Podcast Patron Benefactor Hall of Fame Advocate

      Location:
      New York
      Tinnitus Since:
      11/11
      Cause of Tinnitus:
      Noise
      Buff history here. Lets not go there. We all know how many thousands of American soldiers (my uncle included) died at the front lines on the beaches or Normandy. (Utah, Omaha, Juno, Gold and Sword.) to name some.. Yes Great Britain and Canada and USA fought together. At the time Great Britain lost France and was under-siege .. ugly battle for all involved. .... ANYWAYS........Lets get back to the subject... as it pertains.
       
      • Agree Agree x 1
    8. RaZaH
      Cheeky

      RaZaH Member Benefactor Hall of Fame

      Location:
      Reykjavík, Iceland
      Tinnitus Since:
      2012/04
      Cause of Tinnitus:
      Benzo + loud noise
      And Russians and you could argue that they are the ones that really held back the Nazis.
       
      • Agree Agree x 2
    9. OnceUponaTime
      Busy

      OnceUponaTime Member Podcast Patron Benefactor Hall of Fame Advocate

      Location:
      New York
      Tinnitus Since:
      11/11
      Cause of Tinnitus:
      Noise
      On "their end" they did, they fought tremendously to defend themselves... They did nothing for France. And that's the end of my comments on this subject unless you want to talk it on PM's ...as I said, I do enjoy history tremendously especially WWI and WWII... (You should see my bookshelves! ) But that's conversation for a history forum... although discussing it makes me forget about T!!!! :) So I guess that is good. Picking my brain! :p
       
    10. RaZaH
      Cheeky

      RaZaH Member Benefactor Hall of Fame

      Location:
      Reykjavík, Iceland
      Tinnitus Since:
      2012/04
      Cause of Tinnitus:
      Benzo + loud noise
      Im a WWI and WWII buff as well , I guess I do have a different perspective then a lot of "popular" history.
      But yeah..back on topic.
       
    11. Sailboardman
      Frustrated

      Sailboardman Member Benefactor

      Location:
      Florida
      Tinnitus Since:
      04/21/2014
      Cause of Tinnitus:
      Sensorineural hearing loss right ear.
      Forget about WW1 and WW2, where's everybody stand on WW3? You know, the next "Big One!" };-)
       
    12. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      More like Russia...
       
    13. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      I'm in WW3; it's called tinnitus lol
       
      • Funny Funny x 5
    14. Sailboardman
      Frustrated

      Sailboardman Member Benefactor

      Location:
      Florida
      Tinnitus Since:
      04/21/2014
      Cause of Tinnitus:
      Sensorineural hearing loss right ear.
      Thought you were cured with Trobalt & Keppra?
       
    15. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Well, not so, it came back...But I took some more trobalt and it vanished. So god knows?
       
      • Like Like x 1
    16. Sailboardman
      Frustrated

      Sailboardman Member Benefactor

      Location:
      Florida
      Tinnitus Since:
      04/21/2014
      Cause of Tinnitus:
      Sensorineural hearing loss right ear.
      Guess you have to stay on Trobalt then? Considering there aren't many more choices left.
       
    17. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      I know...It's a sad life, very sad...But we must sail onward to SF! Shipshape and Bristol fashion ^_^
       
    18. Joan A.
      No Mood

      Joan A. Member

      Tinnitus Since:
      2000/ spike 2006/ massive 2009
      Cause of Tinnitus:
      unknow
      Hi all and forgive my ignorance;

      i have received an email by this forum few days ago and even on the main page there is a comunication about the failure of this drug. My question would be; how is possible to establish that a drug, so new and in developement, have already failed?
      how do scientists to have this certainty after such a short time ? thx
       
    19. erik
      Cool

      erik Member Benefactor Hall of Fame

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012 or earlier?
      Cause of Tinnitus:
      Most likely hearing loss
      Basically it came down to people testing and found that it didn't work on people
       
    20. Joan A.
      No Mood

      Joan A. Member

      Tinnitus Since:
      2000/ spike 2006/ massive 2009
      Cause of Tinnitus:
      unknow
      Thank You @erik . I don't have the possibility to connect and watch more news. I remained at the point that they were enrolling suffers because it was promising. It is a punch in the stomach for me because even if it was not imminent but it sound more better than the prescription of cipralex that i got in those days by my ent.

      p.s. I'm doing the trt retraining therapy by more than 2 years and now... ironically i have developed another tinnitus on the right side! really really disappointed

      thank you
       
    21. Hotspur

      Hotspur Member

      Tinnitus Since:
      02/2014
      Hi guys,just thought id let you know i find out which pill i got in March 2016
       
      • Informative Informative x 4
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    22. Jay_Dee63

      Jay_Dee63 Member Benefactor

      Tinnitus Since:
      2012
      They won't tell you until another 5 months?
       
      • Good Question Good Question x 3
    23. jeannie
      Stressed

      jeannie Member

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Noise-induced, Ear Infection, Medication... Who knows?
      I still think this pill would have helped at least some of us on here...we didn't stand a fighting chance ...alot of talk before about hidden hearing loss...so if the trial for that isn't cancelled and goes to market ,wonder if we will have to be 60 to get the pill,?maybe once the loss is better the tinnitus will get better!!!!!
       
    24. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      Just venting out loud, but it sure would be nice if the powers that be would allow people in desperate need to try a medication before it's officially approved. We have states in the US that allow Dr. assisted suicide, so why not allow one try a med like Aut or SF, if one shows enough desperation? We have numerous people in our T community who either commit suicide, or seriously contemplate it, so what's the harm in letting some try an experimental med, as long as they indemnify the manufacturer? I'd risk trying Aut, at a higher dose than 800mg, and for a longer duration perhaps. Sure, it may not work, but the rats received a higher dose than the trial members. Too much litigation and gov oversight/control IMHO. In fairness, there are some terminal patients who get to receive experimental meds in the US, I just wish that program would be expanded for people like us.
       
      • Agree Agree x 2
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    25. dan
      Chatty

      dan Member Hall of Fame

      Location:
      Toronto, Canada
      Tinnitus Since:
      06/2011
      Cause of Tinnitus:
      Loud noise
      Because technically we arent immediately dying from tinnitus...and they dont give a @#$% about complications from tinnitus suffering, i.e. if a person ideates suicide on a daily basis for 10 years, what do you think is happening to his insides?
       
      • Agree Agree x 4
    26. jeannie
      Stressed

      jeannie Member

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Noise-induced, Ear Infection, Medication... Who knows?
      If they approve it for hearing loss,then wouldn't some people on here be able to get it at there doctor if they have loss?
      If the hearing loss is made better with it then so would the tinnitus?!
       
    27. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      I agree with you 100%. Sucks:(
       
    28. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
      They have been promising effective treatments using the model you describe above for a long time. Again, the capitalist approach to drug discovery is a very good business model but not very good for the sufferer.
      Excluding preventative measures, I think expecting a pill to reverse tinnitus is foolish.
      A ceiling has already been reached in what can be done with chemical intervention as evidenced buy the enormous amount of money poured into trials (such as this) and the disturbingly poor yield, and that is why science is shifting to the study of the stem cell.

      As for the tinfoil hat stuff, who do you think invests into these ventures? These people have inside information, is it that much of a jump to imagine they place their financial interests (often tied to long term portfolios) ahead of furthering the science? This is very similar to the SSRI situation, its not an exact science, and they are pissing away money on mickey mouse drug trials wasting time. I don't have any faith in pharma, I anxiously wait to stand corrected, although I might be standing for while. My worry is our generation will pause their suspicion into these drug companies and we will all suffer as a result.

      Hopefully whoever was in charge of this trial gets the bullet. That at least would be progress.
       
    29. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
      Thanks for that second paper, I had not given that serious consideration. As the old expression goes a millions zero is still nothing.
       
    30. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012

      Cellular repair of the ear will virtually eradicate the need for prosthetic devices. They are well aware of this.
       
      • Agree Agree x 1

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