Brivaracetam — KV3.1 Modulator

Discussion in 'Research News' started by Danny Boy, Apr 2, 2015.

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    1. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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      This is basically a more potent version of keppra, 10 times more potent. It works on the KV3.1 potassium channels, so is the same target as Autifony's new drug but is in phase 3 and been tested for 8 years already, so should be out sooner and could potentially help with tinnitus.

      "Sudies conducted by Prof Len Kaczmarek’s group at Yale University suggest that Autifony’s Kv3 modulators may help to restore the timing of firing of neurons in the auditory brainstem important for central auditory processing."

      http://www.ncbi.nlm.nih.gov/pubmed/17199019

      http://www.zacks.com/stock/news/156795/ucb-reports-phase-iii-data-on-epilepsy-drug-to-file-in-2015
       
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    2. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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      Here's what I don't get only 2 million people in the U.S, have epilepsy...Yet 50 million have tinnitus, so why nothing for tinnitus!? It's a bigger business yet nothing!? I honestly, don't get it. There's so many drugs for epilepsy, not even one for tinnitus!? I am so confused, honestly.
       
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    3. Stink

      Stink Member

      Location:
      US
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      09/2000
      https://www.tinnitustalk.com/threads/only-10-12m-of-350m-americans-have-chronic-tinnitus.8763/

      chronic debilitating tinnitus is rare! epilepsy worse.

      epilepsy gets money, tinnitus not
       
    4. Craig in Cali
      Spaced

      Craig in Cali Member Benefactor

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      Here's where good old capitalism might eventually come to our aid. As soon as any of these first drugs hits the market and starts making some money, hopefully everyone will see the potential and the storm of drug research will ensue.
       
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    5. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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    6. Stink

      Stink Member

      Location:
      US
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      09/2000
      that's bs

      10 mil may have experienced temp tinnitus but 10 mil wont have chronic (twenty four hour seven days a week) tinnitus

      approximately 100,000 - 300,000 uk people will have DEBILITATING chronic tinnitus. ask BTA or anyone
       
    7. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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      Still a large figure for an illness.

      About one in ten adults in the UK have mild tinnitus and up to 1% have tinnitus that affects their quality of life.
       
    8. thesaint
      Confused

      thesaint Member Benefactor

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      that's 650,000 people, about the same as the population of Toledo, Ohio
       
    9. Robb
      Question it

      Robb Member Benefactor

      Location:
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      Hi Danny Boy,

      @Danny Boy why is it factually you think this drug will reduce T and not H only?

      Thx
       
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    10. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

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      Yet another potential drug. Me like! :)
       
    11. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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      It could help with h maybe, but I can't say that it can, as I haven't tried it and since my h is gone, I can no longer test it. I say it can help with tinnitus as it's the same target as Autifony's drug and is far more potent vs keppra.

      Yep, and it'll be out maybe this year or next...still less waiting time vs Autifony.
       
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    12. Viking
      No Mood

      Viking Member Benefactor

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      this is not exactly.... think to all speculators who apply scam,fantateraphy,and more more other by years and years...thank to tinnitus!
       
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    13. Robb
      Question it

      Robb Member Benefactor

      Location:
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      @Danny Boy than that is an incredible find of you! This brivaracetam is really not much covered in news or something as i also almost daily perform searches regarding T developments. Again good find!
      BTW i had to laugh about your norbalt joke that with the monkeys and secret was the best of it! haha

      Happy Easter
       
    14. JeffDamsko

      JeffDamsko Member

      Tinnitus Since:
      2010
      Nice find Danny boy !!
       
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    15. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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      Thanks! Hopefully, this can help us as god knows when Autifony's new drug is gonna come out.
       
    16. DebInAustralia

      DebInAustralia Member Benefactor Team Research

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      Thankyou for sharing danny
       
    17. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Because for 98% of those 50 million people, most are not bothered by there tinnitus nor do they care.
       
    18. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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      I'm sure if they were asked if they wanted a cure, they would say yes...Who wouldn't want silence, total silence?
       
    19. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Possibly. I think I had tinnitus far longer than before 2012; however, I didn't really know what it was, didn't pay attention to it but more than that I didn't think something was wrong so it never really bothered me. Then in 2012, once I really noticed it, then it became a problem for me.

      Good find though, Danny!
       
    20. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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      Thanks...Still wondering when it comes out? I'll be going straight to my doctor.
       
    21. nills
      Barefooter

      nills Member Benefactor

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      Woohoow :) what a great find man! ... another boost for our hopes!

      :thankyousign:
       
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    22. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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      Well, I reckon it'll be out next year...I hope I can get it.
       
      • Optimistic Optimistic x 1
    23. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
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      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
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      Its the same for me. I've had tinnitus for a long long time. The only times I really noticed it is when I got my hearing tests done in total silence. Since my hearing has been declining quickly, but really its slowly over time, my body had time to adjust absorb and habituate. It was only 6 months of stress that gave me H and loud T. H is gone, but T now remains. I'm pretty sure its the same tinnitus I had before I got stressed, but I'm now noticing it all the time. I think for people with T it takes a traumatic event, or maybe something in my head broke, to bring about louder tinnitus, which they will then notice and bother them. I'm still trying to figure out how to get to where I was before. The weird thing is I went a long time with hearing loss in the -50 to -100db range without really noticing it. Some people get hearing loss of -30db only in the 8k range and it hits them. So yes, you can have really bad hearing and tinnitus and ignore it for a long time. I guess this is what makes it so difficult to fix.
       
    24. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
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      Hm, hearing loss scares me, as my tinnitus could get louder...That's why I chickened out of AM-101...Because it could make it worse.
       
    25. skoupidis

      skoupidis Member

      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma or mvc
      You could try it and prefered RTG instead?
       
    26. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
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      Well, I nearly did but the needle scared me to hell lol
       
    27. skoupidis

      skoupidis Member

      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma or mvc
      Can't blame you. It does penetrate the eardrum, doesn't it?
       
    28. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
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      Cause of Tinnitus:
      Ear infection
      Yeah and it could potentially cause hearing loss...Plus, some people said it made tinnitus worse...
       
    29. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      Yeah thats why I'm waiting for a pill. I can only imagine what kind of spike I would get if someone penetrated my eardrum.
       
    30. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
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      Yeah, that scared me tremendously.
       

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