Decibel Therapeutics & Oricula Therapeutics Anti-Ototoxic Applications (ORC-13661 / DB-041)

Discussion in 'Research News' started by Contrast, Nov 7, 2018.

    1. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      Decibel Therapeutics finally announces something!
      ORC-13661/DB-041

      These are drugs for preserving hearing during chemotherapy and certain ototoxic medicine, a preventive measure for SNHL in ototoxic environments.

      https://decibeltx.com/wp-content/uploads/2018/09/Decibel_Oricula_Press_Release_FINAL_PROOF_en.pdf
      upload_2018-11-7_14-29-41.png


      https://www.oricularx.com/products/
      upload_2018-11-7_14-36-49.png
      More info and rumors about what they are working on, obviously this is the oral medication but I'm not sure if both are entering the trial together.

      https://xconomy.com/boston/2018/06/...o-bring-multiple-hearing-drugs-to-the-clinic/
      upload_2018-11-7_14-39-0.png



      Let's hope they are working on a treatment for cochlear synapse damage in the near future, (that should help both tinnitus and hearing loss) but right now I'm very happy they are challenging the status quo when ENT's say treating the inner ear is impossible.
       
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    2. Red
      Crappy

      Red Member

      Location:
      Northeast USA
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      06/2017
      Cause of Tinnitus:
      Noise Exposure (Headphones)
      I wonder if this will be just for chemotherapy and antibiotics. I guess it will depend on the side effects. I wouldn't mind taking this concurrently with ADs. It's some cruel joke that we feel locked out of antidepressants.
       
    3. AUTHOR
      AUTHOR
      Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
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      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      I don't think anti depressants are ototoxic, not any of the mainstream ones.
       
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    4. Red
      Crappy

      Red Member

      Location:
      Northeast USA
      Tinnitus Since:
      06/2017
      Cause of Tinnitus:
      Noise Exposure (Headphones)
      70% of all medications have ototoxicity of varying degrees. ADs aren't anywhere near aminoglycoside antibiotics or cisplatin but still pretty frequent, especially SSRIs.
       
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    5. PDodge
      Cowboy

      PDodge Member Benefactor

      Location:
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      Bear ate my Cochlea
      I would like to try some ADs but now I'm too afraid.
       
    6. AUTHOR
      AUTHOR
      Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      show me the source, and we won't count it as ototoxic if it is an extremely rare side effect.

      This forum is known for causing paranoia by calling everything ototoxic.
       
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    7. Red
      Crappy

      Red Member

      Location:
      Northeast USA
      Tinnitus Since:
      06/2017
      Cause of Tinnitus:
      Noise Exposure (Headphones)
      From ATA
      and the more controversial Neil Bauman

      And I can't remember where I got this brochure from.
       

      Attached Files:

    8. lymebite
      Vegged out

      lymebite Member Benefactor

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      I agree it is unhelpful to simply label a med "ototoxic" without discussing what kind of effects and if they are rare or common. I think the following guide is helpful to get more useful info on each med.

      Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide

      This guide characterizes the effect of meds by probabilities and four different categories of effect:

      a Very common (≥ 10%)
      b Common (≥ 1% e < 10%)
      c Uncommon (≥ 0,1% e <1%)
      d Rare ( ≥ 0,01% e < 0,1%)
      e Very rare (< 0,01%)
      f Unknown, because available data is insufficient

      1. Drugs with the explicit indication, by the pharmaceutical company and/or the Health Department, of “potentially otologically harmful”, generally indicated as ototoxicity (ototoxic drugs); ototoxicity is meant as a neurosensorial hearing damage (going from light hearing impairment to deafness) and may include both the possible associated symptomatology of labyrinthical alteration vertigo and the possible generation of tinnitus;

      2. Drugs with the explicit indication, by the pharmaceutical company and/or the Health Department, as potentially tinnitus-generating, generally called tinnitus, hissing ear, or acouphene (drugs openly declared as tinnitus generating); a potential tinnitus risk is reported for these drugs and there is no mention of ototoxicity;

      3. Drugs with the explicit indication, by the pharmaceutical company and/or the Health Department, as potentially vertigo-generating drugs, generally called vertigo or dizziness (drugs openly declared as vertigo generating). Information of potential vertigo associated with the drug is reported while there is no mention of ototoxicity;

      4. Drugs with possible audiologic effects, indicated as “hearing disturbances” (drugs with aspecific otologic side effects), it is advisable to have a conservative approach to these drugs and to evaluate in each case the possible intensity and type of adverse reaction.

      http://www.europeanreview.org/wp/wp-content/uploads/956.pdf
       
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    9. Red
      Crappy

      Red Member

      Location:
      Northeast USA
      Tinnitus Since:
      06/2017
      Cause of Tinnitus:
      Noise Exposure (Headphones)
      @lymebite Have you any websites that list the percentages? I remember seeing at least one in the past. Bauman's ebook has some side effect report percentages but only for some medications and it would be nice to find another source for that.

      The AD my doctor prescribed is 1-3%. Personally would feel a lot better about taking medicines if I knew the exact break down. Mostly just find sites like these: https://www.rxlist.com/wellbutrin-side-effects-drug-center.htm#overview
       
    10. lymebite
      Vegged out

      lymebite Member Benefactor

      Location:
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      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Unknown
      The guide I posted includes percentages when percentage data is available. If you open the PDF you can search on meds of interest.

      To take an example, Ciprofloxacin is categorized as 2d, 3c, and 4d. Use the key to the numbers and letters as I posted above (and is included in the PDF) to know what it means in terms of percentages. For example, 2d means it is tinnitus-generating in rare cases (≥ 0.01% e < 0.1%).

      Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide

      http://www.europeanreview.org/wp/wp-content/uploads/956.pdf
       
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    11. Tinker Bell

      Tinker Bell Member Hall of Fame

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      Cause of Tinnitus:
      SSHL from virus
      Can we even count Bauman as a credible source? He is not a medical doctor and his claims are based on anecdotal information that fails to consider any other circumstances that may have either affected a drug’s use or have been the actual tinnitus cause.
       
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    12. The Frenchie
      Insomnious

      The Frenchie Member

      Location:
      Quebec, Canada
      Tinnitus Since:
      2013, worsened 2018
      Cause of Tinnitus:
      Noise induced / Maybe ETD
      @lymebite
      Thanks a lot. I was actually wondering if my Concerta (36 mg daily) was bad for my tinnitus.

      Seems like it's not:

      Central nervous system stimulants and drugs used for attention deficit disorders and hyperactivity.

      • Atomoxetine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
      Metilphenidate hydrochloride . . . . . . . . . . . . . . . 3
      • Modafinil . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3


      Metilphenidate = Concerta and Ritalin.
       
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    13. Red
      Crappy

      Red Member

      Location:
      Northeast USA
      Tinnitus Since:
      06/2017
      Cause of Tinnitus:
      Noise Exposure (Headphones)
      In his ebook he does give a lot of anecdotes but he gives a lot of statistical information too. There is an extensive amount citations for the book but I am not going to go through all of those.
       
    14. just1morething
      Benevolent

      just1morething Member Benefactor

      Location:
      U.S.
      Tinnitus Since:
      2008
      Cause of Tinnitus:
      barotrauma, noise exposure, TMJ, neck?
      I wonder how many $'s he makes off his e-books? Reminds me of Tinnitus Miracle.
       
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    15. Samir
      Obedient

      Samir Manager Staff Benefactor Ambassador Advocate

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      I was wondering why no one was reporting on this news piece. It may not be as remarkable as the Frequency Therapeutics trial for hearing restoration. But you have to start somewhere, and starting with hearing protection seems fitting for Decibel Therapeutics.
       
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    16. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      When are they saying that this medication is coming to the market?
       
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