Deep Brain Stimulation (DBS) for Tinnitus

Discussion in 'Research News' started by dan, Feb 18, 2014.

    1. dan
      Chatty

      dan Member

      Tinnitus Since:
      06/2011
      This study will test the safety and effectiveness of deep brain stimulation (DBS) for patients with a big or very big problem with tinnitus (a sensation of noise in the head).

      First received: November 13, 2013
      Last updated: February 3, 2014
      Last verified: February 2014

      http://clinicaltrials.gov/ct2/show/NCT01988688
       
      • Informative Informative x 1
    2. AUTHOR
      AUTHOR
      dan
      Chatty

      dan Member

      Tinnitus Since:
      06/2011
      J Neurosurg. 2013 Jan;118(1):192-4. doi: 10.3171/2012.9.JNS12594. Epub 2012 Oct 19.
      A stroke of silence: tinnitus suppression following placement of a deep brain stimulation electrode with infarction in area LC.

      Abstract
      The authors report on a case of tinnitus suppression following deep brain stimulation (DBS) for Parkinson disease. A perioperative focal vascular injury to area LC, a locus of the caudate at the junction of the head and body of the caudate nucleus, is believed to be the neuroanatomical correlate. A 56-year-old woman underwent surgery for implantation of a DBS lead in the subthalamic nucleus to treat medically refractory motor symptoms. She had comorbid tinnitus localized to both ears. The lead trajectory was adjacent to area LC. Shortly after surgery, she reported tinnitus suppression in both ears. Postoperative MRI showed focal hyperintensity of area LC on T2-weighted images. At 18 months, tinnitus localized to the ipsilateral ear remained completely silenced, and tinnitus localized to the contralateral ear was substantially suppressed due to left area LC injury. To the authors' knowledge, this is the first report of a discrete injury to area LC that resulted in bilateral tinnitus suppression. Clinicians treating patients with DBS may wish to include auditory phantom assessment as part of the neurological evaluation.
       
      • Genius Genius x 2
      • Informative Informative x 1
      • Useful Useful x 1
    3. jazz
      No Mood

      jazz Member Benefactor

      Location:
      US
      Tinnitus Since:
      8/2012
      Cause of Tinnitus:
      eardrum rupture from virus; barotrauma from ETD
      If efficacious, this therapy won't be available for many years. Currently, a DBS pilot study for tinnitus is recruiting members. See this link.

      The estimated completion date is March, 2019. If anyone is seriously considering this treatment for intractable, intrusive tinnitus, I'd contact the researchers at the link above.
       
    4. Lisa88

      Lisa88 Member

      Tinnitus Since:
      11/2013
      I have met Dr. Steven Cheung who leads this study. A brilliant man.
      Although intrusive, this research to me is the most hopeful to date.
      Taking into account that the basal ganglia of the brain acts as a gating system for tinnitus. And has already worked on several Parkinson's patients to completely suppress their tinnitus.
       
      • Agree Agree x 1
    5. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      I had some contact with the people doing this research and they implied that even if I wasn't in the area, they might be able to pay some/all associated travel costs.

      Note, though -- this is a phase I trial. That means they really have no idea if it will work, or not. This procedure is used in other conditions, so there are a number of people out there walking around with these implants. But, this is experimental brain surgery, and is extremely risky for any number of reasons.
       
      • Agree Agree x 1
      • Informative Informative x 1
    6. Codaz

      Codaz Member

      A new PhD paper has been released for the treatment of tinnitus with Deep Brain Stimulation.

      "Exploring deep brain stimulation as a treatment for tinnitus":
       

      Attached Files:

      • Like Like x 1
      • Informative Informative x 1
    7. spedgas
      Gloomy

      spedgas Member Benefactor

      Tinnitus Since:
      09/2018
      Cause of Tinnitus:
      Unknown
      I’m an operating room RN and participate weekly in DBS cases for Parkinson’s. One of the surgeons I work with has seen occasional tinnitus reduction as an unintentional side effect of DBS treatment. This technology has come a long way since this thread was started. The equipment used has come a long way and the surgery is faster than it used to be. We’ve started taking CT scans in the operating room and matching it up with live action 3D brain tracking. My hospital even has a robot that helps with electrode placement.

      In my opinion the things holding this back are that it still requires surgery to access the brain. We still need to drill a hole in your skull in order to place the electrodes and make a pocket elsewhere to place a generator. Once in the brain they need to have a target they believe will relieve the tinnitus.

      This is absolutely brain surgery. The OR time, anesthesia costs, and equipment costs will be massive. It will be a tough sell to get insurance to pay for this.

      Until DBS can be done reliably without being this invasive it won’t be a viable treatment.
       
      • Agree Agree x 3
      • Informative Informative x 1
      • Creative Creative x 1
    8. ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      Deep Brain Stimulation Offers New Hope for Severe Tinnitus

      Bilateral deep brain stimulation (DBS) of the caudate nucleus appears safe and effective for patients with severe refractory tinnitus, early research suggests.

      Results of a small open-label study showed a 60% to 80% response rate for efficacy outcomes.

      In addition, surgery-related and stimulation-related adverse events (AEs) were transient and expected.

      ht_190924_steven_cheung1_120x156.jpg
      Dr Steven Cheung

      "For scientists, this is very exciting, and it represents a new biology," lead author Steven W. Cheung, MD, professor in the Department of Otolaryngology – Head and Neck Surgery, University of California, San Francisco, told Medscape Medical News.

      Full text study article:
      Phase I trial of caudate deep brain stimulation for treatment-resistant tinnitus
       
      • Informative Informative x 4
      • Like Like x 2
    9. Lynny

      Lynny Member

      Tinnitus Since:
      December 2018
      Cause of Tinnitus:
      Unknown, possibly stress
    10. all to gain

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      Incompetency of GP! Own naivety!
      It does sound promising. Years away from hitting the operating table though. Will be very expensive, too.

      I would be a guinea pig for this, but I would be disqualified immediately due to anxiety etc.

      I saw one of the participants had a lawn mower and table saw sound to his tinnitus.
       
      • Agree Agree x 1
    11. JohnAdams
      Studious

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      No way this works.
       
    12. all to gain

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      Incompetency of GP! Own naivety!
      Why do you say that?
       
    13. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      It works.

      It's insanely invasive... it's when you're super chronic and basically going for a mild lobotomy... if it works, and I think 60 to 80 percent are not the most reassuring figures, you may feel a lot better.

      There is one bloke on this forum who had it done as I recall and said he'd do it again. If the shit hits the fan really bad, it's an option. @spedgas explained the procedure extensively. Last resort, but glad they are researching it, they are getting in and meddling with the brain and brain stem and learning a whole lot.
       
      • Agree Agree x 2
    14. JohnAdams
      Studious

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I thought I changed my comment.
       
    15. all to gain

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      Incompetency of GP! Own naivety!
      How much did it help the bloke?

      So it doesn't eradicate tinnitus, it just lessens it?

      I just saw "has seen occasional tinnitus reduction" in spedgas' post.
       
    16. AVIYT
      Wishful

      AVIYT Member Benefactor

      Tinnitus Since:
      January 2019
      Cause of Tinnitus:
      Pregabalin
      My tinnitus spiked for no apparent reason this morning. I couldn't fall sleep for 3-4 hours as it kept getting noticeably worse. It still remains very loud, very severe. No clue why.

      Even before the spike, I haven't had a single day of relief since this has all started.

      I'd go for this treatment. If it helps reduce tinnitus, why not. I'll take my chances. When you're facing the end of the barrel anyways, you have little to lose.
       
      • Agree Agree x 5
      • Hug Hug x 1
    17. Sevv

      Sevv Member Benefactor

      Tinnitus Since:
      14.04.2019
      Cause of Tinnitus:
      Loud concert
      As far as I've read, DBS usually doesnt completely remove the motor symptoms of parkinson's either. It's usually a 40-60% improvement. So a 60-80% improvement for tinnitus is similar. We're one to two decades away to precisely silence each hyperactive cell in the brain to reduce tinnitus by 100%. We'll get there when Neuralink's method has been perfected.
       
      • Optimistic Optimistic x 2
      • Like Like x 1
    18. Sevv

      Sevv Member Benefactor

      Tinnitus Since:
      14.04.2019
      Cause of Tinnitus:
      Loud concert
      Ah yeah, I read about this a couple months ago. https://sonimodul.ch/home/parkinson/
      It's essentially a precision method to fry parts of the brain with ultrasound that have become hyperactive and cause parkinson's. The result is about equal to DBS, but far less invasive. The downside is that the tissue in the brain is lost. DBS on the other side corrects the abnormal behaviour.

      In theory maybe we can a two-step process in the future that hopefully works for tinnitus too:
      1. fry the faulty parts
      2. use some medicine to regrow new neurons. Check this out: https://www.fromthegrapevine.com/videos/health/there-drug-can-actually-reverse-brain-damage

      Edit: pretty interesting read actually: https://sonimodul.ch/home/concept/
       
      • Genius Genius x 1
      • Informative Informative x 1
    19. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      As I recall it helped him a lot.

      This is a last resort procedure, in my darkest hours I was very open to it. If my tinnitus went back up to a constant 10, this is the procedure.

      I consider it a lobotomy in laymen’s terms. This is an operation on the brain and brain stem. That would qualify as invasive. They have been doing this in California for some years I believe and if you check clinical trials, I bet they are still recruiting. Brave people have undergone this surgery and have given scientists a rare opportunity to actually get in there and meddle with the brain. It’s fascinating, and nice to know it’s there as a back up.

      In the future they may be able to do this surgery with absolute precision and gain fantastic results. That’s not an unrealistic vision.
       
      • Agree Agree x 1
    20. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      UCSF does them, I know they recently finished one and the results should be published on a journal soon.
       
    21. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      You are most correct. UCSF, fascinating and cutting edge research... I think this may be one of the ways to help chronic sufferers... fingers crossed for good luck.

      Take care CBM.
       
      • Like Like x 1

Share This Page

Loading...