Deep Brain Stimulation (DBS) for Tinnitus

Discussion in 'Research News' started by dan, Feb 18, 2014.

tinnitus forum
    1. dan
      Chatty

      dan Member

      Tinnitus Since:
      06/2011
      This study will test the safety and effectiveness of deep brain stimulation (DBS) for patients with a big or very big problem with tinnitus (a sensation of noise in the head).

      First received: November 13, 2013
      Last updated: February 3, 2014
      Last verified: February 2014

      http://clinicaltrials.gov/ct2/show/NCT01988688
       
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    2. dan
      Chatty

      dan Member

      Tinnitus Since:
      06/2011
      J Neurosurg. 2013 Jan;118(1):192-4. doi: 10.3171/2012.9.JNS12594. Epub 2012 Oct 19.
      A stroke of silence: tinnitus suppression following placement of a deep brain stimulation electrode with infarction in area LC.
      Larson PS, Cheung SW.
      Author information
      • Department of Neurological Surgery, University of California, San Francisco, California 94143-0112, USA. larsonp@neurosurg.ucsf.edu
      Abstract
      The authors report on a case of tinnitus suppression following deep brain stimulation (DBS) for Parkinson disease. A perioperative focal vascular injury to area LC, a locus of the caudate at the junction of the head and body of the caudate nucleus, is believed to be the neuroanatomical correlate. A 56-year-old woman underwent surgery for implantation of a DBS lead in the subthalamic nucleus to treat medically refractory motor symptoms. She had comorbid tinnitus localized to both ears. The lead trajectory was adjacent to area LC. Shortly after surgery, she reported tinnitus suppression in both ears. Postoperative MRI showed focal hyperintensity of area LC on T2-weighted images. At 18 months, tinnitus localized to the ipsilateral ear remained completely silenced, and tinnitus localized to the contralateral ear was substantially suppressed due to left area LC injury. To the authors' knowledge, this is the first report of a discrete injury to area LC that resulted in bilateral tinnitus suppression. Clinicians treating patients with DBS may wish to include auditory phantom assessment as part of the neurological evaluation.
       
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    3. LadyDi
      Busy

      LadyDi Member Benefactor

      Location:
      Florida, USA
      Tinnitus Since:
      06/2013
      Cause of Tinnitus:
      Barotrauma/airplane
      Damn. Yet another possible treatment area from which I will be excluded because I have a metal clip in my brain, due to a ruptured aneurysm. I know I shouldn't feel cranky about this, given I was darn lucky to survive the cerebral hemorrhage and stroke. But many of these treatments (including electro-magnetic stimulation) will not take patients with metal brain implants.

      Wonder if anyone else on this board has this issue -- or has had a stroke? I may post a separate thread on it. My doctors think that while my stroke (1999) did not cause my tinnitus, the area of brain death it left may be making it more difficult for me to habituate.
       
    4. mmacabre
      Ape-like

      mmacabre Member

      Tinnitus Since:
      2011
      Welp, of course hyperacusis is included in the exclusion criteria
       
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    5. Grace
      No Mood

      Grace Member

      Tinnitus Since:
      11/14/2013
      Ah this is what i just read and completely forgot it was already posted... But since they were able to completly get rid of tinnitus on 2 patients with parkinsons when stimulating the caudate mucleus.. Then this is good news right? And there now gonna do a trial on it too see if it gets rid of others
      T too when stimulated?
       
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    6. Champ
      Woot

      Champ Member Benefactor Team Tech

      Location:
      Boston, MA
      Tinnitus Since:
      1/2013
      Cause of Tinnitus:
      Acoustic trauma from headphones
      That's exactly what they're doing. This seems geared only for folks with extreme tinnitus.
       
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    7. Grace
      No Mood

      Grace Member

      Tinnitus Since:
      11/14/2013
      Oh ok but extreme or not extreme if its gonna get rid of it then it should be used on everyone eventually!!!! :)
       
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    8. Erlend
      Question it

      Erlend Member Benefactor

      Location:
      Scandinavia
      Tinnitus Since:
      05/2013
      Why only people who have it real bad? Serious side effects?
       
    9. Markku
      Inspired

      Markku Director Staff Benefactor Hall of Fame Team Trobalt Team Tech Team Awareness Team Research

      Tinnitus Since:
      04/2010
      Cause of Tinnitus:
      Syringing
      Yeah, it's not exactly the simplest of the procedures. Even though it doesn't involve the destruction of brain tissue, and is reversible. Also, it costs tens of thousands of dollars and I'm sure insurance companies and/or public health care systems want to offer it only to the extreme cases -- whatever criteria they may come up with. If it works well for tinnitus to begin with, that is. DBS has been a godsend to some Parkinson's and Essential tremor patients.

      Patient Guide to Deep Brain Stimulation (DBS)...
       
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    10. dan
      Chatty

      dan Member

      Tinnitus Since:
      06/2011
      I guess tinnitus can be cured, it depends how far you're willing to go lol.
       
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    11. Erlend
      Question it

      Erlend Member Benefactor

      Location:
      Scandinavia
      Tinnitus Since:
      05/2013
      if that cured my t i would do it
       
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    12. Stina
      Psychedelic

      Stina Member Benefactor

      Location:
      Tartu
      Tinnitus Since:
      11/13
      or how much you are willing to pay..
       
    13. Champ
      Woot

      Champ Member Benefactor Team Tech

      Location:
      Boston, MA
      Tinnitus Since:
      1/2013
      Cause of Tinnitus:
      Acoustic trauma from headphones
      My tinnitus drives me crazy sometimes but having that inserted into my brain... I'd have to think about it.

      It's not like it's unsafe, but it's not without it's cons. The tech is coming along so hopefully we get smaller and smaller and less invasive devices.
       
    14. II Packy II
      Doubtful

      II Packy II Member

      Tinnitus Since:
      05/2012
      Well if it meant no more abnormal hearing and no ringing, I'd happily lie on a table.

      And science is progressing rapidly in the hearing department. They've developed a implant smaller than the size of a penny and wirelessly recharges that is going to essentially make the outer cochlear implant obsolete. It's already been surgically implanted in patients with complete deafness with resounding success.
       
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    15. Champ
      Woot

      Champ Member Benefactor Team Tech

      Location:
      Boston, MA
      Tinnitus Since:
      1/2013
      Cause of Tinnitus:
      Acoustic trauma from headphones
      Hey man, maybe you should change your mood from doubtful then :p Nothing to be doubtful from this kind of news imo.
       
    16. Venture

      Venture Member

      Tinnitus Since:
      09/2010
      Probably the extraordinary cost and the possibility of death from meningoencephalitis.
       
    17. Sound Wave
      Curious

      Sound Wave Member Benefactor Team Tech

      Location:
      Finland
      Tinnitus Since:
      12/2013
      Cause of Tinnitus:
      Probably headphones
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    18. jazz
      No Mood

      jazz Member Benefactor

      Location:
      US
      Tinnitus Since:
      8/2012
      Cause of Tinnitus:
      eardrum rupture from virus; barotrauma from ETD
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    19. Grace
      No Mood

      Grace Member

      Tinnitus Since:
      11/14/2013
      I keep coming across this and to me it really seems like this could be a cure? Since they say there starting trials now and it ends 2019 will we not know any results until 2019? Confused
       
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    20. ralph j begley

      ralph j begley Member

      Tinnitus Since:
      1980
      Just got rejected for clinical trial using Deep Brain Stimulation to control Tinnitus volume. Hey, having had a brain hemorrhage knocks me out of the race. Oh well, I'm alive and happy and not starving in Africa or Haiti or in a cancer ward doing chemo.
      Interesting article in N.Y. Times today about implantation of stimulation device to suppress epilepsy seizures. When the solution for Tinnitus arrives, it's going to be cybernetic.
       
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    21. Hudson
      Cowboy

      Hudson Member Benefactor

      Tinnitus Since:
      2003
      I for one, will welcome our new cyborg overlords.
       
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    22. ralph j begley

      ralph j begley Member

      Tinnitus Since:
      1980
      Definitely.
       
    23. J. Wing

      J. Wing Member

      Tinnitus Since:
      10/1999
      Sound Wave, Sent you a personal message. Thank You.
       
    24. lapidus

      lapidus Member

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      I know a dude who has had this procedure for something else. He didnt have T though. He actually got temporary T and H from another incident later in life but is all good now.
       
    25. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
      What is it about? Do you have link?
      Greets Tom
       
    26. lapidus

      lapidus Member

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      I think it takes time to follow all these 10 participants, especially if they don't get the procedure done at the same time. It also states that they will test different settings on the device etc. I guess that could take a while. Too bad none of those 10 persons are on TT and can give us some updates.
       
    27. bill 112
      Studious

      bill 112 Member

      Location:
      Republic Of Ireland
      Tinnitus Since:
      02/2012
      Cause of Tinnitus:
      Noise exposure
      I recently seen a very interesting documentary following the life of a Parkinsons patient and how far brain surgery has come over the years,starting from labotomys to DBS stimulation over the years is considered an amazing feat in medical technology and research for obvious reasons.When they first meet the parkinsons patient he can barely move and has to sit in the exact same position for hours as his body control and strength was completely depleted.The interviewer decides to meet with the patient one year after he recieves the operation to fit the DBS stimulaters and the difference is dramatic to say the least.The patient now has full control over his body and was walking around his house cleaning and making tea for the interviewer and his camera crew,he appeared to be a completely normal human being although he did jerk and twitch on occasion his progress was amazing.He then proceeded to show the interviewer the device,which consisted of two protruding electrodes on either side of his skull and a long wire running down his neck under his skin to a battery box located at his collar bone.Now this had worked miracles for the Parkinsons patient but do I believe its practical for the T patient?No not really to be honest,the procedure is extremely invasive for a start and reqires the patient to have these protrudeing electrodes pointing out through the skull,which for anyone conscious of their appearance is a no go.Also the occasional jerk the patient displayed wasnt due fully to the Parkinsons they stated,it was more because of the electrode stimulateing his brain that caused the sudden unexplained jerk.Now even though this was happening for the Parkinsons patient in his situation the pros seriously outweigied the cons of the procedure,sure he may have to have these huge electrodes sitting on his skull for the rest of his life and have the occasional twitch and jerk for no reason but at least he had regained mobility and the ability to look after himself once again and go walking and visit family.For a T patient the pros of this procedure wouldnt necessarily outweigh the cons,fair enough they were stimulateing a particular part of his brain and this could be the reason for the unexplained jerks but it was stated in the documentery that jerks and other side effects are quite common from the procedure.He has to make regular visits to the hospital to check the device and its functionality and I just cant see this being a viable procedure for T patients,in my opinion the cons dont outweigh the pros and I believe this procedure is only truely intended for extreme neurological conditions,T not being one of them.Just an observation and an opinion.Best wishes Bill.
       
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    28. lapidus

      lapidus Member

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      If DBS works for severe hyperacusis, would the cons still outweigh the pros? As I said before, I got a friend with a DBS device and he lives a completely normal life. I would do this procedure in a heartbeat if it worked.
       
    29. t-man
      Suicidal

      t-man Member

      Tinnitus Since:
      2009
      Ditto. If I got the money, do the procedure.
       
    30. bill 112
      Studious

      bill 112 Member

      Location:
      Republic Of Ireland
      Tinnitus Since:
      02/2012
      Cause of Tinnitus:
      Noise exposure
      Oh yeah big time I agree Id do it in a second if given the chance and that would only be if it quaranteed to cure the condition but I just dont see this becoming big if you get me,or even worth it,also as with everything T related H is in the exclusion criteria so this isnt to benefit H.VNS will basically do the same job but much much less invasive and risky.I just dont see this as a practical treatment for T and I dont believe it will become the norm in T treatments.Maybe if the implants became much much smaller then it may be considered a more practical treatment option but as of yet I dont believe so.I just see it as a treatment option for extreme neurological conditions like parkinsons and other similar conditions.Im glad they are testing this method on people but I dont believe it will be commonly used or used at all for that matter in the future,I hope Im wrong.
       

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