Frequency Therapeutics — FX-345

Discussion in 'Research News' started by Diesel, Nov 9, 2021.

    1. SmallRonnie
      Ape-like

      SmallRonnie Member Podcast Patron Benefactor

      Location:
      Ireland
      Tinnitus Since:
      H since 2018. T since 2021
      Cause of Tinnitus:
      Loud noise
      There's a lot more funding going to other incurable diseases that actually kill people, like cancer.

      I know hearing loss is terrible but at least it's not killing people.

      You are a tad optimistic on your profit predictions. Frequency Therapeutics and others have provided guesstimates on what the market is worth. The fact that hearing loss is a growing issue is the main point they put into their pitch decks.
       
      • Agree Agree x 2
      • Like Like x 1
    2. Jonno02
      Wishful

      Jonno02 Member Benefactor

      Tinnitus Since:
      2022
      Cause of Tinnitus:
      Loud music / ETD
      Disagree. The WHO state at least 1.5 billion people worldwide have hearing loss or issues. It’s probably a lot higher in reality, but we’ll take that at face value.

      If you could treat hearing loss right now for those people, the profits would not only be in the tens or hundreds of billions over the course of a few years. The sham that is Lenire costs thousands per person and doesn’t even seem to work.

      And again I disagree. Hearing loss does kill people. People are driven to suicide every day by tinnitus.
       
      • Agree Agree x 5
      • Like Like x 1
      • Winner Winner x 1
    3. Artemis2K
      Kick ass

      Artemis2K Member Benefactor

      Location:
      South Carolina
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I had tinnitus for as long as I can remember. Got bad later.
      Also, if someone can't hear someone call out "Watch out!" they could also end up losing their life. Very concerning if they work in a dangerous environment.

      Not only that, but the fact that hearing loss can lead to dementia is a bit alarming.
       
      • Like Like x 3
      • Agree Agree x 2
    4. in_LA

      in_LA Member

      Location:
      Los Angeles
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Loud music
      Do we know why some people didn't respond as well? Was it because of their advanced age? Did they have long-term hearing loss?
       
      • Good Question Good Question x 1
    5. SmallRonnie
      Ape-like

      SmallRonnie Member Podcast Patron Benefactor

      Location:
      Ireland
      Tinnitus Since:
      H since 2018. T since 2021
      Cause of Tinnitus:
      Loud noise
      How many people die like this compared to all the people that die of cancer, what do you think?

      I get it that you guys want a treatment but you need to be realistic and take facts as they are.
       
      • Like Like x 3
      • Funny Funny x 1
    6. HopeForSilence
      Sad

      HopeForSilence Member Podcast Patron Benefactor

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      Explosion/noise
      What are the realistic facts, that you are talking about? Let's take a view from the economic perspective:

      Companies want to make money in the first place. Investor/company decisions don't exclusively depend on how much people die from a disease. The hearing regeneration market is a big financial opportunity with a lot of unmet needs. The cancer market is saturated - many big companies are already targeting that disease and are working on various treatments.
       
      • Agree Agree x 3
      • Like Like x 1
      • Genius Genius x 1
    7. CarlosEstan
      Inspired

      CarlosEstan Member Benefactor

      Tinnitus Since:
      12/2022
      Cause of Tinnitus:
      Noise Induced
      When there is a lot of money to be made, there are even more people eager to make it. I'm glad someone else sees it, nearly everyone will experience hearing loss in their life. It's a never ending demand. Elderly and veterans being a hot market for these drugs is a given; though I also see many ENTs using this in clinic after a round of Prednisone even if the hearing loss was not substantial just to further cover their bases.

      All this of course banks on not only the efficacy, but the safety of the drug. If they are right about their formulation, I suspect many forum users will be enjoying their new beach houses, and condos.
       
      • Like Like x 2
      • Agree Agree x 2
    8. SmallRonnie
      Ape-like

      SmallRonnie Member Podcast Patron Benefactor

      Location:
      Ireland
      Tinnitus Since:
      H since 2018. T since 2021
      Cause of Tinnitus:
      Loud noise
      There is not trillions of dollars of profits to be made on anything in the entire world.

      If there was great potential, then there would be more investment. The people investing do it as their job. They do know what they are doing.

      With how every single hearing regeneration company has already failed, it's not the most attractive investment.

      The hearing aid market alone is only $7.5b. There are probably less people with tinnitus than with hearing aids. Or less people with severe tinnitus anyway.
       
      • Like Like x 1
    9. HopeForSilence
      Sad

      HopeForSilence Member Podcast Patron Benefactor

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      Explosion/noise
      I doubt what you are saying. The veterans' compensation for tinnitus in the US alone is higher then your stated hearing aid market value. Why are you so pessimistic? People need hope, that's the only thing we got with this terrible affliction.
       
      • Agree Agree x 2
      • Like Like x 1
    10. Jonno02
      Wishful

      Jonno02 Member Benefactor

      Tinnitus Since:
      2022
      Cause of Tinnitus:
      Loud music / ETD
      No, sorry. It's not that simple. Without giving too much away (in reference to my other posts) I am a development scientist for a medical company. I can't tell you how many projects with absolutely astronomical market value do not get fully started because "this is a new area, so... rather than invest £50M of our own money in research costs to show proof of principal, why don't we wait until someone else figures out the basics and then build our own treatment off of that research. That means we don't risk our 50M upfront." Investors do not look at people's suffering, they do not look at "what could this be worth in 10 years" - they look at "what's a proven, safe, semi-decent return for my clients' money."

      And 'treating cancer' isn't a thing in of itself. There are approximately 200 types of cancer. Most of which will require independent, specific and/or specialised treatment pathways. It's not a case of "this tablet cures testicular cancer, so it'll cure brain cancer too." Money given to cancer research labs isn't taking money away from hearing loss research labs. It's that hearing loss research labs are not getting the funding at all.
      Compared to diseases like cancer, the funding being given to hearing loss research is so tiny it's not even on the map (believe me... I know). Without the huge funding cancer has received, the treatment would be far worse than what's available today. With how many hundreds of billions (possible more?) have been invested in cancer globally, you'd think we'd have a cure, no? No, cancer treatment has remained unchanged for some time now. Does that means it's a dead end and an unattractive investment since there's no cure-all-cancer-pill yet? Of course not.
      Non relevant comparison. In the UK alone, 6 million+ people require hearing aids, yet only 2 million are prescribed them through choice. Either social issues (I don't want a hearing aid) or denial. 1 in 6 UK adults have hearing loss. 1 in 10 have a degree of tinnitus. Many people are told their hearing is bad, but not bad enough to benefit from a hearing aid, so aren't even given the option.

      If somebody told you "you can have these hearing aids for the rest of your life", most people would say no thank you.

      If somebody told you "we'll schedule an appointment, a small injection in your ear and within a few months you'll have regained x% of your hearing", most people would say sign me up.

      I see where you're coming from, but in the next decade or so, hearing loss occurrence is going to reach critical mass; how many kids these days do you see with headphones permanently in? But it seems only a few companies are forward thinking or willing to take the risk in development the cornerstone technology that will cure hearing loss. And I hope when successful, their researchers and investors reap the rewards.
       
      • Winner Winner x 5
      • Agree Agree x 3
      • Informative Informative x 2
    11. DeanD

      DeanD Member

      Tinnitus Since:
      10/2022
      Cause of Tinnitus:
      Microsuction
      Unfortunately it will take investment from sources passionate or impacted by hearing loss and tinnitus to find even a fraction of investment needed to find a 'cure'.

      Otonomy was co-founded by a millionaire who was impacted by Meniere's. It didn't succeed of course after 14 years, but the initial launch of the company was based upon someone impacted, rather than an investment house looking for a ROI for its clients - although this came later through a series of fund rounds.

      It needs someone(s) with incredibly deep pockets who have been terribly afflicted or impacted by this as a serious condition who has the capital necessary to launch one or more companies in search of an ultimate cure.

      Even 10% wealth of all celebrities who say they 'suffer' with tinnitus would raise a substantial sum towards research, but it isn't coming.

      Hopefully Dr. Susan Shore's device, and maybe a breakthrough in neuromodulation and medication by Prof. Dirk De Ridder - or maybe XEN1101 will show equal promise for tinnitus sufferers - will pave a way to narrow down the parameters and allow investments in to startups focusing on a more targeted solution.

      If not - we always have Mr Musk - who, tbh, is kind of my outside bet here.
       
      • Agree Agree x 4
      • Winner Winner x 2
    12. Ken219
      Frustrated

      Ken219 Member

      Location:
      New York Area
      Tinnitus Since:
      Summer of 1990
      Cause of Tinnitus:
      Noise exposure?
      It is the cost that prevents most people from purchasing hearing aids.
       
      • Like Like x 2
      • Agree Agree x 1
    13. Jonno02
      Wishful

      Jonno02 Member Benefactor

      Tinnitus Since:
      2022
      Cause of Tinnitus:
      Loud music / ETD
      Hearing aids are free in the UK.
       
      • Agree Agree x 1
    14. in_LA

      in_LA Member

      Location:
      Los Angeles
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Loud music
      I have to say that hearing aids are more expensive than ever but the government should definitely step in to make sure everyone has access to at least a midranger to help people get their life back to some normalcy.
       
    15. RingingBrother

      RingingBrother Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise induced hearing loss
      Has FREQ ever applied for a DoD grant for hearing loss treatments?
       
      • Good Question Good Question x 4
    16. AUTHOR
      AUTHOR
      Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      They received a grant from the DoD prior to the FX-322 Phase 1/2.
       
      • Informative Informative x 2
Loading...

Share This Page