Frequency Therapeutics — Hearing Loss Regeneration

This is a dumb question, but in terms of noise distortions, I'm assuming FX-322 would help with that, correct? Or is that a synapse issue?

 

Didn't your doctor suspect cochlear hydrops in your case (which can cause distortions) or am I thinking of someone else?

 

Frequency Therapeutics has mentioned in recent research that outer hair cell death is believed to be associated with distorted hearing.

 

You're probably thinking of someone else. Although, he did prescribe me a diuretic which I haven't taken. I'm seeing another doctor to get a second opinion in a few weeks. I had a few days of no distortions but came back with a vengeance and I have no idea why.

 

Thank you for the answer! I really hope this is available in the next few years...

 

I have this same problem. I took the diuretic and it helped. But I also had an MRI that confirmed I don’t have hydrops or Meniere’s. I’m not sure what is going on. Might just be a distortion form of tinnitus.

 

It’s March, baby!

 

It would be awesome if they released the results today.

 

Happy readout month.

 

FEELS LIKE NEW YEARS EVE.

 

Yeah, we're gonna "ring" in the new month with some great results!

 

Oh God Bless us in the month of March, please our hearts.

 

I finally joined Tinnitus Talk, just in time for the big update. This could be it guys! I'm so nervous and so excited.

 

My panic attacks from tinnitus are gone, now I get panic attacks thinking what if FX-322 doesn't show improvements.

March is a new beginning indeed, we got spring (regeneration) and hopefully news about regeneration of new hair cells.

Btw, thank you for your replies on my question earlier.

If FX-322 doesn’t work, I’ll go back to unprescribed Prednisone without any choice.

 

Hopefully, everyone can do FX-322 shots to bring in the New Ear.

 

This is a crucial month. I appreciate what Frequency Therapeutics is doing. Hopefully it will somehow reach us non US citizens. If I can't take a plane because of my ears I'll take a boat.

 

Not so funny how we have to post our Audiograms here to have them interpreted properly as opposed to be being told that all it means is we need hearing aids immediately.

 

Jell-o shots... except they'll eventually need to reformulate the jell-o.

 

I like you! Me too!

 

Just beer bong it into the cochlea... I'm sure it will get deep enough then hehe.

 

Does anybody think FX-322 will be effective for tinnitus caused by ototoxic medication (SSRI)?

 

I don't think SSRIs destroy or damage hair cells but I could be wrong.

 

Yes.

 

This has me dying.

 

Frequency Therapeutics themselves have mentioned that SNHL from ototoxic medication is something they are aiming to treat with FX-322. That said, the damage in question needs to be hair cell related of course.

 

If for some reason, hair cell damage is incurred, then why not? Usually with SSRI, the tinnitus is caused by drug side effects or even a direct result of higher serotonin (a neurotransmitter linked to tinnitus).

 

I see you are in the 4 Jell-o shot cohort...

 

Out of curiosity: Can't we use the pharmacokinetics model of FX-322 as a basis to assume how deep OTO-413 might reach?

I mean if we compare the typical time for the VPA to reach its peak at ~2 kHz (roughly at 3 hours) and compare it with the slides from OTO-413 from December, where the concentration drops by a factor of 100 within 7 days, we might deduce that OTO-413 can arguably reach below 1 kHz. Vice versa one could start speculating what FX-322 might be capable of if it had the same half time as OTO-413...

 

If you knew the difference in diffusion properties (molecular weights, polarity, etc) between VPA and OTO-413 and factored in the different gels... maybe.

But it might be easier just to ask Otonomy on a podcast if they know how far it goes .