Here's a Safe Benzo Drug for Tinnitus Sufferers: Tofisopam (Emandaxin, Grandaxin, Sériel)

Discussion in 'Support' started by peter91, Sep 13, 2020.

    1. peter91

      peter91 Member Benefactor

      Tinnitus Since:
      Nov 2019
      Cause of Tinnitus:
      cocaine with anabolic steroids + HGH
      If you have anxiety and want a safe benzo without potential for addiction/withdrawal, there's Tofisopam (Emandaxin, Grandaxin, Sériel).

      I used it for 2 weeks with somewhat good results.

      I actually have no idea why it's not widely used because its effect is good and it's safe.

      Just wanted to let you know.
       
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    2. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      Why do you think this is safer than any other benzo? As someone who responds strongly and would love to be on a benzo (Xanax basically makes my tinnitus a non-issue), curious on your logic here.
       
    3. OnceUponaTime
      Busy

      OnceUponaTime Member Podcast Patron Benefactor Hall of Fame Advocate

      Location:
      New York
      Tinnitus Since:
      11/11
      Cause of Tinnitus:
      Noise
      What was your dosage and why did you stop taking it?
       
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    4. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      https://en.wikipedia.org/wiki/Tofisopam

      The wiki says it is "safer" but still has potential for withdrawal. I just did a superficial search. I haven't looked into it more.
       
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    5. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      "Tofisopam is 2,3-benzodiazepine, unilke tradiconal benzodiazepines it does not bind to the benzodiazepine binding site of the GABA A receptor. It does not have anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties. It also been found that it is PED inhibitor which may play role in cognitive improvement. And it does something with dopamine receptors."

      From someone more knowledgeable than me - so not sure it would have any effect on tinnitus directly.
       
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    6. AUTHOR
      AUTHOR
      peter91

      peter91 Member Benefactor

      Tinnitus Since:
      Nov 2019
      Cause of Tinnitus:
      cocaine with anabolic steroids + HGH
      100mg / day.

      After cocaine, I got some gut issues. I mean, lately I can't even drink coffee without a feeling of discomfort. Unfortunately, I had abdominal pain from Grandaxin. Still looking with doctors why.
      I actually used it and quit CT without any kind of discomfort (though some psychotherapists suggest tapering, but not as slow as Xanax). Also, my psychotherapist told me it's not comparable in terms of dependence to traditional benzos (Xanax, Lorazepam etc etc) and one could take it safely up to 3 months.
      I felt some positive difference in tinnitus, but maybe it's because of the anxiety levels dropped.
       
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    7. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      Thanks - definitely appreciate the response!
       
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    8. Jack Straw
      Balanced

      Jack Straw Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Location:
      US
      Tinnitus Since:
      1990s
      Cause of Tinnitus:
      Infection, Acoustic Trauma
      This seems to strange. It is a benzo, but is a different kind that doesn't have the sedative effect? Does it have a dependence issue like other benzos?
       
    9. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      beliefs are makyo and reality ignores them
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      Well, it's super weird. Structurally it's a benzo, but it doesn't actually bind to the benzo receptor, and it seems to potentiate some BDZ drugs but not others?

      Because this is something which is mass produced overseas as a pharma drug but is not used or controlled here, it is super easy to obtain online.

      I will leave that to the more intrepid, since my daily Klonopin keeps me good, but I look forward to what anyone has to say about this. On the other hand, weird anxiolytic drugs from Russian markets are a dime a dozen and most of them are useless.
       
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    10. AUTHOR
      AUTHOR
      peter91

      peter91 Member Benefactor

      Tinnitus Since:
      Nov 2019
      Cause of Tinnitus:
      cocaine with anabolic steroids + HGH
      Yes, no sedative effect. Rather energizing a bit.

      Dependence isn't that strong if one keep take it up to 3 months. I mean, you can't compare dependence of traditional benzo to it, no way.
      Agree, it's weird. But this is how it is.

      It is not useless but not as strong as Xanax. Rather like Atarax (Hydroxyzine).
      Also, it has some positive effect on cognition, rather than making memory worse as other benzos.

      About safety -- as far as I know it's really safe (if you compare it to Hydroxyzine).
       
    11. Jack Straw
      Balanced

      Jack Straw Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Location:
      US
      Tinnitus Since:
      1990s
      Cause of Tinnitus:
      Infection, Acoustic Trauma
      Do you take this everyday or as needed?
       
    12. AUTHOR
      AUTHOR
      peter91

      peter91 Member Benefactor

      Tinnitus Since:
      Nov 2019
      Cause of Tinnitus:
      cocaine with anabolic steroids + HGH
      Supposed to be taken daily. I took it daily. However one can take it situationally, e.g. before/after stress.
       
    13. Turgy

      Turgy Member

      Location:
      Germany
      Tinnitus Since:
      2008
      Cause of Tinnitus:
      acoustic trauma
      where can I buy it?
       
    14. AUTHOR
      AUTHOR
      peter91

      peter91 Member Benefactor

      Tinnitus Since:
      Nov 2019
      Cause of Tinnitus:
      cocaine with anabolic steroids + HGH
      In my country at any Pharma shop provided you have prescription for it. You can search over the internet. But I would strongly suggest checking if it is legal to buy this online in your country (it's a prescription benzo drug mate!!)
       
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    15. Jack Straw
      Balanced

      Jack Straw Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Location:
      US
      Tinnitus Since:
      1990s
      Cause of Tinnitus:
      Infection, Acoustic Trauma
      You don't need a doctor to prescribe it where you are from?

      Keep us updated as to how it goes!
       
    16. AUTHOR
      AUTHOR
      peter91

      peter91 Member Benefactor

      Tinnitus Since:
      Nov 2019
      Cause of Tinnitus:
      cocaine with anabolic steroids + HGH
      In my country you still need a doctor to prescribe it.

      But you know, if you really want... you can get almost anything...
       
    17. Chinmoku

      Chinmoku Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Started with a cold, possibly worsened by medication/noise
      There is a Japanese study for tinnitus but in the context of dysautonomia and apparently low pitched:

      https://www.jstage.jst.go.jp/article/jibirin1925/82/1/82_1_133/_article

      Clinical Evaluation of Tofisopam in the Treatment of Tinnitus

      Abstract
      Our previous reports dealt with tinnitus and impaired hearing as autonomic dysfunction in the field of otorhinolaryngology. In 46 patients, tinnitus without hearing loss or with impaired hearing of low-pitched sounds was the manifestation of autonomic dysfunction, as diagnosed by Schellong's test and T. M. I. These patients were treated orally with Tofisopam 150mg daily (50mg three times a day), and changes in the severity of tinnitus were monitored. The treatment was markedly effective or somewhat effective in 32 (70%) of the 46 patients. Schellong's test done at intervals of 2 weeks became negative in 70% of the 20 patients. These results indicate that Tofisopam is effective in the treatment of tinnitus.
       
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    18. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      I'm kinda looping back to consider this. Xanax literally saves my ass - if I could use something more liberally that had fewer issues, I would love to. That being said I know this is less potent than Xanax as it binds to fewer receptors, so I'd be really curious to see how it affects my tinnitus if at all. If it did have an effect on tinnitus, pairing it with an anxiolytic like CBD would be easy.

      Xanax sort of has the effect on my tinnitus people seem to describe in the positive Lenire reviews - the sound is still there but so much more tame and soft - functionally I don't really mind it so it's as if I'm cured.
       
    19. Chinmoku

      Chinmoku Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Started with a cold, possibly worsened by medication/noise
      Definitely worth looking into, you might stumble into a lucky combination. I wish CBD worked for me. It spikes my tinnitus :(

      As for benzos the jury is out on whether GABA drugs have contributed to make my tinnitus the agony it currently is. This one looks quite different though.
       
    20. Greg Sacramento

      Greg Sacramento Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      April 2011
      Cause of Tinnitus:
      syringing and now somatic T dental work
      • Good Question Good Question x 1
    21. Chinmoku

      Chinmoku Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Started with a cold, possibly worsened by medication/noise
      Thank you Greg. I have saved it in my laptop folder. At the moment I'm too distressed to read but I'll try in the evening when I can tolerate this horrid electric signal a little better.
       
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