Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      I have read a lot and I dont think there are any concrete answers to these questions. I also read that if you have profound hearing loss that fx322 would not work, but at what level of loss and for how long? During the Genvec trials they were looking for people with profound hearing loss and that turned the supporting cells into new hair cells. Maybe it didnt work well because there werent enough supporting cells in those people? The results were hit and miss and I'm not sure even they understand why it worked for a few people and not for a few others. Either way I dont think you will get any answers at least not for now.
       
    2. TeslaGuy

      TeslaGuy Member Benefactor

      Location:
      Finland
      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Acoustic trauma
      What levels of hearing loss the patients had who attended this FX-322 trial? I thought that they believe that with hearing loss only hear cells are lost but everything else is there such as the progenitor cells.
       
    3. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      1. A pure tone average of 70 dB or greater at 500Hz, 1000Hz, 2000Hz, and 4000Hz in the ear to be injected.
      This is the criteria for the trial.

      From what I remember initially Frequency said if you were at a profound stage of loss it would not work. I thought they updated this and said that it might work in a future video. Either way I dont think anyone knows for sure unless someone wants to chime in with any info I have missed.
       
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    4. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      The concern is that if one has perfect hearing on an audiogram but has profound losses in the higher ranges, where their tinnitus frequency resides, then hearing cell restoration may not work and tinnitus may not theoretically be alleviated.
       
    5. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Why wouldn't this work on high frequency hearing cells? Because it's profound?
       
    6. Bndsmheowqhe

      Bndsmheowqhe Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Loud noise exposure
      Now I'm concerned. I mostly have high frequency damage.
       
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    7. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      Yes that would be the issue. It would mean profound hair cell damage would also presume non-regeneratable progenitor cells too. I don't know if that is true of course, I'm just speculating from Frequency's admission that profound hearing loss may not be recoverable with FX-322.
       
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    8. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Hopefully though it could at least regenerate enough to eliminate tinnitus.
       
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    9. jdjd09

      jdjd09 Member

      I have been watching this thread and others, but can’t always keep up with it. I have heard some on the forum claiming that a hearing loss cure (aka, one that brings back most of someone lost hearing) could be ready in 5 years or less. Is this true?

      I had a massive issue happen recently and could really use some hope and very stressed right now.
       
    10. Contrast
      No Mood

      Contrast Member Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      noise injury
      Only if the community is vocal will Frequency Therapeutics have a higher chance of success.

      If you care more about normie things then we'll be here another 15-20 years riding the carousel of palliative medicine.

      I myself have no interest in hair cell regeneration, as I have very little hearing loss on the tonal audiogram and my hearing loss is nerve related, not hair cell death but still I understand it's needed for millions.
       
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    11. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      Yes, it's true. 'Cautious optimism' is the byword.
       
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    12. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      @SashaG

      My hearing damage was caused from a mixture of NSAID overuse and loud noise from a guitar amp.
       
      • Informative Informative x 1
    13. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Yes, it is very possible. The technology is viable and restoring hearing will alleviate or eliminate tinnitus. There is already an effective treatment being performed by a pioneering doctor in Seoul South Korea and I know this because I have gotten it. For those that don't trust him there are other companies going through clinical trials right now with drugs that will achieve the same results.
       
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    14. SashaG
      Alone

      SashaG Member

      Tinnitus Since:
      03/2019
      Cause of Tinnitus:
      MRI, Stress
      Great to hear that! I hope that many more will be able to profit from these treatments. I often wonder where we could be today, if we wouldnt think too much about "what is right and what is wrong" if we talk about maniplulating cells and organ material.

      I hope your recovery will go on!
       
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    15. just1morething
      Benevolent

      just1morething Member Benefactor

      Location:
      U.S.
      Tinnitus Since:
      2008
      Cause of Tinnitus:
      barotrauma, noise exposure, TMJ, neck?
      Would you say you are 80-90% back to normal? I had a large bowl of mongolian food yesterday (I should have known better) and my head is hissing something fierce again. Have you tested your ears out recently with salty or spicy food? It seems damaged inner ears act up with salt and MSG for quite a few people with tinnitus.
       
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    16. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      It's kinda hard to put a percentage on it. Because it switches on and off now up to 3 times a day. When it's off it's like 90-95% gone and I have to plug my ear to hear it at all. I only slept like 6 hours last night so its here today, but only in my left ear and it's very low.

      I can't tell if any food affects it. I'm thinking no.
       
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    17. Artemis2K
      Kick ass

      Artemis2K Member Benefactor

      Location:
      South Carolina
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I had tinnitus for as long as I can remember. Got bad later.
      Sleep definitely does. Get 8 hours as much as possible.
       
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    18. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
      aGREED
      49914574_2301431643201440_2245592336107044864_o.jpg
       
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    19. jeff W

      jeff W Member

      Location:
      nakatomi plaza
      Tinnitus Since:
      04/2012
      The exact purpose of the support cells is unknown, the effects of their removal or even modification are as of yet unknown. Salient questions you ask.
       
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    20. Manny
      Dead

      Manny Member Benefactor Hall of Fame

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      1/2018
      Cause of Tinnitus:
      central gain << NIHL
      • Good Question Good Question x 3
    21. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Command a premium.... please someone verify this QUOTE.
       
    22. PDodge
      Cowboy

      PDodge Member Benefactor

      Location:
      Woods of Alberta
      Tinnitus Since:
      01/2017
      Cause of Tinnitus:
      Bear ate my Cochlea
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    23. Ray552

      Ray552 Member

      Tinnitus Since:
      12/18
      Cause of Tinnitus:
      Noise trauma
      Do we have any reason to believe that this may help hyperacusis too ?
       
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    24. john paul
      English

      john paul Member

      Tinnitus Since:
      11/11/17
      Cause of Tinnitus:
      acoustic trauma
      They were put there so that us losers with tinnitus can have our lives back.
       
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    25. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      If hyperacusis is caused from disruptions in auditory input and restoring hearing fixes that then yes.
       
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    26. Ray552

      Ray552 Member

      Tinnitus Since:
      12/18
      Cause of Tinnitus:
      Noise trauma
      Did prp improve your h?
       
    27. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      My HA has improved, however, it would be dishonest to claim it was a result of my treatment for a fact.
       
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    28. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Cool, glad it's improved... why for a fact? What's your theory.
       
    29. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Because there is certainly a chance I recovered spontaneously. Do I think that's the case? No. But the chance is still there and I would be dishonest not to acknowledge that.
       
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    30. Hariz Nonis
      Loved

      Hariz Nonis Member

      Location:
      Singapore
      Tinnitus Since:
      09/2015
      Cause of Tinnitus:
      Unknown
      Is it a specific NSAID or just NSAID in general?
       

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