Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. Hariz Nonis
      Loved

      Hariz Nonis Member

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      Exactly which nerves, if I may ask?
       
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    2. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

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      Well i was taking a brand called BC Powder.
       
    3. Hariz Nonis
      Loved

      Hariz Nonis Member

      Location:
      Singapore
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      09/2015
      Cause of Tinnitus:
      Unknown
      Just did a quick Google search. It seems to contain Aspirin. I wonder if that's not good for our hearing
       
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    4. tomytl
      Grumpy

      tomytl Member Benefactor

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    5. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      "And by studying why some cells populations become depleted, the research team may be able to identify a population of cells that do retain the ability to regenerate, and, crucially, to understand why."

      So basically they are like 20 steps behind Frequency Therapeutics and asking questions that have already been answered. NEAT!!!
       
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    6. Contrast

      Contrast Member Benefactor Hall of Fame

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    7. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      Can anyone give me a straight answer as to why they aren't testing NT-3 on humans since they have proven that it restores cochlear synapses in mice?

      Anybody?
       
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    8. Rubenslash

      Rubenslash Member

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      Maybe that's what Otonomy is going to use for the upcoming hidden hearing loss clinical trial?
       
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    9. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      Its BDNF. That is promising too.
       
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    10. Daniel Lion
      Ape-like

      Daniel Lion Member Benefactor

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      When's the trial?
       
    11. Rubenslash

      Rubenslash Member

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      Phase 1 will start later this year I believe.
       
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    12. Daniel Lion
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      Daniel Lion Member Benefactor

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      Ok thanks, I've been looking on ClinicalTrials.gov and haven't seen anything. If you find a listing, please post.

      Thank you so much, I'm super interested and would love to participate.

      Daniel
       
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    13. Rubenslash

      Rubenslash Member

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      http://www.otonomy.com/pipeline/hearing-loss-programs/

      OTO-413 (BDNF)
      OTO-413 is a proprietary, sustained-exposure formulation of brain-derived neurotrophic factor (BDNF) which is a naturally occurring protein involved in neuron growth and repair. Nonclinical studies by Otonomy and other research groups have demonstrated that local administration of BDNF repairs ribbon synapses damaged due to noise trauma or exposure to ototoxic chemicals and restores hearing function. We expect to initiate a Phase 1/2 clinical trial for OTO-413 in hearing loss patients in the third quarter of 2019 with results in the second half of 2020. The initial indication for OTO-413 will be patients with synaptopathy-related hearing loss that is characterized by speech-in-noise hearing difficulty.
       
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    14. Jim51042

      Jim51042 Member

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      This is the one near term thing Otonomy is doing that I'm very interested in learning the results. Honestly people on this site should be a lot more interested in these nerve targeted products. Shame on all the members here for missing an untapped and less complicated target for new drug candidates. Still while everyone else is asleep at the wheel @JohnAdams and I will be in on these Tinnitus fixing drugs and living the quiet life;)

      Also want to see what solution they produce with OTO-613 (hopefully sooner rather than later). OTO-313 is unlikely to work so I've been skipping over mentions of that product.
       
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    15. erik
      Cool

      erik Member Benefactor

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      OTO-613 has been in research for 5 years and I would estimate that if this is viable, it is still 10-15 years out.
       
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    16. Daniel Lion
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      Daniel Lion Member Benefactor

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      Thank you for the info... cheers.
       
    17. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

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      because when the hair cell regenerates it produces chemicals that the nerve sniffs out and then starts forming new connections.
       
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    18. Ray552

      Ray552 Member

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      So Prp would result in new synapses too ?
       
    19. JohnAdams
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      JohnAdams Member Benefactor Hall of Fame

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      Well, if the end result is better hearing, then wouldn't that have to have occurred?

      Besides it's not about PRP, it's about IGF-1 and I can point to multiple studies and multiple human clinical trials that show that IGF-1 can restore hearing as well as proliferate supporting cells, and probably regenerate hair cells. IGF-1 was also shown to be safe in the trial participants.

      What blows my mind is that there hasn't been any follow-ups after their very successful results. Also, it hasn't been approved in America for human use, even though it's been shown to be safe. Why can't we have this if we want it? Why is the BTA still focusing on management strategies when their are very clear signs that the ability to cure hearing loss, and thus tinnitus, are upon us now?

      Why is everyone just rolling over and accepting that it will take a decade to run all of this through the process? That's nonsense.

      And there's other stuff like NT-3 and BDNF. OTO-413 is BDNF. What is the hold up here?
       
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    20. erik
      Cool

      erik Member Benefactor

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      Because mice hearing and human hearing are not that similar. Actually mice, rats and humans are not really that similar at all but studies are done on them all the time and studies that work initially in mice and rats often fail in human trials.

      Mice have a far more dynamic range of hearing up to 100hz than humans so developing a comparable treatment for humans is far more difficult. Add to that that the drug was delivered to mice using a cancer treatment drug to stimulate NT3 proteins and the tested mice only had partial temporary hearing loss whereas in humans the damage to the ribbon synapse is generally permanent, making it that much more challenging to replicate a similar treatment.
       
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    21. briano
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      briano Member

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      Where can I read about your experiences in South Korea?
       
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    22. lapidus

      lapidus Member Benefactor

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    23. briano
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      briano Member

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    24. Artazanasss
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      Artazanasss Member

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      https://www.eu-startups.com/2019/05...se-hearing-loss-through-stem-cell-technology/
      Rinri Therapeutics raises €1.6 million seed to reverse hearing loss through stem cell technology
      Rinri is based on the pioneering work of Professor Marcelo Rivolta, a world leader in the field of sensory stem cell biology. Rinri’s technology is based on innovative stem cell research, and seeks to reverse SNHL through the repair of damage to the inner ear, which occurs when there is damage to the hair cells in the cochlear and/or the auditory nerve.

      “I am delighted that the Board has asked me to guide Rinri as we work to transition our exciting preclinical program into the clinic, and to move closer to the realization of an effective treatment for the many patients with SNHL,” said Dr. Chandler, CEO of Rinri Therapeutics.

      “We have known Marcelo and followed his ground-breaking research, which was published in Nature, for many years, and are pleased to contribute to the creation of Rinri,” commented Dr Mennerich, Investment Director at Boehringer Ingelheim Venture Fund. “If the impressive pre-clinical in vivo regeneration data translates to humans, the technology has the potential to be a game-changer in the way SNHL is being treated. We look forward to working with Rinri’s team to support its growth and help further realise the technology’s potential.”

      Another player in the race towards hearing loss cure.
       
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    25. Markku
      Inspired

      Markku Founder Staff Benefactor Hall of Fame Advocate

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      We will actually be interviewing Professor Rivolta next week for one of our upcoming Tinnitus Talk Podcast episodes.

      Get your questions in before Friday 24th May:

      Ask Questions from Marcelo Rivolta, PhD, on Hearing Regeneration and Related Topics
       
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