Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. ThomasRobert

      ThomasRobert Member Benefactor

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      New research from Jeff T. Corwin at the University of Virginia appears to have uncovered the reason for the permanent nature of hair cell loss in humans. The findings identify why certain creatures can recover from hearing damage and why humans cannot.
      The team behind the research, part of Corwin’s Laboratory of Inner Ear Sensory Hair Cell Regeneration, has discovered a pharmacological treatment that could “wake up” the special supporting cells that can allow lost hair cells to regenerate in humans.

      — which was published on February 20, 2020 in the Journal of Neuroscience

      https://www.jneurosci.org/content/early/2020/02/18/JNEUROSCI.2630-19.2020.long
       
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    2. Sevv

      Sevv Member Benefactor

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      Some evidence from cochlear implants for the mechanism of hearing regeneration, though it might have already been discussed:

      Studies on cochlear implants and tinnitus improvement:
      1. "A Unilateral Cochlear Implant for Tinnitus" (http://www.tinnitusjournal.com/articles/a-unilateral-cochlear-implant-for-tinnitus-10831.html): This study reports findings from several other studies regarding unilateral tinnitus. Estimated from all studies, about 25% of patients reported complete reduction, most others improvement. No worsening was observed.
      2. "The Cochlear Implant as a Tinnitus Treatment": 20 patients fitted with unilateral cochlear implant. When activated, 65% of patients reported improvement/disappearance in the ear with the device and 50% of patients in the other ear. The numbers dropped to 50% and 45% respectively when the device was turned off. In 10% of patients (two people), tinnitus appeared in the ear with the device.
      3. "A Prospective Study of the Effect of Cochlear Implantation on Tinnitus": 44 patients, most with bilateral tinnitus. Complete reduction was observed in 8 patients, while 14 reported improvement. It is noted that these 8 patients had tinnitus for a much shorter time on average (about 5 years) than the rest of patients (32 years on average). It is speculated that not necessarily the "imprinting" of tinnitus in the brain is responsible for this, but the years of hearing loss.
      4. "Tinnitus before and 6 Months after Cochlear Implantation": 174 patients, 125 of them with tinnitus. Six months after implantation, 20% reported abolition, 51% reduction, 22% no change and 7% a deterioration. 5 of the 49 patients without tinnitus developed T.
      5. "Tinnitus and cochlear implants": 36 patients, 36% reported suppression, 42% a reduction.

      I guess hearing regeneration should be more efficient since it restores the natural state, while a cochlear implant is always going to be some sort of alteration and not a restoration of natural input.
       
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    3. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      On top of that, CIs do not cover the full hearing range. If they did, I think they would be even more effective. They are working on light-based (vs electrical based) CIs now which should have better frequency coverage.
       
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    4. Sevv

      Sevv Member Benefactor

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      Man, if we all got tinnitus in 2030, we could choose our treatments from a menu card.
       
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    5. Pink Noise
      Artistic

      Pink Noise Member

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      Haggling for the best price.
       
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    6. serendipity1996
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      serendipity1996 Member Podcast Patron

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    7. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

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    8. ThomasRobert

      ThomasRobert Member Benefactor

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      Strekin AG Completes Phase 3 Clinical Study of STR001 to Restore Hearing in Patients with SSNHL

      Strekin AG, a Swiss-based biopharmaceutical company focused on developing new treatments to reverse hearing loss, has completed its Phase 3 clinical trial of the investigational drug STR001 in patients with Sudden Sensorineural Hearing Loss (SSNHL).

      If the results are promising, STR001 could become the first approved treatment for SSNHL patients.

      Source:
      https://clinicaltrials.gov/ct2/show/NCT03331627?type=Intr
       
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    9. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      This is good news for acute cases but, unfortunately, it isn't useful for chronic cases.
       
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    10. Momme

      Momme Member

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      Loud noise?
      Do they have a website?
       
    11. Rb86

      Rb86 Member

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      Awesome news but, correct me if I'm wrong, this drug is only effective for noise induced hearing loss acquired in a 96 hour timeline. So extremely acute cases.

      I got really excited as I haven't heard of this company or drug and completing phase 3 sounds really promising. But I'm nearing a year into tinnitus from noise induced hearing loss.
       
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    12. Piney

      Piney Member

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      Since the trial is over I wonder if anyone on here was a participant and has any news.
       
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    13. briano
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      briano Member

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      This looks great!
       
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    14. all to gain
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      all to gain Member Podcast Patron Benefactor

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      Is this only for hearing loss in the acute stage?
       
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    15. xyz
      Alienated

      xyz Member

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      Completed phase 3 trial sounds like they have made it quite far. Why it is only for the acute cases? Looks like some hearing regeneration drug as FX-322.
       
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    16. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      It's not a regenerative drug. It's an anti-oxidant that prevents acute injury from leading to permanent damage.

      And from their trial inclusion requirements from clinicaltrials.gov:

      Inclusion Criteria:

      1. Male or female patients aged ≥ 18
      2. Patients with a SSHL within 96 hours of its perception
      Within 96 hours is for very acute cases.
       
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    17. Jorge1984
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      Jorge1984 Member

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      What are those acute cases?
       
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    18. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      Acute means the treatment happens in a short time after the symptom onset. In his case, this drug is designed to help but only if given within 96 hours of the hearing loss.
       
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    19. ThomasRobert

      ThomasRobert Member Benefactor

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      "SSHNL may be caused by surgery, acoustic trauma, or sudden deafness, a phenomenon in which hearing loss occurs without obvious cause. Further symptoms may include ringing in the ears (tinnitus) and dizziness (vertigo)."

      Tinnitus included as a symptom...

      Website:
      https://www.strekin.com/company/scientific-experts.html

      Contact:
      Alexander Bausch,
      CEO, Strekin AG
      Email: Alexander.Bausch@strekin.com
       
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    20. serendipity1996
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    21. xyz
      Alienated

      xyz Member

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      But how could the auditory nerve be damaged? Only through acoustic neuroma, some drug or maybe some badly run surgery. Probably most have tinnitus and hyperacusis noise induced and so fixing hair cells would be enough. And these new approaches FX-322, Audion, HEI don't seem to use stem cells which is even better because I think the cancer problem with stem cells was never solved.
       
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    22. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

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      I assume this could have implications for cochlear synaptopathy.
       
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    23. xyz
      Alienated

      xyz Member

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      Okay, so someone with perfectly fine audiogram nevertheless having tinnitus and hyperacusis might suffer from cochlear synaptopathy and the hearing regeneration drugs might not have any positive effect at all since there is no major loss of hair cells. I hope they make some progress also in diagnostic tests to check what's actually damaged in our ears.
       
    24. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      This seems like it would be especially good news for those with Auto-immune auditory neuropathies.
      OTO-413, and Hough pill are both synaptopathy drugs. PIPE-505 in pre-clinical is also.

      Hair cell regeneration drugs will not effect cochlear synaptopathy but synapse regeneration drugs should.

      But agree, better diagnostics are sorely needed.
       
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    25. all to gain
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      all to gain Member Podcast Patron Benefactor

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      Which do you feel is the most promising of these three and why?
       
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    26. FGG
      No Mood

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      Truthfully I am not sure. The Hough pill maybe because it also seems to produce more neurite outgrowth but I am not sure how to tell who needs that and who doesn't.
       
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    27. briano
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      briano Member

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      Add FX-322 to this list also.
       
    28. xyz
      Alienated

      xyz Member

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      Cause of Tinnitus:
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      Does FX-322 also help with cochlear synaptopathy? What is definitely on the positive side for the Hough pill and Pipeline is that they explicitly mention tinnitus. Hopefully they receive enough funding to push these drugs through the clinical trial phases, so that we have not years of endless waiting ahead of us.
       
    29. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

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      It's not a synaptopathy drug specifically but, as far as we know, it does restore the synapse *if* its corresponding hair cell is damaged.
       
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    30. serendipity1996
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