Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. Artemis2K
      Kick ass

      Artemis2K Member Benefactor

      Location:
      South Carolina
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I had tinnitus for as long as I can remember. Got bad later.
      No surgery can be done to accommodate for that, huh?
       
    2. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      The BLB lines the cavities of the vestibular system, so, no way. There are ways to temporarily increase the permeability of it though, such as with manitol injections into your bloodstream. Trying to get medicine into your cochlea this was would be potentially very dangerous. It could be possible but this is the type of thing that would in fact require animal testing before trying it on a human. Even then, I'm not aware of any medicine that would even be useful in this regard.
       
      • Informative Informative x 1
    3. Rogi Cetpla
      Frustrated

      Rogi Cetpla Member Benefactor

      Location:
      Europe
      Tinnitus Since:
      T 2010 / IT 2015 / VIT 2019
      Cause of Tinnitus:
      Noise exposure / Head trauma
      • Informative Informative x 1
    4. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      “The most significant aspect of the current study is the fact that the fully mature mammalian inner ear still retains the capacity to divide and regenerate if it is sufficiently reprogrammed, which removes a fundamental barrier that has prevented the inner-ear regeneration necessary for hearing restoration,” Chen added.

      Does it mean it would be a silver bullet ?
       
      • Good Question Good Question x 1
    5. Rogi Cetpla
      Frustrated

      Rogi Cetpla Member Benefactor

      Location:
      Europe
      Tinnitus Since:
      T 2010 / IT 2015 / VIT 2019
      Cause of Tinnitus:
      Noise exposure / Head trauma
      Let's hope so...

      By the way I see you are French and live in the South... have you ever considered consulting Cilcare in Montpellier?

      https://www.cilcare.com/who-we-are-2/
       
      • Like Like x 1
    6. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      @Rogi Cetpla
      you remind me of the approach I made to them :

      https://www.tinnitustalk.com/thread...rch-tinnitus-hl-treatments.17305/#post-371344

      https://www.tinnitustalk.com/thread...rch-tinnitus-hl-treatments.17305/#post-371679

      In fact, this is a company dedicated to labs which want to develop their products (in order to speed up their process), so their "consulting" web page is aimed to other businesses and not patients. This is not a tinnitus clinic at all.

      https://www.cilcare.com/our-services/consulting/

      I did not recontact them since. Maybe I should to see if there has been a big step forward in their research. I will first check their website thoroughly.
       
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    7. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      • Informative Informative x 2
    8. Rogi Cetpla
      Frustrated

      Rogi Cetpla Member Benefactor

      Location:
      Europe
      Tinnitus Since:
      T 2010 / IT 2015 / VIT 2019
      Cause of Tinnitus:
      Noise exposure / Head trauma
      Thank you for the information... please let me know if you recontact them.

      I understand that Montpellier is an important centre in France for tinnitus research.

      I also found this site:
      http://www.inmfrance.com/inmfrance-j3/index.php/en/

      I am currently in Switzerland and would also consider travelling to France if worthwhile.

      Let's stay in touch.

      By the way I also recently came across an interview on YouTube (herewith) with Alain Londero, a French ENT surgeon based in Paris, who seems to run a Tinnitus and Hyperacusis clinic. He seems to be working on a new technique based on virtual reality... It is further North for you but might possibly be an another interesting lead.

      Alain Londero on Virtual Reality for Tinnitus...
       
    9. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      Shit, Shim did NT-3 too? I may have to go this route.
       
      • Creative Creative x 1
    10. Aleksa Uzunovic

      Aleksa Uzunovic Member

      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Noise induced hearing loss
      • Good Question Good Question x 1
    11. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Dr. Shim will not offer this to you. Why would you assume he is the only ENT I have dealt with?

      The point I am trying to make is that we are sitting around while tinnitus organizations waste money on nonsensical non curative research when there are things available right now, sitting on shelves, sitting in refrigerators, that could help many of us in our desperately tragic situations to reduce our torture but we are at the mercy of corporations and huge regulatory hurdles that will ensure that it will be years and years before we are allowed to have these therapies.

      This community could do well to organize.
       
      • Agree Agree x 3
      • Winner Winner x 2
    12. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      American ENTs offering this service would be news to me. If you could share with me any details I’d be grateful. Not holding up well as of late.
       
      • Like Like x 1
    13. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I unfortunately cannot offer any instructions on how to obtain this treatment. As a community we need to be organized to the point where we could have an avenue to work with our doctors to have such an intervention. Whether or not efficacy data exists in human trials, which it doesn't, there is evidence that it is safe and we should have the right to pay an ENT to mix this with a hydrogel and administer it to us.
       
      • Agree Agree x 2
    14. rei

      rei Member

      Tinnitus Since:
      2006 but not a problem till 10/19
      Cause of Tinnitus:
      loud music spiked with lyme disease
      Damn straight!
       
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    15. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      @Rogi Cetpla : Of course, I systematically relay information.

      About Montpellier:
      http://www.inmfrance.com/inmfrance-j3/index.php/en/hearing
      The Director of the Department is Jean-Luc Puel. But this is an Institute (University), that means they do basic research and not applied research: at the end of a certain stage, they transfer the product of their research to a pharmaceutical laboratory. If I remember correctly, INM worked on Gacyclidine and transfered their results to Auris Medical and/or Otonomy. This is not a tinnitus clinic with consultations for patients.

      About Londero:
      you can see the thread I posted:
      https://www.tinnitustalk.com/thread...-londero-neurofeedback-virtual-reality.36929/
      But I am living to far from the clinical trial centers (Paris and Toulouse).
       
      • Helpful Helpful x 1
    16. Nonomat
      Wishful

      Nonomat Member Benefactor

      Location:
      France
      Tinnitus Since:
      06/2019 (mild) - 11/2019 (intrusive)
      Cause of Tinnitus:
      Noise induced
      Yes, Sensorion was a start-up here too.

      I don't know how it works on clinicaltrials.gov but the study isn't up to date and is completed. They didn't publish the results as of yet but Zeta Technologies did a presentation about it in September.

      I think I will post more about it in your thread and not digress more here.
       
    17. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
    18. MRItechssuck
      Disappointed

      MRItechssuck Member

      Location:
      USA
      Tinnitus Since:
      Mild 2000-2018 sev 10/17/2019
      Cause of Tinnitus:
      Loud noise, MRI
      Interesting article... but:

      “Hearing Restoration Project, a privately funded consortium of 15 scientists from around the world who are seeking to develop strategies for hair-cell regeneration to restore hearing loss.”

      15 scientists? I wish we could link this to climate change, there would be thousands. :)
       
      • Like Like x 1
    19. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      ... and they would all be totally ignored.
       
      • Agree Agree x 3
    20. MRItechssuck
      Disappointed

      MRItechssuck Member

      Location:
      USA
      Tinnitus Since:
      Mild 2000-2018 sev 10/17/2019
      Cause of Tinnitus:
      Loud noise, MRI
      That’s because the world ends in 12 years...just when Dr. Shore finishes her study .....kidding :)
       
    21. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      We can't?
       
      • Funny Funny x 1
    22. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      I'm not sure Shore herself has 12 years left. She's no spring chicken.
       
      • Funny Funny x 2
    23. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      That seems unnecessarily callous, especially towards a person who is working to free you from a lifetime curse.

      How about a nice email to her instead, thanking her and her team for the work that they do? I did that a long time ago, and she personally responded, which felt really good for some reason.
       
      • Agree Agree x 4
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    24. MRItechssuck
      Disappointed

      MRItechssuck Member

      Location:
      USA
      Tinnitus Since:
      Mild 2000-2018 sev 10/17/2019
      Cause of Tinnitus:
      Loud noise, MRI
      A little levity is never harmful especially as I sit here listening to my tinnitus. Some have said she and / or her staff have tinnitus, can anyone confirm?

      After every email I sent her staff and Dr. Shore (never heard back from Dr. Shore) I mentioned how they are saving lives. I was denied from the trial for being 50 miles too far.
       
    25. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      I just think anyone over the age of 50 should approach their work with more of a sense of urgency, that's all. History is littered with those who put many years working slowly on some mega-project and wound up leaving an incomplete legacy.

      "Carpe diem. Seize the day." - Dead...
       
    26. Jim51042

      Jim51042 Member

      Tinnitus Since:
      3/28/16
      Cause of Tinnitus:
      Headphone use
      Acknowledging that all life eventually has an endpoint is not cruel it is simply self-aware. No one is immortal. Understanding that fact is part of being human.
       
    27. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      You don't know that.
       
      • Agree Agree x 1
    28. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      https://glive.co.uk/Online/tickets-royal-surrey-nhs-guildford-2020

      Just came across this! A seminar on tinnitus and hearing loss is being held on Feb 3 by the NHS in Surrey, UK. Anyone is welcome to attend and tickets are free of charge. Five experts on tinnitus and hyperacusis will be speaking including Prof Richard J. Salvi from Buffalo (pretty sure his name rings a bell!)
       
      • Informative Informative x 1
    29. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      Another recent article in the mainstream media (Jan 21) bringing awareness to hidden hearing loss. It's great to see this topic gaining more awareness and will hopefully spur the search for solutions.

      https://www.popsci.com/story/health/early-hearing-loss/

      This part gives me such hope lmao:

      "That’s why Kujawa, Liberman, and international groups are racing to understand the condition. Their research is leading the biotechnology industry toward treatments that could reverse the damage by coaxing synapses to regrow and give people back their normal, clamorous lives."
       
      • Like Like x 7
    30. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      • Like Like x 1
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