Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. WillBeNimble
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      WillBeNimble Member Podcast Patron Benefactor

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    2. tommyd87

      tommyd87 Member

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      Sorry I cannot understand what you are talking about and I could not see anything about this on that link.
       
    3. Thuan

      Thuan Member

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      Where did you get that information? It's not in that article nor is there any info on the Otonomy website.
       
    4. WillBeNimble
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      WillBeNimble Member Podcast Patron Benefactor

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      Was basing it off kyorins pipeline. It's all preclinical and doesn't go into what it even is though.I mean, it makes sense, but would be nice to know what they're going to try that's different.
       
    5. Thuan

      Thuan Member

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      That explanation with the neutrophils and anti-inflammation doesn't make much sense in restoring SSHL unless it's used as an early preventative measure (since active infection's inflammation do damage the ear). Otherwise, it sounds like BS to boost public relations.
       
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    6. tommyd87

      tommyd87 Member

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      @WillBeNimble it is looking like that the treatment at the bottom box is completely different to this hearing loss drug.

      In fact I feel that this is just a note about this drug being in development.
       
    7. FGG
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    8. WillBeNimble
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      WillBeNimble Member Podcast Patron Benefactor

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      Thanks FGG, yeah, I realized that a bit later. Makes sense, I was expecting that there was some data they went off of, though. It's probably all confidential right now, though.
       
    9. d'Wooluf

      d'Wooluf Member

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      I read it the opposite. Otonomy are paying Kyorin.
       
    10. tommyd87

      tommyd87 Member

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    11. Greg Sacramento

      Greg Sacramento Member Benefactor Hall of Fame

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      Interesting article, where with other support and reference articles, seems to express one of a few important area of needed focus.

      In this context, future studies will be needed to also identify the dedicated output neurons and associated ascending circuits needed to process centrally the peripheral information encoded by each individual SG neuron type.

      https://www.nature.com/articles/s41...OHYMfKL8jceMmZ4ew9-Eh1hwjPG9JjXcpJuGvjkFuPOs=
       
    12. Jurger

      Jurger Member

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      Great news, whatever the method. The more options the better it is for patients. Eventually something will work, or multiple drugs that are complimentary to each other.
       
    13. serendipity1996
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      serendipity1996 Member Podcast Patron

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    14. tomytl
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      tomytl Member Benefactor

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      It's nice to see, that one more company does drive a regeneration programm to the clinic.
      But this will take years even they start with human Phase 1 trials.
      Let's hope that Frequency or Audion come to the market within the next 5 years.
       
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    15. tomytl
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      tomytl Member Benefactor

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    16. Diesel

      Diesel Member Benefactor

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      Interesting. If I am understanding it correctly, it may have an effect on restoring broken synapses between hair cells and the nerve?
       
    17. tomytl
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      tomytl Member Benefactor

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    18. Thuan

      Thuan Member

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      Here's also a research article of biphosphonates in regards to cochlear synapses by Harvard Medical School: https://www.frontiersin.org/articles/10.3389/fnmol.2020.00087/full

      Biphosphonates have been used for cancer treatment and some other bone disease, osteoporosis, but it's been known to have very severe side effects, such as jaw necrosis (your jaw bones literally dies) and in extreme cases coma. It is quite scary.
       
    19. tommyd87

      tommyd87 Member

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      Apparently it wasn't doing enough for what they wanted it to do although apparently they got results in some patients.
       
    20. FGG
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    21. d'Wooluf

      d'Wooluf Member

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    22. xyz
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      xyz Member

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      Nice find.

      The team further suggested that their finding provides possible mechanisms that could explain why some patients in the clinic have improved their ability to recognize speech after bisphosphonate treatment.

      So if this bisphosphonate is already in use clinically this clinical trial process can be probably pushed through much faster?
      Yes, as it states in the article:

      The scientists administered bisphosphonates to mice 24 hours after noise exposure. They found that the medication had a dramatic effect at regenerating the synapses between inner hair cells and spiral ganglion neurons found in the ear, and restoring cochlear function.

      I am just wondering if this is for acute or chronic tinnitus.
       
    23. Thuan

      Thuan Member

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      Unfortunately, 24 hours is not chronic. :(
       
    24. d'Wooluf

      d'Wooluf Member

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      A previous study analysed data going back 5 years or more and found some evidence that hearing loss stabilised or slightly improved over that time. It wasn't a very rigorous study and I don't have a link to it right now. Sorry.
       
    25. xyz
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      xyz Member

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      Yes, but the ones who got treated with this bisphosphonate probably did not get treated for sudden hearing loss with it, so probably it will work also for more chronic cases. Hopefully the BDNF OTO-413 has less side effects and also repairs our synapses.
       
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    26. BBakkers
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      I've lost track of which research is going on. There is a lot going on. I can remember somoene made a nice overview of all the type of research (modulation, regeneration, etc). Do we have thread for this? Like a research track thread overview?
       
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    27. tommyd87

      tommyd87 Member

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      https://elifesciences.org/articles/55249

      upload_2020-8-18_3-1-34.jpeg

      Interesting, however it seems that this research of looking inside the cochlear has somewhat been done already by other companies such as Frequency Therapeutics. In fact it seems that many of these university based research organisations are well behind when compared to the private companies engaging in research in this sphere, though I could be wrong, and this might be novel.
       
    28. Reinier
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      • Informative Informative x 1
    29. WillBeNimble
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      WillBeNimble Member Podcast Patron Benefactor

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      Do you mean that age related hearing loss is not just hair loss, or do you mean that loss is connected to cognitive decline?

      Because a study on hearing loss and such just released makes it seem like it is just hair loss from NIHL.
       
    30. Reinier
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      Reinier Member Podcast Patron Benefactor

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      Unfortunately we keep reading that hearing loss could contribute to cognitive decline.
      I was just looking at the mechanism of age related hearing loss in this publication.

      From what I can understand, age related hearing loss is not just hair cell loss. It is much more complicated.
       

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