Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. BBakkers
      Tired

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
      I found this pretty interesting. Just like to share it.

      To compare tinnitus patients who have normal hearing between 250 Hz and 8 kHz with normal controls with regard to the ability of each group to hear extended high-frequency pure tone thresholds.

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804091/
       
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    2. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Well of course. If only more ENTs would update their knowledge on this!
       
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    3. Clmnt
      Depressed

      Clmnt Member

      Tinnitus Since:
      11/2016
      Cause of Tinnitus:
      Sound Trauma
      Why not develop an approach on ex vivo cochlea. It is not yet finalized but it could be a more ethical approach towards animals and more convincing results.
       
    4. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      An ex vivo cochlea is a better place to start for sure. But you still need to test for systemic effects. But I agree it would be better to start with expanded tissues or cell cultures first and often that's how it is done.
       
    5. Alex0o_o0
      Confused

      Alex0o_o0 Member Benefactor

      Location:
      Belgium
      Tinnitus Since:
      01/10/2018 - 04/04/2020
      Cause of Tinnitus:
      Whiplash/concussion - Sound trauma
      I know right!?

      I've added the audiogram of my tinnitus ear. When I went to see the ENT, I first saw an ENT in training who prescribed an extended audiogram. The results are quite obvious. When she went to consult with the head of the ENT department (a professor doctor nonetheless),the response of the prof was that it's useless to do an extended audiogram, because there's no literature on it's relation to tinnitus. Just another example of how much your average ENT cares about tinnitus..
       

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    6. BBakkers
      Tired

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
      Oh wow! That is crazy. I had a similar encounter yesterday. I planned to remove my earwax. This time not my usual ENT (who is really good and understanding) removed it, but a different one. We discussed tinnitus briefly. I told him my hearing looks fairly normal on a 8kHz audiogram. He then immediately starting talking that tinnitus can also arise from other things than noise trauma. He didn't even consider that the higher frequencies needs to be tested or can be the cause of it.

      Nonetheless, my audiogram looks similar to yours until the 8kHz. I planned my extended audiogram to see how my hearing is from 8kHz to 20kHz. Let's see.
       
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    7. BBakkers
      Tired

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
      The funny part is that it is a research from 2009, you thought they would have catched up by now.
       
      • Agree Agree x 3
    8. briano
      Wishful

      briano Member

      Tinnitus Since:
      09/2013
      I'm willing to bet that there would be many human volunteers.
       
    9. Alex0o_o0
      Confused

      Alex0o_o0 Member Benefactor

      Location:
      Belgium
      Tinnitus Since:
      01/10/2018 - 04/04/2020
      Cause of Tinnitus:
      Whiplash/concussion - Sound trauma
      And many who would regret volunteering afterwards. Even drugs that have gone through animal testing can cause horrible side effects, ranging from losing limbs to developing rate auto immune diseases. Take for example trobalt, which led to people turning blue, getting VS,... and this was a drug that webt through all the trials. There is a reason pharma pays big bucks for people participating to drug trials.
       
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    10. aot
      Bookworm

      aot Member Benefactor

      Location:
      USA
      Tinnitus Since:
      2016. Worsened 11/2019.
      Cause of Tinnitus:
      Probably sound induced, worsened due to noise expouse + flu.
      Like tinnitus, for example.
      Wtf. Really?
       
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    11. Alex0o_o0
      Confused

      Alex0o_o0 Member Benefactor

      Location:
      Belgium
      Tinnitus Since:
      01/10/2018 - 04/04/2020
      Cause of Tinnitus:
      Whiplash/concussion - Sound trauma
      Turning blue might be a bit of an exaggeration, but there are multiple reports of people having skin discoloration and retinal pigment abnormalities. To be honest if that would have been the only side effect and it would cure my tinnitus, I would have been running around like Papa Smurf by now :hungry:.
       
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    12. briano
      Wishful

      briano Member

      Tinnitus Since:
      09/2013
      What does VS stand for?
       
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    13. Dave111
      Breezy

      Dave111 Member

      Location:
      Nederland
      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Makeing music in band and headphone on to long.
      Visual Snow
       
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    14. fade2black244
      Inspired

      fade2black244 Member Benefactor

      Tinnitus Since:
      03/2017
      Cause of Tinnitus:
      Noise Induced
      Not to mention maybe even make their tinnitus worse. Not a chance in hell I will try it unless they've got sound science backing it before.
       
    15. DoNotGoGentle

      DoNotGoGentle Member Benefactor

      Tinnitus Since:
      10/15 got worse 11/16
      Cause of Tinnitus:
      Earbuds, inner ear infection NHL and high frequency loss
      • Informative Informative x 4
    16. BBakkers
      Tired

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
      • Agree Agree x 4
    17. thinlay
      Chicken

      thinlay Member

      Location:
      PARIS
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      syndrome of costen ? not sure
      Has your tinnitus returned to the baseline level?
       
    18. BBakkers
      Tired

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
      Nope unfortunately not.
       
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    19. serendipity1996

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
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    20. xyz

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      Conclusion
      Our original finding that Intracochlear BDNF can improve hearing in guinea pigs was confirmed, but the improvement demonstrated by the methods in this paper is too small for clinical application.

      So then this means the outlook for OTO-413 is not very good. Maybe they better should have tested how this BNDF affects tinnitus & hyperacusis.
       
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    21. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      The study also says:

      “Perhaps multiple applications, a different dose or other method would show more response. We plan to pursue a multiple dose regimen in future work.”

      Another interesting point is that they saw hearing improvement in the entire range of hearing.

      Besides, isn’t OTO-413 for hidden hearing loss instead of sensorineural hearing loss?
       
    22. xyz

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      When this BNDF gives enough hearing improvement to quieten noise induced tinnitus to some extent then this should definitely be further investigated. If this works across the whole frequency range, this would be even better. Since FX-322 so far as I understood works only in the high frequencies.
       
    23. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      Yup, it's for hidden hearing loss/synapse repair.
       
    24. Juan

      Juan Member

      Tinnitus Since:
      08/2014
      Cause of Tinnitus:
      Several causes
      I don't see how exchanging normal hearing for a cochlear implant can be good news.
       
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    25. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      That’s because the effect is more or less the same; more/restoration of auditory input.
       
    26. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Hidden hearing loss is called that because it doesn't affect your audiogram. It only makes sense they didn't see an improvement. Hair cells affect pure tone, synapses affect things like speech in noise, which can't be measured in animals.

      BDNF is for synaptopathy.
       
      • Informative Informative x 1
    27. Juan

      Juan Member

      Tinnitus Since:
      08/2014
      Cause of Tinnitus:
      Several causes
      I don't think anything can substitute, resemble, or emulate natural hearing.
       
    28. Christiaan
      Vegged out

      Christiaan Member Podcast Patron Benefactor

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Bloody headphones in 2016,worsened in 2020
      Perhaps hope on the horizon for those who have a lack of supporting cells in damaged areas of the cochlea, hopefully even for those with flat epithelia (profound hearing loss):

      Title:
      Microenvironment Can Induce Development of Auditory Progenitor Cells from Human Gingival Mesenchymal Stem Cells

      ''Here, we report the potential of GMSCs (gingival mesenchymal stem cells) to differentiate into auditory progenitor cells while supporting them with an optimized three-dimensional scaffold and certain growth factors (......) Our in vitro and in vivo studies confirmed the auditory differentiation potential of GMSCs within the engineered microenvironment''

      Link: https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.9b01795
       
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    29. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      The researcher I spoke to thought it was a solvable problem for even those with flat epithelial but her time line (15-20 years) was discouraging :(.
       
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    30. serendipity1996

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      Is Chen at Harvard working on this?
       

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