N-Acetylcysteine (NAC)

Discussion in 'Treatments' started by tweak, May 16, 2012.

    1. Greg Sacramento

      Greg Sacramento Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      April 2011
      Cause of Tinnitus:
      syringing and now somatic T dental work
      If you place - is Rosuvastatin or Crestor dangerous - into an internet search - a lot of discussion comes up.

      I didn't want to answer your question in discussion above by saying, not to use this drug, so I said - I would do what your doing. Your doing some really good stuff.

      Crestor -
      https://www.worstpills.org/results.cfm?drug_id=1025
       
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    2. all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
      -
      Cause of Tinnitus:
      -
      This is enough to put me off:

      "In summary, rosuvastatin has no proven health benefit as discussed above, it can cause potentially serious kidney toxicity that is not seen with the other statins, it is the only statin that caused rhabdomyolysis, a life-threatening adverse drug reaction, in pre-approval clinical trials, and there are already three ."

      I shall proceed as I am just losing weight, eating healthier and doing lots of exercise.
       
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    3. Fanny1

      Fanny1 Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Unknown
      So? Karen... is that you? Just kidding, I like those memes.

      :)

      I know you are being helpful, excuse my joke.

      My turmeric says one capsule too... and people are taking 5-7 times that amount... many threads on here discuss taking more. I found this.... ”There is no recommended daily allowance for NAC, because unlike vitamins, it's not an essential nutrient. The dosage used to prevent radio contrast dye damage is 600 mg to 1200 mg every 12 hours for 48 hours.”

      Having had severe tinnitus with no resolution, you try different stuff... but I draw the line at mood/mind altering meds... but that is just me. :)
       
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    4. Greg Sacramento

      Greg Sacramento Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      April 2011
      Cause of Tinnitus:
      syringing and now somatic T dental work
      From our discussion above.
      Given its complicated regime, NAC has a high potential for iatrogenic errors, including overdose.[15] A 23-year-old female developed hemolysis, thrombocytopenia, metabolic acidosis and acute renal failure after NAC overdose. She erroneously received 100 gm instead of 10 gm of NAC. She then required daily hemodialysis but eventually died after developing hemolytic uremic syndrome.[16] Another case report describes a 20-year-old female, who developed hemolysis and elevated serum bilirubin. She improved with supportive measures, and her liver function tests and anemia improved within a few days.[17] Massive accidental NAC administration in the order of 100 mg/kg/hr had resulted in cerebral edema, seizures, uncal herniation and permanent brain injury in another patient with APAP overdose.[18]

      https://www.ncbi.nlm.nih.gov/books/NBK537183/

      This article discusses NAC for Toxicity - Emergency ER procedure guidelines for using NAC for toxicity go back decades. NAC is being used for more toxic indications now within large trauma ERs in the USA.
       
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    5. Fanny1

      Fanny1 Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Unknown
      Yikes... ok thanks. I’m taking at most 1.8 grams... but I do appreciate the warning. :)
       
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    6. Thuan

      Thuan Member

      Location:
      California
      Tinnitus Since:
      05/2018
      Cause of Tinnitus:
      Ear infection right ear 2018. Sound trauma left ear 2020.
      Did anyone who have taken NAC experience runny nose (like allergies)? It's so weird. I thought it was my allergies acting up but the runny nose only happens from 10 minutes after taking the NAC pill that lasts one or two hours. My normal allergies happen throughout the whole day, not just an hour or two. Also, tinnitus seems to have spiked a little.
       
    7. wwtsai
      Assassinator

      wwtsai Member Podcast Patron Benefactor

      Location:
      San Francisco
      Tinnitus Since:
      Mild (2016) Bothersome (8/20)
      Cause of Tinnitus:
      SNHL
      Have you continued taking NAC? Has there been any noticeable change in your tinnitus at all?
       
    8. Thuan

      Thuan Member

      Location:
      California
      Tinnitus Since:
      05/2018
      Cause of Tinnitus:
      Ear infection right ear 2018. Sound trauma left ear 2020.
      I stopped taking NAC after getting stomach ache and tinnitus spikes afterwards. It did not help my tinnitus.
       
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    9. Zaccq

      Zaccq Member

      Tinnitus Since:
      6/2020
      Cause of Tinnitus:
      Unknown
      What do people think about taking
      glucoraphanin+myrosinase supplements, this then increases sulforaphane concentrations in the body, which activates NRF2 which then increases NAC production?
       
    10. Zaccq

      Zaccq Member

      Tinnitus Since:
      6/2020
      Cause of Tinnitus:
      Unknown
      Also just a comment, I find taking smaller doses of NAC more often during the day, e.g. during meals, is better than taking one large dose once a day.

      This less likely causes side effects like an upset stomach, and is more therapeutic as it more consistently remains in the bloodstream.

      Thoughts?
       
    11. Steph1710
      Old hag

      Steph1710 Member Podcast Patron Benefactor Ambassador Hall of Fame

      Location:
      England
      Tinnitus Since:
      08/04/2020
      Cause of Tinnitus:
      Antibiotics - I think
      I've been taking NAC 600mg a day since April 2020, and for me it definitely reduces my tinnitus.

      Stopping it even for a few days, my tinnitus becomes much more noticeable.

      I've taken a plethora of vitamins/supplements, and NAC is the only one which does anything for me.

      We're all so different.
       
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    12. AnxiouslyWaiting
      No Mood

      AnxiouslyWaiting Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Anxiety maybe?
      Do you take it in the morning or at night? I think it might give me spikes but I’m not sure.
       
    13. Steph1710
      Old hag

      Steph1710 Member Podcast Patron Benefactor Ambassador Hall of Fame

      Location:
      England
      Tinnitus Since:
      08/04/2020
      Cause of Tinnitus:
      Antibiotics - I think
      I take it in the morning with my breakfast.

      I believe (or so I've been told) it's suppose to help protect your hearing rather than reduce the tinnitus - though I could be completely wrong.

      However, it definitely does reduce mine.
       
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    14. Zaccq

      Zaccq Member

      Tinnitus Since:
      6/2020
      Cause of Tinnitus:
      Unknown
      I am finding some days are better than others, but my tinnitus is slowly improving and NAC could be one thing assisting in this. But I do caution against taking too much of it because I broke out in a chicken-pox like rash because I took too much.
       
    15. wwtsai
      Assassinator

      wwtsai Member Podcast Patron Benefactor

      Location:
      San Francisco
      Tinnitus Since:
      Mild (2016) Bothersome (8/20)
      Cause of Tinnitus:
      SNHL
      How much was too much for you?
       
    16. Zaccq

      Zaccq Member

      Tinnitus Since:
      6/2020
      Cause of Tinnitus:
      Unknown
      I went through 150g in something like 2-3 weeks. That was way too much, but it's easy to do.

      It recommends 1g a day.
       
    17. wwtsai
      Assassinator

      wwtsai Member Podcast Patron Benefactor

      Location:
      San Francisco
      Tinnitus Since:
      Mild (2016) Bothersome (8/20)
      Cause of Tinnitus:
      SNHL
      I saw in another post that NAC was giving you chest/back pain. Is that still the case?
       
    18. Steph1710
      Old hag

      Steph1710 Member Podcast Patron Benefactor Ambassador Hall of Fame

      Location:
      England
      Tinnitus Since:
      08/04/2020
      Cause of Tinnitus:
      Antibiotics - I think
      Turns out it was the curcumin! Not the NAC.
       
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    19. wwtsai
      Assassinator

      wwtsai Member Podcast Patron Benefactor

      Location:
      San Francisco
      Tinnitus Since:
      Mild (2016) Bothersome (8/20)
      Cause of Tinnitus:
      SNHL
      Thanks! Just took my first 600mg pill and was concerned lol.
       
    20. T_Almost_Gone
      Mellow

      T_Almost_Gone Member Benefactor

      Tinnitus Since:
      March 2020
      Cause of Tinnitus:
      Bupropion nalextrone
      In the last 4 days I doubled my NAC dose to 1200 mg per day & my tinnitus is at the lowest its ever been.

      Yesterday I didn't take the tablet until 1 p.m. so later than my usual in the morning and and I'm quite sure that my tinnitus increased slightly.

      I've come here to share my experience with NAC. Overall I've been experiencing a very slow downward trend where the volume decreases slightly about every 6 weeks. So it's possible that my volume was going to decrease anyway.

      But I do think that NAC is making a difference. Potentially as mine was closed by antidepressants -- supposedly this helps the neurotransmitters balance. I've ordered a bottle of 120 so let's see
       
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    21. wwtsai
      Assassinator

      wwtsai Member Podcast Patron Benefactor

      Location:
      San Francisco
      Tinnitus Since:
      Mild (2016) Bothersome (8/20)
      Cause of Tinnitus:
      SNHL
      Did you notice any benefit while taking the original 600 mg dosage? Also, did the effect on your tinnitus happen instantly or did it take some time? Asking because I'm up to day 3 on 600 mg and haven't really noticed any change so far.
       
    22. T_Almost_Gone
      Mellow

      T_Almost_Gone Member Benefactor

      Tinnitus Since:
      March 2020
      Cause of Tinnitus:
      Bupropion nalextrone
      Hi there, best thing is to read through my own thread. I've posted regular updates from when I first got tinnitus. Because my volume has steadily slowly declined over time it's hard to be objective. But there is a good chance that when I doubled my dose that's when I saw marked results. On 600 mg along with the other supplements I was taking I don't think there was an impact. Especially as I would forget to take my supplements sometimes for days at a time.

      But when I doubled the NAC dose I noticed quietening. In fact the reason I logged on today was to post another update; the volume has slightly reduced again.
       
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    23. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      It’s supposed to regulate levels of Glutamate which should decrease tinnitus, but it spikes me, not sure why...
       
    24. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      Why not just take Sulforaphane or NAC directly?
       
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    25. Juan

      Juan Member

      Tinnitus Since:
      08/2014
      Cause of Tinnitus:
      Several causes
      Hi Steph, did you decide to try NAC by yourself or was it prescribed by your doctor? Which specific brand are you taking?
       
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    26. Steph1710
      Old hag

      Steph1710 Member Podcast Patron Benefactor Ambassador Hall of Fame

      Location:
      England
      Tinnitus Since:
      08/04/2020
      Cause of Tinnitus:
      Antibiotics - I think
      Hi Juan.

      No advice from doctor. I just decided to take it myself.

      The brand I buy is from a store in England called Holland & Barrett.

      Steph
       
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    27. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      So from what I read, this seems to be the most consistently effective supplement. I'm giving 1200 mg a day a shot for my hyperacusis, hopefully this will decrease the intensity of spikes and setbacks.
       
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    28. Zaccq

      Zaccq Member

      Tinnitus Since:
      6/2020
      Cause of Tinnitus:
      Unknown
      Sulforaphane degrades very quickly.

      Our bodies produce and regulate NAC, Sulforaphane apparently increases production.

      However I now don't think it's worth doing, just a small amount of NAC is enough.
       
    29. B18c1vtech

      B18c1vtech Member

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Head Trauma??, poor diet, sleep, stress, etc..
      What's the best dosage of NAC for acoustic trauma?

      I have 600mg NAC capsules. Should I take two, despite the bottle saying to take one? Is it worth going up to 1000mg capsules?
       
    30. Kendra

      Kendra Member

      Tinnitus Since:
      08/2017
      Cause of Tinnitus:
      SSNHL/ Acoustic Trauma
      Not sure but I’ve taken 2x 600mg and have been fine.
       
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