Naltrexone as a Tinnitus Treatment

Discussion in 'Treatments' started by Bill Bauer, Nov 27, 2017.

    1. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      He said he's been continuing on 25 mg and his tinnitus has been lower at a 2/10.
       
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    2. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Hall of Fame Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      12/2013
      Are you also considering taking it? LDN or higher dose Naltrexone? I can't make up my mind there.
       
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    3. Wrfortiscue
      Cowabunga

      Wrfortiscue Member Benefactor Hall of Fame

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Trauma
      Damn, maybe I should take this...
       
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    4. Jerad

      Jerad Member

      Location:
      Ohio; United States
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Medication ototoxicity
      I was considering Naltrexone as a good option for my tinnitus, but I see some have bad experiences with it. In the LDN thread, a user reported the above reaction, which was quite bad. This is why tinnitus is such an evil disorder — pretty much every single option for treating it is like playing Russian roulette. And you risk permanent worsenings. Trying something to just see if it works is like playing a deadly game.
       
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    5. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      I'll see if my ENT will prescribe it on the 7th of April. I'll start low and move to 25 mg if I don't see results.
       
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    6. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
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    7. Johnny Karate
      Barefooter

      Johnny Karate Member

      Location:
      USA
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Zoloft, Viagra, Naproxen, loud noises for years
      I take 25 mg a night. Half a 50 mg pill.
       
    8. Johnny Karate
      Barefooter

      Johnny Karate Member

      Location:
      USA
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Zoloft, Viagra, Naproxen, loud noises for years
      I had some panic attacks. I cut out a lot of caffeine and started moving my OMAD to lunch instead of supper. Eating made the anxiety I was experiencing around noon go away.

      I have had some stomach pains that only last a second or so. I can fall asleep much easier than prior.... which is awesome. I have felt some slight depressive moments but I have suffered from depression and anxiety in the past, so I know how to handle when these things try to creep up on me. These are all common side effects from the meds.
       
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    9. blamingeverything

      blamingeverything Member Benefactor

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      high frequency hearing loss
      Given your experience with anxiety and depression, and I can speak from experience here too, it becomes pretty difficult to delineate what anxieties would have been present with/without the meds, right?
       
    10. Johnny Karate
      Barefooter

      Johnny Karate Member

      Location:
      USA
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Zoloft, Viagra, Naproxen, loud noises for years
      Well I was 100% anxiety free for around 13 years prior to having panic again. They have all been medicine induced. The other medication that induces panic and depression for me is steroids, and I wake up to panic with sleeping meds like night time cough syrup. So for me it is a stark contrast.
       
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    11. blamingeverything

      blamingeverything Member Benefactor

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      high frequency hearing loss
      Good context, thanks!
       
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    12. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Hall of Fame Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      12/2013
      I hope you get relief. Let us know how you go.
       
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    13. danielthor

      danielthor Member

      Location:
      Denmark
      Tinnitus Since:
      04/2020
      Cause of Tinnitus:
      Unknown
      My doctor accidentally prescribed me regular Naltrexone instead of my usual low dose. It comes in 75 mg pills and I’m thinking of trying it just because I’m running out of options anyway with regards to brain-inflammation-disorder-thingy, and plus I won’t get my LDN because my doctor is busy as fuck and takes weeks to reply.
       
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    14. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      Thanks. I ended up getting a pair of Widex hearing aids today. I have mild hearing loss but the tinnitus masking features and the ability to connect the hearing aids to a TV are great to cover the multiple tinnitus tones.

      Still going to see an ENT for more ideas since I'm only 2 months in.

      I ordered Psilocybin mushrooms as a last resort.
       
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    15. Johnny Karate
      Barefooter

      Johnny Karate Member

      Location:
      USA
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Zoloft, Viagra, Naproxen, loud noises for years
      I got you bro. Follow these instructions:

      https://altarp.com/how-to-prepare-low-dose-naltrexone-ldn/

      Did it myself once and still have it in the fridge... I guess I'll take 25 ml of it tonight so it doesn't go to waste. I was going to do LDN and just switched back to 25 mg pills.
       
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    16. flashoverride

      flashoverride Member

      Tinnitus Since:
      2003
      Cause of Tinnitus:
      Generators and Guns
      Hey all, recently got prescribed Naltrexone for alcohol abuse (trying to quit for good again) and was doing some research on it and ran across some of the threads on here. Anyone had any experience with the regular dose (25/50 mg)? Most of what I saw was low dose.

      I've had tinnitus permanently since at least 2003, thanks to being young and stupid. Both constant exposure to generator/ECU noise in communication centers and trailers and exposure to 120 dB+ impulse noise from firing automatic weapons (including inside buildings).

      Most days I'd say I'm at a 5/10 or so, but even though the intensity changes it's OMNIPRESENT. The usual crap makes it worse - caffeine, lack of sleep, etc. I spent a long time drinking myself to sleep. I'm in a better place mentally now, but I've had days that were REALLY not good. Just couldn't bear the thought of leaving my kids with something like that.
       
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    17. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Hall of Fame Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      12/2013
      You could try the higher dose since Johnny Karate has experienced significant relief from taking higher doses as documented on this thread.

      But if you want to still do the LDN, you can do this by using this formula:

      Stock required/stock strength x volume/1.
       
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    18. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Hall of Fame Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      12/2013
      Congratulations for your decision to address your alcohol addiction.

      If you scroll up, you will see Johnny Karate's significant improvement using higher doses of Naltrexone (25 mg) for his severe tinnitus.

      I don't know of anyone here on the forum who has taken higher doses that you would be prescribed.

      Prof. Dirk De Ridder has written a paper noting that higher doses of Naltrexone can lower the distress of tinnitus.

      A friend of mine has significant relief from using 1 mg LDN - she believes hers is inflammatory/hormonal as she previously responded also to steroids and Curcumin.
       
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    19. danielthor

      danielthor Member

      Location:
      Denmark
      Tinnitus Since:
      04/2020
      Cause of Tinnitus:
      Unknown
      Thanks, but I’m not exactly sure what you mean by this. Could you elaborate?
       
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    20. Blix M. Paraglot

      Blix M. Paraglot Member

      Tinnitus Since:
      mild since 90s - serious since 2000s
      Cause of Tinnitus:
      Loud music.
      @Johnny Karate, you weren't kidding about these side effects. After a few days of Naltrexone (titrating up from a very low dose, 1/4 of a 50 mg pill, still only taking 12.5 mg a day so far) I have already thought about quitting the stuff. One very bad spike that lasted an hour, heart pounding, feeling like I want to come out of my skin. But you've been through all this. It looks like you went into remission and rode off into the sunset. You haven't been seen here since 1 April.

      My tinnitus and hyperacusis are dire. I was coping okay last year but my loud tinnitus cranked itself up louder and my H is so bad I feel lucky I can still work (but only part time now). I am willing to go through side effects if this medication might save me. Every few years I must be reminded that I am very sensitive to medications, particularly those with neurological effects. I am holding on tight. Something has to work, because otherwise, I feel like I am backed up to the edge of a steep drop.
       
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    21. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Hall of Fame Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      12/2013
      Example:

      Stock required = 1mg/stock strength = 25mg× volume = 25ml/ x1

      Therefore, 1 ml = 1 mg.

      I hope that makes sense.
       
    22. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Hall of Fame Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      12/2013
      I'm sorry this is happening to you.

      I spoke to @Johnny Karate today. He is still doing well on 25 mg.

      But, I know he had a hard time with the return of panic attacks and a few spikes along the way.

      Since it modulates serotonin and dopamine pathways, I'm not surprised panic and spikes can occur.

      I know he stopped Naltrexone for a few days after a panic attack, and decided to go back on it. He said he felt eating around the time he took the drug seem to stop any panic attacks.
       
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    23. Blix M. Paraglot

      Blix M. Paraglot Member

      Tinnitus Since:
      mild since 90s - serious since 2000s
      Cause of Tinnitus:
      Loud music.
      Thank you, @DebInAustralia. I feel fine this morning, and I calmed down a bit after posting yesterday. I was fearing a night of insomnia, but I slept surprisingly well last night. The worst effect was the first two hours or so after I took the dose. Suddenly my tinnitus perception went from all over / everywhere to a sharp focus that seemed to have a specific location, at the base of my skull. Like it was a needle poking me there, but auditory, if that makes any sense. And it was louder. And I felt like I was tripping, at least for the first two hours. Hyper-awareness, wanting to clamp my jaw shut.

      I am glad you are in touch with @Johnny Karate. I am keeping his success story in the front of my mind, and the details of the study at the beginning of this thread. I intend to carry on with this. The side effects are frightening in the moment, but I have been through worse. My body can adapt to this.

      I take a low dose beta blocker at bedtime for hypertension. I'm planning on taking one with my Naltrexone dose today, to soften the edge. I'm supposed to take two a day anyway, but usually only take one.
       
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    24. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      I tried 25 mg for about 10 days, which did nothing for me personally. Tried dropping to 12.5 mg but no change. I did not try LDN doses. I'm sure it works for some people but just wanted to add my data point.

      I had no anxiety or other side effects.
       
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    25. Johnny Karate
      Barefooter

      Johnny Karate Member

      Location:
      USA
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Zoloft, Viagra, Naproxen, loud noises for years
      I just happened to drop by the forum today out of boredom. I would like to report to you that those side effects went away after around 2 weeks. I am back to drinking 2 to 3 cups of coffee in the morning, Red Bulls on the weekends and also back to OMAD for supper. The anxiety went away completely. I still on rare occasion get a quick stomach pain/cramp low in the gut. That is my only side effect now. It's like eating a Tic Tac. I almost gave up twice because of those very same side effects. The panic WAS BRUTAL although short lived. I empathize with you and hope your side effects subside quickly.
       
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    26. blamingeverything

      blamingeverything Member Benefactor

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      high frequency hearing loss
      Interesting. So you're getting good effects on your tinnitus?
       
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    27. Johnny Karate
      Barefooter

      Johnny Karate Member

      Location:
      USA
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Zoloft, Viagra, Naproxen, loud noises for years
      Yes. I have no plans to stop taking Naltrexone at this time. I'm starting to wonder if doubling the dose might silence my tinnitus after some time. I doubt it, but who knows really.
       
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    28. Jerad

      Jerad Member

      Location:
      Ohio; United States
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Medication ototoxicity
      @Johnny Karate, your tinnitus sounds similar to mine. It’s such a high frequency that it’s heard over everything. But worst thing about it is that it hurts, too. It’s not just a sound, but a feeling, too. Feels like electricity zapping. It’s a pulsating noise like 2 knives being sharpened against one another. Feels like it’s cutting into the nerves or something. Such pressure and force. Sometimes, it sounds like cicadas or hissing, but it’s in a wave form, up and down constantly. It’s not one volume. And then there are bursts of electricity (zaps). Some describe this, I think, as the train breaks squealing sound. Not sure that their sounds hurt, though.

      Did yours “hurt” the same way as mine prior to Naltrexone? And if so, has that subsided with the improvement?

      Thanks for the help.
       
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    29. blamingeverything

      blamingeverything Member Benefactor

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      high frequency hearing loss
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    30. Marshall

      Marshall Member

      Location:
      ND
      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      Not sure/virus/noise trauma/cumulative noise damage
      Sounds exactly like mine to the T except no pain but I get pinging zapping as well.
       
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