New University of Michigan Tinnitus Discovery — Signal Timing

Discussion in 'Research News' started by Hudson, Jun 20, 2013.

    1. DoNotGoGentle

      DoNotGoGentle Member Benefactor

      Tinnitus Since:
      10/15 got worse 11/16
      Cause of Tinnitus:
      Earbuds, inner ear infection NHL and high frequency loss
      I don't think it will be a cure it might lower the sound. Help people get some silence back. It is helpful that this is from a university study. The study I believe was partly funded by ATA American Tinnitus in 2013. Cheers mate!!
       
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    2. RonnieCarzatto
      Cynical

      RonnieCarzatto Member

      Location:
      Canada
      Tinnitus Since:
      Feb 01 2017
      Cause of Tinnitus:
      Mild head injury maybe... but who knows...
      I'm sure a lot of people with eye problems were sold different gadgets and pills, etc.. Eventually, here you now have Lasik clinics everywhere. It's a trial and error.
       
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    3. RonnieCarzatto
      Cynical

      RonnieCarzatto Member

      Location:
      Canada
      Tinnitus Since:
      Feb 01 2017
      Cause of Tinnitus:
      Mild head injury maybe... but who knows...
      A participant who travelled to Michigan and was part of a study for this posted his experience on Reddit:

      "It was a double blind crossover model, so everyone got the real treatment and the sham treatment at separate times. I was not unblinded following the experiment. However, I felt that I reacted moderately to one of the two periods and not the other, and this was reflected in both my THI scores as well as, I believe, objective volume matching performed in the lab.

      They were able to tell me that some people responded to both the experimental protocol as well as the sham protocol, some people did not respond to either, and some people responded to the real treatment but not the sham treatment. Further, no one responded to the sham treatment and not to the real treatment. Therefore, since I responded to one and not the other, I responded to the experimental protocol.

      My tinnitus did not disappear, but my ratings for volume decreased moderately, and my ratings for distress plummeted as a result. The effect wore off after a couple days of not using the device.

      I have had other periods where my T has been less significant, unrelated to any treatment -- but the 2-3 weeks that it seemed to be working, it did so much more consistently, and in some cases dramatically, than it does in general.

      Worth noting that I spent some amount of time and money traveling regularly from DC to MI to participate, so I have a bias in that I want to believe this is a real thing. The animal data is pretty compelling to me, though."​


      This same user also posted their tinnitus background on the same page on reddit:

      "14khz CRT-monitor whine, predominantly on my left side, where I also (shockingly, I know) have a dip in my hearing thresholds around 14khz. Other tones and sounds, too, but that one is the only one that consciously bothers me.

      I can only guess, but I believe it's some combination of noise exposure, chronic anxiety, TMJ, and possibly exposure to and withdrawal from drugs including benzos, SSRIs and Wellbuterin. The thing which really made it bad was a single concert without hearing protection, attended during an extremely stressful period... but the anxiety of all that drove me back to benzos, and the tinnitus didn't really set in as a chronic thing until I withdrew from the benzos again a couple years later. I was also a premature baby with a bunch of serious childhood ear infections. So your guess is as good as mine."​
       
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    4. SilverSpiral
      Sad

      SilverSpiral Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      ACOUSTIC TRAUMA
      I want to try it.
       
    5. Rubenslash

      Rubenslash Member

      Location:
      Zurich
      Tinnitus Since:
      04/2016
      Cause of Tinnitus:
      Bad luck and bad decisions
    6. Wojtek Kalka
      Badass

      Wojtek Kalka Member Benefactor

      Location:
      Bangkok
      Tinnitus Since:
      1994
      Cause of Tinnitus:
      Very loud concert.
      Price, availability ever?
       
    7. RonnieCarzatto
      Cynical

      RonnieCarzatto Member

      Location:
      Canada
      Tinnitus Since:
      Feb 01 2017
      Cause of Tinnitus:
      Mild head injury maybe... but who knows...
      @Wojtek Kalka, I believe more clinical testing will be done later this year, and from what I understand, there weren't many people tested the first time around. That's an encouraging post on Reddit there however one must be patient for these things.
       
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    8. Markku
      Inspired

      Markku Founder Staff Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      04/2010
      Cause of Tinnitus:
      Syringing
      Yes, this was the latest we got in January this year:
      As per above, international patients wouldn't be able to participate. (Assuming you don't have US citizenship).
       
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    9. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      STOP DOXXING MY REDDIT POSTS NOW YOU GUYS WILL KNOW HOW MUCH TIME AND MONEY I SINK INTO MAGIC THE GATHERING CARDS
       
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    10. DoNotGoGentle

      DoNotGoGentle Member Benefactor

      Tinnitus Since:
      10/15 got worse 11/16
      Cause of Tinnitus:
      Earbuds, inner ear infection NHL and high frequency loss
      Would you take part in the next trial?
       
    11. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      Well, at the time of the last trial, I was living with good airport access (and direct flights to MI) in a loud city I disliked, with no real responsibilities other than work which is something I can do remotely from anywhere with an internet connection. If I was in that same situation, I'd absolutely do it again -- I did ultimately spend maybe $4-5000 on the travel related to the trial, but, I used it as an excuse to do some sightseeing in Michigan, scope out Ann Arbor as a potential place to live, and reconnect with a college friend.

      However, my life circumstances have changed dramatically. I am now in a quiet, woodsy place that I adore, and became a father within the last year. Thus, my free time, and money, needs to be allocated pretty differently -- and I am now much further from a regional airport, which would mean longer, more complicated flight plans.

      If there is another trial, they have told me they would like to have me in it since it sounds like I was one of the better responders... but that will depend a lot on where it is and what's involved in getting there.
       
    12. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      I have a fairly solid grasp on what would be involved in constructing a device that functions as theirs does, and I think it's something that any third-year compsci or eleceng student could cobble together. However, testing that the device output is to spec is a much more complicated problem. I know enough about good test design to understand the difficulties there, and conceptually what would need to be done to test it... but I'm a software guy, and the test obstacles here are purely hardware oriented. Put simply, the device itself could be made with a $200 aurdino kit and 40 hours of aurdino coding. Testing it would require being able to connect it to a much more sophisticated computer capable of analyzing the audio and electrical output of the device, and ensuring they are synchronized to less than 1-millisecond accuracy. That's not "put a man on the moon" level difficulty, but it's a hell of a lot harder than anything I've ever had to design.

      If you were off by some small margin, and if the device design itself is sound, then you would expect that using it would actually increase tinnitus activity (based on what the people involved in the study told me). Additionally, even thinking about this, is flirting with conspiracy to commit patent fraud or something. I'm not an IP lawyer; I think it's possible that one could make something like this for oneself using publicly available data and not be too worried about it, but the second you think about selling it or probably even giving it away, you can (and should) be sued into oblivion.
       
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    13. Alue
      No Mood

      Alue Member

      Tinnitus Since:
      01/2016
      Cause of Tinnitus:
      Acoustic Trauma
      HAHA I was pretty sure I knew it was you long before seeing that post. I have multiple reddit accounts. :)
       
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    14. Nick07
      Balanced

      Nick07 Member

      Tinnitus Since:
      10/2016
      Cause of Tinnitus:
      possibly noise or unknown
      linearb it's nice to see another magic player on here
       
    15. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      what are your formats of choice and do you play on MTG Online? :D
       
    16. Nick07
      Balanced

      Nick07 Member

      Tinnitus Since:
      10/2016
      Cause of Tinnitus:
      possibly noise or unknown
      I play mostly modern and some limited. I haven't played MTG Online in years.
       
    17. Marlino
      Cowboy

      Marlino Member

      Location:
      Germany
      Tinnitus Since:
      02/2016
      Cause of Tinnitus:
      unknown
      This thread is interesting.
      I also have this somatic kind of tinnitus, which is very weird. I suspect it to be nerve compression and pressing on the jaw, yawning etc presses even more on the already irritated nerve and by this altering my t. Currently trying pregabaline, since it can be used for trigeminus neuralgia.
      The effect is unconclusive. It might help. I will increase the dosage to say for sure.

      But this alternative DCN theory makes also sense to me for some reasons...
       
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    18. DoNotGoGentle

      DoNotGoGentle Member Benefactor

      Tinnitus Since:
      10/15 got worse 11/16
      Cause of Tinnitus:
      Earbuds, inner ear infection NHL and high frequency loss

      Yeah DCN! Also check this video out if you have not.
      Americans afflicted with 'phantom...
       
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    19. Marlino
      Cowboy

      Marlino Member

      Location:
      Germany
      Tinnitus Since:
      02/2016
      Cause of Tinnitus:
      unknown
      I've to say you are a hero. Congratulations!
       
    20. Marlino
      Cowboy

      Marlino Member

      Location:
      Germany
      Tinnitus Since:
      02/2016
      Cause of Tinnitus:
      unknown
      Can you provide more details? When I google for Mute Button, many people seem disappointed with the first version. So you were in the trial for the second version right? What was your impression, is it a promising therapy?
       
    21. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      @davidamee86 the U of M researchers told me that despite being bimodal devices, the mutebutton tech is fundamentally different than what U of M is doing. I'm afraid I don't remember the details
       
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    22. DoNotGoGentle

      DoNotGoGentle Member Benefactor

      Tinnitus Since:
      10/15 got worse 11/16
      Cause of Tinnitus:
      Earbuds, inner ear infection NHL and high frequency loss
      We might have treatment for regrowing ear hair cells and synaptic connections and then we have this device. Sounds like we have have hope for future. Don't give up people!!!! Rise up and press on!!!!
       
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    23. RonnieCarzatto
      Cynical

      RonnieCarzatto Member

      Location:
      Canada
      Tinnitus Since:
      Feb 01 2017
      Cause of Tinnitus:
      Mild head injury maybe... but who knows...
      @DoNotSoGentle Love your optimism. Be cautious though. But still, it is a new age.
       
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    24. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Good on him having hope it's what keeps me going !
       
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    25. DoNotGoGentle

      DoNotGoGentle Member Benefactor

      Tinnitus Since:
      10/15 got worse 11/16
      Cause of Tinnitus:
      Earbuds, inner ear infection NHL and high frequency loss
      "might have" is the key word ;)
       
    26. RonnieCarzatto
      Cynical

      RonnieCarzatto Member

      Location:
      Canada
      Tinnitus Since:
      Feb 01 2017
      Cause of Tinnitus:
      Mild head injury maybe... but who knows...
    27. davidamee86
      Breezy

      davidamee86 Member Benefactor

      Location:
      Co. Clare, Ireland
      Tinnitus Since:
      Nov 2015
      Cause of Tinnitus:
      Road Accident
      They seem to be fairly similar though. Both used headphones to stimulate the auditory neurons and both use an electrical stimulation to excite either the tongue or the face which stimulate neurons which seem to run past or around the auditory neurons. The researcher in Dublin told me it was all about timing more than anything else.
       
    28. davidamee86
      Breezy

      davidamee86 Member Benefactor

      Location:
      Co. Clare, Ireland
      Tinnitus Since:
      Nov 2015
      Cause of Tinnitus:
      Road Accident
      I would give it a 5 out of 10. I used to wear it for an hour. For most of the therapy I did 30 mins in the morning and 30 at night. Once I would take it off my tinnitus was much sharper and probably a little bit worse but near the end of the therapy I started doing it just before I would go to bed for a full hour and I often woke up and the tinnitus would start flickering on and off. Unfortunately it never stayed off but it reduced my tinnitus by like 25% and also if was to use it again I would keep using it just before bed because it seemed to be making a slow and steady improvement.
       
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    29. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      Hi @davidamee86! Has your tinnitus reduction of 25% persisted to date following your trial with the Mutebutton? Would it have reduced further and permanently, with continued use, in your opinion? I'm interested to know how it's been for you since then.
       
      • Good Question Good Question x 1
    30. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      @DoNotGoGentle, did you end up speaking to Susan Shore's office in May? Have they published any new trial outcomes as far as you're aware and is she still planning on further trials this year? They've been very quiet over there of late.
       
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