New University of Michigan Tinnitus Discovery — Signal Timing

Discussion in 'Research News' started by Hudson, Jun 20, 2013.

    1. Bambam0
      Cool

      Bambam0 Member Podcast Patron Benefactor

      Tinnitus Since:
      2/2018
      Cause of Tinnitus:
      Drums/Guns/Motorcycles
      I've been watching Republic campaigns pretty closely as my company is preparing to launch one with them. I bet this thing raises a TON. They're pretty strict about who they accept. Lol that said - this company, which allows pets to communicate with their owners has raised $400k. Imagine how much a company claiming to treat a huge problem with no current solution on the market can raise ;) Very excited to see this launch.
       
      • Informative Informative x 1
    2. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Unfortunately I wouldn’t be surprised if that company generated more funding than Dr. Shore's device!
       
      • Agree Agree x 2
    3. Bambam0
      Cool

      Bambam0 Member Podcast Patron Benefactor

      Tinnitus Since:
      2/2018
      Cause of Tinnitus:
      Drums/Guns/Motorcycles
      Bet!
       
    4. Suaimhneach

      Suaimhneach Member

      Location:
      Ireland
      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Unknown
      I was wondering the same, plus would it allow us to "jump the queue" when it comes to launch. I'll try and back it with a few quid anyway!
       
    5. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      I’m really being sarcastic but honestly only the people who suffer from tinnitus care about it.
       
      • Agree Agree x 2
    6. Bambam0
      Cool

      Bambam0 Member Podcast Patron Benefactor

      Tinnitus Since:
      2/2018
      Cause of Tinnitus:
      Drums/Guns/Motorcycles
      Lol me too. Did you email the CEO?
       
    7. Suaimhneach

      Suaimhneach Member

      Location:
      Ireland
      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Unknown
      The CEO's LinkedIn says he has been working with the company for the last two years. I wonder what he has been up to.
       
    8. Harder Calm
      Frustrated

      Harder Calm Member Benefactor

      Location:
      Europe
      Tinnitus Since:
      02/2021
      Cause of Tinnitus:
      Stress
      Not sure if this was posted before, but here's an interesting link mostly on Lenire, and also a comparison with Shore/Auricle:

      https://www.scientificamerican.com/...ent-alleviates-annoying-ringing-in-the-ears1/

      In particular I found that comparison is interesting, e.g.:

      “You can think of it as two ways to treat tinnitus,” Lim says. “One is you can try to find [the tinnitus cells] and shut them down.

      Our approach is to make everything in the auditory system much more hyperactive to everything but the tinnitus.”
       
      • Informative Informative x 4
    9. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
      "Shut them down" or actually reset them? I prefer Susan Shore's approach.
       
      • Agree Agree x 1
    10. antonio77

      antonio77 Member

      Tinnitus Since:
      1991
      Cause of Tinnitus:
      unknown
      “You can think of it as two ways to treat tinnitus,” Lim says. “One is you can try to find [the tinnitus cells] and shut them down.

      Our approach is to make everything in the auditory system much more hyperactive to everything but the tinnitus.”

      I prefer the 1st option. I am afraid that everything will be stimulated and, since it is not a perfect device, the tinnitus will also be stimulated. That means that with Lenire it can get worse. Better try to turn off the tinnitus cells.
       
    11. DimLeb

      DimLeb Member

      Tinnitus Since:
      14/03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy Or Maybe Loud Music
      What I understand is that it will only work for those who have a defined frequency? I mean there are a lot of people who have multiple sounds, broadband noise, hissing or tones that are just way too hard to pinpoint. So sad if that's the case...
       
    12. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
      Susans Shore's device? Fuck that - it will work for everyone.
       
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    13. DimLeb

      DimLeb Member

      Tinnitus Since:
      14/03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy Or Maybe Loud Music
      @Uklawyer, yes, I sure hope so! Even though I live in a European country that only god knows if and when I may get it lol.

      But the whole "program the device to each patient's case" sounds like there may be issues designing the sounds to match one's specific tones. Especially when it's not just one frequency. Even I, a music producer / sound engineer for years, have a lot of difficulty recreating my multi-tone+hissing and still haven't managed.

      I just can't imagine a person, not familiar with sound design, describing to an audiologist, doctor (?) precisely what their tinnitus sounds like...
       
      • Agree Agree x 4
    14. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Where did you come up with that?
       
      • Good Question Good Question x 1
    15. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      I don’t know of course, but it would seem that as long as the portions of your audiological system that express your tinnitus can be stimulated then this should work.
       
    16. DimLeb

      DimLeb Member

      Tinnitus Since:
      14/03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy Or Maybe Loud Music
      Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts

      "The auditory stimulus will be individualized based on subject baseline audiogram and tinnitus test results and is presented through a calibrated earphone."

      This is what the research paper says. I may misunderstand this though, and it just means that they use a more broad range of stimulus, rather than one's exact tinnitus sounds. If anyone knows more, I'd be glad for more info!
       
    17. Suaimhneach

      Suaimhneach Member

      Location:
      Ireland
      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Unknown
      There are enough Europeans on this forum that we should probably just rent a private plane to fly over when it launches - pick me up last! :LOL:
       
      • Genius Genius x 1
    18. Harder Calm
      Frustrated

      Harder Calm Member Benefactor

      Location:
      Europe
      Tinnitus Since:
      02/2021
      Cause of Tinnitus:
      Stress
      Yes, it seems a lot more like the right thing to do, even though I wonder how it works differently on a technical level! Another difference of course is jaw/neck stimulation vs. tongue. Again, it seems plausible since quite a few people seem to be able to influence it by jaw/neck movements. Well, at least I hope this approach is more refined then Lenire, which apparently got some mixed feedback...
      Yes, fully agree, I guess that's where the main challenge is. The technique of bimodal stimulation (playing tones + electrical stimulation) seems rather simple, but how it is actually done could make the difference between improving things or making things worse. But apparently they also made it work for guinea pigs, who really can't tell about their sound!
       
    19. DimLeb

      DimLeb Member

      Tinnitus Since:
      14/03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy Or Maybe Loud Music
      @Harder Calm, oh yeah you're probably right about the guinea pigs, I didn't have that in mind! Like everyone else, I don't know a lot more, so I'm trying to figure out anything I can...
       
    20. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      So I did have communication with the CEO, this is what he told me:

      - The majority (anywhere between 60-80%) of tinnitus sufferers have somatic tinnitus and actually a lot of people don’t realize they have somatic tinnitus until they are shown or instructed how to do the proper somatic maneuvers.
      - He stated that this device should be safe and effective for a wide range of tinnitus sufferers.
       
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    21. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      Has the CEO mentioned a hypothetical timeline for when it might be publicly available?
       
    22. Bambam0
      Cool

      Bambam0 Member Podcast Patron Benefactor

      Tinnitus Since:
      2/2018
      Cause of Tinnitus:
      Drums/Guns/Motorcycles
      Yum Yum. Did he talk about launch date at all?
       
    23. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      I did not ask. But I would assume they want to launch soon seeing Lenire is close to being launched in the US. Competition is good.

      His email address is a couple of posts above. Ask him yourself if you want. The worst that can happen is he doesn't email you back. He wrote back to me in like 10 minutes.
       
    24. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      If it does turn out to be an improvement or enhancement over Lenire, if it were me, I'd enter into discussions on a technology licensing agreement. Neuromod have the manufacturing and logistics capability, audiologist network (soon to become global), brand recognition, solid financial backing, etc.

      It'd take a new company years to get to that scale and Neuromod isn't standing still on the technology side either and I do think we'll see their offering continue to evolve/improve.

      From a UoM standpoint, they get to market quicker and with much lower risk.

      Of course, neither party might have interest for different reasons, but still...
       
    25. Paul1980

      Paul1980 Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Music, prescription drugs
      What if the first approach is at least 10-20 years away? If the problem is indeed that your auditory system is making up for sounds it can no longer perceive, and these devices stimulate those signals, why can't the 2nd option be a viable approach? Of course I would rather swallow a pill, if it works. I am keeping an open mind.
       
    26. F-u-T

      F-u-T Member Podcast Patron Benefactor

      Location:
      AZ USA
      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Acoustic Trama
      I believe the first approach is how Shore’s device works. It’s in all reality 1-3 years before available for consumers.
       
    27. Padraigh Griffin

      Padraigh Griffin Member Podcast Patron Benefactor

      Tinnitus Since:
      05/2020
      Cause of Tinnitus:
      Unknown/Stress
      I think this is a completely logical move for both parties, particularly if the Michigan product is superior to Lenire. Completes the marketing mix.
       
    28. Mathew Gould

      Mathew Gould Member Benefactor

      Tinnitus Since:
      6/2017
      Cause of Tinnitus:
      Neck/Jaw misalignment
      Did Susan Shore's group post the data for the trial they did with the few hundred people?
       
    29. Bambam0
      Cool

      Bambam0 Member Podcast Patron Benefactor

      Tinnitus Since:
      2/2018
      Cause of Tinnitus:
      Drums/Guns/Motorcycles
      It's probably good to temper expectations but I bet it's on the shorter end of that time frame. Typically when studies end is also when funding ends - meaning they need to have commercialization funding secured well ahead of time. Given the study is supposedly ending May/2022 it makes sense for them to ramp up fundraising right now.

      What I don't know is how you raise funding off of a study that isn't completed. Like how do they know this is worth their time? Is it based off of first trial? Do they get some sort of mid-pivotal trial update? Maybe an early cohort completed the study already and the news was good?
       
    30. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
      I wonder how many people on this forum would help raise finance for the commercialisation of Susan Shore's device, if required, and what sum we would get to.

      I am sure that previous/current funders will be following the trial closely and would be ready to make further investment if the outcome were positive.

      I didn't realise the trial goes to May 2022. I was hoping they'd get the results really soon and move forward. Like my audiologist told me: "You have to be patient".
       
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